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Conserved domains on  [gi|27369878|ref|NP_766203|]
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run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform b [Mus musculus]

Protein Classification

run domain Beclin-1-interacting and cysteine-rich domain-containing protein( domain architecture ID 17730331)

run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) is part of a Beclin-1-Vps34-containing autophagy complex; it negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process

CATH:  1.20.58.900
Gene Symbol:  RUBCN
Gene Ontology:  GO:1901981|GO:0006914|GO:0006897
PubMed:  11166556
SCOP:  4001476

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-RING_9 pfam13901
Putative zinc-RING and/or ribbon; This is a family of cysteine-rich proteins. Many members ...
 706-906 6.08e-104

Putative zinc-RING and/or ribbon; This is a family of cysteine-rich proteins. Many members also carry a pleckstrin-homology domain, pfam00169


:

Pssm-ID: 464030  Cd Length: 205  Bit Score: 321.49  E-value: 6.08e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   706 RYCEYLGKYFCQCCHENAQMVVPSRILRKWDFSKYYVSNFSKDLLLKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQL 785
Cdd:pfam13901   1 RLCDYTGKYYCSGCHWNDTSVIPARILHNWDFKKYPVSKFAKQLLDSIYSQPLLNLSDLNPSLYSKVKELAKVRELREQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   786 YHMKNMFKTCRLA--KELLDSFDVV-PGHLTEDLHLYSLSDLTATKKGELGPRLAELTRAGAAHVERCMLCQAKGFICEF 862
Cdd:pfam13901  81 KLLKDYLKTCRFAaeEELLKLFRLRpRHHLLEDSHLYSLQDLVDIKNGSLLPFLEELVQFAEKHVTNCELCQGKGFICEL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 27369878   863 CQNeEDVIFPFELHKCRTCEECKACYHKTCFKSGR--CPRCERLQA 906
Cdd:pfam13901 161 CNS-DDIIFPFDIDTTSRCEKCKAVFHKSCFRSGAspCPKCERLQK 205
RUN_RUBCN cd17686
RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing ...
 35-191 2.80e-69

RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) and similar proteins; RUBCN, also called rubicon, or beclin-1 associated RUN domain containing protein (Baron), is part of a Beclin-1-Vps34-containing autophagy complex. It negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. It is also an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion. This model contains the RUN domain of RUBCN.


:

Pssm-ID: 439048  Cd Length: 151  Bit Score: 226.77  E-value: 2.80e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878  35 TTVEGLVSANCPNVWSKYGGLERLCRDMQNILYHGLIHDQVCCRQADYWQFVKDIRWLSPHSALHVEKFISLHESDQSDT 114
Cdd:cd17686   1 STVEGLLLSRSSNVWSTYGGLQRLCRAVENILQHGLKEFQGLNKEIDDWEFVQGLRWLQPTLAPSIEQQSRSSPSESEVS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27369878 115 DsvseraVAELWLQHSLQCHCLSAQLRPLLGDRQYIRKFYTETAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASM 191
Cdd:cd17686  81 D------KGRLWLRQSLQQHCLSSQLQWLVSDKELLRKYYEDEAFLRQEGYATALLICLTAVELNQPSLLAQIDPSL 151
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 198-408 1.41e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   198 SPLLVTKS----QSLTALPGSTYTPPASYAQHSyfgSSSSLQSMPQSSHSSERRSTSFSLSGPSWQPQED---------- 263
Cdd:pfam05109 431 SPTLNTTGfaapNTTTGLPSSTHVPTNLTAPAS---TGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNgteskapdmt 507

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   264 ----------RECLSPAETQTTPAPLPSDSTLAQDSPLTAQEMSDSTLTSPLEASWVSSQNDSPSDVSEGPEYLAIGNPA 333
Cdd:pfam05109 508 sptsavttptPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPT 587

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   334 PH------GRTASCESHSSNGESSSSHLFSSSSSQKLESAASSLGDQEEGRQSQAGSVLRRSSFSEgQTAPVASGTKKSH 407
Cdd:pfam05109 588 PNatsptvGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISE-TLSPSTSDNSTSH 666


                  .
gi 27369878   408 I 408
Cdd:pfam05109 667 M 667
 
Name Accession Description Interval E-value
zf-RING_9 pfam13901
Putative zinc-RING and/or ribbon; This is a family of cysteine-rich proteins. Many members ...
 706-906 6.08e-104

Putative zinc-RING and/or ribbon; This is a family of cysteine-rich proteins. Many members also carry a pleckstrin-homology domain, pfam00169


Pssm-ID: 464030  Cd Length: 205  Bit Score: 321.49  E-value: 6.08e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   706 RYCEYLGKYFCQCCHENAQMVVPSRILRKWDFSKYYVSNFSKDLLLKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQL 785
Cdd:pfam13901   1 RLCDYTGKYYCSGCHWNDTSVIPARILHNWDFKKYPVSKFAKQLLDSIYSQPLLNLSDLNPSLYSKVKELAKVRELREQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   786 YHMKNMFKTCRLA--KELLDSFDVV-PGHLTEDLHLYSLSDLTATKKGELGPRLAELTRAGAAHVERCMLCQAKGFICEF 862
Cdd:pfam13901  81 KLLKDYLKTCRFAaeEELLKLFRLRpRHHLLEDSHLYSLQDLVDIKNGSLLPFLEELVQFAEKHVTNCELCQGKGFICEL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 27369878   863 CQNeEDVIFPFELHKCRTCEECKACYHKTCFKSGR--CPRCERLQA 906
Cdd:pfam13901 161 CNS-DDIIFPFDIDTTSRCEKCKAVFHKSCFRSGAspCPKCERLQK 205
RUN_RUBCN cd17686
RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing ...
 35-191 2.80e-69

RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) and similar proteins; RUBCN, also called rubicon, or beclin-1 associated RUN domain containing protein (Baron), is part of a Beclin-1-Vps34-containing autophagy complex. It negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. It is also an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion. This model contains the RUN domain of RUBCN.


Pssm-ID: 439048  Cd Length: 151  Bit Score: 226.77  E-value: 2.80e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878  35 TTVEGLVSANCPNVWSKYGGLERLCRDMQNILYHGLIHDQVCCRQADYWQFVKDIRWLSPHSALHVEKFISLHESDQSDT 114
Cdd:cd17686   1 STVEGLLLSRSSNVWSTYGGLQRLCRAVENILQHGLKEFQGLNKEIDDWEFVQGLRWLQPTLAPSIEQQSRSSPSESEVS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27369878 115 DsvseraVAELWLQHSLQCHCLSAQLRPLLGDRQYIRKFYTETAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASM 191
Cdd:cd17686  81 D------KGRLWLRQSLQQHCLSSQLQWLVSDKELLRKYYEDEAFLRQEGYATALLICLTAVELNQPSLLAQIDPSL 151
RUN smart00593
domain involved in Ras-like GTPase signaling;
123-183 8.15e-12

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 61.09  E-value: 8.15e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27369878    123 AELWLQHSLQCHCLSAQLRPLLGDRQYIRKFYTETAFLLSDAHVT---AMLQCLEAVEQNNPRL 183
Cdd:smart00593   1 FRAWIRLALNEKLLSSWLNLLLSDEELLSKYYEPWAFLRDPEEGEqllGLLVGLSALDFNLPVD 64
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 198-408 1.41e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   198 SPLLVTKS----QSLTALPGSTYTPPASYAQHSyfgSSSSLQSMPQSSHSSERRSTSFSLSGPSWQPQED---------- 263
Cdd:pfam05109 431 SPTLNTTGfaapNTTTGLPSSTHVPTNLTAPAS---TGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNgteskapdmt 507

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   264 ----------RECLSPAETQTTPAPLPSDSTLAQDSPLTAQEMSDSTLTSPLEASWVSSQNDSPSDVSEGPEYLAIGNPA 333
Cdd:pfam05109 508 sptsavttptPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPT 587

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   334 PH------GRTASCESHSSNGESSSSHLFSSSSSQKLESAASSLGDQEEGRQSQAGSVLRRSSFSEgQTAPVASGTKKSH 407
Cdd:pfam05109 588 PNatsptvGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISE-TLSPSTSDNSTSH 666


                  .
gi 27369878   408 I 408
Cdd:pfam05109 667 M 667
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 57-174 3.14e-03

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 38.80  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878    57 RLCRDMQNILYHGLIHDQVCC-------RQADYWQFVKDIRWLSPHSALHVEKFISLHESdqsdTDSVSERAVAELWLQH 129
Cdd:pfam02759   1 QLCAALEALLSHGLKRSSLLIlraagllPERSFWALLERVGKLVPPAEELLSSVQELEQI----HTPYSPDGRGRAWIRL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 27369878   130 SLQCHCLSAQLRPLLGDRQYIRKFYTETAFLLSDAHVTAMLQCLE 174
Cdd:pfam02759  77 ALNEKLLDQWLKLLLSNKELLSEYYEPWALLADPEFGEILLGLLV 121
 
Name Accession Description Interval E-value
zf-RING_9 pfam13901
Putative zinc-RING and/or ribbon; This is a family of cysteine-rich proteins. Many members ...
 706-906 6.08e-104

Putative zinc-RING and/or ribbon; This is a family of cysteine-rich proteins. Many members also carry a pleckstrin-homology domain, pfam00169


Pssm-ID: 464030  Cd Length: 205  Bit Score: 321.49  E-value: 6.08e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   706 RYCEYLGKYFCQCCHENAQMVVPSRILRKWDFSKYYVSNFSKDLLLKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQL 785
Cdd:pfam13901   1 RLCDYTGKYYCSGCHWNDTSVIPARILHNWDFKKYPVSKFAKQLLDSIYSQPLLNLSDLNPSLYSKVKELAKVRELREQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   786 YHMKNMFKTCRLA--KELLDSFDVV-PGHLTEDLHLYSLSDLTATKKGELGPRLAELTRAGAAHVERCMLCQAKGFICEF 862
Cdd:pfam13901  81 KLLKDYLKTCRFAaeEELLKLFRLRpRHHLLEDSHLYSLQDLVDIKNGSLLPFLEELVQFAEKHVTNCELCQGKGFICEL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 27369878   863 CQNeEDVIFPFELHKCRTCEECKACYHKTCFKSGR--CPRCERLQA 906
Cdd:pfam13901 161 CNS-DDIIFPFDIDTTSRCEKCKAVFHKSCFRSGAspCPKCERLQK 205
RUN_RUBCN cd17686
RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing ...
 35-191 2.80e-69

RUN domain found in Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) and similar proteins; RUBCN, also called rubicon, or beclin-1 associated RUN domain containing protein (Baron), is part of a Beclin-1-Vps34-containing autophagy complex. It negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. It is also an important negative regulator of the innate immune response, enhances viral replication and may play a role in viral immune evasion. This model contains the RUN domain of RUBCN.


Pssm-ID: 439048  Cd Length: 151  Bit Score: 226.77  E-value: 2.80e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878  35 TTVEGLVSANCPNVWSKYGGLERLCRDMQNILYHGLIHDQVCCRQADYWQFVKDIRWLSPHSALHVEKFISLHESDQSDT 114
Cdd:cd17686   1 STVEGLLLSRSSNVWSTYGGLQRLCRAVENILQHGLKEFQGLNKEIDDWEFVQGLRWLQPTLAPSIEQQSRSSPSESEVS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27369878 115 DsvseraVAELWLQHSLQCHCLSAQLRPLLGDRQYIRKFYTETAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASM 191
Cdd:cd17686  81 D------KGRLWLRQSLQQHCLSSQLQWLVSDKELLRKYYEDEAFLRQEGYATALLICLTAVELNQPSLLAQIDPSL 151
RUN cd17671
RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new ...
 38-178 3.19e-20

RUN domain; RUN domain, named after RPIP8 (Rap2 interacting protein 8), UNC-14 and NESCA (new molecule containing SH3 at the carboxyl-terminus), is a less conserved protein motif that comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. RUN domains are often found in proteins linked particularly to the functions of GTPases in the Rap and Rab families, suggesting the RUN domain may be involved in Rab-mediated membrane trafficking, possibly as a Rab-binding site. RUN domain-containing proteins could hence play important roles in multiple Ras-like GTPase signalling pathways.


Pssm-ID: 439038  Cd Length: 154  Bit Score: 88.25  E-value: 3.19e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878  38 EGLVSANCPNVWSKYGGLERLCRDMQNILYHGLIHDQVCCRQADYWQFVKDIRWL--SPHSALHVEKFISLHESDqsdtd 115
Cdd:cd17671  14 GEADDSAALTLTDDDPVVGRLCAALEAILSHGLKPKRFGGGKVSFWDFLEALEKLlpAPSLKQAIRDINSLSNVK----- 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27369878 116 svSERAVAELWLQHSLQCHCLSAQLRPLLGDRQYIRKFYTETAFLLSDAHVTAMLQCLEAVEQ 178
Cdd:cd17671  89 --TDDGRGRAWIRLALNEKSLESYLAALLSDQSLLRKYYEPWALLRDPEEAELFLSLLVGLSS 149
RUN smart00593
domain involved in Ras-like GTPase signaling;
123-183 8.15e-12

domain involved in Ras-like GTPase signaling;


Pssm-ID: 214736 [Multi-domain]  Cd Length: 64  Bit Score: 61.09  E-value: 8.15e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27369878    123 AELWLQHSLQCHCLSAQLRPLLGDRQYIRKFYTETAFLLSDAHVT---AMLQCLEAVEQNNPRL 183
Cdd:smart00593   1 FRAWIRLALNEKLLSSWLNLLLSDEELLSKYYEPWAFLRDPEEGEqllGLLVGLSALDFNLPVD 64
RUN_PLEKHM2 cd17680
RUN domain found in pleckstrin homology domain-containing family M member 2 (PLEKHM2) and ...
 55-177 2.71e-07

RUN domain found in pleckstrin homology domain-containing family M member 2 (PLEKHM2) and similar proteins; PLEKHM2, also called PH domain-containing family M member 2, or Salmonella-induced filaments A (SifA) and Kinesin-Interacting Protein (SKIP), is the lysosome, melanosome and lytic granule cargo adaptor that controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain. In addition to kinesin-1, it also interacts with several Rabs to affect endosomal trafficking. This model represents the RUN domain of PLEKHM2.


Pssm-ID: 439042  Cd Length: 145  Bit Score: 50.70  E-value: 2.71e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878  55 LERLCRDMQNILYHGLIHDQVCcrqadYWQFVKDIRWLSphsalhVEKFISLHESDQSDTDsvseRAVAelWLQHSLQCH 134
Cdd:cd17680  34 LQRLCEALDHALLHGLRRGNRG-----YWPFVKEFTHKE------TIKQIENLPNVTTDLG----RGRA--WLYLALNEG 96

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 27369878 135 CLSAQLRPLLGDRQYIRKFYTETAFLLSDAHVTAMLQCLEAVE 177
Cdd:cd17680  97 SLESYLRSFLENRKLVKKFYHKHALLRDSQRLELLLTLLSGLE 139
RUN_RUFY4_like cd17682
RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil ...
 32-176 2.28e-04

RUN domain found in RUN and FYVE domain-containing protein 4 (RUFY4), FYVE and coiled-coil domain-containing protein 1 (FYCO1), and similar proteins; The family includes RUFY4 and FYCO1. RUFY4 acts as a positive regulator that enhances autophagy and lysosome tethering in response to Interleukin-4. It is expressed in a cell-specific manner or under specific immunological conditions associated with IL4 expression such as allergic asthma. FYCO1, also called zinc finger FYVE domain-containing protein 7 (ZFYVE7), is a multidomain autophagy adaptor protein that interacts with kinesin motor proteins and with the autophagosomal membrane components microtubule-associated protein 1 light chain 3 (LC3), Rab7, and phosphatidylinositol 3-phosphate (PI3P), to mediate microtubule plus-end-directed autophagosome transport. Both RUFY4 and FYCO1 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between; this model represents the RUN domain.


Pssm-ID: 439044  Cd Length: 150  Bit Score: 42.60  E-value: 2.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878  32 NLKTTVEGLVSANCPNVWSKYGGLERLCRDMQNILYHGLI-HDQVCCRQADYWQFVKDI---RWLSPHSALHVEKFIslh 107
Cdd:cd17682   1 DLKGCVLDLKSEFGEITDPDNPYLRPFCETLEKILRKGLKeKVSLGGRRKDYWDWLEELlkkLNKIPKSLSDAVKFV--- 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27369878 108 esdQSDTDSVSERAVAELWLQHSLQCHCLSAQLRPLLGDRQYIRKFYTETAFLLSDAHVTAMLQCLEAV 176
Cdd:cd17682  78 ---KSCKKVKTNQGRGRLFIRYALNKKCLHDPVQQLVKNPKLLSDYYSPDSILGNEILSEILLSLLYQL 143
RUN_SNX29 cd17689
RUN domain found in sorting nexin-29 (SNX29) and similar proteins; SNX29, also called RUN ...
 81-170 2.97e-04

RUN domain found in sorting nexin-29 (SNX29) and similar proteins; SNX29, also called RUN domain-containing protein 2A (RUNDC2A), belongs to the sorting nexin family. Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain, a phospholipid-binding motif, or through protein-protein interactions with membrane-associated protein complexes. Some sorting nexin family members have been shown to facilitate protein sorting. This model contains the RUN domain of SNX29.


Pssm-ID: 439051  Cd Length: 166  Bit Score: 42.60  E-value: 2.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878  81 DYWQFVKDIrwLSPHSalhVEKFISLHesdQSDTDSVSERAvaelWLQHSLQCHCLSAQLRPLLGDRQYIRKFYTETAFL 160
Cdd:cd17689  73 TFWPFVKEH--LTKHE---LERFELLK---NIWTDIGRGRA----WLRSALNEHSLERYLHILLSNENLLRQYYEDWAFL 140

                        90
                ....*....|
gi 27369878 161 LsDAHVTAML 170
Cdd:cd17689 141 R-DEERSSML 149
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 198-408 1.41e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   198 SPLLVTKS----QSLTALPGSTYTPPASYAQHSyfgSSSSLQSMPQSSHSSERRSTSFSLSGPSWQPQED---------- 263
Cdd:pfam05109 431 SPTLNTTGfaapNTTTGLPSSTHVPTNLTAPAS---TGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNgteskapdmt 507

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   264 ----------RECLSPAETQTTPAPLPSDSTLAQDSPLTAQEMSDSTLTSPLEASWVSSQNDSPSDVSEGPEYLAIGNPA 333
Cdd:pfam05109 508 sptsavttptPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPT 587

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878   334 PH------GRTASCESHSSNGESSSSHLFSSSSSQKLESAASSLGDQEEGRQSQAGSVLRRSSFSEgQTAPVASGTKKSH 407
Cdd:pfam05109 588 PNatsptvGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISE-TLSPSTSDNSTSH 666


                  .
gi 27369878   408 I 408
Cdd:pfam05109 667 M 667
RUN pfam02759
RUN domain; This domain is present in several proteins that are linked to the functions of ...
 57-174 3.14e-03

RUN domain; This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.


Pssm-ID: 460679  Cd Length: 134  Bit Score: 38.80  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369878    57 RLCRDMQNILYHGLIHDQVCC-------RQADYWQFVKDIRWLSPHSALHVEKFISLHESdqsdTDSVSERAVAELWLQH 129
Cdd:pfam02759   1 QLCAALEALLSHGLKRSSLLIlraagllPERSFWALLERVGKLVPPAEELLSSVQELEQI----HTPYSPDGRGRAWIRL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 27369878   130 SLQCHCLSAQLRPLLGDRQYIRKFYTETAFLLSDAHVTAMLQCLE 174
Cdd:pfam02759  77 ALNEKLLDQWLKLLLSNKELLSEYYEPWALLADPEFGEILLGLLV 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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