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Conserved domains on  [gi|25148409|ref|NP_741633|]
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Intraflagellar transport protein 52 C-terminal domain-containing protein [Caenorhabditis elegans]

Protein Classification

motility-associated ABC transporter substrate-binding family protein( domain architecture ID 581101)

motility-associated ABC transporter substrate-binding family protein such as the human intraflagellar transport protein Ift52, which is involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IFT52_CTD cd23683
C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 ...
 362-428 1.82e-20

C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 is involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance, and functioning of primary cilia. It is required for the anterograde transport of IFT88. IFT52 is a component of the IFT complex B that consists of a 9-subunit salt-stable core and several peripheral subunits. The model corresponds to the C-terminal domain of IFT52, which is responsible for binding to the C-terminal domain of IFT46.


:

Pssm-ID: 467897  Cd Length: 69  Bit Score: 84.90  E-value: 1.82e-20
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 25148409 362 FDLDEQFSSPEIQLSQLANR-SEEEDLIFFIEKAGEITGISAELTRSERTPKKIIELAVSKLMLFKRS 428
Cdd:cd23683   1 FDLDEAFASERVRLAQLTNKcTADDDLEYYIRECGDILGITSKLPEDERSAKHILEHVFRQLVEFKKL 68
GldG super family cl43813
ABC-type uncharacterized transport system involved in gliding motility, auxiliary component ...
 27-142 1.98e-09

ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility];


The actual alignment was detected with superfamily member COG3225:

Pssm-ID: 442458 [Multi-domain]  Cd Length: 494  Bit Score: 59.56  E-value: 1.98e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148409  27 QISLISGFRGVARHLKSVLtveINTEPINLNG----LEDVRMLIIPQPKTSFGTGEIEAIWKFVEEGGSLMIL------- 95
Cdd:COG3225 179 ELSLDRDLSDFVEALEEKG---YDVAPLNLDSaaeiPEDADVLVIAGPTKAFSEEEKYALDQYLMRGGKLLWLldpvnae 255

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 25148409  96 --SGEGGERQSLNEMIAKYGITVNKDSVIrtvflkyfDPKEALVANGVI 142
Cdd:COG3225 256 ldSLAFPRDLGLDDLLFKYGVRLNPGLVV--------DLSSAGIPLGYL 296
 
Name Accession Description Interval E-value
IFT52_CTD cd23683
C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 ...
 362-428 1.82e-20

C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 is involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance, and functioning of primary cilia. It is required for the anterograde transport of IFT88. IFT52 is a component of the IFT complex B that consists of a 9-subunit salt-stable core and several peripheral subunits. The model corresponds to the C-terminal domain of IFT52, which is responsible for binding to the C-terminal domain of IFT46.


Pssm-ID: 467897  Cd Length: 69  Bit Score: 84.90  E-value: 1.82e-20
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 25148409 362 FDLDEQFSSPEIQLSQLANR-SEEEDLIFFIEKAGEITGISAELTRSERTPKKIIELAVSKLMLFKRS 428
Cdd:cd23683   1 FDLDEAFASERVRLAQLTNKcTADDDLEYYIRECGDILGITSKLPEDERSAKHILEHVFRQLVEFKKL 68
GldG COG3225
ABC-type uncharacterized transport system involved in gliding motility, auxiliary component ...
 27-142 1.98e-09

ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility];


Pssm-ID: 442458 [Multi-domain]  Cd Length: 494  Bit Score: 59.56  E-value: 1.98e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148409  27 QISLISGFRGVARHLKSVLtveINTEPINLNG----LEDVRMLIIPQPKTSFGTGEIEAIWKFVEEGGSLMIL------- 95
Cdd:COG3225 179 ELSLDRDLSDFVEALEEKG---YDVAPLNLDSaaeiPEDADVLVIAGPTKAFSEEEKYALDQYLMRGGKLLWLldpvnae 255

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 25148409  96 --SGEGGERQSLNEMIAKYGITVNKDSVIrtvflkyfDPKEALVANGVI 142
Cdd:COG3225 256 ldSLAFPRDLGLDDLLFKYGVRLNPGLVV--------DLSSAGIPLGYL 296
ABC_transp_aux pfam09822
ABC-type uncharacterized transport system; This domain is found in various eukaryotic and ...
 50-122 4.52e-05

ABC-type uncharacterized transport system; This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins.


Pssm-ID: 430853  Cd Length: 264  Bit Score: 44.95  E-value: 4.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148409    50 NTEPINLNGL----EDVRMLIIPQPKTSFGTGEIEAIWKFVEEGGSLMIL-------------SGEGGERQSLNEMIAKY 112
Cdd:pfam09822 175 DVEEVDLDSVailpEDFDVLVIAKPTKDLSEEEKYALDQFLMNGGKLLWFvdpvavdldslggALAAPRDLNLDDLLFKY 254

                          90
                  ....*....|
gi 25148409   113 GITVNKDSVI 122
Cdd:pfam09822 255 GVRINPDLVL 264
 
Name Accession Description Interval E-value
IFT52_CTD cd23683
C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 ...
 362-428 1.82e-20

C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 is involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance, and functioning of primary cilia. It is required for the anterograde transport of IFT88. IFT52 is a component of the IFT complex B that consists of a 9-subunit salt-stable core and several peripheral subunits. The model corresponds to the C-terminal domain of IFT52, which is responsible for binding to the C-terminal domain of IFT46.


Pssm-ID: 467897  Cd Length: 69  Bit Score: 84.90  E-value: 1.82e-20
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 25148409 362 FDLDEQFSSPEIQLSQLANR-SEEEDLIFFIEKAGEITGISAELTRSERTPKKIIELAVSKLMLFKRS 428
Cdd:cd23683   1 FDLDEAFASERVRLAQLTNKcTADDDLEYYIRECGDILGITSKLPEDERSAKHILEHVFRQLVEFKKL 68
GldG COG3225
ABC-type uncharacterized transport system involved in gliding motility, auxiliary component ...
 27-142 1.98e-09

ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility];


Pssm-ID: 442458 [Multi-domain]  Cd Length: 494  Bit Score: 59.56  E-value: 1.98e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148409  27 QISLISGFRGVARHLKSVLtveINTEPINLNG----LEDVRMLIIPQPKTSFGTGEIEAIWKFVEEGGSLMIL------- 95
Cdd:COG3225 179 ELSLDRDLSDFVEALEEKG---YDVAPLNLDSaaeiPEDADVLVIAGPTKAFSEEEKYALDQYLMRGGKLLWLldpvnae 255

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 25148409  96 --SGEGGERQSLNEMIAKYGITVNKDSVIrtvflkyfDPKEALVANGVI 142
Cdd:COG3225 256 ldSLAFPRDLGLDDLLFKYGVRLNPGLVV--------DLSSAGIPLGYL 296
ABC_transp_aux pfam09822
ABC-type uncharacterized transport system; This domain is found in various eukaryotic and ...
 50-122 4.52e-05

ABC-type uncharacterized transport system; This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins.


Pssm-ID: 430853  Cd Length: 264  Bit Score: 44.95  E-value: 4.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148409    50 NTEPINLNGL----EDVRMLIIPQPKTSFGTGEIEAIWKFVEEGGSLMIL-------------SGEGGERQSLNEMIAKY 112
Cdd:pfam09822 175 DVEEVDLDSVailpEDFDVLVIAKPTKDLSEEEKYALDQFLMNGGKLLWFvdpvavdldslggALAAPRDLNLDDLLFKY 254

                          90
                  ....*....|
gi 25148409   113 GITVNKDSVI 122
Cdd:pfam09822 255 GVRINPDLVL 264
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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