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Conserved domains on  [gi|125991228|ref|NP_776108|]
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G-patch domain and KOW motifs-containing protein [Mus musculus]

Protein Classification

pre-mRNA-splicing factor SPP2; KOW domain-containing RNA-binding protein( domain architecture ID 10576965)

pre-mRNA-splicing factor SPP2 is involved in pre-mRNA splicing; specifically in the final stages of spliceosome maturation| KOW domain-containing RNA-binding protein similar to the KOW motif in 60S ribosomal protein L27, which is a component of the large ribosomal subunit; the KOW domain is known as an RNA-binding motif that is shared among some families of ribosomal proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KOW_GPKOW_A cd13152
KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat A; GPKOW ...
 244-298 1.11e-21

KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat A; GPKOW contains one G-patch domain and two KOW motifs. GPKOW is a nuclear protein that regulated by catalytic (C) subunit of Protein Kinase A (PKA) and bind RNA in vivo. PKA may be involved in regulating multiple steps in post-transcriptional processing of pre-mRNAs. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. GPKOW is also known as T54 protein or MOS2 homolog.


:

Pssm-ID: 240516  Cd Length: 57  Bit Score: 88.01  E-value: 1.11e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 125991228 244 GRAVVVLSGPYRGLYGKVEGLDPDNVRAMVRLAVGNRIVTVSEYCLRPVSQQEFD 298
Cdd:cd13152    1 GAYVKILSGKHKGLYGKVEGFDEDNSRVIVKLAIGGETVSVSEFAVKLVTKKEYK 55
G-patch_2 pfam12656
G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ...
 154-211 1.15e-20

G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ATP-dependent DExH-box splicing factor Prp2. As this interaction involves the G-patch sequence in Spp2 and is required for the recruitment of Prp2 to the spliceosome before the first catalytic step of splicing, it is proposed that Spp2 might be an accessory factor that confers spliceosome specificity on Prp2.


:

Pssm-ID: 432700 [Multi-domain]  Cd Length: 61  Bit Score: 85.41  E-value: 1.15e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 125991228  154 PEEA---DYEAVPVEAYGLAMLRGMGWKPGKGIGNTFSQVVKPRVNSIRPKGLGLGANRME 211
Cdd:pfam12656   1 PDEAsleDYEKVPVEEFGAAMLRGMGWKPGQGIGKNKKGDVKPKEYKRRPGGLGLGAKPAE 61
KOW_GPKOW_B cd13153
KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat B; GPKOW ...
 431-481 8.61e-14

KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat B; GPKOW contains one G-patch domain and two KOW motifs. GPKOW is a nuclear protein that regulated by catalytic (C) subunit of Protein Kinase A (PKA) and bind RNA in vivo. PKA may be involved in regulating multiple steps in post-transcriptional processing of pre-mRNAs. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. GPKOW is also known as the T54 protein or MOS2 homolog.


:

Pssm-ID: 240517  Cd Length: 51  Bit Score: 65.65  E-value: 8.61e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 125991228 431 GHRVMVVLGPHAGKVGLLRSRDRAQSHALVQLRRENQVVELHYNAICQYMG 481
Cdd:cd13153    1 GAYVMVVRGKHRGQVGKLLERDKKKETAVVQLLDDFSVVTLSYDDICEYTG 51
 
Name Accession Description Interval E-value
KOW_GPKOW_A cd13152
KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat A; GPKOW ...
 244-298 1.11e-21

KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat A; GPKOW contains one G-patch domain and two KOW motifs. GPKOW is a nuclear protein that regulated by catalytic (C) subunit of Protein Kinase A (PKA) and bind RNA in vivo. PKA may be involved in regulating multiple steps in post-transcriptional processing of pre-mRNAs. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. GPKOW is also known as T54 protein or MOS2 homolog.


Pssm-ID: 240516  Cd Length: 57  Bit Score: 88.01  E-value: 1.11e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 125991228 244 GRAVVVLSGPYRGLYGKVEGLDPDNVRAMVRLAVGNRIVTVSEYCLRPVSQQEFD 298
Cdd:cd13152    1 GAYVKILSGKHKGLYGKVEGFDEDNSRVIVKLAIGGETVSVSEFAVKLVTKKEYK 55
G-patch_2 pfam12656
G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ...
 154-211 1.15e-20

G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ATP-dependent DExH-box splicing factor Prp2. As this interaction involves the G-patch sequence in Spp2 and is required for the recruitment of Prp2 to the spliceosome before the first catalytic step of splicing, it is proposed that Spp2 might be an accessory factor that confers spliceosome specificity on Prp2.


Pssm-ID: 432700 [Multi-domain]  Cd Length: 61  Bit Score: 85.41  E-value: 1.15e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 125991228  154 PEEA---DYEAVPVEAYGLAMLRGMGWKPGKGIGNTFSQVVKPRVNSIRPKGLGLGANRME 211
Cdd:pfam12656   1 PDEAsleDYEKVPVEEFGAAMLRGMGWKPGQGIGKNKKGDVKPKEYKRRPGGLGLGAKPAE 61
KOW_GPKOW_B cd13153
KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat B; GPKOW ...
 431-481 8.61e-14

KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat B; GPKOW contains one G-patch domain and two KOW motifs. GPKOW is a nuclear protein that regulated by catalytic (C) subunit of Protein Kinase A (PKA) and bind RNA in vivo. PKA may be involved in regulating multiple steps in post-transcriptional processing of pre-mRNAs. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. GPKOW is also known as the T54 protein or MOS2 homolog.


Pssm-ID: 240517  Cd Length: 51  Bit Score: 65.65  E-value: 8.61e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 125991228 431 GHRVMVVLGPHAGKVGLLRSRDRAQSHALVQLRRENQVVELHYNAICQYMG 481
Cdd:cd13153    1 GAYVMVVRGKHRGQVGKLLERDKKKETAVVQLLDDFSVVTLSYDDICEYTG 51
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 162-208 8.15e-07

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 45.61  E-value: 8.15e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 125991228   162 VPVEAYGLAMLRGMGWKPGKGIGNTFSQVVKPRVNSIRPKGLGLGAN 208
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGAV 47
KOW pfam00467
KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, ...
 244-273 4.87e-04

KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.


Pssm-ID: 425698 [Multi-domain]  Cd Length: 32  Bit Score: 37.37  E-value: 4.87e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 125991228  244 GRAVVVLSGPYRGLYGKVEGLDPDNVRAMV 273
Cdd:pfam00467   2 GDVVRVIAGPFKGKVGKVVEVDDKKNRVLV 31
 
Name Accession Description Interval E-value
KOW_GPKOW_A cd13152
KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat A; GPKOW ...
 244-298 1.11e-21

KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat A; GPKOW contains one G-patch domain and two KOW motifs. GPKOW is a nuclear protein that regulated by catalytic (C) subunit of Protein Kinase A (PKA) and bind RNA in vivo. PKA may be involved in regulating multiple steps in post-transcriptional processing of pre-mRNAs. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. GPKOW is also known as T54 protein or MOS2 homolog.


Pssm-ID: 240516  Cd Length: 57  Bit Score: 88.01  E-value: 1.11e-21
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 125991228 244 GRAVVVLSGPYRGLYGKVEGLDPDNVRAMVRLAVGNRIVTVSEYCLRPVSQQEFD 298
Cdd:cd13152    1 GAYVKILSGKHKGLYGKVEGFDEDNSRVIVKLAIGGETVSVSEFAVKLVTKKEYK 55
G-patch_2 pfam12656
G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ...
 154-211 1.15e-20

G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ATP-dependent DExH-box splicing factor Prp2. As this interaction involves the G-patch sequence in Spp2 and is required for the recruitment of Prp2 to the spliceosome before the first catalytic step of splicing, it is proposed that Spp2 might be an accessory factor that confers spliceosome specificity on Prp2.


Pssm-ID: 432700 [Multi-domain]  Cd Length: 61  Bit Score: 85.41  E-value: 1.15e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 125991228  154 PEEA---DYEAVPVEAYGLAMLRGMGWKPGKGIGNTFSQVVKPRVNSIRPKGLGLGANRME 211
Cdd:pfam12656   1 PDEAsleDYEKVPVEEFGAAMLRGMGWKPGQGIGKNKKGDVKPKEYKRRPGGLGLGAKPAE 61
KOW_GPKOW_B cd13153
KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat B; GPKOW ...
 431-481 8.61e-14

KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat B; GPKOW contains one G-patch domain and two KOW motifs. GPKOW is a nuclear protein that regulated by catalytic (C) subunit of Protein Kinase A (PKA) and bind RNA in vivo. PKA may be involved in regulating multiple steps in post-transcriptional processing of pre-mRNAs. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. GPKOW is also known as the T54 protein or MOS2 homolog.


Pssm-ID: 240517  Cd Length: 51  Bit Score: 65.65  E-value: 8.61e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 125991228 431 GHRVMVVLGPHAGKVGLLRSRDRAQSHALVQLRRENQVVELHYNAICQYMG 481
Cdd:cd13153    1 GAYVMVVRGKHRGQVGKLLERDKKKETAVVQLLDDFSVVTLSYDDICEYTG 51
KOW cd00380
KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known ...
 244-298 2.34e-07

KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. The KOW motif contains an invariants glycine residue and comprises alternating blocks of hydrophilic and hydrophobic residues.


Pssm-ID: 240504  Cd Length: 49  Bit Score: 47.21  E-value: 2.34e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 125991228 244 GRAVVVLSGPYRGLYGKVEGLDPDNVRAMVRLAVGNRIVTvseyclRPVSQQEFD 298
Cdd:cd00380    1 GDVVRVLRGPYKGREGVVVDIDPRFGIVTVKGATGSKGAE------LKVRFDDVD 49
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 162-208 8.15e-07

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 45.61  E-value: 8.15e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 125991228   162 VPVEAYGLAMLRGMGWKPGKGIGNTFSQVVKPRVNSIRPKGLGLGAN 208
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGAV 47
KOW_KIN17 cd13155
KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the ...
 244-287 1.41e-06

KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the RNA-binding properties of the whole protein. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KIN17 is conserved from yeast to human that ubiquitously expressed at low levels in mammals tissue and have functions in DNA replication, DNA repair and cell cycle control.


Pssm-ID: 240519  Cd Length: 54  Bit Score: 45.22  E-value: 1.41e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 125991228 244 GRAVVVLSGPYRGLYGKVEGLDPDNVRAMVRLAVG---NRIVTVSEY 287
Cdd:cd13155    2 GGRVLVVNGAYRGCEATLESIDEDKFSATVRLDSGplkGRVVEGVPY 48
KOW_GPKOW_B cd13153
KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat B; GPKOW ...
 244-285 3.79e-04

KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat B; GPKOW contains one G-patch domain and two KOW motifs. GPKOW is a nuclear protein that regulated by catalytic (C) subunit of Protein Kinase A (PKA) and bind RNA in vivo. PKA may be involved in regulating multiple steps in post-transcriptional processing of pre-mRNAs. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. GPKOW is also known as the T54 protein or MOS2 homolog.


Pssm-ID: 240517  Cd Length: 51  Bit Score: 38.30  E-value: 3.79e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 125991228 244 GRAVVVLSGPYRGLYGKVEGLDPDNVRAMVRLAVGNRIVTVS 285
Cdd:cd13153    1 GAYVMVVRGKHRGQVGKLLERDKKKETAVVQLLDDFSVVTLS 42
KOW pfam00467
KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, ...
 244-273 4.87e-04

KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.


Pssm-ID: 425698 [Multi-domain]  Cd Length: 32  Bit Score: 37.37  E-value: 4.87e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 125991228  244 GRAVVVLSGPYRGLYGKVEGLDPDNVRAMV 273
Cdd:pfam00467   2 GDVVRVIAGPFKGKVGKVVEVDDKKNRVLV 31
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 168-208 1.98e-03

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 35.95  E-value: 1.98e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 125991228  168 GLAMLRGMGWKPGKGIGNTFSQVVKPRVNSIRPKGLGLGAN 208
Cdd:pfam01585   5 GFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
KOW_Spt5_5 cd06085
KOW domain of Spt5, repeat 5; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 244-291 5.07e-03

KOW domain of Spt5, repeat 5; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240509  Cd Length: 52  Bit Score: 35.15  E-value: 5.07e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 125991228 244 GRAVVVLSGPYRGLYGKVEGLDPDNVRamVRLAVGNRIVTVSEYCLRP 291
Cdd:cd06085    7 GKTVRIRKGPYKGYIGIVKDATGTTAR--VELHSKNKTITVDRSRLAV 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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