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Conserved domains on  [gi|1905532685|ref|NP_775839|]
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uromodulin-like 1 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
1121-1361 1.01e-39

Zona pellucida-like domain;


:

Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 148.52  E-value: 1.01e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685 1121 CEIEKVVVAIQKRFLQQeSIPESSLYL---SHPSCNVSHSNGTH--VLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQE 1195
Cdd:pfam00100    1 CTPDTMTVSISKCLLVP-SGLLSSLSLlggLDPSCKPVSNTNGSpaVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685 1196 GIIHHLKILS--PIYCAFQNDLLTSSGFTLEWGVYTIIEDlhGAGNFVTEMQLFIGDS----PIPQNYSVSASDDVRIEV 1269
Cdd:pfam00100   80 SGIIRRTITRrlPFSCSYPRSSLVSLLVVAPPSPVPITVS--GSGVFLVSMDLYYDSSytspYSPYPVTVLLGDPLYVEV 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685 1270 GL-YRQKSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTN---VIENGNSNKAQFKLRIFSFINDSI--VYLHC 1343
Cdd:pfam00100  158 SLlSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYpvsSLSNGPSHYVRFSFKAFRFVGSSIsqVYLHC 237

                          250
                   ....*....|....*...
gi 1905532685 1344 KLRVCmESPGATCKINCN 1361
Cdd:pfam00100  238 SVSVC-SSDSNSCGKSCS 254
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 117-157 2.07e-10

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


:

Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 57.05  E-value: 2.07e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1905532685  117 RPGACPAEG-PEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAP 157
Cdd:pfam00095    1 KPGCCPRLGaRGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 562-783 3.30e-09

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 61.86  E-value: 3.30e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  562 GLSAATgvTVPGLGTGTAALGLENFTLSPSPGYPQGTPAAGQAWTPEPSPRRGGSNVVGYDRNNTGKGVEQEVP-STAPG 640
Cdd:pfam05109  447 GLPSST--HVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPnATSPT 524

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  641 LGMDQGSPSQVNPSQGSPSQGSLRQESTSQASPSQRSTSQGSPSQVNPSQRSTSHANSSQGSPSQGSpsqeSPSQGSTSQ 720
Cdd:pfam05109  525 PAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNAT----SPTVGETSP 600

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1905532685  721 ASPSHRNTIGviGTTSSPKATGSTHSFPPGATDGPLALPGQLQGNSIMEPPSW-----PSPTEDPTGH 783
Cdd:pfam05109  601 QANTTNHTLG--GTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSIsetlsPSTSDNSTSH 666
EGF_CA pfam07645
Calcium-binding EGF domain;
507-537 7.21e-07

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.85  E-value: 7.21e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1905532685  507 DWDECVDSAeHDCSPAAWCINLEGSYTCQCR 537
Cdd:pfam07645    1 DVDECATGT-HNCPANTVCVNTIGSFECRCP 30
SEA super family cl02507
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 924-1011 3.42e-06

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


The actual alignment was detected with superfamily member smart00200:

Pssm-ID: 470595  Cd Length: 121  Bit Score: 47.41  E-value: 3.42e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685   924 VRIKNVRYSESFRNASSQEYRDFLELFFRMVRGSLPATmcqHMDAGGVRMEVVSVTNGSIVVEFHLL----IIADVDVQE 999
Cdd:smart00200   14 VEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKT---DLKPDFVGTEVIEFRNGSVVVDLGLLfnegVTNGQDVEE 90

                            90
                    ....*....|..
gi 1905532685  1000 VSAAFLTAFQTV 1011
Cdd:smart00200   91 DLLQVIKQAAYS 102
EGF_CA smart00179
Calcium-binding EGF-like domain;
1025-1056 4.07e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 4.07e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1905532685  1025 DYDECERKeDDCVPGTSCRNTLGSFTCSCEGG 1056
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPG 31
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 398-474 5.41e-06

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


:

Pssm-ID: 460188  Cd Length: 100  Bit Score: 46.46  E-value: 5.41e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1905532685  398 QVFEVTIKIVNHNLTEKLLNRSSVEYQDFSRQLLHEVESSFPPvvSDLyRSGKLRMQIVSL--QAGSVVVRLKLTVQDP 474
Cdd:pfam01390    1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRN--SSL-RKQYIKSHVLRLrpDGGSVVVDVVLVFRFP 76
EGF_CA smart00179
Calcium-binding EGF-like domain;
264-294 2.33e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.33e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1905532685   264 DVNECfyEELNACSGRELCANLEGSYWCVCH 294
Cdd:smart00179    1 DIDEC--ASGNPCQNGGTCVNTVGSYRCECP 29
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
1121-1361 1.01e-39

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 148.52  E-value: 1.01e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685 1121 CEIEKVVVAIQKRFLQQeSIPESSLYL---SHPSCNVSHSNGTH--VLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQE 1195
Cdd:pfam00100    1 CTPDTMTVSISKCLLVP-SGLLSSLSLlggLDPSCKPVSNTNGSpaVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685 1196 GIIHHLKILS--PIYCAFQNDLLTSSGFTLEWGVYTIIEDlhGAGNFVTEMQLFIGDS----PIPQNYSVSASDDVRIEV 1269
Cdd:pfam00100   80 SGIIRRTITRrlPFSCSYPRSSLVSLLVVAPPSPVPITVS--GSGVFLVSMDLYYDSSytspYSPYPVTVLLGDPLYVEV 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685 1270 GL-YRQKSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTN---VIENGNSNKAQFKLRIFSFINDSI--VYLHC 1343
Cdd:pfam00100  158 SLlSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYpvsSLSNGPSHYVRFSFKAFRFVGSSIsqVYLHC 237

                          250
                   ....*....|....*...
gi 1905532685 1344 KLRVCmESPGATCKINCN 1361
Cdd:pfam00100  238 SVSVC-SSDSNSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 1121-1361 1.87e-30

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 121.72  E-value: 1.87e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  1121 CEIEKVVVAIQKRFLQQESIPESSLYLSHPSCNVSHS--NGTHVLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQEGII 1198
Cdd:smart00241    2 CGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPQFTdaTSAFVSFEVPLNGCGTRRQVNPDGIVYSNTLVVSPFHPGFI 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  1199 HHLKILS-PIYCAFQNDLLTSSGFTLEWGVYTIIEDLhGAGNFVTEMQLFIGD--SPIPQNYSVSASDDVRIEVG-LYRQ 1274
Cdd:smart00241   82 TRDDRAAyHFQCFYPENEKVSLNLDVSTIPPTELSSV-SEGPLTCSYRLYKDDsfGSPYQSADYVLGDPVYHEWEcDGAD 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  1275 KSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTNVIE--NGNSNKAQFKLRIFSFINDSIVYLHCKLRVCMESP 1352
Cdd:smart00241  161 DPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGYLDSTIPynSNPLHRARFSVKVFKFADRSLVYFHCQIRLCDKDD 240

                           250
                    ....*....|
gi 1905532685  1353 GATCK-INCN 1361
Cdd:smart00241  241 GSSCDgPACS 250
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 117-157 2.07e-10

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 57.05  E-value: 2.07e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1905532685  117 RPGACPAEG-PEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAP 157
Cdd:pfam00095    1 KPGCCPRLGaRGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 562-783 3.30e-09

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 61.86  E-value: 3.30e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  562 GLSAATgvTVPGLGTGTAALGLENFTLSPSPGYPQGTPAAGQAWTPEPSPRRGGSNVVGYDRNNTGKGVEQEVP-STAPG 640
Cdd:pfam05109  447 GLPSST--HVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPnATSPT 524

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  641 LGMDQGSPSQVNPSQGSPSQGSLRQESTSQASPSQRSTSQGSPSQVNPSQRSTSHANSSQGSPSQGSpsqeSPSQGSTSQ 720
Cdd:pfam05109  525 PAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNAT----SPTVGETSP 600

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1905532685  721 ASPSHRNTIGviGTTSSPKATGSTHSFPPGATDGPLALPGQLQGNSIMEPPSW-----PSPTEDPTGH 783
Cdd:pfam05109  601 QANTTNHTLG--GTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSIsetlsPSTSDNSTSH 666
EGF_CA pfam07645
Calcium-binding EGF domain;
507-537 7.21e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.85  E-value: 7.21e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1905532685  507 DWDECVDSAeHDCSPAAWCINLEGSYTCQCR 537
Cdd:pfam07645    1 DVDECATGT-HNCPANTVCVNTIGSFECRCP 30
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 924-1011 3.42e-06

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 47.41  E-value: 3.42e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685   924 VRIKNVRYSESFRNASSQEYRDFLELFFRMVRGSLPATmcqHMDAGGVRMEVVSVTNGSIVVEFHLL----IIADVDVQE 999
Cdd:smart00200   14 VEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKT---DLKPDFVGTEVIEFRNGSVVVDLGLLfnegVTNGQDVEE 90

                            90
                    ....*....|..
gi 1905532685  1000 VSAAFLTAFQTV 1011
Cdd:smart00200   91 DLLQVIKQAAYS 102
EGF_CA smart00179
Calcium-binding EGF-like domain;
1025-1056 4.07e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 4.07e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1905532685  1025 DYDECERKeDDCVPGTSCRNTLGSFTCSCEGG 1056
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPG 31
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 398-474 5.41e-06

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 46.46  E-value: 5.41e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1905532685  398 QVFEVTIKIVNHNLTEKLLNRSSVEYQDFSRQLLHEVESSFPPvvSDLyRSGKLRMQIVSL--QAGSVVVRLKLTVQDP 474
Cdd:pfam01390    1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRN--SSL-RKQYIKSHVLRLrpDGGSVVVDVVLVFRFP 76
EGF_CA pfam07645
Calcium-binding EGF domain;
1025-1056 1.49e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.99  E-value: 1.49e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1905532685 1025 DYDECERKEDDCVPGTSCRNTLGSFTCSCEGG 1056
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
509-537 2.08e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.08e-05
                            10        20
                    ....*....|....*....|....*....
gi 1905532685   509 DECVDsaEHDCSPAAWCINLEGSYTCQCR 537
Cdd:smart00179    3 DECAS--GNPCQNGGTCVNTVGSYRCECP 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1025-1056 3.73e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.73e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1905532685 1025 DYDECERkEDDCVPGTSCRNTLGSFTCSCEGG 1056
Cdd:cd00054      1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 509-537 1.15e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.15e-04
                           10        20
                   ....*....|....*....|....*....
gi 1905532685  509 DECVDsaEHDCSPAAWCINLEGSYTCQCR 537
Cdd:cd00054      3 DECAS--GNPCQNGGTCVNTVGSYRCSCP 29
PHA03247 PHA03247
large tegument protein UL36; Provisional
 590-831 1.36e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 1.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  590 PSPGYPQGTPAAG--QAWTPEPSPRRGGSNVVGYDRNnTGKGVEQEVPSTAPGLGMDQGSPSQVNPS------------Q 655
Cdd:PHA03247  2552 PPPLPPAAPPAAPdrSVPPPRPAPRPSEPAVTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLppdthapdppppS 2630

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  656 GSPSQGSLRQESTSQASPSQRSTSQGSPSQVNPSQRSTSHANSSQGSpsqgspsqeSPSQGSTSQASPShrnTIGVIGTT 735
Cdd:PHA03247  2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS---------SPPQRPRRRAARP---TVGSLTSL 2698

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  736 SSPKATGSTHSFPPGATDG--PLALPGQLQGNSIMEPPSWPSPTEDPTGHFL-----WHATRSTRETLLNPTWLRNEDSG 808
Cdd:PHA03247  2699 ADPPPPPPTPEPAPHALVSatPLPPGPAAARQASPALPAAPAPPAVPAGPATpggpaRPARPPTTAGPPAPAPPAAPAAG 2778

                          250       260
                   ....*....|....*....|...
gi 1905532685  809 PSGSVDLPLTSTLTALKTPACVP 831
Cdd:PHA03247  2779 PPRRLTRPAVASLSESRESLPSP 2801
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 117-157 1.79e-04

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 40.90  E-value: 1.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1905532685  117 RPGACPA-EGPEPSTSP--CSLDIDCPGLEKCCPWSGGRYCMAP 157
Cdd:cd00199     16 KPGRCPMvNPPSLGIPPnrCSSDSDCPGDKKCCENGCGKSCLTP 59
WAP smart00217
Four-disulfide core domains;
117-158 2.34e-04

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 40.05  E-value: 2.34e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1905532685   117 RPGACPAE-----GPEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAPA 158
Cdd:smart00217    1 KPGSCPWPtiascPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
EGF_CA smart00179
Calcium-binding EGF-like domain;
264-294 2.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.33e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1905532685   264 DVNECfyEELNACSGRELCANLEGSYWCVCH 294
Cdd:smart00179    1 DIDEC--ASGNPCQNGGTCVNTVGSYRCECP 29
EGF_CA pfam07645
Calcium-binding EGF domain;
264-293 2.69e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 2.69e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1905532685  264 DVNECFyEELNACSGRELCANLEGSYWCVC 293
Cdd:pfam07645    1 DVDECA-TGTHNCPANTVCVNTIGSFECRC 29
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
1121-1361 1.01e-39

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 148.52  E-value: 1.01e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685 1121 CEIEKVVVAIQKRFLQQeSIPESSLYL---SHPSCNVSHSNGTH--VLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQE 1195
Cdd:pfam00100    1 CTPDTMTVSISKCLLVP-SGLLSSLSLlggLDPSCKPVSNTNGSpaVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685 1196 GIIHHLKILS--PIYCAFQNDLLTSSGFTLEWGVYTIIEDlhGAGNFVTEMQLFIGDS----PIPQNYSVSASDDVRIEV 1269
Cdd:pfam00100   80 SGIIRRTITRrlPFSCSYPRSSLVSLLVVAPPSPVPITVS--GSGVFLVSMDLYYDSSytspYSPYPVTVLLGDPLYVEV 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685 1270 GL-YRQKSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTN---VIENGNSNKAQFKLRIFSFINDSI--VYLHC 1343
Cdd:pfam00100  158 SLlSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYpvsSLSNGPSHYVRFSFKAFRFVGSSIsqVYLHC 237

                          250
                   ....*....|....*...
gi 1905532685 1344 KLRVCmESPGATCKINCN 1361
Cdd:pfam00100  238 SVSVC-SSDSNSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 1121-1361 1.87e-30

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 121.72  E-value: 1.87e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  1121 CEIEKVVVAIQKRFLQQESIPESSLYLSHPSCNVSHS--NGTHVLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQEGII 1198
Cdd:smart00241    2 CGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPQFTdaTSAFVSFEVPLNGCGTRRQVNPDGIVYSNTLVVSPFHPGFI 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  1199 HHLKILS-PIYCAFQNDLLTSSGFTLEWGVYTIIEDLhGAGNFVTEMQLFIGD--SPIPQNYSVSASDDVRIEVG-LYRQ 1274
Cdd:smart00241   82 TRDDRAAyHFQCFYPENEKVSLNLDVSTIPPTELSSV-SEGPLTCSYRLYKDDsfGSPYQSADYVLGDPVYHEWEcDGAD 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  1275 KSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTNVIE--NGNSNKAQFKLRIFSFINDSIVYLHCKLRVCMESP 1352
Cdd:smart00241  161 DPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGYLDSTIPynSNPLHRARFSVKVFKFADRSLVYFHCQIRLCDKDD 240

                           250
                    ....*....|
gi 1905532685  1353 GATCK-INCN 1361
Cdd:smart00241  241 GSSCDgPACS 250
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 117-157 2.07e-10

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 57.05  E-value: 2.07e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1905532685  117 RPGACPAEG-PEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAP 157
Cdd:pfam00095    1 KPGCCPRLGaRGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 562-783 3.30e-09

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 61.86  E-value: 3.30e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  562 GLSAATgvTVPGLGTGTAALGLENFTLSPSPGYPQGTPAAGQAWTPEPSPRRGGSNVVGYDRNNTGKGVEQEVP-STAPG 640
Cdd:pfam05109  447 GLPSST--HVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPnATSPT 524

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  641 LGMDQGSPSQVNPSQGSPSQGSLRQESTSQASPSQRSTSQGSPSQVNPSQRSTSHANSSQGSPSQGSpsqeSPSQGSTSQ 720
Cdd:pfam05109  525 PAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNAT----SPTVGETSP 600

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1905532685  721 ASPSHRNTIGviGTTSSPKATGSTHSFPPGATDGPLALPGQLQGNSIMEPPSW-----PSPTEDPTGH 783
Cdd:pfam05109  601 QANTTNHTLG--GTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSIsetlsPSTSDNSTSH 666
EGF_CA pfam07645
Calcium-binding EGF domain;
507-537 7.21e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.85  E-value: 7.21e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1905532685  507 DWDECVDSAeHDCSPAAWCINLEGSYTCQCR 537
Cdd:pfam07645    1 DVDECATGT-HNCPANTVCVNTIGSFECRCP 30
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 924-1011 3.42e-06

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 47.41  E-value: 3.42e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685   924 VRIKNVRYSESFRNASSQEYRDFLELFFRMVRGSLPATmcqHMDAGGVRMEVVSVTNGSIVVEFHLL----IIADVDVQE 999
Cdd:smart00200   14 VEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKT---DLKPDFVGTEVIEFRNGSVVVDLGLLfnegVTNGQDVEE 90

                            90
                    ....*....|..
gi 1905532685  1000 VSAAFLTAFQTV 1011
Cdd:smart00200   91 DLLQVIKQAAYS 102
EGF_CA smart00179
Calcium-binding EGF-like domain;
1025-1056 4.07e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 4.07e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1905532685  1025 DYDECERKeDDCVPGTSCRNTLGSFTCSCEGG 1056
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPG 31
SEA pfam01390
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 398-474 5.41e-06

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


Pssm-ID: 460188  Cd Length: 100  Bit Score: 46.46  E-value: 5.41e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1905532685  398 QVFEVTIKIVNHNLTEKLLNRSSVEYQDFSRQLLHEVESSFPPvvSDLyRSGKLRMQIVSL--QAGSVVVRLKLTVQDP 474
Cdd:pfam01390    1 QYYTGSFKITNLQYTPDLGNPSSQEFKSLSRRIESLLNELFRN--SSL-RKQYIKSHVLRLrpDGGSVVVDVVLVFRFP 76
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 539-794 9.00e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 50.30  E-value: 9.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  539 TRDATPSRAGRACEGDLVS-PMGGGLSAATGVTVPGLGTGTAALGlenfTLSPSPGYPQGTPAAGQAWTPEPSPRRGGSN 617
Cdd:pfam05109  531 TPNATSPTLGKTSPTSAVTtPTPNATSPTPAVTTPTPNATIPTLG----KTSPTSAVTTPTPNATSPTVGETSPQANTTN 606

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  618 vvgydrNNTGKGVEQEVPSTAPGLGMDQGSPSQVNPSQGSPSQGSLRQESTSQA---SPSQRSTSQ------GSPS---- 684
Cdd:pfam05109  607 ------HTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETlspSTSDNSTSHmplltsAHPTggen 680

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  685 --QVNPSQRSTSHANssqgspsqgsPSQESPSQGSTSQASPShrntiGVIGTTSSPKATGSTHSFPPGATDGPLALPGQL 762
Cdd:pfam05109  681 itQVTPASTSTHHVS----------TSSPAPRPGTTSQASGP-----GNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQK 745

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1905532685  763 QGNSIMEPPSWPSPTEDPTGHFLWHATRSTRE 794
Cdd:pfam05109  746 TAVPTVTSTGGKANSTTGGKHTTGHGARTSTE 777
EGF_CA pfam07645
Calcium-binding EGF domain;
1025-1056 1.49e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.99  E-value: 1.49e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1905532685 1025 DYDECERKEDDCVPGTSCRNTLGSFTCSCEGG 1056
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 514-763 1.64e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 49.19  E-value: 1.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  514 SAEHDCSPAAWciNLEGSYTCQCRTTRDATPSRAGRACEGDLVSPMGGGLSAATGVTVPGLGTGTAALGlenfTLSPSPG 593
Cdd:pfam17823  166 SAPHAASPAPR--TAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVG----NSSPAAG 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  594 ypqGTPAAGQAWTPEpsprrggsnVVGydrnnTGKGVEQEVPSTAPGLGMDQGSPSQVNPSQGSPSQGSLRQESTSQASP 673
Cdd:pfam17823  240 ---TVTAAVGTVTPA---------ALA-----TLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQ 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  674 SQRSTSQGSPSQ--VNPSQRST-SHANSSQGSPSQGSPSQESPSQGSTSQAS---PShRNTIGVIGTTSSP--KATGSTH 745
Cdd:pfam17823  303 AQGPIIQVSTDQpvHNTAGEPTpSPSNTTLEPNTPKSVASTNLAVVTTTKAQakePS-ASPVPVLHTSMIPevEATSPTT 381

                          250
                   ....*....|....*...
gi 1905532685  746 SFPPGATDGPLALPGQLQ 763
Cdd:pfam17823  382 QPSPLLPTQGAAGPGILL 399
EGF_CA smart00179
Calcium-binding EGF-like domain;
509-537 2.08e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.08e-05
                            10        20
                    ....*....|....*....|....*....
gi 1905532685   509 DECVDsaEHDCSPAAWCINLEGSYTCQCR 537
Cdd:smart00179    3 DECAS--GNPCQNGGTCVNTVGSYRCECP 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1025-1056 3.73e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.73e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1905532685 1025 DYDECERkEDDCVPGTSCRNTLGSFTCSCEGG 1056
Cdd:cd00054      1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 509-537 1.15e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.15e-04
                           10        20
                   ....*....|....*....|....*....
gi 1905532685  509 DECVDsaEHDCSPAAWCINLEGSYTCQCR 537
Cdd:cd00054      3 DECAS--GNPCQNGGTCVNTVGSYRCSCP 29
PHA03247 PHA03247
large tegument protein UL36; Provisional
 590-831 1.36e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 1.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  590 PSPGYPQGTPAAG--QAWTPEPSPRRGGSNVVGYDRNnTGKGVEQEVPSTAPGLGMDQGSPSQVNPS------------Q 655
Cdd:PHA03247  2552 PPPLPPAAPPAAPdrSVPPPRPAPRPSEPAVTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLppdthapdppppS 2630

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  656 GSPSQGSLRQESTSQASPSQRSTSQGSPSQVNPSQRSTSHANSSQGSpsqgspsqeSPSQGSTSQASPShrnTIGVIGTT 735
Cdd:PHA03247  2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS---------SPPQRPRRRAARP---TVGSLTSL 2698

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  736 SSPKATGSTHSFPPGATDG--PLALPGQLQGNSIMEPPSWPSPTEDPTGHFL-----WHATRSTRETLLNPTWLRNEDSG 808
Cdd:PHA03247  2699 ADPPPPPPTPEPAPHALVSatPLPPGPAAARQASPALPAAPAPPAVPAGPATpggpaRPARPPTTAGPPAPAPPAAPAAG 2778

                          250       260
                   ....*....|....*....|...
gi 1905532685  809 PSGSVDLPLTSTLTALKTPACVP 831
Cdd:PHA03247  2779 PPRRLTRPAVASLSESRESLPSP 2801
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 117-157 1.79e-04

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 40.90  E-value: 1.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1905532685  117 RPGACPA-EGPEPSTSP--CSLDIDCPGLEKCCPWSGGRYCMAP 157
Cdd:cd00199     16 KPGRCPMvNPPSLGIPPnrCSSDSDCPGDKKCCENGCGKSCLTP 59
WAP smart00217
Four-disulfide core domains;
117-158 2.34e-04

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 40.05  E-value: 2.34e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1905532685   117 RPGACPAE-----GPEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAPA 158
Cdd:smart00217    1 KPGSCPWPtiascPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 522-737 2.77e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 45.44  E-value: 2.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  522 AAWCINLEGsytcQCRTTRDATPSRA-----------GRACEGDLVSPMGGGLSAATGVTVPGLGTGTAAlglenftLSP 590
Cdd:PRK14959   330 ACWQMTLEG----QRRVLTSLEPAMAlellllnlamlPRLMPVESLRPSGGGASAPSGSAAEGPASGGAA-------TIP 398

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  591 SPGY--PQGT-PAAG----QAWTPEPSPRRGGSNVVGYDrnntgkgveqEVPSTAPglgmDQGSPSQVNPSQGSPSQGSL 663
Cdd:PRK14959   399 TPGTqgPQGTaPAAGmtpsSAAPATPAPSAAPSPRVPWD----------DAPPAPP----RSGIPPRPAPRMPEASPVPG 464

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1905532685  664 RQESTSqaspsqrSTSQGSPSQVNPSQRSTSHANSSQGSPSQGSPSQESPSQGSTS-----QASPSHRNTIGVIGTTSS 737
Cdd:PRK14959   465 APDSVA-------SASDAPPTLGDPSDTAEHTPSGPRTWDGFLEFCQGRNGQGGRLatvlrQATPEHADGRLRLATMSS 536
PHA03378 PHA03378
EBNA-3B; Provisional
 595-780 2.84e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.44  E-value: 2.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  595 PQGTPAAGQAWTPEPSPRRGGSNVVGYDRNNTGKGVEQEVPSTAPglgmdqGSPSQVNPSQGSPSQgslRQESTSQASPS 674
Cdd:PHA03378   727 PAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAP------GAPTPQPPPQAPPAP---QQRPRGAPTPQ 797

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1905532685  675 QRSTSQGSPSQVNPSQRSTSHANSSQGSPSQGSPSQESpsqGSTSQASPSHRNTIGVIGTTSSPKATGSTHS------FP 748
Cdd:PHA03378   798 PPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKR---GRPSLKKPAALERQAAAGPTPSPGSGTSDKIvqapvfYP 874

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1905532685  749 PGATdgPLALPGQLQGNSIMEPPSWP-SPTEDP 780
Cdd:PHA03378   875 PVLQ--PIQVMRQLGSVRAAAASTVTqAPTEYT 905
EGF_CA smart00179
Calcium-binding EGF-like domain;
264-294 2.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.33e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1905532685   264 DVNECfyEELNACSGRELCANLEGSYWCVCH 294
Cdd:smart00179    1 DIDEC--ASGNPCQNGGTCVNTVGSYRCECP 29
EGF_CA pfam07645
Calcium-binding EGF domain;
264-293 2.69e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 2.69e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1905532685  264 DVNECFyEELNACSGRELCANLEGSYWCVC 293
Cdd:pfam07645    1 DVDECA-TGTHNCPANTVCVNTIGSFECRC 29
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 517-538 5.41e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.04  E-value: 5.41e-03
                           10        20
                   ....*....|....*....|..
gi 1905532685  517 HDCSPAAWCINLEGSYTCQCRT 538
Cdd:pfam12947    6 GGCHPNATCTNTGGSFTCTCND 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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