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Conserved domains on  [gi|31981999|ref|NP_742162|]
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intraflagellar transport protein 52 homolog [Mus musculus]

Protein Classification

motility-associated ABC transporter substrate-binding family protein( domain architecture ID 581101)

motility-associated ABC transporter substrate-binding family protein such as the human intraflagellar transport protein Ift52, which is involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IFT52_CTD cd23683
C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 ...
 355-422 1.73e-38

C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 is involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance, and functioning of primary cilia. It is required for the anterograde transport of IFT88. IFT52 is a component of the IFT complex B that consists of a 9-subunit salt-stable core and several peripheral subunits. The model corresponds to the C-terminal domain of IFT52, which is responsible for binding to the C-terminal domain of IFT46.


:

Pssm-ID: 467897  Cd Length: 69  Bit Score: 133.05  E-value: 1.73e-38
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31981999 355 FDLDETFSSEKARLAQITNKCT-DEDLEFYVRKCGDILGVTSKLPKDQQDAKHILEHIFFQVVEFKKLN 422
Cdd:cd23683   1 FDLDEAFASERVRLAQLTNKCTaDDDLEYYIRECGDILGITSKLPEDERSAKHILEHVFRQLVEFKKLN 69
ABC_transp_aux super family cl23805
ABC-type uncharacterized transport system; This domain is found in various eukaryotic and ...
 28-116 1.30e-06

ABC-type uncharacterized transport system; This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins.


The actual alignment was detected with superfamily member pfam09822:

Pssm-ID: 451555  Cd Length: 264  Bit Score: 49.57  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981999    28 LQKRLRSNWKIQSLkdEITSEKLI--GVKLWITAGPREKFTAAEFEVLKKYLDSGGDILVM----------LGEGGESRF 95
Cdd:pfam09822 166 FLEELSENYDVEEV--DLDSVAILpeDFDVLVIAKPTKDLSEEEKYALDQFLMNGGKLLWFvdpvavdldsLGGALAAPR 243

                          90       100
                  ....*....|....*....|.
gi 31981999    96 DTNINFLLEEYGIMVNNDAVV 116
Cdd:pfam09822 244 DLNLDDLLFKYGVRINPDLVL 264
 
Name Accession Description Interval E-value
IFT52_CTD cd23683
C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 ...
 355-422 1.73e-38

C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 is involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance, and functioning of primary cilia. It is required for the anterograde transport of IFT88. IFT52 is a component of the IFT complex B that consists of a 9-subunit salt-stable core and several peripheral subunits. The model corresponds to the C-terminal domain of IFT52, which is responsible for binding to the C-terminal domain of IFT46.


Pssm-ID: 467897  Cd Length: 69  Bit Score: 133.05  E-value: 1.73e-38
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31981999 355 FDLDETFSSEKARLAQITNKCT-DEDLEFYVRKCGDILGVTSKLPKDQQDAKHILEHIFFQVVEFKKLN 422
Cdd:cd23683   1 FDLDEAFASERVRLAQLTNKCTaDDDLEYYIRECGDILGITSKLPEDERSAKHILEHVFRQLVEFKKLN 69
ABC_transp_aux pfam09822
ABC-type uncharacterized transport system; This domain is found in various eukaryotic and ...
 28-116 1.30e-06

ABC-type uncharacterized transport system; This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins.


Pssm-ID: 430853  Cd Length: 264  Bit Score: 49.57  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981999    28 LQKRLRSNWKIQSLkdEITSEKLI--GVKLWITAGPREKFTAAEFEVLKKYLDSGGDILVM----------LGEGGESRF 95
Cdd:pfam09822 166 FLEELSENYDVEEV--DLDSVAILpeDFDVLVIAKPTKDLSEEEKYALDQFLMNGGKLLWFvdpvavdldsLGGALAAPR 243

                          90       100
                  ....*....|....*....|.
gi 31981999    96 DTNINFLLEEYGIMVNNDAVV 116
Cdd:pfam09822 244 DLNLDDLLFKYGVRINPDLVL 264
 
Name Accession Description Interval E-value
IFT52_CTD cd23683
C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 ...
 355-422 1.73e-38

C-terminal domain of intraflagellar transport protein 52 (IFT52) and similar proteins; IFT52 is involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance, and functioning of primary cilia. It is required for the anterograde transport of IFT88. IFT52 is a component of the IFT complex B that consists of a 9-subunit salt-stable core and several peripheral subunits. The model corresponds to the C-terminal domain of IFT52, which is responsible for binding to the C-terminal domain of IFT46.


Pssm-ID: 467897  Cd Length: 69  Bit Score: 133.05  E-value: 1.73e-38
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31981999 355 FDLDETFSSEKARLAQITNKCT-DEDLEFYVRKCGDILGVTSKLPKDQQDAKHILEHIFFQVVEFKKLN 422
Cdd:cd23683   1 FDLDEAFASERVRLAQLTNKCTaDDDLEYYIRECGDILGITSKLPEDERSAKHILEHVFRQLVEFKKLN 69
ABC_transp_aux pfam09822
ABC-type uncharacterized transport system; This domain is found in various eukaryotic and ...
 28-116 1.30e-06

ABC-type uncharacterized transport system; This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins.


Pssm-ID: 430853  Cd Length: 264  Bit Score: 49.57  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31981999    28 LQKRLRSNWKIQSLkdEITSEKLI--GVKLWITAGPREKFTAAEFEVLKKYLDSGGDILVM----------LGEGGESRF 95
Cdd:pfam09822 166 FLEELSENYDVEEV--DLDSVAILpeDFDVLVIAKPTKDLSEEEKYALDQFLMNGGKLLWFvdpvavdldsLGGALAAPR 243

                          90       100
                  ....*....|....*....|.
gi 31981999    96 DTNINFLLEEYGIMVNNDAVV 116
Cdd:pfam09822 244 DLNLDDLLFKYGVRINPDLVL 264
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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