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Conserved domains on  [gi|27806251|ref|NP_776946|]
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coronin-1A [Bos taurus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-461 6.79e-117

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 351.50  E-value: 6.79e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251    9 SKFRHVFGQPAKADQCYEDVRVSQNTWD-SGFCAVNPKFVALICEASGGGAflVLPLGKTGRVDKNVPMVCGHTAPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251   88 AWCPHNDNVIASGSEDCSVMVWEIPDGGLTLPLREPVVTLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGVAV 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  168 LTLGSdvHPDTIYSVDWSRDGALICTSCRDKRVRIIEPRKGTIVAEKDrPHEGTRPVRAVFVSDGK-ILTTGFSRMSERQ 246
Cdd:PTZ00421 162 EVIKC--HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  247 VALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRG 326
Cdd:PTZ00421 239 IMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWS 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  327 LEVNKCEIARFYKLHERKCEPIAMTVPRK-SDL-FQEDLYPPTAGPDAALTAEEWLGGRDAGPLLISLKDGYvppKSREL 404
Cdd:PTZ00421 317 LDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVF---DGTSP 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  405 RVNRGLDTGRKRT-------TPEASGA--------------PSSDAISRLEEE-----MRKLQATVQELQKR---LDRLE 455
Cdd:PTZ00421 394 ELMGASALSPSGKprhsgvsVPASTSAmthsfddntskhadPCAMGVKRMDEGilderLGRLQALSEKLRTQheeIKRCR 473


                 ....*.
gi 27806251  456 ETVQAK 461
Cdd:PTZ00421 474 EALQKK 479
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-461 6.79e-117

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 351.50  E-value: 6.79e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251    9 SKFRHVFGQPAKADQCYEDVRVSQNTWD-SGFCAVNPKFVALICEASGGGAflVLPLGKTGRVDKNVPMVCGHTAPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251   88 AWCPHNDNVIASGSEDCSVMVWEIPDGGLTLPLREPVVTLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGVAV 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  168 LTLGSdvHPDTIYSVDWSRDGALICTSCRDKRVRIIEPRKGTIVAEKDrPHEGTRPVRAVFVSDGK-ILTTGFSRMSERQ 246
Cdd:PTZ00421 162 EVIKC--HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  247 VALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRG 326
Cdd:PTZ00421 239 IMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWS 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  327 LEVNKCEIARFYKLHERKCEPIAMTVPRK-SDL-FQEDLYPPTAGPDAALTAEEWLGGRDAGPLLISLKDGYvppKSREL 404
Cdd:PTZ00421 317 LDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVF---DGTSP 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  405 RVNRGLDTGRKRT-------TPEASGA--------------PSSDAISRLEEE-----MRKLQATVQELQKR---LDRLE 455
Cdd:PTZ00421 394 ELMGASALSPSGKprhsgvsVPASTSAmthsfddntskhadPCAMGVKRMDEGilderLGRLQALSEKLRTQheeIKRCR 473


                 ....*.
gi 27806251  456 ETVQAK 461
Cdd:PTZ00421 474 EALQKK 479
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 3.24e-36

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 127.62  E-value: 3.24e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27806251     4 QVVRSSKFRHVFGQPAKADQCYEDVRVSQNTWDSGFCAVNPKFVALICEASGGGAFLVLPLGKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 COG2319
WD40 repeat [General function prediction only];
79-293 8.17e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.02  E-value: 8.17e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  79 GHTAPVLDIAWCPhNDNVIASGSEDCSVMVWEIPDGgltlplrEPVVTLEGHTKRVGIVAWHPTAQnVLLSAGCDNVILV 158
Cdd:COG2319 202 GHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRL 272

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251 159 WDVGTGVAVLTLGSdvHPDTIYSVDWSRDGALICTSCRDKRVRIIEPRKGTIVaekdRPHEG-TRPVRAV-FVSDGKILT 236
Cdd:COG2319 273 WDLATGELLRTLTG--HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL----RTLTGhTGAVRSVaFSPDGKTLA 346

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27806251 237 TGFsrmSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNIVYLCGkGDSSIR 293
Cdd:COG2319 347 SGS---DDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGRTLASGS-ADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-302 9.08e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.44  E-value: 9.08e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  78 CGHTAPVLDIAWCPHnDNVIASGSEDCSVMVWEIPDGgltlplrEPVVTLEGHTKRVGIVAWHPTAQnVLLSAGCDNVIL 157
Cdd:cd00200  48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG-------ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251 158 VWDVGTGVAVLTLGSdvHPDTIYSVDWSRDGALICTSCRDKRVRIIEPRKGTIVAEkdrpHEG-TRPVRAV-FVSDG-KI 234
Cdd:cd00200 119 VWDVETGKCLTTLRG--HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT----LTGhTGEVNSVaFSPDGeKL 192

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27806251 235 LTTGfsrmSERQVALWDTKhleeplSLQELDTSSGVLLPF----FDPDTNIVyLCGKGDSSIRYFEITSEAP 302
Cdd:cd00200 193 LSSS----SDGTIKLWDLS------TGKCLGTLRGHENGVnsvaFSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-110 8.95e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 8.95e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 27806251     79 GHTAPVLDIAWCPhNDNVIASGSEDCSVMVWE 110
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-461 6.79e-117

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 351.50  E-value: 6.79e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251    9 SKFRHVFGQPAKADQCYEDVRVSQNTWD-SGFCAVNPKFVALICEASGGGAflVLPLGKTGRVDKNVPMVCGHTAPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251   88 AWCPHNDNVIASGSEDCSVMVWEIPDGGLTLPLREPVVTLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGVAV 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  168 LTLGSdvHPDTIYSVDWSRDGALICTSCRDKRVRIIEPRKGTIVAEKDrPHEGTRPVRAVFVSDGK-ILTTGFSRMSERQ 246
Cdd:PTZ00421 162 EVIKC--HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  247 VALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRG 326
Cdd:PTZ00421 239 IMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWS 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  327 LEVNKCEIARFYKLHERKCEPIAMTVPRK-SDL-FQEDLYPPTAGPDAALTAEEWLGGRDAGPLLISLKDGYvppKSREL 404
Cdd:PTZ00421 317 LDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVF---DGTSP 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  405 RVNRGLDTGRKRT-------TPEASGA--------------PSSDAISRLEEE-----MRKLQATVQELQKR---LDRLE 455
Cdd:PTZ00421 394 ELMGASALSPSGKprhsgvsVPASTSAmthsfddntskhadPCAMGVKRMDEGilderLGRLQALSEKLRTQheeIKRCR 473


                 ....*.
gi 27806251  456 ETVQAK 461
Cdd:PTZ00421 474 EALQKK 479
PTZ00420 PTZ00420
coronin; Provisional
 18-394 1.46e-67

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 225.98  E-value: 1.46e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251   18 PAKADQCYEDVRVSQNTWDSGFCAVNPKFVALICEASGGGAFLVLPLGKTGRvdkNVPMVC--GHTAPVLDIAWCPHNDN 95
Cdd:PTZ00420  12 PDPSNNLFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR---KPPVIKlkGHTSSILDLQFNPCFSE 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251   96 VIASGSEDCSVMVWEIPDGGLTL-PLREPVVTLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGVAVLTLgsdV 174
Cdd:PTZ00420  89 ILASGSEDLTIRVWEIPHNDESVkEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQI---N 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  175 HPDTIYSVDWSRDGALICTSCRDKRVRIIEPRKGTIvAEKDRPHEGTRPVRAVFV-----SDGKILTTGFSRMSERQVAL 249
Cdd:PTZ00420 166 MPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEI-ASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  250 WDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRGLEV 329
Cdd:PTZ00420 245 WDLKNTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDV 322

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27806251  330 NKCEIARFYK-LHERKCEPIAMTVPRK-SDLFQEDLYPPTAGPDAALTAEEWLGGRDAGPLLISLKD 394
Cdd:PTZ00420 323 YKCEIGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD 389
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 3.24e-36

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 127.62  E-value: 3.24e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27806251     4 QVVRSSKFRHVFGQPAKADQCYEDVRVSQNTWDSGFCAVNPKFVALICEASGGGAFLVLPLGKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 COG2319
WD40 repeat [General function prediction only];
79-293 8.17e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.02  E-value: 8.17e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  79 GHTAPVLDIAWCPhNDNVIASGSEDCSVMVWEIPDGgltlplrEPVVTLEGHTKRVGIVAWHPTAQnVLLSAGCDNVILV 158
Cdd:COG2319 202 GHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRL 272

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251 159 WDVGTGVAVLTLGSdvHPDTIYSVDWSRDGALICTSCRDKRVRIIEPRKGTIVaekdRPHEG-TRPVRAV-FVSDGKILT 236
Cdd:COG2319 273 WDLATGELLRTLTG--HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL----RTLTGhTGAVRSVaFSPDGKTLA 346

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27806251 237 TGFsrmSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNIVYLCGkGDSSIR 293
Cdd:COG2319 347 SGS---DDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGRTLASGS-ADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-302 9.08e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.44  E-value: 9.08e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  78 CGHTAPVLDIAWCPHnDNVIASGSEDCSVMVWEIPDGgltlplrEPVVTLEGHTKRVGIVAWHPTAQnVLLSAGCDNVIL 157
Cdd:cd00200  48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG-------ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251 158 VWDVGTGVAVLTLGSdvHPDTIYSVDWSRDGALICTSCRDKRVRIIEPRKGTIVAEkdrpHEG-TRPVRAV-FVSDG-KI 234
Cdd:cd00200 119 VWDVETGKCLTTLRG--HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT----LTGhTGEVNSVaFSPDGeKL 192

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27806251 235 LTTGfsrmSERQVALWDTKhleeplSLQELDTSSGVLLPF----FDPDTNIVyLCGKGDSSIRYFEITSEAP 302
Cdd:cd00200 193 LSSS----SDGTIKLWDLS------TGKCLGTLRGHENGVnsvaFSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
Trimer_CC pfam08954
trimerization motif; This domain is predominantly found in the structural protein coronin, and ...
 410-461 2.79e-29

trimerization motif; This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It appears to have the function of stabilising the topology of short coiled-coils in proteins.


Pssm-ID: 462646  Cd Length: 52  Bit Score: 108.86  E-value: 2.79e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 27806251   410 LDTGRKRTTPEASGAPSSDAISRLEEEMRKLQATVQELQKRLDRLEETVQAK 461
Cdd:pfam08954   1 LDSGRRRATPEASGTPSSDAVSRLEEEMRKLQATVQELQKRLDRLEETVQAK 52
WD40 COG2319
WD40 repeat [General function prediction only];
79-303 1.08e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 1.08e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  79 GHTAPVLDIAWCPhNDNVIASGSEDCSVMVWEIPDGgltlplrEPVVTLEGHTKRVGIVAWHPTAQnVLLSAGCDNVILV 158
Cdd:COG2319 118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251 159 WDVGTGVAVLTLgsDVHPDTIYSVDWSRDGALICTSCRDKRVRIIEPRKGTIVAekdRPHEGTRPVRAVFVS-DGKILTT 237
Cdd:COG2319 189 WDLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFSpDGRLLAS 263

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27806251 238 GfsrMSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNIVyLCGKGDSSIRYFEITSEAPF 303
Cdd:COG2319 264 G---SADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLL 323
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-296 1.94e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 1.94e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  79 GHTAPVLDIAWCPHNDnVIASGSEDCSVMVWEIPDGgltlplrEPVVTLEGHTKRVGIVAWHPTAQnVLLSAGCDNVILV 158
Cdd:cd00200  91 GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251 159 WDVGTGVAVLTLGSdvHPDTIYSVDWSRDGALICTSCRDKRVRIIEPRKGTIVAEKdRPHEGtrPVRAV-FVSDGKILTT 237
Cdd:cd00200 162 WDLRTGKCVATLTG--HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGHEN--GVNSVaFSPDGYLLAS 236

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 27806251 238 GFsrmSERQVALWDTKHLEEPLSLQEldTSSGVLLPFFDPDTNIVYLCGKgDSSIRYFE 296
Cdd:cd00200 237 GS---EDGTIRVWDLRTGECVQTLSG--HTNSVTSLAWSPDGKRLASGSA-DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
79-202 4.07e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.76  E-value: 4.07e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  79 GHTAPVLDIAWCPhNDNVIASGSEDCSVMVWEIPDGgltlplrEPVVTLEGHTKRVGIVAWHPTAQnVLLSAGCDNVILV 158
Cdd:COG2319 286 GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRL 356

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 27806251 159 WDVGTGVAVLTLGSdvHPDTIYSVDWSRDGALICTSCRDKRVRI 202
Cdd:COG2319 357 WDLATGELLRTLTG--HTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 345-387 3.21e-19

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 80.63  E-value: 3.21e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 27806251   345 CEPIAMTVPRKS-DLFQEDLYPPTAGPDAALTAEEWLGGRDAGP 387
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 126-299 6.68e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 6.68e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251 126 TLEGHTKRVGIVAWHPTaQNVLLSAGCDNVILVWDVGTGVAVLTLGsdVHPDTIYSVDWSRDGALICTSCRDKRVRIIEP 205
Cdd:cd00200   4 TLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251 206 RKGTIVAEKdRPHEGtrPVRAV-FVSDGKILTTGfsrMSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNIVYl 284
Cdd:cd00200  81 ETGECVRTL-TGHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGTFVA- 151

                       170
                ....*....|....*
gi 27806251 285 CGKGDSSIRYFEITS 299
Cdd:cd00200 152 SSSQDGTIKLWDLRT 166
WD40 COG2319
WD40 repeat [General function prediction only];
79-163 1.27e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 1.27e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251  79 GHTAPVLDIAWCPhNDNVIASGSEDCSVMVWEIPDGGLtlplrepVVTLEGHTKRVGIVAWHPTAQnVLLSAGCDNVILV 158
Cdd:COG2319 328 GHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGEL-------LRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRL 398


                ....*
gi 27806251 159 WDVGT 163
Cdd:COG2319 399 WDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-110 8.95e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 8.95e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 27806251     79 GHTAPVLDIAWCPhNDNVIASGSEDCSVMVWE 110
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
116-262 2.75e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 2.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251 116 LTLPLREPVVTLEGHTKRVGIVAWHPTAQNVLLSAGcDNVILVWDVGTGVAVLTLGSdvHPDTIYSVDWSRDGALICTSC 195
Cdd:COG2319  21 LAAALGALLLLLLGLAAAVASLAASPDGARLAAGAG-DLTLLLLDAAAGALLATLLG--HTAAVLSVAFSPDGRLLASAS 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27806251 196 RDKRVRIIEPRKGTIVAEkDRPHEGtrPVRAVFVS-DGKILTTGFsrmSERQVALWDTKHLEEPLSLQ 262
Cdd:COG2319  98 ADGTVRLWDLATGLLLRT-LTGHTG--AVRSVAFSpDGKTLASGS---ADGTVRLWDLATGKLLRTLT 159
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 121-160 3.40e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.40e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 27806251    121 REPVVTLEGHTKRVGIVAWHPTaQNVLLSAGCDNVILVWD 160
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
79-110 1.64e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.64e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 27806251    79 GHTAPVLDIAWCPhNDNVIASGSEDCSVMVWE 110
Cdd:pfam00400   9 GHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
121-160 3.64e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 3.64e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 27806251   121 REPVVTLEGHTKRVGIVAWHPTaQNVLLSAGCDNVILVWD 160
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
175-202 5.38e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 5.38e-04
                          10        20
                  ....*....|....*....|....*...
gi 27806251   175 HPDTIYSVDWSRDGALICTSCRDKRVRI 202
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-202 7.19e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 7.19e-04
                           10        20
                   ....*....|....*....|....*...
gi 27806251    175 HPDTIYSVDWSRDGALICTSCRDKRVRI 202
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKL 38
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
133-292 7.45e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.14  E-value: 7.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251 133 RVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGVAVLTLGSDVHPDTIYSVDWSRDGA-LICTSCRDKRVRIIEPRKGTIV 211
Cdd:COG3391  24 AVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRrLYVANSGSGRVSVIDLATGKVV 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27806251 212 AEKDrphEGTRPVRAVFVSDGKIL--TTGFSRmserQVALWDTKHLEEPLSLQELDTSSGVLlpfFDPDTNIVYLCGKGD 289
Cdd:COG3391 104 ATIP---VGGGPRGLAVDPDGGRLyvADSGNG----RVSVIDTATGKVVATIPVGAGPHGIA---VDPDGKRLYVANSGS 173


                ...
gi 27806251 290 SSI 292
Cdd:COG3391 174 NTV 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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