NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|27807461|ref|NP_777183|]
View 

NPC intracellular cholesterol transporter 1 precursor [Bos taurus]

Protein Classification

Niemann-Pick C type protein family( domain architecture ID 11489961)

Niemann-Pick C (NPC) type protein family is essential for sterol homeostasis that drive sterol integration into the lysosomal membrane before redistribution to other cellular membranes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 25-1251 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


:

Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 1790.24  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461     25 CIWYGECGIASGDKRYNCRYSGPPEPLPQDGYDLVQELCpGFFFGNVS--LCCDVQQLHTLKDNLQLPLQFLSRCPSCFY 102
Cdd:TIGR00917    1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVRCPACLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    103 NLVNLFCELTCSPRQSQFLNVTATEDyvdpatNQTKTNVKELQYYVGESFANAMYNSCRDVEAPSSNEKALGLLCGREAS 182
Cdd:TIGR00917   80 NFLNLFCELTCSPDQSLFINVTSTTK------VKTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKN 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    183 ACNATNWIEYMFNKDNGQAPFTITPVFSDLP-THGMEPMNNATKGCDESVDEVTGPCSCQDCSAVCGPKPQPPPPPVPWK 261
Cdd:TIGR00917  154 FKEWFNWIGQKAGVNLPGAPYGIAFLPTPCPvSSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSI 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    262 ILGLDAMYVIMWSTYMAFLLVFFG--AFFAVWCYRKRYFVSEFTPIDGNIPFSINASDKGGPTCCDPLGAAFEAHLRRLF 339
Cdd:TIGR00917  234 KLGVKCVDFILAILYIVLVSVFLGggLLHPVRGKKKTSQMGTLSEADGEINSVNQQKDQNTPQRNWGQLSTVQGHLARFF 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    340 EWWGSFCVRHPGCVVFFSVAFIAACSSGLVFIQVTTDPVDLWSAPGSQARLEKEYFDTHFGPFFRTEQLIIRAPHTPPHi 419
Cdd:TIGR00917  314 GKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIATVQTSSH- 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    420 yepypsgadVPFGPPLAVNILHQVLDLQTAIESITASYNNETVTLRDICVAPLSPYNqnCTILSVLNYFQNSHSVLDHQV 499
Cdd:TIGR00917  393 ---------EKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIYSTCKKLQNMYSKLKPEN 461

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    500 GDDFFVyADYHTHFLYWVRAPaslndtsllhDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQR 579
Cdd:TIGR00917  462 YDDYGG-VDYVKYCFEHFTSP----------ESCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVTFPVNNFVNKTNKTEK 530

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    580 AQAWEKEFINFVQNYENPNL--TISFKAERSIEDELNRESNSDVFTVLISYGVMFLYISIALGHIKSCRRLLVDSKILLG 657
Cdd:TIGR00917  531 AVAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLG 610

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    658 IAGVLIVLSPVACSLGFFSYWGSPLTLIVIEVIPFLVLAVGVDNIFILVQTYQIDERLQGE---------TLDQQVGRVL 728
Cdd:TIGR00917  611 LSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQvgvdneqelTLERRLSRAL 690

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    729 GEVAPSMFLSSFAETVAFFLGGLSVMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNQLDVLCCVGGAADD- 807
Cdd:TIGR00917  691 MEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSi 770

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    808 ----AGIQASESCLFRFFRNSYAPLLLKDWMRPLVVAVFVGVLSFSIAVLNKVEIGLDQSLSMPDDSYVTDYFQSLNQYL 883
Cdd:TIGR00917  771 saekGSGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLL 850

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    884 HAGPPVYFVLEEGHDYTSTKGQNMVCGGLGCNNDSLVQQvftaaqLDSYTRIGFAPSSWIDDYFDWVKPQSSCCRIYNST 963
Cdd:TIGR00917  851 EVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDYLVWLSPQASCCCRKFTN 924

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    964 EQFCNasVVNPTCVRCRPLTPEGKQRPQGADFMRFLPMFLSDNPNPKCGKGGHAAYSAAVNILDNGTRVGATYFMTYHTV 1043
Cdd:TIGR00917  925 GTFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQGYATIIQASSFRTYHTP 1002

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1044 LQTSADFIDAMEKARLIASNITRtmnqqGGDHRVFPYSVFYVFYEQYLTMIDDTIFNLSVSLGAIFLVAVVLLGCELWSA 1123
Cdd:TIGR00917 1003 LNTQVDFINAMRAAQEFAAKVSR-----SSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSV 1077

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1124 VIMCATIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSTKGSRVERAEEALSHMGSSVFSGITL 1203
Cdd:TIGR00917 1078 VNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITL 1157

                         1210      1220      1230      1240
                   ....*....|....*....|....*....|....*....|....*...
gi 27807461   1204 TKFGGIIVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIG 1251
Cdd:TIGR00917 1158 TKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 25-1251 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 1790.24  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461     25 CIWYGECGIASGDKRYNCRYSGPPEPLPQDGYDLVQELCpGFFFGNVS--LCCDVQQLHTLKDNLQLPLQFLSRCPSCFY 102
Cdd:TIGR00917    1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVRCPACLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    103 NLVNLFCELTCSPRQSQFLNVTATEDyvdpatNQTKTNVKELQYYVGESFANAMYNSCRDVEAPSSNEKALGLLCGREAS 182
Cdd:TIGR00917   80 NFLNLFCELTCSPDQSLFINVTSTTK------VKTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKN 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    183 ACNATNWIEYMFNKDNGQAPFTITPVFSDLP-THGMEPMNNATKGCDESVDEVTGPCSCQDCSAVCGPKPQPPPPPVPWK 261
Cdd:TIGR00917  154 FKEWFNWIGQKAGVNLPGAPYGIAFLPTPCPvSSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSI 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    262 ILGLDAMYVIMWSTYMAFLLVFFG--AFFAVWCYRKRYFVSEFTPIDGNIPFSINASDKGGPTCCDPLGAAFEAHLRRLF 339
Cdd:TIGR00917  234 KLGVKCVDFILAILYIVLVSVFLGggLLHPVRGKKKTSQMGTLSEADGEINSVNQQKDQNTPQRNWGQLSTVQGHLARFF 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    340 EWWGSFCVRHPGCVVFFSVAFIAACSSGLVFIQVTTDPVDLWSAPGSQARLEKEYFDTHFGPFFRTEQLIIRAPHTPPHi 419
Cdd:TIGR00917  314 GKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIATVQTSSH- 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    420 yepypsgadVPFGPPLAVNILHQVLDLQTAIESITASYNNETVTLRDICVAPLSPYNqnCTILSVLNYFQNSHSVLDHQV 499
Cdd:TIGR00917  393 ---------EKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIYSTCKKLQNMYSKLKPEN 461

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    500 GDDFFVyADYHTHFLYWVRAPaslndtsllhDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQR 579
Cdd:TIGR00917  462 YDDYGG-VDYVKYCFEHFTSP----------ESCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVTFPVNNFVNKTNKTEK 530

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    580 AQAWEKEFINFVQNYENPNL--TISFKAERSIEDELNRESNSDVFTVLISYGVMFLYISIALGHIKSCRRLLVDSKILLG 657
Cdd:TIGR00917  531 AVAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLG 610

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    658 IAGVLIVLSPVACSLGFFSYWGSPLTLIVIEVIPFLVLAVGVDNIFILVQTYQIDERLQGE---------TLDQQVGRVL 728
Cdd:TIGR00917  611 LSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQvgvdneqelTLERRLSRAL 690

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    729 GEVAPSMFLSSFAETVAFFLGGLSVMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNQLDVLCCVGGAADD- 807
Cdd:TIGR00917  691 MEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSi 770

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    808 ----AGIQASESCLFRFFRNSYAPLLLKDWMRPLVVAVFVGVLSFSIAVLNKVEIGLDQSLSMPDDSYVTDYFQSLNQYL 883
Cdd:TIGR00917  771 saekGSGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLL 850

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    884 HAGPPVYFVLEEGHDYTSTKGQNMVCGGLGCNNDSLVQQvftaaqLDSYTRIGFAPSSWIDDYFDWVKPQSSCCRIYNST 963
Cdd:TIGR00917  851 EVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDYLVWLSPQASCCCRKFTN 924

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    964 EQFCNasVVNPTCVRCRPLTPEGKQRPQGADFMRFLPMFLSDNPNPKCGKGGHAAYSAAVNILDNGTRVGATYFMTYHTV 1043
Cdd:TIGR00917  925 GTFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQGYATIIQASSFRTYHTP 1002

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1044 LQTSADFIDAMEKARLIASNITRtmnqqGGDHRVFPYSVFYVFYEQYLTMIDDTIFNLSVSLGAIFLVAVVLLGCELWSA 1123
Cdd:TIGR00917 1003 LNTQVDFINAMRAAQEFAAKVSR-----SSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSV 1077

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1124 VIMCATIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSTKGSRVERAEEALSHMGSSVFSGITL 1203
Cdd:TIGR00917 1078 VNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITL 1157

                         1210      1220      1230      1240
                   ....*....|....*....|....*....|....*....|....*...
gi 27807461   1204 TKFGGIIVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIG 1251
Cdd:TIGR00917 1158 TKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
NPC1_N pfam16414
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ...
 23-267 1.63e-96

Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.


Pssm-ID: 465110  Cd Length: 239  Bit Score: 308.38  E-value: 1.63e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461     23 QSCIWYGECGIAS-GDKRYNCRYSGPPEPLPQDGYDLVQELCPGFFFGNVSLCCDVQQLHTLKDNLQLPLQFLSRCPSCF 101
Cdd:pfam16414    1 GRCAWYGECGKKSlFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSRCPACK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    102 YNLVNLFCELTCSPRQSQFLNVTATEdyvdpATNQTKTNVKELQYYVGESFANAMYNSCRDVEAPSSNEKALGLLCGRea 181
Cdd:pfam16414   81 KNFANLFCEFTCSPNQSTFLNVTKTK-----KSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICGG-- 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    182 sACNATNWIEYMFNKDNGQAPFTITPVF-SDLPTHGMEPMNNATKGCDESVDEvTGPCSCQDCSAVCGPKPQP-PPPPVP 259
Cdd:pfam16414  154 -ACNYTRWLKFMGDKKNGGSPFQINFPDpPEEDPSGMVPLNPNTKDCNESYDA-SYACSCVDCPLSCPPPPQLpPPPHGP 231


                   ....*...
gi 27807461    260 WKILGLDA 267
Cdd:pfam16414  232 CKVGGLDG 239
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
336-1258 2.31e-33

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 139.22  E-value: 2.31e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  336 RRLFEWWGSFCVRHPGCVVFFSVAFIAACSSGLVFIQVTTDPVDlWSAPGSQARLEKEYFDTHFGPffrTEQLIIrAPHT 415
Cdd:COG1033    1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVV-AVEG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  416 PPHIYEPypsgadvpfgpplavNILHQVLDLQTAIESItasynnETVTlrdicvaplspynqncTILSVLNyFQNSHSVL 495
Cdd:COG1033   76 KDDIFTP---------------ETLEALRELTEELEEI------PGVD----------------SVTSLTN-VRATEGTE 117

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  496 DHQVGDDFFvyADYhthflyWVRAPASLND--TSLLHDPclgtfggpvfpwlvlgGYDDQNYNN---ATALVITFpvnNY 570
Cdd:COG1033  118 DGLTVEPLI--PDE------LPASPEELAElrEKVLSSP----------------LYVGRLVSPdgkATLIVVTL---DP 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  571 YNDTEKLQRAQAWEkEFINFVQNYENPNLTISFKAERSIEDELNRESNSDVFT-VLISYGVMFLYISIALGHIKScrrll 649
Cdd:COG1033  171 DPLSSDLDRKEVVA-EIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIfFPLALLLILLLLFLFFRSLRG----- 244

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  650 vdskILLGIAGVLIVlspVACSLGFFSYWGSPLTLIVIeVIPFLVLAVGVDNIFILVQTYQiDERLQGETLDQQVGRVLG 729
Cdd:COG1033  245 ----VLLPLLVVLLA---VIWTLGLMGLLGIPLSPLTI-LVPPLLLAIGIDYGIHLLNRYR-EERRKGLDKREALREALR 315

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  730 EVAPSMFLSSFAETVAFFLGGLSVMPAVHTFSLFAGMAVLIDFLLQIT---CFVSLLGLDIKRQEKNQldvlccvggaad 806
Cdd:COG1033  316 KLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTllpALLSLLPRPKPKTRRLK------------ 383

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  807 dagiqaSESCLFRFFRNsyapllLKDWMRP---LVVAVFVGVLSFSIAVLNKVEIGLDQSLSMPDDS-------YVTDYF 876
Cdd:COG1033  384 ------KPPELGRLLAK------LARFVLRrpkVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSpirqdldFIEENF 451

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  877 QSLNqylhagpPVYFVLEEGHDYtstkgqnmvcgglGCNNDSLVQQVFTAAQ-LDSYTRIGFAPSswIDDYFDWVKpqss 955
Cdd:COG1033  452 GGSD-------PLEVVVDTGEPD-------------GLKDPEVLKEIDRLQDyLESLPEVGKVLS--LADLVKELN---- 505

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  956 ccRIYNSTEqfcnasvvnptcvrcrpltPEGKQRPQGADFMRFLPMFLSDNPNpkcgkgghaaySAAVNILD-NGTRVGA 1034
Cdd:COG1033  506 --QALNEGD-------------------PKYYALPESRELLAQLLLLLSSPPG-----------DDLSRFVDeDYSAARV 553

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461 1035 TYFMTYHtvlqtSADFIDAMEKArlIASNITRTMNQQGGDHRVfpYSVFYVFYEQYLTMIDDTIFNLSVSLGAIFLVAVV 1114
Cdd:COG1033  554 TVRLKDL-----DSEEIKALVEE--VRAFLAENFPPDGVEVTL--TGSAVLFAAINESVIESQIRSLLLALLLIFLLLLL 624

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461 1115 LLGcELWSAVIMCATIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFT--VSTKGSRVERAEEALSH 1192
Cdd:COG1033  625 AFR-SLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYReeRRKGGDLEEAIRRALRT 703

                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27807461 1193 MGSSV-FSGITLtkFGGIIVLAFAKSQIFQIFYFRMYLAMV--LLGAthgLIFLPVLLSYIGPSINKAK 1258
Cdd:COG1033  704 TGKAIlFTSLTL--AAGFGVLLFSSFPPLADFGLLLALGLLvaLLAA---LLLLPALLLLLDPRIAKKR 767
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
1094-1165 5.50e-03

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 41.16  E-value: 5.50e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27807461  1094 IDDTIFNLSVSLGAIFLVAVVLLGcELWSAVIMCATIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVE 1165
Cdd:NF033617  329 IDEVESTLLEAVALVILVVFLFLR-NLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVD 399
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 25-1251 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 1790.24  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461     25 CIWYGECGIASGDKRYNCRYSGPPEPLPQDGYDLVQELCpGFFFGNVS--LCCDVQQLHTLKDNLQLPLQFLSRCPSCFY 102
Cdd:TIGR00917    1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVRCPACLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    103 NLVNLFCELTCSPRQSQFLNVTATEDyvdpatNQTKTNVKELQYYVGESFANAMYNSCRDVEAPSSNEKALGLLCGREAS 182
Cdd:TIGR00917   80 NFLNLFCELTCSPDQSLFINVTSTTK------VKTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKN 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    183 ACNATNWIEYMFNKDNGQAPFTITPVFSDLP-THGMEPMNNATKGCDESVDEVTGPCSCQDCSAVCGPKPQPPPPPVPWK 261
Cdd:TIGR00917  154 FKEWFNWIGQKAGVNLPGAPYGIAFLPTPCPvSSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSI 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    262 ILGLDAMYVIMWSTYMAFLLVFFG--AFFAVWCYRKRYFVSEFTPIDGNIPFSINASDKGGPTCCDPLGAAFEAHLRRLF 339
Cdd:TIGR00917  234 KLGVKCVDFILAILYIVLVSVFLGggLLHPVRGKKKTSQMGTLSEADGEINSVNQQKDQNTPQRNWGQLSTVQGHLARFF 313

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    340 EWWGSFCVRHPGCVVFFSVAFIAACSSGLVFIQVTTDPVDLWSAPGSQARLEKEYFDTHFGPFFRTEQLIIRAPHTPPHi 419
Cdd:TIGR00917  314 GKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIATVQTSSH- 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    420 yepypsgadVPFGPPLAVNILHQVLDLQTAIESITASYNNETVTLRDICVAPLSPYNqnCTILSVLNYFQNSHSVLDHQV 499
Cdd:TIGR00917  393 ---------EKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIYSTCKKLQNMYSKLKPEN 461

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    500 GDDFFVyADYHTHFLYWVRAPaslndtsllhDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQR 579
Cdd:TIGR00917  462 YDDYGG-VDYVKYCFEHFTSP----------ESCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVTFPVNNFVNKTNKTEK 530

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    580 AQAWEKEFINFVQNYENPNL--TISFKAERSIEDELNRESNSDVFTVLISYGVMFLYISIALGHIKSCRRLLVDSKILLG 657
Cdd:TIGR00917  531 AVAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLG 610

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    658 IAGVLIVLSPVACSLGFFSYWGSPLTLIVIEVIPFLVLAVGVDNIFILVQTYQIDERLQGE---------TLDQQVGRVL 728
Cdd:TIGR00917  611 LSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQvgvdneqelTLERRLSRAL 690

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    729 GEVAPSMFLSSFAETVAFFLGGLSVMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNQLDVLCCVGGAADD- 807
Cdd:TIGR00917  691 MEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSi 770

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    808 ----AGIQASESCLFRFFRNSYAPLLLKDWMRPLVVAVFVGVLSFSIAVLNKVEIGLDQSLSMPDDSYVTDYFQSLNQYL 883
Cdd:TIGR00917  771 saekGSGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLL 850

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    884 HAGPPVYFVLEEGHDYTSTKGQNMVCGGLGCNNDSLVQQvftaaqLDSYTRIGFAPSSWIDDYFDWVKPQSSCCRIYNST 963
Cdd:TIGR00917  851 EVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDYLVWLSPQASCCCRKFTN 924

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    964 EQFCNasVVNPTCVRCRPLTPEGKQRPQGADFMRFLPMFLSDNPNPKCGKGGHAAYSAAVNILDNGTRVGATYFMTYHTV 1043
Cdd:TIGR00917  925 GTFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQGYATIIQASSFRTYHTP 1002

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1044 LQTSADFIDAMEKARLIASNITRtmnqqGGDHRVFPYSVFYVFYEQYLTMIDDTIFNLSVSLGAIFLVAVVLLGCELWSA 1123
Cdd:TIGR00917 1003 LNTQVDFINAMRAAQEFAAKVSR-----SSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSV 1077

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1124 VIMCATIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSTKGSRVERAEEALSHMGSSVFSGITL 1203
Cdd:TIGR00917 1078 VNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITL 1157

                         1210      1220      1230      1240
                   ....*....|....*....|....*....|....*....|....*...
gi 27807461   1204 TKFGGIIVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIG 1251
Cdd:TIGR00917 1158 TKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
NPC1_N pfam16414
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ...
 23-267 1.63e-96

Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.


Pssm-ID: 465110  Cd Length: 239  Bit Score: 308.38  E-value: 1.63e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461     23 QSCIWYGECGIAS-GDKRYNCRYSGPPEPLPQDGYDLVQELCPGFFFGNVSLCCDVQQLHTLKDNLQLPLQFLSRCPSCF 101
Cdd:pfam16414    1 GRCAWYGECGKKSlFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSRCPACK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    102 YNLVNLFCELTCSPRQSQFLNVTATEdyvdpATNQTKTNVKELQYYVGESFANAMYNSCRDVEAPSSNEKALGLLCGRea 181
Cdd:pfam16414   81 KNFANLFCEFTCSPNQSTFLNVTKTK-----KSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICGG-- 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    182 sACNATNWIEYMFNKDNGQAPFTITPVF-SDLPTHGMEPMNNATKGCDESVDEvTGPCSCQDCSAVCGPKPQP-PPPPVP 259
Cdd:pfam16414  154 -ACNYTRWLKFMGDKKNGGSPFQINFPDpPEEDPSGMVPLNPNTKDCNESYDA-SYACSCVDCPLSCPPPPQLpPPPHGP 231


                   ....*...
gi 27807461    260 WKILGLDA 267
Cdd:pfam16414  232 CKVGGLDG 239
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 481-1248 1.64e-70

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 253.05  E-value: 1.64e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    481 ILSVLNYFQNSHSVldhQVGDDFFVYADYHTHFLYW---VRAPASLNDTSLLHD-------PCLGTFGGPVFPWLVLGG- 549
Cdd:pfam02460   67 IYQLNDYISTNVEI---QVDGIIISFKDLCSRYCDLncpVNKHYNGMLLSRRHNtridityPIMPVLGTPIYLGPHFGGv 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    550 --YDDQNYNNATALVITFPVNnyYNDTEKLQRAQAWEKEFINFVQN-YENPNLTISFKAERSIEDELNRESNSDVFTVLI 626
Cdd:pfam02460  144 dfEPPGNISYAKAIVLWYFLK--FDEEEVEEDSKEWEDELSQLLHNkYASEHIQFTIFHDQILNDELVRNALTLTPFFVI 221

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    627 SYGVMFLYISIALGHIKSCRRLLVDSKILLGIAGVLIVLSPVACSLGFFSYWGSPLTLIVIeVIPFLVLAVGVDNIFILV 706
Cdd:pfam02460  222 GFFLLLTFSIIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVC-VTPFLVLAIGVDDMFLMV 300

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    707 QTYQIDERLQgeTLDQQVGRVLGEVAPSMFLSSFAETVAFFLGGLSVMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLD 786
Cdd:pfam02460  301 AAWQRTTATL--SVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAIC 378

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    787 IKRQEKNQLDVLCCV---------GGAADDAGiQASESCLFRFFRNSYAPLLLKDWMRPLVVAVFVGVLSFSIAVLNKVE 857
Cdd:pfam02460  379 AKPEAEGRHCLFVWAtsspqridsEGSEPDKS-HNIEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIK 457

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    858 IGLDQSLSMPDDSYVTDYFQSLNQYL-HAGPPVYFVLEEGHDYTSTKgqnmvcgglgcNNDSLvQQVFTAAQLDSYTRIG 936
Cdd:pfam02460  458 EGLEPDKLVLEDSPLVEYLSLREKHFwPEGLQIQVAVNNPPNLTIPE-----------SRDRM-NEMVDEFENTPYSLGP 525

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    937 FAPSSWIDDYFDwvkpqssccriYNSTEQFcnasvvnptcvrcrpltpEGKQRPQGADFMRFLPMFLSdnpnpkcgKGGH 1016
Cdd:pfam02460  526 NSTLFWLREYEN-----------FLSTLNM------------------EEEEDEEKEWSYGNLPSFLK--------APGN 568

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1017 AAYSAAVNILDNGTRVGATYFMTYHTVLQTSADFIDAMEKARLIASNitrtmnqqggdHRVFPYSVF---YVFYEQYLTM 1093
Cdd:pfam02460  569 SHWAGDLVWDDNTTMVTKFRFTLAGKGLSTWNDRTRALQEWRSIADQ-----------YPEFNVTVFdedAPFADQYLTI 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1094 IDDTIFNLSVSLGAIFLVAVVLLGCELWSAVIMCAtIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRA 1173
Cdd:pfam02460  638 LPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLA-IASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYH 716

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27807461   1174 FTVSTKGSRVERAEEALSHMGSSVFSGITLTkFGGIIVLAFAKSQIFQIFYFRMYLaMVLLGATHGLIFLPVLLS 1248
Cdd:pfam02460  717 FVRSRGDTPAERVVDALEALGWPVFQGGLST-ILGVLVLLFVPSYMVVVFFKTVFL-VVAIGLLHGLFILPIILS 789
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
327-1252 1.33e-59

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 224.38  E-value: 1.33e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    327 LGAAFEAHLRRLfewwGSFCVRHPGCVVFFSVAFIAACSSGLVFIQVTTDPVDLWSAPGSQARLEKEYFDTHFGP-FFRT 405
Cdd:TIGR00918   39 LRAKFQRLLFTL----GCYIQKHCGKVLFVGLLVFSAFAVGLRAANIETNVEQLWVEVGGRVSQELAYTRQKIGEeAMFT 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    406 EQLIIRAPHTPphiyepypsGADVpfgppLAVNILHQVLDLQTAIESITASYNNETVTLRDICVAPLSPYNQN------- 478
Cdd:TIGR00918  115 PQLLIQTPHQE---------GANV-----LTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPSTEGgyieqil 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    479 -----CTILSVLNYF------QNSHSVLDHQ-----VGDDFFVYADYHTHFLYWVRAPASLNDTS-----LLHDPCL--- 534
Cdd:TIGR00918  181 eklipCLIITPLDCFwegaklQGGTAYLPGKpplqwTNLDPASFLEELKQKMSQVESWEEMLKKAavgqgYMERPCLnpa 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    535 -------------------------GTFG--GPVFPW---LVLGGY---DDQNYNNATALVITFPV-----------NNY 570
Cdd:TIGR00918  261 dpdcpdtapnknstqppdvaavlsgGCYGlsAKYMHWqeeLIVGGTkrnRSGKLLSAQALQSMFQLmtpkqmyehfkGYY 340

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    571 Y------NDTEKLQRAQAWEKEFINFVQNY--ENPNLTISFKAERSIEDELNRESNSDVFTVLISYGVMFLYISIALghi 642
Cdd:TIGR00918  341 KvhhigwNEEKAAAVLEAWQRNFSEEVQQSlpKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLAYACLTM--- 417

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    643 ksCRRLLVDSKILLGIAGVLIVLSPVACSLGFFSYWGSPLTLIVIEVIPFLVLAVGVDNIFILVQTYQidERLQGETLDQ 722
Cdd:TIGR00918  418 --LRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFS--ETGQNIPFEE 493

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    723 QVGRVLGEVAPSMFLSSFAETVAFFLGGLSVMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNQLDVLCC-- 800
Cdd:TIGR00918  494 RTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCff 573

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    801 ----------------------VGGAA----------DDAGIQASESC-------------------------------- 816
Cdd:TIGR00918  574 spcsarviqiepqayadgsappVYSSHmqstvqlrteYDPGTQHYYTTneprshlsvqpsdplscqspdiagstrdllsq 653

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    817 -----------------LFRFFRNSYAPLLLKDWMRPLVVAVFVGVLSFSIAVLNKVEIGLDQSLSMPDDSYVTDYFQSL 879
Cdd:TIGR00918  654 fedskaaclslpcarwtLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQ 733

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    880 NQYLhAGPPVYFVLEEGHDYTSTKgqnmvcgglgcnndslvQQVFTAAQldSYTRI--------GFAPSSWIDDYFDWVK 951
Cdd:TIGR00918  734 FRYF-SFYNMYAVTQGNFDYPTQQ-----------------QLLYDLHQ--SFSSVkyvlkednGQLPRMWLHYFRDWLQ 793

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    952 P-QSSCCRIYNS----TEQFCNAS--------VVNPTCVRCRPLTPE--GKQRPQGAD-------FMRFLPMFLSDNP-- 1007
Cdd:TIGR00918  794 GlQKAFDEDWRDgritKENYRNGSddavlaykLLVQTGHRDKPVDKEqlTTQRLVNADgiinpnaFYIYLSAWVSNDPva 873

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1008 --------NPKCGKGGHAAYSAAVNILDNGTRVGATY--FMTYHTVLQTSADFIDAMEKARLIASNITRTmnqqgGDHRv 1077
Cdd:TIGR00918  874 yaasqaniYPHPPEWLHDKNDYDPENLRIPAAEPLEYaqFPFYLNGLRETSQFVEAIEHVRAICNNYEGF-----GLPS- 947

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1078 FPYSVFYVFYEQYLTMIDDTIFNLSVSLGAIFLVAVVLLgCELWSAVIMCATIAMILVNMFGVMWLWGISLNAVSLVNLV 1157
Cdd:TIGR00918  948 YPSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLL-LNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILI 1026

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1158 MSCGISVEFCSHITRAFtVSTKGSRVERAEEALSHMGSSVFSGITLTKFGgiiVLAFAKSQI-FQIFYFRMYLAMV-LLG 1235
Cdd:TIGR00918 1027 ASVGIGVEFTVHIALGF-LTAIGDRNRRAVLALEHMFAPVLDGALSTLLG---VLMLAGSEFdFIVRYFFAVLAVLtCLG 1102

                         1130
                   ....*....|....*..
gi 27807461   1236 ATHGLIFLPVLLSYIGP 1252
Cdd:TIGR00918 1103 VLNGLVLLPVLLSMFGP 1119
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 649-801 3.43e-59

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 200.12  E-value: 3.43e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    649 LVDSKILLGIAGVLIVLSPVACSLGFFSYWGSPLTLIVIEVIPFLVLAVGVDNIFILVQTYQIDERLQGEtlDQQVGRVL 728
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDV--SERIAEAL 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27807461    729 GEVAPSMFLSSFAETVAFFLGGLSVMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNQLDVLCCV 801
Cdd:pfam12349   79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCI 151
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
336-1258 2.31e-33

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 139.22  E-value: 2.31e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  336 RRLFEWWGSFCVRHPGCVVFFSVAFIAACSSGLVFIQVTTDPVDlWSAPGSQARLEKEYFDTHFGPffrTEQLIIrAPHT 415
Cdd:COG1033    1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVV-AVEG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  416 PPHIYEPypsgadvpfgpplavNILHQVLDLQTAIESItasynnETVTlrdicvaplspynqncTILSVLNyFQNSHSVL 495
Cdd:COG1033   76 KDDIFTP---------------ETLEALRELTEELEEI------PGVD----------------SVTSLTN-VRATEGTE 117

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  496 DHQVGDDFFvyADYhthflyWVRAPASLND--TSLLHDPclgtfggpvfpwlvlgGYDDQNYNN---ATALVITFpvnNY 570
Cdd:COG1033  118 DGLTVEPLI--PDE------LPASPEELAElrEKVLSSP----------------LYVGRLVSPdgkATLIVVTL---DP 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  571 YNDTEKLQRAQAWEkEFINFVQNYENPNLTISFKAERSIEDELNRESNSDVFT-VLISYGVMFLYISIALGHIKScrrll 649
Cdd:COG1033  171 DPLSSDLDRKEVVA-EIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIfFPLALLLILLLLFLFFRSLRG----- 244

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  650 vdskILLGIAGVLIVlspVACSLGFFSYWGSPLTLIVIeVIPFLVLAVGVDNIFILVQTYQiDERLQGETLDQQVGRVLG 729
Cdd:COG1033  245 ----VLLPLLVVLLA---VIWTLGLMGLLGIPLSPLTI-LVPPLLLAIGIDYGIHLLNRYR-EERRKGLDKREALREALR 315

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  730 EVAPSMFLSSFAETVAFFLGGLSVMPAVHTFSLFAGMAVLIDFLLQIT---CFVSLLGLDIKRQEKNQldvlccvggaad 806
Cdd:COG1033  316 KLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTllpALLSLLPRPKPKTRRLK------------ 383

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  807 dagiqaSESCLFRFFRNsyapllLKDWMRP---LVVAVFVGVLSFSIAVLNKVEIGLDQSLSMPDDS-------YVTDYF 876
Cdd:COG1033  384 ------KPPELGRLLAK------LARFVLRrpkVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSpirqdldFIEENF 451

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  877 QSLNqylhagpPVYFVLEEGHDYtstkgqnmvcgglGCNNDSLVQQVFTAAQ-LDSYTRIGFAPSswIDDYFDWVKpqss 955
Cdd:COG1033  452 GGSD-------PLEVVVDTGEPD-------------GLKDPEVLKEIDRLQDyLESLPEVGKVLS--LADLVKELN---- 505

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  956 ccRIYNSTEqfcnasvvnptcvrcrpltPEGKQRPQGADFMRFLPMFLSDNPNpkcgkgghaaySAAVNILD-NGTRVGA 1034
Cdd:COG1033  506 --QALNEGD-------------------PKYYALPESRELLAQLLLLLSSPPG-----------DDLSRFVDeDYSAARV 553

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461 1035 TYFMTYHtvlqtSADFIDAMEKArlIASNITRTMNQQGGDHRVfpYSVFYVFYEQYLTMIDDTIFNLSVSLGAIFLVAVV 1114
Cdd:COG1033  554 TVRLKDL-----DSEEIKALVEE--VRAFLAENFPPDGVEVTL--TGSAVLFAAINESVIESQIRSLLLALLLIFLLLLL 624

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461 1115 LLGcELWSAVIMCATIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFT--VSTKGSRVERAEEALSH 1192
Cdd:COG1033  625 AFR-SLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYReeRRKGGDLEEAIRRALRT 703

                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27807461 1193 MGSSV-FSGITLtkFGGIIVLAFAKSQIFQIFYFRMYLAMV--LLGAthgLIFLPVLLSYIGPSINKAK 1258
Cdd:COG1033  704 TGKAIlFTSLTL--AAGFGVLLFSSFPPLADFGLLLALGLLvaLLAA---LLLLPALLLLLDPRIAKKR 767
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
334-783 1.55e-13

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 75.28  E-value: 1.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  334 HLRRLFEWWGSFCVRHPGCVVFFSVAFIAACSSGLVFIQVTTDPVDlWSAPGSQARLEKEYFDTHFGPFFRTEqLIIRAP 413
Cdd:COG1033  387 ELGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFED-YLPEDSPIRQDLDFIEENFGGSDPLE-VVVDTG 464

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  414 HtPPHIYEPypsgadvpfgpplavNILHQVLDLQTAIESItasynnETVTlrdicvaplspynqncTILSVLNYFQnshs 493
Cdd:COG1033  465 E-PDGLKDP---------------EVLKEIDRLQDYLESL------PEVG----------------KVLSLADLVK---- 502

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  494 vldhqvgddfFVYADYHTHFLYWVRAPASLNDTSLLHDPCLGTFGGpvfpwlVLGGYDDQNYNNAtalVITFPVNNyyND 573
Cdd:COG1033  503 ----------ELNQALNEGDPKYYALPESRELLAQLLLLLSSPPGD------DLSRFVDEDYSAA---RVTVRLKD--LD 561

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  574 TEKLQRAQAWEKEFINfvQNYENPNLTISFKAERSIEDELNRE-SNSDVFTVLISYGVMFLYISIALGHIKscrrllvds 652
Cdd:COG1033  562 SEEIKALVEEVRAFLA--ENFPPDGVEVTLTGSAVLFAAINESvIESQIRSLLLALLLIFLLLLLAFRSLR--------- 630

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  653 kilLGIAGVLIVLSPVACSLGFFSYWGSPLTLIVIEVIPfLVLAVGVDN-IFILvqTYQIDERLQGETLDQQVGRVLGEV 731
Cdd:COG1033  631 ---LGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYtIHFL--SRYREERRKGGDLEEAIRRALRTT 704

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 27807461  732 APSMFLSSFAETVAFFLGGLSVMPAVHTFSLFAGMAVLIDFLLQITCFVSLL 783
Cdd:COG1033  705 GKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALL 756
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1042-1262 8.84e-12

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 69.89  E-value: 8.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461 1042 TVLQTSADFIDAMEKARLIASNItrtmnqQGGDHRVFPYSVFYVFYEQYLTMIDDTIFNLSVSLGAIFLVAVVLLGCeLW 1121
Cdd:COG1033  171 DPLSSDLDRKEVVAEIRAIIAKY------EDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRS-LR 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461 1122 SAVIMCATIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFT--VSTKGSRVERAEEALSHMGSSVFS 1199
Cdd:COG1033  244 GVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYReeRRKGLDKREALREALRKLGPPVLL 323

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27807461 1200 GiTLTKFGGIIVLAFAKSQIFQIFYFRMYLAMVLLGATHgLIFLPVLLSYIGPSINKAKSLTT 1262
Cdd:COG1033  324 T-SLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS-LTLLPALLSLLPRPKPKTRRLKK 384
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 571-803 9.79e-10

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 62.93  E-value: 9.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    571 YNDTEKlqraqawEKEFINFVQNYE---NPNLTISFKAERSIEDELNResnsdvfTVLISYGVMFLyisIALGHIKSCRR 647
Cdd:TIGR00921  157 YNDVER-------SLERTNPPSGKFldvTGSPAINYDIEREFGKDMGT-------TMAISGILVVL---VLLLDFKRWWR 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    648 LLVdskillgiaGVLIVLSPVACSLGFFSYWGSPLTLIVIEVIPfLVLAVGVDNIFILVQTYQiDERLQGETLDQQVGRV 727
Cdd:TIGR00921  220 PLL---------PLVIILFGVAWVLGIMGWLGIPLYATTLLAVP-MLIGVGIDYGIQTLNRYE-EERDIGRAKGEAIVTA 288

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27807461    728 LGEVAPSMfLSSFAETVAFFLG-GLSVMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNQLDVLCCVGG 803
Cdd:TIGR00921  289 VRRTGRAV-LIALLTTSAGFAAlALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIDIGREKVKKEIIAIGGK 364
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 658-785 1.02e-07

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 55.38  E-value: 1.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    658 IAGVLIVLS---PVACSLGFFSYWG---------SPLTLIVIevipfLVLAVGVD-NIFiLVQTYQiDERLQGETLDQQV 724
Cdd:pfam03176  167 VAALLPLLTvglSLGAAQGLVAILAhilgiglstFALNLLVV-----LLIAVGTDyALF-LVSRYR-EELRAGEDREEAV 239

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27807461    725 GRVLGEVAPSMFLSSFaeTVAFFLGGLSV--MPAVHTFSLFAGMAVLIDFLLQITCFVSLLGL 785
Cdd:pfam03176  240 IRAVRGTGKVVTAAGL--TVAIAMLALSFarLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
1092-1214 1.52e-07

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 56.19  E-value: 1.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461 1092 TMIDDTIFNLSVSL--GAIfLVAVVL---LGcELWSAVIMCATIAMILVNMFGVMWLWGISLNAVSLVNLVMSCG----- 1161
Cdd:COG3696  328 DLIDRAIHTVTKNLleGAL-LVILVLflfLG-NLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDFGiivdg 405

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 27807461 1162 --ISVEFC-SHITRAFTVSTKGSRVERAEEALSHMGSSVFSGITltkfggIIVLAF 1214
Cdd:COG3696  406 avVMVENIlRRLEENRAAGTPRERLEVVLEAAREVRRPIFFATL------IIILVF 455
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1093-1258 1.52e-06

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 52.80  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461 1093 MIDDTIFNLsvsLGAIFLVAVVL---LGcELWSAVIMCATIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISV----- 1164
Cdd:COG0841  329 SIEEVVKTL---LEAILLVVLVVflfLR-SWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVddaiv 404

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461 1165 --EfcsHITRAFtvsTKG-SRVERAEEALSHMGSSVFSgITLTkfggIIV----LAFAKSQIFQIFYfrmYLAMVLLGAT 1237
Cdd:COG0841  405 vvE---NIERHM---EEGlSPLEAAIKGAREVAGAVIA-STLT----LVAvflpLAFMGGITGQLFR---QFALTVAIAL 470

                        170       180
                 ....*....|....*....|....*.
gi 27807461 1238 -----HGLIFLPVLLSYIGPSINKAK 1258
Cdd:COG0841  471 lislfVALTLTPALCARLLKPHPKGK 496
2A060605 TIGR00920
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ...
 611-792 8.15e-06

3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273339 [Multi-domain]  Cd Length: 886  Bit Score: 50.24  E-value: 8.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    611 DELNRESNS-DVFTVLISYGVMFLYISIALGHIkscRRLlvDSKILLGIAGVLIVLSPVACSLGFFSYWGSPLTLIViEV 689
Cdd:TIGR00920   51 PKFEEEYLSsDVIVMTITRCIAVLYIYYQFCNL---RQL--GSKYILGIAGLFTIFSSFVFSTAVIHFLGSELTGLN-EA 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461    690 IPFLVLAVGVDNIFILVQtYQIDERLQGETLDqQVGRVLGEVAPSMFLSSFAETVAFFLGGLSVMPAVHTFSLFAGMAVL 769
Cdd:TIGR00920  125 LPFFLLLIDLSKASALAK-FALSSNSQDEVRD-NIARGMAILGPTITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVL 202

                          170       180
                   ....*....|....*....|....*.
gi 27807461    770 IDFLLQITCF---VSLLgLDIKRQEK 792
Cdd:TIGR00920  203 ANYFVFMTFFpacLSLV-LELSRSGR 227
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
 1078-1248 1.46e-04

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 46.13  E-value: 1.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1078 FPYSVFY-VFYEQYLTmIDDTIFNLSVSLG-AIFLVAVVL---LGcELWSAVIMCATIAMILVNMFGVMWLWGISLNAVS 1152
Cdd:pfam00873  310 FPQGVEIvVVYDTTPF-IRASIEEVVKTLLeAIVLVILVMflfLQ-NWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLT 387

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1153 LVNLVMSCGISV-------EFCSHITRA-----FTVSTKGSR-VERAEEALSHMGSSVFsgITLTKFGGIIvlafakSQI 1219
Cdd:pfam00873  388 LGGLVLAIGLVVddaivvvENIERVLEEnglkpLEAAYKSMGeIGGALVAIALVLSAVF--LPILFLGGLT------GRI 459

                          170       180
                   ....*....|....*....|....*....
gi 27807461   1220 FQIFYFRMYLAMvLLGATHGLIFLPVLLS 1248
Cdd:pfam00873  460 FRQFAITIVLAI-LLSVLVALTLTPALCA 487
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 1099-1260 2.56e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 45.21  E-value: 2.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1099 FNLSVSLGAIFLVAVVLLGCELWSAVIMCATIAMILVNM-FGVMWLWGISLNAVSLVNLVMSCGISVEFCSHI-TRAFTV 1176
Cdd:TIGR00921  195 MGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTlNRYEEE 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461   1177 STKGSRVERA-EEALSHMGSSVFSGITLTKFGgiiVLAFAKSQIFQIFYFRMYLAM-VLLGATHGLIFLPVLLSYIgPSI 1254
Cdd:TIGR00921  275 RDIGRAKGEAiVTAVRRTGRAVLIALLTTSAG---FAALALSEFPMVSEFGLGLVAgLITAYLLTLLVLPALLQSI-DIG 350


                   ....*.
gi 27807461   1255 NKAKSL 1260
Cdd:TIGR00921  351 REKVKK 356
COG4258 COG4258
Predicted exporter [General function prediction only];
1086-1250 1.24e-03

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 43.30  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461 1086 FYEQYLtmiDDTIFNLSVSLGAIFLVAVVLLGcELWSAVIMCATIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVE 1165
Cdd:COG4258  633 LFGRYR---NDALWLLLLALLLILLLLLLRLR-SLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGID 708

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461 1166 FCSHITRAFTvstkgsrveRAEEALSHMGSSVFSGI-TLTKFGgiiVLAFAKSQIFQIFYfrmylAMVLLGathglIFLP 1244
Cdd:COG4258  709 YALFFTEGLL---------DKGELARTLLSILLAALtTLLGFG---LLAFSSTPALRSFG-----LTVLLG-----ILLA 766


                 ....*.
gi 27807461 1245 VLLSYI 1250
Cdd:COG4258  767 LLLAPL 772
COG4258 COG4258
Predicted exporter [General function prediction only];
624-775 1.58e-03

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 42.92  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  624 VLISYGVMFLYISIALGhikscrrllvdskillGIAGVLIVLSP----VACSLGFFSYWGSPLTLIVIeVIPFLVLAVGV 699
Cdd:COG4258  645 LLLALLLILLLLLLRLR----------------SLRRALRVLLPpllaVLLTLAILGLLGIPLNLFHL-IALLLVLGIGI 707

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27807461  700 D-NIFILVQTYQIDERLqgetldqqvgRVLgevaPSMFLSSFAETVAFFLGGLSVMPAVHTFSLF----AGMAVLIDFLL 774
Cdd:COG4258  708 DyALFFTEGLLDKGELA----------RTL----LSILLAALTTLLGFGLLAFSSTPALRSFGLTvllgILLALLLAPLL 773


                 .
gi 27807461  775 Q 775
Cdd:COG4258  774 A 774
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
1094-1165 5.50e-03

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 41.16  E-value: 5.50e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27807461  1094 IDDTIFNLSVSLGAIFLVAVVLLGcELWSAVIMCATIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVE 1165
Cdd:NF033617  329 IDEVESTLLEAVALVILVVFLFLR-NLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVD 399
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH