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Conserved domains on  [gi|154689957|ref|NP_766298|]
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protein sel-1 homolog 3 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
684-875 2.25e-38

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 143.53  E-value: 2.25e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  684 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 763
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  764 SKGLHQAVNGLGWYYHK---FRKNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGGHI 840
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 154689957  841 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 875
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
684-875 2.25e-38

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 143.53  E-value: 2.25e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  684 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 763
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  764 SKGLHQAVNGLGWYYHK---FRKNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGGHI 840
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 154689957  841 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 875
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 801-839 1.01e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 40.62  E-value: 1.01e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 154689957    801 PDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGGH 839
Cdd:smart00671    1 AEAQYNLGQMYEYGL--GVP-KDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 736-766 1.33e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.20  E-value: 1.33e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 154689957   736 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 766
Cdd:pfam08238    5 YRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
684-875 2.25e-38

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 143.53  E-value: 2.25e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  684 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 763
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  764 SKGLHQAVNGLGWYYHK---FRKNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGGHI 840
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 154689957  841 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 875
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
682-836 6.29e-32

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 125.04  E-value: 6.29e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  682 FMWLKHEATRGNAAAQQRLAQMLFWGqQGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKK 761
Cdd:COG0790    87 LEWFEKAAEQGDAEAQYNLGLMYEEG-LGVPQDYAKALEWYEKAA-EQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRK 164

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 154689957  762 AASKGLHQAVNGLGWYYHKFR---KNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQ 836
Cdd:COG0790   165 AAEQGDADAQYNLGVLYENGRgvpKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGE--GVE-KDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
683-907 4.66e-29

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 116.95  E-value: 4.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  683 MWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDPALiYDYAIVLFKGQGVKKNRRLALELMKKA 762
Cdd:COG0790    15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQ-YNLGLMYAEGRGVPKDYEKALEWFEKA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  763 ASKGLHQAVNGLGWYYHK---FRKNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGGH 839
Cdd:COG0790    94 AEQGDAEAQYNLGLMYEEglgVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGE--GVP-KDPAKAAEWYRKAAEQGD 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 154689957  840 IEGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEKngylGHV--IRKGLNAYLEGLW-----HEALLYYVLAAE 907
Cdd:COG0790   171 ADAQYNLGVLYENG--RGVPKDPAKALEWYRKAAEQ----GDAdaQYNLGRLYLNGEGvekdlEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
706-923 5.91e-21

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 93.45  E-value: 5.91e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  706 WGQQGVAKNPEAAIEWYAKGALETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAASKGLHQAVNGLGWYYHK---FR 782
Cdd:COG0790     1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEgrgVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  783 KNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGGHIEGTLWCSLYYITGnlETFPRDP 862
Cdd:COG0790    81 KDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGL--GVP-QDYAKALEWYEKAAEQGDADAQYNLGLLYLNG--EGVPKDP 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 154689957  863 EKAVVWAKHVAEkNGY------LGhvirkglNAYLEGL-----WHEALLYYVLAAETGIEVSQTNLAHICEE 923
Cdd:COG0790   156 AKAAEWYRKAAE-QGDadaqynLG-------VLYENGRgvpkdPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
TPR COG0790
TPR repeat [General function prediction only];
753-1006 2.67e-11

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 64.95  E-value: 2.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  753 RLALELMKKAASKGLHQAVNGLGWYYHKFRKNYAKAAKYWLKAEEMGNPDASYNLGVLYLDGIfpGVPgRNLTLAGEYFH 832
Cdd:COG0790    15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGR--GVP-KDYEKALEWFE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  833 KAAQGGHIEGTLWCSLYYITGnlETFPRDPEKAVVWakhvaekngylghvirkglnayleglwheallyYVLAAETGIEV 912
Cdd:COG0790    92 KAAEQGDAEAQYNLGLMYEEG--LGVPQDYAKALEW---------------------------------YEKAAEQGDAD 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  913 SQTNLahiceerpdlagrylgvncvwryynfsvfqidapsfaylkmGDLYYYGHQNQsQDLELSVQMYAQAALDGDSQGF 992
Cdd:COG0790   137 AQYNL-----------------------------------------GLLYLNGEGVP-KDPAKAAEWYRKAAEQGDADAQ 174

                         250
                  ....*....|....
gi 154689957  993 FNLAALIEEGAVIP 1006
Cdd:COG0790   175 YNLGVLYENGRGVP 188
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 692-803 5.82e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 49.62  E-value: 5.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  692 GNAAAQQRLAQMLFWgqqgvAKNPEAAIEWYAKG-ALETEDPALIYDYAIVLFKGQGVKKnrrlALELMKKAASK--GLH 768
Cdd:COG4235    15 NDAEGWLLLGRAYLR-----LGRYDEALAAYEKAlRLDPDNADALLDLAEALLAAGDTEE----AEELLERALALdpDNP 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 154689957  769 QAVNGLGWYYHKfRKNYAKAAKYWLKAEEMGNPDA 803
Cdd:COG4235    86 EALYLLGLAAFQ-QGDYAEAIAAWQKLLALLPADA 119
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 801-839 1.01e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 40.62  E-value: 1.01e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 154689957    801 PDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGGH 839
Cdd:smart00671    1 AEAQYNLGQMYEYGL--GVP-KDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 736-766 1.33e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.20  E-value: 1.33e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 154689957   736 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 766
Cdd:pfam08238    5 YRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
693-813 4.93e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  693 NAAAQQRLAQMLFwgQQGvakNPEAAIEWYAKG-ALETEDPALIYDYAIVLFKgqgvKKNRRLALELMKKAASK--GLHQ 769
Cdd:COG0457     7 DAEAYNNLGLAYR--RLG---RYEEAIEDYEKAlELDPDDAEALYNLGLAYLR----LGRYEEALADYEQALELdpDDAE 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 154689957  770 AVNGLGWYYHKfRKNYAKAAKYWLKAEEM--GNPDASYNLGVLYLD 813
Cdd:COG0457    78 ALNNLGLALQA-LGRYEEALEDYDKALELdpDDAEALYNLGLALLE 122
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 685-812 8.10e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.10  E-value: 8.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154689957  685 LKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGAL-ETEDPALIYDYAIVLFKGQGvkkNRRLALELMKKA- 762
Cdd:COG5010     5 EGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRdKLAKAFAIESPSDNLYNKLG---DFEESLALLEQAl 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 154689957  763 -ASKGLHQAVNGLGWYYHKfRKNYAKAAKYWLKAEEM--GNPDASYNLGVLYL 812
Cdd:COG5010    82 qLDPNNPELYYNLALLYSR-SGDKDEAKEYYEKALALspDNPNAYSNLAALLL 133
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 694-726 8.18e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 37.89  E-value: 8.18e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 154689957   694 AAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGA 726
Cdd:pfam08238    1 AEAQYRLGYLYLYGL-GVPKDPEKALEWYEKAA 32
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 801-838 1.78e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 37.12  E-value: 1.78e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 154689957   801 PDASYNLGVLYLDGIfpGVPgRNLTLAGEYFHKAAQGG 838
Cdd:pfam08238    1 AEAQYRLGYLYLYGL--GVP-KDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 736-766 2.70e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 36.38  E-value: 2.70e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 154689957    736 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 766
Cdd:smart00671    5 YNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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