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Conserved domains on  [gi|443906724|ref|NP_775161|]
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disks large-associated protein 3 isoform 1 [Rattus norvegicus]

Protein Classification

disks large-associated family protein( domain architecture ID 11744133)

disks large-associated family protein functions as a membrane-associated guanylate kinases

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GKAP pfam03359
Guanylate-kinase-associated protein (GKAP) protein;
626-977 0e+00

Guanylate-kinase-associated protein (GKAP) protein;


:

Pssm-ID: 460897  Cd Length: 341  Bit Score: 563.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724  626 QRKWRPSIGVQV---ETISDSDTENRSRREFHSIGVQVEEDKRRARFKRSNSVTAGVQADLELEGLAGLAT-VATEDKAL 701
Cdd:pfam03359   1 PKKKRSSIGIQVdciETVSDSDEESKPLREFQSIGVQVEDDKRRARFKRSNSVTAAVQADLELEGFPGLSLeVPTEDKGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724  702 QFGRSFQRHASEPQPgprAPTYSVFRTVHTQGQWAYREGYPLPYEPPATDGSpgpppvpapgpgsgrrDSWMERGSRSLP 781
Cdd:pfam03359  81 QFGGSFQRHSSEPAS---TSQYSIQRSVHTQGQWAYREDYDPALDPSSLPPP----------------DPWLEDGPRSLP 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724  782 DSGRTSP-CPRDGEWFIKMLRAEVEKLEHWCQQMEREAEDYELPEEILEKIRSAVGSTQLLLSQKVQQFFRLCQQSLDPT 860
Cdd:pfam03359 142 DSGRASPvCRRDGEWFLKLLQAETERMEGWCQQMEREAEENDLPEEILGKIRSAVGSAQLLMSQKFQQFRGLCEQNLNPN 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724  861 AFPVPTFQDLAGFWDLLQLSIEDVTLKFLELQQLKANSWKL---LEPKEEKKVPPPIPKKPSRGRGVPVKERSLDSVDRQ 937
Cdd:pfam03359 222 ANPRPTSQDLAGFWDLLQLSIEDISMKFDELHQLKANNWKLedpPEKKENKKLPPPVPKKPSKGRPPLVRERSLDSVDRQ 301
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 443906724  938 RQEARKRLLAAKRAASFRHSSATESADSIEIYIPEAQTRL 977
Cdd:pfam03359 302 RQEARKRLMAAKRAASVRQNSATESADSIEIYIPEAQTRL 341
PHA03418 super family cl25519
hypothetical E4 protein; Provisional
515-607 3.62e-03

hypothetical E4 protein; Provisional


The actual alignment was detected with superfamily member PHA03418:

Pssm-ID: 177646 [Multi-domain]  Cd Length: 230  Bit Score: 40.11  E-value: 3.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724 515 CLPLLAAPASVSGRPGSSFNfrKAPPPIPPGSQAPPRIS-------ITAQSS---TDSAHESFTAAEG-----PARRCSS 579
Cdd:PHA03418  32 CLPLLPAPHHPNPQEDPDKN--PSPPPDPPLTPRPPAQPnghnkppVTKQPGgegTEEDHQAPLAADAdddprPGKRSKA 109
                         90       100       110
                 ....*....|....*....|....*....|.
gi 443906724 580 ADGLDGPTMGART---LELAPVPPRASPKPP 607
Cdd:PHA03418 110 DEHGPAPGRAALApfkLDLDQDPLHGDPDPP 140
 
Name Accession Description Interval E-value
GKAP pfam03359
Guanylate-kinase-associated protein (GKAP) protein;
626-977 0e+00

Guanylate-kinase-associated protein (GKAP) protein;


Pssm-ID: 460897  Cd Length: 341  Bit Score: 563.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724  626 QRKWRPSIGVQV---ETISDSDTENRSRREFHSIGVQVEEDKRRARFKRSNSVTAGVQADLELEGLAGLAT-VATEDKAL 701
Cdd:pfam03359   1 PKKKRSSIGIQVdciETVSDSDEESKPLREFQSIGVQVEDDKRRARFKRSNSVTAAVQADLELEGFPGLSLeVPTEDKGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724  702 QFGRSFQRHASEPQPgprAPTYSVFRTVHTQGQWAYREGYPLPYEPPATDGSpgpppvpapgpgsgrrDSWMERGSRSLP 781
Cdd:pfam03359  81 QFGGSFQRHSSEPAS---TSQYSIQRSVHTQGQWAYREDYDPALDPSSLPPP----------------DPWLEDGPRSLP 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724  782 DSGRTSP-CPRDGEWFIKMLRAEVEKLEHWCQQMEREAEDYELPEEILEKIRSAVGSTQLLLSQKVQQFFRLCQQSLDPT 860
Cdd:pfam03359 142 DSGRASPvCRRDGEWFLKLLQAETERMEGWCQQMEREAEENDLPEEILGKIRSAVGSAQLLMSQKFQQFRGLCEQNLNPN 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724  861 AFPVPTFQDLAGFWDLLQLSIEDVTLKFLELQQLKANSWKL---LEPKEEKKVPPPIPKKPSRGRGVPVKERSLDSVDRQ 937
Cdd:pfam03359 222 ANPRPTSQDLAGFWDLLQLSIEDISMKFDELHQLKANNWKLedpPEKKENKKLPPPVPKKPSKGRPPLVRERSLDSVDRQ 301
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 443906724  938 RQEARKRLLAAKRAASFRHSSATESADSIEIYIPEAQTRL 977
Cdd:pfam03359 302 RQEARKRLMAAKRAASVRQNSATESADSIEIYIPEAQTRL 341
PHA03418 PHA03418
hypothetical E4 protein; Provisional
515-607 3.62e-03

hypothetical E4 protein; Provisional


Pssm-ID: 177646 [Multi-domain]  Cd Length: 230  Bit Score: 40.11  E-value: 3.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724 515 CLPLLAAPASVSGRPGSSFNfrKAPPPIPPGSQAPPRIS-------ITAQSS---TDSAHESFTAAEG-----PARRCSS 579
Cdd:PHA03418  32 CLPLLPAPHHPNPQEDPDKN--PSPPPDPPLTPRPPAQPnghnkppVTKQPGgegTEEDHQAPLAADAdddprPGKRSKA 109
                         90       100       110
                 ....*....|....*....|....*....|.
gi 443906724 580 ADGLDGPTMGART---LELAPVPPRASPKPP 607
Cdd:PHA03418 110 DEHGPAPGRAALApfkLDLDQDPLHGDPDPP 140
 
Name Accession Description Interval E-value
GKAP pfam03359
Guanylate-kinase-associated protein (GKAP) protein;
626-977 0e+00

Guanylate-kinase-associated protein (GKAP) protein;


Pssm-ID: 460897  Cd Length: 341  Bit Score: 563.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724  626 QRKWRPSIGVQV---ETISDSDTENRSRREFHSIGVQVEEDKRRARFKRSNSVTAGVQADLELEGLAGLAT-VATEDKAL 701
Cdd:pfam03359   1 PKKKRSSIGIQVdciETVSDSDEESKPLREFQSIGVQVEDDKRRARFKRSNSVTAAVQADLELEGFPGLSLeVPTEDKGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724  702 QFGRSFQRHASEPQPgprAPTYSVFRTVHTQGQWAYREGYPLPYEPPATDGSpgpppvpapgpgsgrrDSWMERGSRSLP 781
Cdd:pfam03359  81 QFGGSFQRHSSEPAS---TSQYSIQRSVHTQGQWAYREDYDPALDPSSLPPP----------------DPWLEDGPRSLP 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724  782 DSGRTSP-CPRDGEWFIKMLRAEVEKLEHWCQQMEREAEDYELPEEILEKIRSAVGSTQLLLSQKVQQFFRLCQQSLDPT 860
Cdd:pfam03359 142 DSGRASPvCRRDGEWFLKLLQAETERMEGWCQQMEREAEENDLPEEILGKIRSAVGSAQLLMSQKFQQFRGLCEQNLNPN 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724  861 AFPVPTFQDLAGFWDLLQLSIEDVTLKFLELQQLKANSWKL---LEPKEEKKVPPPIPKKPSRGRGVPVKERSLDSVDRQ 937
Cdd:pfam03359 222 ANPRPTSQDLAGFWDLLQLSIEDISMKFDELHQLKANNWKLedpPEKKENKKLPPPVPKKPSKGRPPLVRERSLDSVDRQ 301
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 443906724  938 RQEARKRLLAAKRAASFRHSSATESADSIEIYIPEAQTRL 977
Cdd:pfam03359 302 RQEARKRLMAAKRAASVRQNSATESADSIEIYIPEAQTRL 341
PHA03418 PHA03418
hypothetical E4 protein; Provisional
515-607 3.62e-03

hypothetical E4 protein; Provisional


Pssm-ID: 177646 [Multi-domain]  Cd Length: 230  Bit Score: 40.11  E-value: 3.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 443906724 515 CLPLLAAPASVSGRPGSSFNfrKAPPPIPPGSQAPPRIS-------ITAQSS---TDSAHESFTAAEG-----PARRCSS 579
Cdd:PHA03418  32 CLPLLPAPHHPNPQEDPDKN--PSPPPDPPLTPRPPAQPnghnkppVTKQPGgegTEEDHQAPLAADAdddprPGKRSKA 109
                         90       100       110
                 ....*....|....*....|....*....|.
gi 443906724 580 ADGLDGPTMGART---LELAPVPPRASPKPP 607
Cdd:PHA03418 110 DEHGPAPGRAALApfkLDLDQDPLHGDPDPP 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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