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Conserved domains on  [gi|27369599|ref|NP_766032|]
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thrombospondin type-1 domain-containing protein 4 isoform b precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 53-168 6.35e-35

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 128.08  E-value: 6.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369599    53 VVSGVFKHALtSLGYHRVVEIPQGATKINITEMHKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpnevS 131
Cdd:pfam05986   1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 27369599   132 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 168
Cdd:pfam05986  76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 496-552 5.18e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 5.18e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 27369599   496 WFTGSWSQCSIECGSGTQQREVICVRKnaDTFEVLDPYECSFLEKPPSQQACHLKPC 552
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 320-376 5.39e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 5.39e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 27369599   320 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRslTVQPYRCQHLEKPETTSTCQLKIC 376
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 556-607 6.35e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 6.35e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 27369599   556 WFSTEWSMCSKSCQGGFRVREVRC---LSDDMTPSSLCDPQLKPEERESCNTQDC 607
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 379-433 8.18e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.46  E-value: 8.18e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 27369599   379 WQIrTDWTSCSVPCGVGQRTRDVKCV-SNIGDMVHDEECNMKLRPNDIENCDMGPC 433
Cdd:pfam19030   1 WVA-GPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 615-645 1.41e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


:

Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.39  E-value: 1.41e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 27369599   615 CKDKYYNCNVVVQARLCVYNYYKTACCASCT 645
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 267-316 1.85e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.61  E-value: 1.85e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 27369599   267 TECSTTCGKGSQYPIFRCVHRNTHEEVPESYCDSSMKPtPEEEPCNLFPC 316
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 437-490 2.52e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.75  E-value: 2.52e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 27369599   437 WFLTEWSErCSAECGAGVRTRSVVCMTNHVSSL-PLEGCGNN-RPVEATPCDNGPC 490
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQkKPPETQSCNLKPC 55
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 53-168 6.35e-35

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 128.08  E-value: 6.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369599    53 VVSGVFKHALtSLGYHRVVEIPQGATKINITEMHKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpnevS 131
Cdd:pfam05986   1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 27369599   132 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 168
Cdd:pfam05986  76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 496-552 5.18e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 5.18e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 27369599   496 WFTGSWSQCSIECGSGTQQREVICVRKnaDTFEVLDPYECSFLEKPPSQQACHLKPC 552
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 320-376 5.39e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 5.39e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 27369599   320 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRslTVQPYRCQHLEKPETTSTCQLKIC 376
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 556-607 6.35e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 6.35e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 27369599   556 WFSTEWSMCSKSCQGGFRVREVRC---LSDDMTPSSLCDPQLKPEERESCNTQDC 607
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 379-433 8.18e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.46  E-value: 8.18e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 27369599   379 WQIrTDWTSCSVPCGVGQRTRDVKCV-SNIGDMVHDEECNMKLRPNDIENCDMGPC 433
Cdd:pfam19030   1 WVA-GPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 615-645 1.41e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.39  E-value: 1.41e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 27369599   615 CKDKYYNCNVVVQARLCVYNYYKTACCASCT 645
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 267-316 1.85e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.61  E-value: 1.85e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 27369599   267 TECSTTCGKGSQYPIFRCVHRNTHEEVPESYCDSSMKPtPEEEPCNLFPC 316
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 437-490 2.52e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.75  E-value: 2.52e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 27369599   437 WFLTEWSErCSAECGAGVRTRSVVCMTNHVSSL-PLEGCGNN-RPVEATPCDNGPC 490
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQkKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 559-607 5.31e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.03  E-value: 5.31e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 27369599    559 TEWSMCSKSCQGGFRVREVRCLSDDMT-PSSLCDPQLKpeERESCNTQDC 607
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQnGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 376-433 1.34e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.88  E-value: 1.34e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 27369599    376 CSEWqirTDWTSCSVPCGVGQRTRDVKCVSNIGDmVHDEECNMKLRpnDIENCDMGPC 433
Cdd:smart00209   1 WSEW---SEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 320-343 3.51e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 3.51e-04
                           10        20
                   ....*....|....*....|....
gi 27369599    320 WDIGEWSECSKTCGLGMQHRQVLC 343
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSC 25
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 496-552 4.51e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.64  E-value: 4.51e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 27369599    496 WFTGSWSQCSIECGSGTQQREVICVRKNADtfevLDPYECSflEKPPSQQACHLKPC 552
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ----NGGGPCT--GEDVETRACNEQPC 52
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 53-168 6.35e-35

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 128.08  E-value: 6.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369599    53 VVSGVFKHALtSLGYHRVVEIPQGATKINITEMHKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpnevS 131
Cdd:pfam05986   1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 27369599   132 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 168
Cdd:pfam05986  76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 496-552 5.18e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 5.18e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 27369599   496 WFTGSWSQCSIECGSGTQQREVICVRKnaDTFEVLDPYECSFLEKPPSQQACHLKPC 552
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 320-376 5.39e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 5.39e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 27369599   320 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRslTVQPYRCQHLEKPETTSTCQLKIC 376
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 556-607 6.35e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.85  E-value: 6.35e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 27369599   556 WFSTEWSMCSKSCQGGFRVREVRC---LSDDMTPSSLCDPQLKPEERESCNTQDC 607
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 379-433 8.18e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.46  E-value: 8.18e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 27369599   379 WQIrTDWTSCSVPCGVGQRTRDVKCV-SNIGDMVHDEECNMKLRPNDIENCDMGPC 433
Cdd:pfam19030   1 WVA-GPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 615-645 1.41e-10

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 56.39  E-value: 1.41e-10
                          10        20        30
                  ....*....|....*....|....*....|.
gi 27369599   615 CKDKYYNCNVVVQARLCVYNYYKTACCASCT 645
Cdd:pfam08686   1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 267-316 1.85e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.61  E-value: 1.85e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 27369599   267 TECSTTCGKGSQYPIFRCVHRNTHEEVPESYCDSSMKPtPEEEPCNLFPC 316
Cdd:pfam19030   7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 437-490 2.52e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.75  E-value: 2.52e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 27369599   437 WFLTEWSErCSAECGAGVRTRSVVCMTNHVSSL-PLEGCGNN-RPVEATPCDNGPC 490
Cdd:pfam19030   1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQkKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 559-607 5.31e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.03  E-value: 5.31e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 27369599    559 TEWSMCSKSCQGGFRVREVRCLSDDMT-PSSLCDPQLKpeERESCNTQDC 607
Cdd:smart00209   5 SEWSPCSVTCGGGVQTRTRSCCSPPPQnGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 376-433 1.34e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.88  E-value: 1.34e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 27369599    376 CSEWqirTDWTSCSVPCGVGQRTRDVKCVSNIGDmVHDEECNMKLRpnDIENCDMGPC 433
Cdd:smart00209   1 WSEW---SEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPCTGEDV--ETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
377-433 3.28e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 38.94  E-value: 3.28e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 27369599   377 SEWqirTDWTSCSVPCGVGQRTRDVKCVSNIGDmvhDEECNMKLRPNDIenCDMGPC 433
Cdd:pfam00090   1 SPW---SPWSPCSVTCGKGIQVRQRTCKSPFPG---GEPCTGDDIETQA--CKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 320-343 3.51e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 3.51e-04
                           10        20
                   ....*....|....*....|....
gi 27369599    320 WDIGEWSECSKTCGLGMQHRQVLC 343
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSC 25
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 323-356 8.79e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.64  E-value: 8.79e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 27369599   323 GEWSECSKTCGLGMQHRQvlcrqvyanRSLTVQP 356
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRT---------RTVIVEP 31
TSP_1 pfam00090
Thrombospondin type 1 domain;
323-343 1.33e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.01  E-value: 1.33e-03
                          10        20
                  ....*....|....*....|.
gi 27369599   323 GEWSECSKTCGLGMQHRQVLC 343
Cdd:pfam00090   4 SPWSPCSVTCGKGIQVRQRTC 24
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 496-552 4.51e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.64  E-value: 4.51e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 27369599    496 WFTGSWSQCSIECGSGTQQREVICVRKNADtfevLDPYECSflEKPPSQQACHLKPC 552
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ----NGGGPCT--GEDVETRACNEQPC 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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