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Conserved domains on  [gi|113865956|ref|NP_766074|]
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KRAB-zinc finger protein [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 2.71e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 2.71e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 113865956   12 LLAFKDVAVEFSQEEWGCLDSAQRSLYINVMLENYNNLVSV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-600 1.80e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 1.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 183 KPHQCGKCGKCFSTSSNLTVHQRIHTGEKPYKCNL--CDKSFSQSTTLKTHQRLHTGEKPYkcRECGMSFPYLSSLKVHQ 260
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 261 NLHPGAKPYKCKECDksftikSTLIKHQRNHtgekPYTCNVCDRSFRQCANLKTHQRlhtgekpykckecgKAFTQSSSL 340
Cdd:COG5048  110 LSSSSSNSNDNNLLS------SHSLPPSSRD----PQLPDLLSISNLRNNPLPGNNS--------------SSVNTPQSN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 341 KKHLNLHTgkkpykcEECDKSFTEKSTLTTHKRIHTGKKPYKCNICGKSFNSCTNLKTHQTLHTGEKPYKCKECGKAFPY 420
Cdd:COG5048  166 SLHPPLPA-------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 421 MSSLKIHQNLHPGEKPYKCKECDKSFTLKSSLRTHQIIHTGE-------KPYKCNICGKSFNQCTNLKTHQR--LHTGE- 490
Cdd:COG5048  239 SLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 491 -KPYKCKE--CGKSFHYWSSLKSHQNLHSGEKPYKCK--ECDKSFTEKST------LIKHQRIHTGKKLYKC-NICDKSF 558
Cdd:COG5048  319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLsNSCIRNF 398

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 113865956 559 TWCASLKTHKKFHTGEKP--YKCRKCGKSFPQLSTLKRHQKIHE 600
Cdd:COG5048  399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 2.71e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 2.71e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 113865956   12 LLAFKDVAVEFSQEEWGCLDSAQRSLYINVMLENYNNLVSV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-53 3.67e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 87.26  E-value: 3.67e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 113865956    13 LAFKDVAVEFSQEEWGCLDSAQRSLYINVMLENYNNLVSVE 53
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 8.55e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 8.55e-18
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 113865956  13 LAFKDVAVEFSQEEWGCLDSAQRSLYINVMLENYNNLVS 51
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-600 1.80e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 1.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 183 KPHQCGKCGKCFSTSSNLTVHQRIHTGEKPYKCNL--CDKSFSQSTTLKTHQRLHTGEKPYkcRECGMSFPYLSSLKVHQ 260
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 261 NLHPGAKPYKCKECDksftikSTLIKHQRNHtgekPYTCNVCDRSFRQCANLKTHQRlhtgekpykckecgKAFTQSSSL 340
Cdd:COG5048  110 LSSSSSNSNDNNLLS------SHSLPPSSRD----PQLPDLLSISNLRNNPLPGNNS--------------SSVNTPQSN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 341 KKHLNLHTgkkpykcEECDKSFTEKSTLTTHKRIHTGKKPYKCNICGKSFNSCTNLKTHQTLHTGEKPYKCKECGKAFPY 420
Cdd:COG5048  166 SLHPPLPA-------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 421 MSSLKIHQNLHPGEKPYKCKECDKSFTLKSSLRTHQIIHTGE-------KPYKCNICGKSFNQCTNLKTHQR--LHTGE- 490
Cdd:COG5048  239 SLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 491 -KPYKCKE--CGKSFHYWSSLKSHQNLHSGEKPYKCK--ECDKSFTEKST------LIKHQRIHTGKKLYKC-NICDKSF 558
Cdd:COG5048  319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLsNSCIRNF 398

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 113865956 559 TWCASLKTHKKFHTGEKP--YKCRKCGKSFPQLSTLKRHQKIHE 600
Cdd:COG5048  399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 351-403 2.34e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.23  E-value: 2.34e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 113865956 351 KPYkCEECDKSFTEKSTLTTHKRIHTgkkpYKCNICGKSFNSCTNLKTH-QTLH 403
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
311-336 3.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.28e-04
                          10        20
                  ....*....|....*....|....*.
gi 113865956  311 NLKTHQRLHTGEKPYKCKECGKAFTQ 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-52 2.71e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 2.71e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 113865956   12 LLAFKDVAVEFSQEEWGCLDSAQRSLYINVMLENYNNLVSV 52
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-53 3.67e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 87.26  E-value: 3.67e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 113865956    13 LAFKDVAVEFSQEEWGCLDSAQRSLYINVMLENYNNLVSVE 53
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 8.55e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.82  E-value: 8.55e-18
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 113865956  13 LAFKDVAVEFSQEEWGCLDSAQRSLYINVMLENYNNLVS 51
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-600 1.80e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 1.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 183 KPHQCGKCGKCFSTSSNLTVHQRIHTGEKPYKCNL--CDKSFSQSTTLKTHQRLHTGEKPYkcRECGMSFPYLSSLKVHQ 260
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 261 NLHPGAKPYKCKECDksftikSTLIKHQRNHtgekPYTCNVCDRSFRQCANLKTHQRlhtgekpykckecgKAFTQSSSL 340
Cdd:COG5048  110 LSSSSSNSNDNNLLS------SHSLPPSSRD----PQLPDLLSISNLRNNPLPGNNS--------------SSVNTPQSN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 341 KKHLNLHTgkkpykcEECDKSFTEKSTLTTHKRIHTGKKPYKCNICGKSFNSCTNLKTHQTLHTGEKPYKCKECGKAFPY 420
Cdd:COG5048  166 SLHPPLPA-------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 421 MSSLKIHQNLHPGEKPYKCKECDKSFTLKSSLRTHQIIHTGE-------KPYKCNICGKSFNQCTNLKTHQR--LHTGE- 490
Cdd:COG5048  239 SLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 491 -KPYKCKE--CGKSFHYWSSLKSHQNLHSGEKPYKCK--ECDKSFTEKST------LIKHQRIHTGKKLYKC-NICDKSF 558
Cdd:COG5048  319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLsNSCIRNF 398

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 113865956 559 TWCASLKTHKKFHTGEKP--YKCRKCGKSFPQLSTLKRHQKIHE 600
Cdd:COG5048  399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
119-511 5.58e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 5.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 119 RHRSTHTGEEPYESKHCEKTFSLRSNISQDQRLYTAKKEHRQEEydehfSSTHRLMQQINYIGEKPHQCGKCGKCFSTSS 198
Cdd:COG5048   51 RHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLN-----SKSLPLSNSKASSSSLSSSSSNSNDNNLLSS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 199 NLTVHQRIHTGEKP--YKCNLCDKSFSQSTTLKTHQRLHTGEK-PYKCRECGMSFPYLSSLKVHQNLHPGAKPYKCKECD 275
Cdd:COG5048  126 HSLPPSSRDPQLPDllSISNLRNNPLPGNNSSSVNTPQSNSLHpPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPL 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 276 KSFTIKSTLIKHQRNHTGEKPYTCNVCDRSFRQCANLKTHQRLHTGEKPYKCKECGKAFTQSSSLKKHLNLHTG------ 349
Cdd:COG5048  206 SSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekg 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 350 -KKPYKCEECDKSFTEKSTLTTHKR--IHTGK--KPYKC--NICGKSFNSCTNLKTHQTLHTGEKPYKCKECGKAFPYMS 422
Cdd:COG5048  286 fSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSP 365

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 423 SLKI----HQNLHPGEKPYKCKECDKSFTLKSSLRTH-------QIIHTGEKPYKCNICGKSFNQCTNLKTHQRLHTGEK 491
Cdd:COG5048  366 LLNNeppqSLQQYKDLKNDKKSETLSNSCIRNFKRDSnlslhiiTHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHA 445

                        410       420
                 ....*....|....*....|
gi 113865956 492 PYKCkECGKSFHYWSSLKSH 511
Cdd:COG5048  446 PLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
267-634 1.72e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 267 KPYKCKECDKSFTIKSTLIKHQRNHTGEKPYTCNV--CDRSFRQCANLKTHQRLHTGEKPYKC-KECGKAFTQSSSLKKH 343
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 344 LNLHTGKKPYKCEECDKSFTEKSTLT--THKRIHTGKKPYKCNICGKSFNSCTNLKTHQTLHTGEKPYKCKEcgkafpym 421
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSN-------- 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 422 SSLKIHQNLHPGEKPYKCKECDKSFTLKSSLRTHQIIHTGEKPYKCNICGKSFNQCTNLKTHQRLHTGEKPYKCKECGKS 501
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 502 FHYWSSLKSHQNLHSGE-------KPYKCKECDKSFTEKSTLIKHQR--IHTGKKLYKC----NICDKSFTWCASLKTHK 568
Cdd:COG5048  264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFscpySLCGKLFSRNDALKRHI 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 569 KFHTGEKPYKC--RKCGKSFPQLSTLKRHQKIHEDKGHTGEKL--------------------------------YKCND 614
Cdd:COG5048  344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetlsnscirnfkrdsnlslhiithlsfrpynCKNPP 423

                        410       420
                 ....*....|....*....|
gi 113865956 615 CDRSYSYHSSFRRHQKIHSS 634
Cdd:COG5048  424 CSKSFNRHYNLIPHKKIHTN 443
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 321-401 4.61e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 4.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 321 GEKPYKCK--ECGKAFTQSSSLKKHLnLHTgkkpykceECDKSFTEKSTLTTHKRIHTGKKPYKCNICGKSFNSCTNLKT 398
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 113865956 399 HQT 401
Cdd:COG5189  417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 517-597 4.78e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 4.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 517 GEKPYKCK--ECDKSFTEKSTLiKHQRIHTGkklykcniCDKSFTWCASLKTHKKFHTGEKPYKCRKCGKSFPQLSTLKR 594
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 113865956 595 HQK 597
Cdd:COG5189  417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 405-483 1.76e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 405 GEKPYKCK--ECGKAFPYMSSLKIHQnLHpgekpykcKECDKSFTLKSSLRTHQIIHTGEKPYKCNICGKSFNQCTNLKT 482
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 113865956 483 H 483
Cdd:COG5189  417 H 417
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 351-403 2.34e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.23  E-value: 2.34e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 113865956 351 KPYkCEECDKSFTEKSTLTTHKRIHTgkkpYKCNICGKSFNSCTNLKTH-QTLH 403
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 519-567 2.61e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.85  E-value: 2.61e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 113865956 519 KPYkCKECDKSFTEKSTLIKHQRIHTgkklYKCNICDKSFTWCASLKTH 567
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
311-336 3.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.28e-04
                          10        20
                  ....*....|....*....|....*.
gi 113865956  311 NLKTHQRLHTGEKPYKCKECGKAFTQ 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
479-502 7.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.40e-04
                          10        20
                  ....*....|....*....|....
gi 113865956  479 NLKTHQRLHTGEKPYKCKECGKSF 502
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
350-634 7.69e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 7.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 350 KKPYKCEECDKSFTEKSTLTTHKRIHTGKKPYKCN--ICGKSFNSCTNLKTHQTLHTGEKPYKCK--------------- 412
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssl 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 413 -ECGKAFPYMSSL--------KIHQNLHPGEKPYKCKECDKSFTLKSSLRTHQIIHTgEKPYKCNICGKSFNQCTNLKTH 483
Cdd:COG5048  111 sSSSSNSNDNNLLsshslppsSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSL-HPPLPANSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 484 QRLHTGEKPYKCKECGKSFHYWSSLKSHQNLHSGEKPYKCKECDKSFTEKSTLIKHQRIHTGKKLYKCNICDKSFTWCAS 563
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 113865956 564 LKTHKKFHTGE-------KPYKCRKCGKSFPQLSTLKRHQKIHEDKGHTGEKLYKC-NDCDRSYSYHSSFRRHQKIHSS 634
Cdd:COG5048  270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPySLCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
199-224 1.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 113865956  199 NLTVHQRIHTGEKPYKCNLCDKSFSQ 224
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 349-427 1.72e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 349 GKKPYKCE--ECDKSFTEKSTLTTHKrihtgkkpyKCNICGKSFNSCTNLKTHQTLHTGEKPYKCKECGKAFPYMSSLKI 426
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 113865956 427 H 427
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
451-476 2.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 113865956  451 SLRTHQIIHTGEKPYKCNICGKSFNQ 476
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 209-292 2.16e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 209 GEKPYKCNL--CDKSFSQSTTLKTHqRLHtGEKPYKCRECGMSFPylsslkvHQNLHPGAKPYKCKECDKSFTIKSTLiK 286
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLH-GHQNQKLHENPSPEK-------MNIFSAKDKPYRCEVCDKRYKNLNGL-K 415


                 ....*.
gi 113865956 287 HQRNHT 292
Cdd:COG5189  416 YHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
563-586 2.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.55e-03
                          10        20
                  ....*....|....*....|....
gi 113865956  563 SLKTHKKFHTGEKPYKCRKCGKSF 586
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-392 3.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.26e-03
                          10        20
                  ....*....|....*....|....*
gi 113865956  368 LTTHKRIHTGKKPYKCNICGKSFNS 392
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 489-572 3.66e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 489 GEKPYKCK--ECGKSFHYWSSLKSHQnLHSgekpykckECDKSFTEKSTLIKHQRIHTGKKLYKCNICDKSFTWCASLKT 566
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 113865956 567 HKKFHT 572
Cdd:COG5189  417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
395-418 4.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.34e-03
                          10        20
                  ....*....|....*....|....
gi 113865956  395 NLKTHQTLHTGEKPYKCKECGKAF 418
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
339-363 6.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.24e-03
                          10        20
                  ....*....|....*....|....*
gi 113865956  339 SLKKHLNLHTGKKPYKCEECDKSFT 363
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 435-487 6.30e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 6.30e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 113865956 435 KPYkCKECDKSFTLKSSLrthqIIHTGEKPYKCNICGKSFNQCTNLKTH-QRLH 487
Cdd:cd20908    1 KPW-CYYCDREFDDEKIL----IQHQKAKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
228-250 7.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.16e-03
                          10        20
                  ....*....|....*....|...
gi 113865956  228 LKTHQRLHTGEKPYKCRECGMSF 250
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
507-531 8.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.80e-03
                          10        20
                  ....*....|....*....|....*
gi 113865956  507 SLKSHQNLHSGEKPYKCKECDKSFT 531
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 433-511 9.84e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 9.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 433 GEKPYKCK--ECDKSFTLKSSLRTHQiihtgekpyKCNICGKSFNQCTNLKTHQRLHTGEKPYKCKECGKSFHYWSSLKS 510
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 113865956 511 H 511
Cdd:COG5189  417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 265-343 9.93e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 9.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113865956 265 GAKPYKCK--ECDKSFTIKSTLiKHQRNHTGEKPYTCNVCDRsfrqcanlKTHQRLHTGEKPYKCKECGKAFTQSSSLKK 342
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 113865956 343 H 343
Cdd:COG5189  417 H 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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