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Conserved domains on  [gi|28373113|ref|NP_777617|]
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sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform f [Homo sapiens]

Protein Classification

calcium-transporting ATPase( domain architecture ID 11550595)

calcium-transporting ATPase is a magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell, into the endoplasmic reticulum, or into organelles

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
5-989 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


:

Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 1953.25  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:cd02083   1 HSKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFEEGEEG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  85 TTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLR 164
Cdd:cd02083  81 VTAFVEPFVILLILIANAVVGVWQERNAEKAIEALKEYEPEMAKVLRNG-KGVQRIRARELVPGDIVEVAVGDKVPADIR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 165 LIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEP 244
Cdd:cd02083 160 IIEIKSTTLRVDQSILTGESVSVIKHTDVVPDPRAVNQDKKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEE 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 245 ERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTR 324
Cdd:cd02083 240 EKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 325 RMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGsCLLHEFTISGTTYTPEGEVRQGDQPVRC 404
Cdd:cd02083 320 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVEDD-SSLNEFEVTGSTYAPEGEVFKNGKKVKA 398
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 405 GQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFT 484
Cdd:cd02083 399 GQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVEKMNVFNTDKSGLSKRERANACNDVIEQLWKKEFT 478
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 485 LEFSRDRKSMSVYCTPTRPhptGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSrEQILAKIRDWGSGSDTLRCLAL 564
Cdd:cd02083 479 LEFSRDRKSMSVYCSPTKA---SGGNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAA-IKILILKKVWGYGTDTLRCLAL 554
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 565 ATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD 644
Cdd:cd02083 555 ATKDTPPKPEDMDLEDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGE 634
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 645 TEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGT 724
Cdd:cd02083 635 DEDTTGKSYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGSGT 714
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 725 AVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPA 804
Cdd:cd02083 715 AVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPA 794
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 805 TALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFA 884
Cdd:cd02083 795 TALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYLAIGTYVGLATVGAFAWWFMYYEEGPQVSFYQLTHFMQCSSWEPNFE 874
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 885 GIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSG 964
Cdd:cd02083 875 GVDCEIFEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQITPLSF 954
                       970       980
                ....*....|....*....|....*
gi 28373113 965 RQWVVVLQISLPVILLDEALKYLSR 989
Cdd:cd02083 955 AEWIAVIKISLPVILLDELLKFIAR 979
 
Name Accession Description Interval E-value
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
5-989 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 1953.25  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:cd02083   1 HSKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFEEGEEG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  85 TTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLR 164
Cdd:cd02083  81 VTAFVEPFVILLILIANAVVGVWQERNAEKAIEALKEYEPEMAKVLRNG-KGVQRIRARELVPGDIVEVAVGDKVPADIR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 165 LIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEP 244
Cdd:cd02083 160 IIEIKSTTLRVDQSILTGESVSVIKHTDVVPDPRAVNQDKKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEE 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 245 ERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTR 324
Cdd:cd02083 240 EKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 325 RMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGsCLLHEFTISGTTYTPEGEVRQGDQPVRC 404
Cdd:cd02083 320 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVEDD-SSLNEFEVTGSTYAPEGEVFKNGKKVKA 398
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 405 GQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFT 484
Cdd:cd02083 399 GQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVEKMNVFNTDKSGLSKRERANACNDVIEQLWKKEFT 478
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 485 LEFSRDRKSMSVYCTPTRPhptGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSrEQILAKIRDWGSGSDTLRCLAL 564
Cdd:cd02083 479 LEFSRDRKSMSVYCSPTKA---SGGNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAA-IKILILKKVWGYGTDTLRCLAL 554
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 565 ATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD 644
Cdd:cd02083 555 ATKDTPPKPEDMDLEDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGE 634
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 645 TEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGT 724
Cdd:cd02083 635 DEDTTGKSYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGSGT 714
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 725 AVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPA 804
Cdd:cd02083 715 AVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPA 794
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 805 TALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFA 884
Cdd:cd02083 795 TALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYLAIGTYVGLATVGAFAWWFMYYEEGPQVSFYQLTHFMQCSSWEPNFE 874
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 885 GIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSG 964
Cdd:cd02083 875 GVDCEIFEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQITPLSF 954
                       970       980
                ....*....|....*....|....*
gi 28373113 965 RQWVVVLQISLPVILLDEALKYLSR 989
Cdd:cd02083 955 AEWIAVIKISLPVILLDELLKFIAR 979
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
53-989 0e+00

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 1465.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    53 VLEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRS 132
Cdd:TIGR01116   1 VLEQFEDLLVRILLLAACVSFVLAWFEEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKAIEALKEYESEHAKVLRD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   133 DRKGVqrIRARDIVPGDIVEVAVGDKVPADLRLIEIKstTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGT 212
Cdd:TIGR01116  81 GRWSV--IKAKDLVPGDIVELAVGDKVPADIRVLSLK--TLRVDQSILTGESVSVNKHTESVPDERAVNQDKKNMLFSGT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   213 NITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGA 292
Cdd:TIGR01116 157 LVVAGKARGVVVRTGMSTEIGKIRDEMRAAEQEDTPLQKKLDEFGELLSKVIGLICILVWVINIGHFNDPALGGGWIQGA 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   293 VYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVaea 372
Cdd:TIGR01116 237 IYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCKVVAL--- 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   373 DAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM 452
Cdd:TIGR01116 314 DPSSSSLNEFCVTGTTYAPEGGVIKDDGPVAGGQDAGLEELATIAALCNDSSLDFNERKGVYEKVGEATEAALKVLVEKM 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   453 NVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRDRKSMSVYCTPTRphptgqGSKMFVKGAPESVIERCSSVRVG- 531
Cdd:TIGR01116 394 GLPATKNGVSSKRRPALGCNSVWNDKFKKLATLEFSRDRKSMSVLCKPST------GNKLFVKGAPEGVLERCTHILNGd 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   532 SRTAPLTPTSREQILAKIRDWGSGsDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACI 611
Cdd:TIGR01116 468 GRAVPLTDKMKNTILSVIKEMGTT-KALRCLALAFKDIPDPREEDLLSDPANFEAIESDLTFIGVVGMLDPPRPEVADAI 546
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   612 TRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENL 691
Cdd:TIGR01116 547 EKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDEDVTFKSFTGREFDEMGPAKQRAACRSAVLFSRVEPSHKSELVELL 626
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   692 QSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGE 771
Cdd:TIGR01116 627 QEQGEIVAMTGDGVNDAPALKKADIGIAMGSGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGE 706
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   772 VVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAA 851
Cdd:TIGR01116 707 VVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITGWLFFRYLVVGVYVGLATVGG 786
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   852 ATWWfvydaegphinfYQLRNFLKCSEDN----PLFAGIDCEVFESRFP-TTMALSVLVTIEMCNALNSVSENQSLLRMP 926
Cdd:TIGR01116 787 FVWW------------YLLTHFTGCDEDSfttcPDFEDPDCYVFEGKQPaRTISLSVLVVIEMFNALNALSEDQSLLRMP 854
                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28373113   927 PWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:TIGR01116 855 PWVNKWLIGAICLSMALHFLILYVPFLSRIFGVTPLSLTDWLMVLKLSLPVILVDEVLKFFSR 917
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
1-989 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 949.16  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   1 MEAAHLLPAADVLRHFSVTAEGgLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLawfee 80
Cdd:COG0474   5 LKDWHALSAEEVLAELGTSEEG-LSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL----- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  81 GEetttaFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVP 160
Cdd:COG0474  79 GD-----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGK--WVEIPAEELVPGDIVLLEAGDRVP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 161 ADLRLIEIKSttLRVDQSILTGESVSVTKHTEAIPDPRAVnQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMA 240
Cdd:COG0474 152 ADLRLLEAKD--LQVDESALTGESVPVEKSADPLPEDAPL-GDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQ 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 241 AVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfadpAHGGSWLR----------GAVyyfkiavalavaaiPEG 310
Cdd:COG0474 229 EAEEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGL------LRGGPLLEallfavalavAAI--------------PEG 288
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 311 LPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVvaeadagscllheftiSGTTYT 390
Cdd:COG0474 289 LPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYT----------------GGGTYE 352
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 391 PEGEVRqgdqpvrcgqfDGLVELATICALCNDSALDYNEAkgvyekVGEATETALTCLVEKMNVFDTDLQalsrveraga 470
Cdd:COG0474 353 VTGEFD-----------PALEELLRAAALCSDAQLEEETG------LGDPTEGALLVAAAKAGLDVEELR---------- 405
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 471 cntvikQLMRKEFTLEFSRDRKSMSVYCtptrpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIR 550
Cdd:COG0474 406 ------KEYPRVDEIPFDSERKRMSTVH-----EDPDGKRLLIVKGAPEVVLALCTRVLTGGGVVPLTEEDRAEILEAVE 474
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 551 DWGSgsDTLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKG 630
Cdd:COG0474 475 ELAA--QGLRVLAVAYKELPADPELDSEDD-------ESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPA 545
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 631 TAVAICRRLGIFGDTEdvagKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPA 710
Cdd:COG0474 546 TARAIARQLGLGDDGD----RVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPA 621
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 711 LKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIP 789
Cdd:COG0474 622 LKAADIGIAMGiTGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTP 701
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 790 VQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVaaATWWFVydaegphinfyq 869
Cdd:COG0474 702 IQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTL--LTFALA------------ 767
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 870 lrnflkcsednpLFAGIDCEVFesrfpTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILL 949
Cdd:COG0474 768 ------------LARGASLALA-----RTMAFTTLVLSQLFNVFNCRSERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIY 830
                       970       980       990      1000
                ....*....|....*....|....*....|....*....|
gi 28373113 950 VPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:COG0474 831 VPPLQALFGTVPLPLSDWLLILGLALLYLLLVELVKLLRR 870
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
7-863 1.34e-97

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 328.57  E-value: 1.34e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    7 LPAADVLRHFSvTAEGGLSPAQVTGARERYGPNELPSEEG----KSLWELVLEQFeDLLVRILllaALVSFVLawfeegE 82
Cdd:PRK10517  52 MPEEELWKTFD-THPEGLNEAEVESAREQHGENELPAQKPlpwwVHLWVCYRNPF-NILLTIL---GAISYAT------E 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   83 ETTTAfvepLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSD----RKGVQRIRARDIVPGDIVEVAVGDK 158
Cdd:PRK10517 121 DLFAA----GVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRVIndkgENGWLEIPIDQLVPGDIIKLAAGDM 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  159 VPADLRLIEIKSttLRVDQSILTGESVSVtkhtEAIPDPRAVNQ----DKKNMLFSGTNITSGKAVGVAVATGLHTELGK 234
Cdd:PRK10517 197 IPADLRILQARD--LFVAQASLTGESLPV----EKFATTRQPEHsnplECDTLCFMGTNVVSGTAQAVVIATGANTWFGQ 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  235 IRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINighfadpahG---GSWLRGAVYyfkiAVALAVAAIPEGL 311
Cdd:PRK10517 271 LAGRVSEQDSEPNAFQQGISRVSWLLIRFMLVMAPVVLLIN---------GytkGDWWEAALF----ALSVAVGLTPEML 337
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  312 PAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNqmsvcRMFVVAEADagscllheftISGTTytp 391
Cdd:PRK10517 338 PMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQD-----KIVLENHTD----------ISGKT--- 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  392 egevrqgdqpvrcgqfdglvelaticalcNDSALDYNEAKGVYEkvgeateTALTCLVekmnvfdtDLQALSRVERAGAC 471
Cdd:PRK10517 400 -----------------------------SERVLHSAWLNSHYQ-------TGLKNLL--------DTAVLEGVDEESAR 435
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  472 NtvIKQLMRKEFTLEFSRDRKSMSVYC-TPTRPHptgqgsKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIR 550
Cdd:PRK10517 436 S--LASRWQKIDEIPFDFERRRMSVVVaENTEHH------QLICKGALEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTD 507
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  551 DWGSgsDTLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKG 630
Cdd:PRK10517 508 TLNR--QGLRVVAVATKYLPAREGDYQRAD-------ESDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSEL 578
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  631 TAVAICRRLGIfgdtedVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPA 710
Cdd:PRK10517 579 VAAKVCHEVGL------DAGEVLIGSDIETLSDDELANLAERTTLFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPA 652
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  711 LKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFL-TAILG-LPeaLI 788
Cdd:PRK10517 653 LRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNFGNVFSVLVaSAFLPfLP--ML 730
                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28373113  789 PVQLLWVNLVTDgLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRylAIGVYVGLATVAAAtwWFVYDAEGP 863
Cdd:PRK10517 731 PLHLLIQNLLYD-VSQVAIPFDNVDDEQIQKPQRWNPADLGRFMVFFG--PISSIFDILTFCLM--WWVFHANTP 800
E1-E2_ATPase pfam00122
E1-E2 ATPase;
121-329 1.28e-46

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 165.05  E-value: 1.28e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   121 EYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEiksTTLRVDQSILTGESVSVTKHteaipdprav 200
Cdd:pfam00122   1 SLLPPTATVLRDG--TEEEVPADELVPGDIVLLKPGERVPADGRIVE---GSASVDESLLTGESLPVEKK---------- 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   201 nqdKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfa 280
Cdd:pfam00122  66 ---KGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWL---- 138
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 28373113   281 dpahggSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARK 329
Cdd:pfam00122 139 ------FVGGPPLRALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
5-75 3.27e-17

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 76.85  E-value: 3.27e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28373113      5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVL 75
Cdd:smart00831   5 HALSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
 
Name Accession Description Interval E-value
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
5-989 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 1953.25  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:cd02083   1 HSKTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFEEGEEG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  85 TTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLR 164
Cdd:cd02083  81 VTAFVEPFVILLILIANAVVGVWQERNAEKAIEALKEYEPEMAKVLRNG-KGVQRIRARELVPGDIVEVAVGDKVPADIR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 165 LIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEP 244
Cdd:cd02083 160 IIEIKSTTLRVDQSILTGESVSVIKHTDVVPDPRAVNQDKKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEE 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 245 ERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTR 324
Cdd:cd02083 240 EKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTR 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 325 RMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGsCLLHEFTISGTTYTPEGEVRQGDQPVRC 404
Cdd:cd02083 320 RMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVEDD-SSLNEFEVTGSTYAPEGEVFKNGKKVKA 398
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 405 GQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFT 484
Cdd:cd02083 399 GQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVEKMNVFNTDKSGLSKRERANACNDVIEQLWKKEFT 478
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 485 LEFSRDRKSMSVYCTPTRPhptGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSrEQILAKIRDWGSGSDTLRCLAL 564
Cdd:cd02083 479 LEFSRDRKSMSVYCSPTKA---SGGNKLFVKGAPEGVLERCTHVRVGGGKVVPLTAA-IKILILKKVWGYGTDTLRCLAL 554
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 565 ATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD 644
Cdd:cd02083 555 ATKDTPPKPEDMDLEDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGE 634
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 645 TEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGT 724
Cdd:cd02083 635 DEDTTGKSYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMGSGT 714
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 725 AVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPA 804
Cdd:cd02083 715 AVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPA 794
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 805 TALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFA 884
Cdd:cd02083 795 TALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYLAIGTYVGLATVGAFAWWFMYYEEGPQVSFYQLTHFMQCSSWEPNFE 874
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 885 GIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSG 964
Cdd:cd02083 875 GVDCEIFEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQITPLSF 954
                       970       980
                ....*....|....*....|....*
gi 28373113 965 RQWVVVLQISLPVILLDEALKYLSR 989
Cdd:cd02083 955 AEWIAVIKISLPVILLDELLKFIAR 979
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
53-989 0e+00

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 1465.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    53 VLEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRS 132
Cdd:TIGR01116   1 VLEQFEDLLVRILLLAACVSFVLAWFEEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKAIEALKEYESEHAKVLRD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   133 DRKGVqrIRARDIVPGDIVEVAVGDKVPADLRLIEIKstTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGT 212
Cdd:TIGR01116  81 GRWSV--IKAKDLVPGDIVELAVGDKVPADIRVLSLK--TLRVDQSILTGESVSVNKHTESVPDERAVNQDKKNMLFSGT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   213 NITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGA 292
Cdd:TIGR01116 157 LVVAGKARGVVVRTGMSTEIGKIRDEMRAAEQEDTPLQKKLDEFGELLSKVIGLICILVWVINIGHFNDPALGGGWIQGA 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   293 VYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVaea 372
Cdd:TIGR01116 237 IYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCKVVAL--- 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   373 DAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM 452
Cdd:TIGR01116 314 DPSSSSLNEFCVTGTTYAPEGGVIKDDGPVAGGQDAGLEELATIAALCNDSSLDFNERKGVYEKVGEATEAALKVLVEKM 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   453 NVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRDRKSMSVYCTPTRphptgqGSKMFVKGAPESVIERCSSVRVG- 531
Cdd:TIGR01116 394 GLPATKNGVSSKRRPALGCNSVWNDKFKKLATLEFSRDRKSMSVLCKPST------GNKLFVKGAPEGVLERCTHILNGd 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   532 SRTAPLTPTSREQILAKIRDWGSGsDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACI 611
Cdd:TIGR01116 468 GRAVPLTDKMKNTILSVIKEMGTT-KALRCLALAFKDIPDPREEDLLSDPANFEAIESDLTFIGVVGMLDPPRPEVADAI 546
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   612 TRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENL 691
Cdd:TIGR01116 547 EKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDEDVTFKSFTGREFDEMGPAKQRAACRSAVLFSRVEPSHKSELVELL 626
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   692 QSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGE 771
Cdd:TIGR01116 627 QEQGEIVAMTGDGVNDAPALKKADIGIAMGSGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGE 706
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   772 VVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAA 851
Cdd:TIGR01116 707 VVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITGWLFFRYLVVGVYVGLATVGG 786
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   852 ATWWfvydaegphinfYQLRNFLKCSEDN----PLFAGIDCEVFESRFP-TTMALSVLVTIEMCNALNSVSENQSLLRMP 926
Cdd:TIGR01116 787 FVWW------------YLLTHFTGCDEDSfttcPDFEDPDCYVFEGKQPaRTISLSVLVVIEMFNALNALSEDQSLLRMP 854
                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28373113   927 PWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:TIGR01116 855 PWVNKWLIGAICLSMALHFLILYVPFLSRIFGVTPLSLTDWLMVLKLSLPVILVDEVLKFFSR 917
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
1-989 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 949.16  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   1 MEAAHLLPAADVLRHFSVTAEGgLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLawfee 80
Cdd:COG0474   5 LKDWHALSAEEVLAELGTSEEG-LSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALL----- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  81 GEetttaFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVP 160
Cdd:COG0474  79 GD-----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGK--WVEIPAEELVPGDIVLLEAGDRVP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 161 ADLRLIEIKSttLRVDQSILTGESVSVTKHTEAIPDPRAVnQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMA 240
Cdd:COG0474 152 ADLRLLEAKD--LQVDESALTGESVPVEKSADPLPEDAPL-GDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQ 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 241 AVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfadpAHGGSWLR----------GAVyyfkiavalavaaiPEG 310
Cdd:COG0474 229 EAEEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGL------LRGGPLLEallfavalavAAI--------------PEG 288
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 311 LPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVvaeadagscllheftiSGTTYT 390
Cdd:COG0474 289 LPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYT----------------GGGTYE 352
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 391 PEGEVRqgdqpvrcgqfDGLVELATICALCNDSALDYNEAkgvyekVGEATETALTCLVEKMNVFDTDLQalsrveraga 470
Cdd:COG0474 353 VTGEFD-----------PALEELLRAAALCSDAQLEEETG------LGDPTEGALLVAAAKAGLDVEELR---------- 405
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 471 cntvikQLMRKEFTLEFSRDRKSMSVYCtptrpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIR 550
Cdd:COG0474 406 ------KEYPRVDEIPFDSERKRMSTVH-----EDPDGKRLLIVKGAPEVVLALCTRVLTGGGVVPLTEEDRAEILEAVE 474
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 551 DWGSgsDTLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKG 630
Cdd:COG0474 475 ELAA--QGLRVLAVAYKELPADPELDSEDD-------ESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPA 545
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 631 TAVAICRRLGIFGDTEdvagKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPA 710
Cdd:COG0474 546 TARAIARQLGLGDDGD----RVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPA 621
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 711 LKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIP 789
Cdd:COG0474 622 LKAADIGIAMGiTGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTP 701
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 790 VQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVaaATWWFVydaegphinfyq 869
Cdd:COG0474 702 IQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTL--LTFALA------------ 767
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 870 lrnflkcsednpLFAGIDCEVFesrfpTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILL 949
Cdd:COG0474 768 ------------LARGASLALA-----RTMAFTTLVLSQLFNVFNCRSERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIY 830
                       970       980       990      1000
                ....*....|....*....|....*....|....*....|
gi 28373113 950 VPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:COG0474 831 VPPLQALFGTVPLPLSDWLLILGLALLYLLLVELVKLLRR 870
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
23-822 0e+00

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 752.52  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLawfeeGEEtttafVEPLVIMLILVANA 102
Cdd:cd02089   1 GLSEEEAERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVL-----GEY-----VDAIVIIAIVILNA 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 103 IVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTG 182
Cdd:cd02089  71 VLGFVQEYKAEKALAALKKMSAPTAKVLRDGKK--QEIPARELVPGDIVLLEAGDYVPADGRLIE--SASLRVEESSLTG 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 183 ESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSH 262
Cdd:cd02089 147 ESEPVEKDADTLLEEDVPLGDRKNMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEETEEEKTPLQKRLDQLGKRLAI 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 263 AISVICVAVWVINIGHFADPAhgGSWLRG---AVyyfkiavalavAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSV 339
Cdd:cd02089 227 AALIICALVFALGLLRGEDLL--DMLLTAvslAV-----------AAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAV 293
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 340 ETLGCTSVICSDKTGTLTTNQMSVCRMFVVaeadagscllheftisgttytpegevrqgdqpvrcgqfdglvelatical 419
Cdd:cd02089 294 ETLGSVSVICSDKTGTLTQNKMTVEKIYTI-------------------------------------------------- 323
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 420 cndsaldyneakgvyekvGEATETALTCLVEKMNVFDTDLQALSRveragacntvikqlmrKEFTLEFSRDRKSMSVYct 499
Cdd:cd02089 324 ------------------GDPTETALIRAARKAGLDKEELEKKYP----------------RIAEIPFDSERKLMTTV-- 367
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 500 ptrpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSgsDTLRCLALATR--DAPPRKEDME 577
Cdd:cd02089 368 ----HKDAGKYIVFTKGAPDVLLPRCTYIYINGQVRPLTEEDRAKILAVNEEFSE--EALRVLAVAYKplDEDPTESSED 441
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 578 LddcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDtedvAGKAYTGRE 657
Cdd:cd02089 442 L---------ENDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKELGILED----GDKALTGEE 508
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 658 FDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLS 736
Cdd:cd02089 509 LDKMSDEELEKKVEQISVYARVSPEHKLRIVKALQRKGKIVAMTGDGVNDAPALKAADIGVAMGiTGTDVAKEAADMILT 588
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 737 DDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDI 816
Cdd:cd02089 589 DDNFATIVAAVEEGRTIYDNIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAEPDI 668

                ....*.
gi 28373113 817 MEKLPR 822
Cdd:cd02089 669 MDRKPR 674
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
23-985 0e+00

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 742.16  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLawfeeGEETTTAfveplVIMLILVANA 102
Cdd:cd02080   1 GLTSEEAAERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFL-----GHWVDAI-----VIFGVVLINA 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 103 IVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSttLRVDQSILTG 182
Cdd:cd02080  71 IIGYIQEGKAEKALAAIKNMLSPEATVLRDGKK--LTIDAEELVPGDIVLLEAGDKVPADLRLIEARN--LQIDESALTG 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 183 ESVSVTKHTEAIPdPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSH 262
Cdd:cd02080 147 ESVPVEKQEGPLE-EDTPLGDRKNMAYSGTLVTAGSATGVVVATGADTEIGRINQLLAEVEQLATPLTRQIAKFSKALLI 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 263 AISVICVAVWVInighfadpahgGSWLRG--AVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVE 340
Cdd:cd02080 226 VILVLAALTFVF-----------GLLRGDysLVELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVE 294
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 341 TLGCTSVICSDKTGTLTTNQMSVCRMFvvaeadagscllheftisgttytpegevrqgdqpvrcgqfdglvelaticALC 420
Cdd:cd02080 295 TLGSVTVICSDKTGTLTRNEMTVQAIV--------------------------------------------------TLC 324
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 421 NDSALDYNEakGVYEKVGEATETALTCLVEKMNVFDTDLqaLSRVERAGacntvikqlmrkefTLEFSRDRKSMSvyctp 500
Cdd:cd02080 325 NDAQLHQED--GHWKITGDPTEGALLVLAAKAGLDPDRL--ASSYPRVD--------------KIPFDSAYRYMA----- 381
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 501 TRpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLtptSREQILAKIRDWGSgsDTLRCLALATRDAPPRKEDMELDD 580
Cdd:cd02080 382 TL-HRDDGQRVIYVKGAPERLLDMCDQELLDGGVSPL---DRAYWEAEAEDLAK--QGLRVLAFAYREVDSEVEEIDHAD 455
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 581 CskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDtedvaGKAYTGREFDD 660
Cdd:cd02080 456 L------EGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQLGLGDG-----KKVLTGAELDA 524
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 661 LSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDN 739
Cdd:cd02080 525 LDDEELAEAVDEVDVFARTSPEHKLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAMGiKGTEVAKEAADMVLADDN 604
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 740 FASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEK 819
Cdd:cd02080 605 FATIAAAVEEGRRVYDNLKKFILFTLPTNLGEGLVIIVAILFGVTLPLTPVQILWINMVTAITLGLALAFEPAEPGIMKR 684
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 820 LPRSPREALISGWLFFRYlaigVYVGLATVAAATWWFVYDaegphinfyqlrnflkcsednpLFAGIDCEvfesrFPTTM 899
Cdd:cd02080 685 PPRDPSEPLLSRELIWRI----LLVSLLMLGGAFGLFLWA----------------------LDRGYSLE-----TARTM 733
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 900 ALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVIL 979
Cdd:cd02080 734 AVNTIVVAQIFYLFNCRSLHRSILKLGVFSNKILFLGIGALILLQLAFTYLPFMNSLFGTAPIDLVDWAIILLVGIVVFI 813

                ....*.
gi 28373113 980 LDEALK 985
Cdd:cd02080 814 VVELEK 819
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
33-985 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 570.50  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  33 RERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAfveplviMLILVANAIVgvwQERNA 112
Cdd:cd02085   2 RKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVA-------ILIVVTVAFV---QEYRS 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 113 ESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTGESVSVTKHTE 192
Cdd:cd02085  72 EKSLEALNKLVPPECHCLRDGK--LEHFLARELVPGDLVCLSIGDRIPADLRLFE--ATDLSIDESSLTGETEPCSKTTE 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 193 AIPDPRAVN-QDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLShAISVICVAV 271
Cdd:cd02085 148 VIPKASNGDlTTRSNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLS-LYSFIIIGV 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 272 WVInIGHFadpaHGGSWLRgavyYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSD 351
Cdd:cd02085 227 IML-IGWL----QGKNLLE----MFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSD 297
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 352 KTGTLTTNQMSVCRMFvvaeadagscllheftisgttytpegevrqgdqpvrCGqfdglvelaticALCNDSALDYNEAk 431
Cdd:cd02085 298 KTGTLTKNEMTVTKIV------------------------------------TG------------CVCNNAVIRNNTL- 328
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 432 gvyekVGEATETALTCLVEKMNVFDTDlqalsrveragacNTVIkqlmRKEFtLEFSRDRKSMSVYCtptRPHPTGQGSK 511
Cdd:cd02085 329 -----MGQPTEGALIALAMKMGLSDIR-------------ETYI----RKQE-IPFSSEQKWMAVKC---IPKYNSDNEE 382
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 512 M-FVKGAPESVIERCSSVRVGSRTA-PLTPTSREQILAKIRDWGSGSdtLRCLALAtrdappRKEDMElddcskfvqyet 589
Cdd:cd02085 383 IyFMKGALEQVLDYCTTYNSSDGSAlPLTQQQRSEINEEEKEMGSKG--LRVLALA------SGPELG------------ 442
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 590 DLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEdvagKAYTGREFDDLSPEQQRQA 669
Cdd:cd02085 443 DLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSL----QALSGEEVDQMSDSQLASV 518
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 670 CRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVE 748
Cdd:cd02085 519 VRKVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGrTGTDVCKEAADMILVDDDFSTILAAIE 598
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 749 EGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREAL 828
Cdd:cd02085 599 EGKGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPI 678
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 829 ISGWLFFRYLaigvyVGLATVAAATWWfvydaegphINFYQLRNFLKCSEDnplfagidcevfesrfpTTMALSVLVTIE 908
Cdd:cd02085 679 LTRSLILNVL-----LSAAIIVSGTLW---------VFWKEMSDDNVTPRD-----------------TTMTFTCFVFFD 727
                       890       900       910       920       930       940       950
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28373113 909 MCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALK 985
Cdd:cd02085 728 MFNALSCRSQTKSIFEIGFFSNRMFLYAVGGSLIGQLLVIYFPPLQRVFQTEALGLLDLLFLLGLTSSVFIVSELRK 804
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
7-989 0e+00

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 564.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113     7 LPAADVLRHFSVTAEGGLSPAQ-VTGARERYGPNELPSEEGKSLWELVLEQF-EDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:TIGR01522   7 LSVEETCSKLQTDLQNGLNSSQeASHRRAFHGWNEFDVEEDESLWKKFLSQFvKNPLILLLIASAVISVFMGNIDDAVSI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    85 TTAfveplviMLILVAnaiVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLR 164
Cdd:TIGR01522  87 TLA-------ILIVVT---VGFVQEYRSEKSLEALNKLVPPECHLIREGKL--EHVLASTLVPGDLVCLSVGDRVPADLR 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   165 LIEikSTTLRVDQSILTGESVSVTKHTEAIPDPRAVN-QDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVE 243
Cdd:TIGR01522 155 IVE--AVDLSIDESNLTGETTPVSKVTAPIPAATNGDlAERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIE 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   244 PERTPLQRKLDEFGRQLShAISVICVAVWVInIGHFadpaHGGSWLRgavyYFKIAVALAVAAIPEGLPAVITTCLALGT 323
Cdd:TIGR01522 233 KPKTPLQKSMDLLGKQLS-LVSFGVIGVICL-VGWF----QGKDWLE----MFTISVSLAVAAIPEGLPIIVTVTLALGV 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   324 RRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVaeaDAGSCLLheftiSGTTYTPEGEVRQGDQPVR 403
Cdd:TIGR01522 303 LRMSKKRAIVRKLPSVETLGSVNVICSDKTGTLTKNHMTVTKIWTS---DGLHTML-----NAVSLNQFGEVIVDGDVLH 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   404 CGQFDGLVELATICALCNDSALDyNEAKGVyekVGEATETALTCLVEKMNVFDTDlQALSRVERagacntvikqlmrkef 483
Cdd:TIGR01522 375 GFYTVAVSRILEAGNLCNNAKFR-NEADTL---LGNPTDVALIELLMKFGLDDLR-ETYIRVAE---------------- 433
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   484 tLEFSRDRKSMSVYCTptrpHPTGQGSKMFVKGAPESVIERCSS-VRVGSRTAPLTPTSREQILAKIRDWGSgsDTLRCL 562
Cdd:TIGR01522 434 -VPFSSERKWMAVKCV----HRQDRSEMCFMKGAYEQVLKYCTYyQKKDGKTLTLTQQQRDVIQEEAAEMAS--AGLRVI 506
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   563 ALAtrdapprkedmelddcSKFVQYEtdLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIF 642
Cdd:TIGR01522 507 AFA----------------SGPEKGQ--LTFLGLVGINDPPRPGVKEAVTTLITGGVRIIMITGDSQETAVSIARRLGMP 568
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   643 GDTedvaGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG- 721
Cdd:TIGR01522 569 SKT----SQSVSGEKLDAMDDQQLSQIVPKVAVFARASPEHKMKIVKALQKRGDVVAMTGDGVNDAPALKLADIGVAMGq 644
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   722 SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDG 801
Cdd:TIGR01522 645 TGTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLMGFPNPLNAMQILWINILMDG 724
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   802 LPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVaaatwwFVYdaegphinFYQLRNFLKCSEDnp 881
Cdd:TIGR01522 725 PPAQSLGVEPVDKDVMRKPPRPRNDKILTKDLIKKILVSAIIIVVGTL------FVF--------VREMQDGVITARD-- 788
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   882 lfagidcevfesrfpTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTP 961
Cdd:TIGR01522 789 ---------------TTMTFTCFVFFDMFNALACRSQTKSVFEIGFFSNRMFNYAVGGSIIGQLLVIYFPPLQSVFQTEA 853
                         970       980
                  ....*....|....*....|....*...
gi 28373113   962 LSGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:TIGR01522 854 LSIKDLLFLLLITSSVCIVDEIRKKVER 881
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
33-830 8.06e-167

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 505.97  E-value: 8.06e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  33 RERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEE--GEETTTAFVEPLVIMLILVANAIVGVWQER 110
Cdd:cd02081   5 REVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPfgEGEGKTGWIEGVAILVAVILVVLVTAGNDY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 111 NAESAIEAL-KEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTGESVSVTK 189
Cdd:cd02081  85 QKEKQFRKLnSKKEDQKVTVIRDGE--VIQISVFDIVVGDIVQLKYGDLIPADGLLIE--GNDLKIDESSLTGESDPIKK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 190 HTEaipdpravNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICV 269
Cdd:cd02081 161 TPD--------NQIPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAENEEKTPLQEKLTKLAVQIGKVGLIVAA 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 270 AVWVINIGHFA-DPAHGGSWLRGAVY------YFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETL 342
Cdd:cd02081 233 LTFIVLIIRFIiDGFVNDGKSFSAEDlqefvnFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETM 312
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 343 GCTSVICSDKTGTLTTNQMSVCRMFVvaeadaGSCllheftisgttytpegevrqgdqpvrcgqfdglvelaticalcnd 422
Cdd:cd02081 313 GNATAICSDKTGTLTQNRMTVVQGYI------GNK--------------------------------------------- 341
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 423 saldyneakgvyekvgeaTETALTCLVEKmnvfdtdLQALSRVERAGACNTVIKQlmrkeFTleFSRDRKSMSVYCtptr 502
Cdd:cd02081 342 ------------------TECALLGFVLE-------LGGDYRYREKRPEEKVLKV-----YP--FNSARKRMSTVV---- 385
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 503 PHPTGqGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQIL-AKIRDWGSgsDTLRCLALATRDAPPRKEDMELDDC 581
Cdd:cd02081 386 RLKDG-GYRLYVKGASEIVLKKCSYILNSDGEVVFLTSEKKEEIkRVIEPMAS--DSLRTIGLAYRDFSPDEEPTAERDW 462
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 582 SKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFgdTEDVAGKAYTGREFDDL 661
Cdd:cd02081 463 DDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGIL--TEGEDGLVLEGKEFREL 540
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 662 SPEQQRQACRTA--------RCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAE 732
Cdd:cd02081 541 IDEEVGEVCQEKfdkiwpklRVLARSSPEDKYTLVKGLKDSGEVVAVTGDGTNDAPALKKADVGFAMGiAGTEVAKEASD 620
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 733 MVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPP 812
Cdd:cd02081 621 IILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPP 700
                       810
                ....*....|....*...
gi 28373113 813 DLDIMEKLPRSPREALIS 830
Cdd:cd02081 701 TEDLLKRKPYGRDKPLIS 718
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
23-989 5.56e-166

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 510.46  E-value: 5.56e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSF-VLAWFEEGeetttafveplVIMLILVAN 101
Cdd:cd02086   1 GLTNDEAERRLKEYGENELEGDTGVSAWKILLRQVANAMTLVLIIAMALSFaVKDWIEGG-----------VIAAVIALN 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 102 AIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSttLRVDQSILT 181
Cdd:cd02086  70 VIVGFIQEYKAEKTMDSLRNLSSPNAHVIRSGK--TETISSKDVVPGDIVLLKVGDTVPADLRLIETKN--FETDEALLT 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 182 GESVSVTKHTEAI--PDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKI----RSQMAAVEPER--------- 246
Cdd:cd02086 146 GESLPVIKDAELVfgKEEDVSVGDRLNLAYSSSTVTKGRAKGIVVATGMNTEIGKIakalRGKGGLISRDRvkswlygtl 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 247 ----------------TPLQRKLDEFGRQLsHAISVIC-VAVWVINIGHFADpahggswlRGAVYyfkiAVALAVAAIPE 309
Cdd:cd02086 226 ivtwdavgrflgtnvgTPLQRKLSKLAYLL-FFIAVILaIIVFAVNKFDVDN--------EVIIY----AIALAISMIPE 292
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 310 GLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscllheftisgtty 389
Cdd:cd02086 293 SLVAVLTITMAVGAKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVV-------------------------- 346
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 390 tpegevRQGDQPvrcgqfdglvelatiCALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMnvfdtDLQALSRVERAG 469
Cdd:cd02086 347 ------RQVWIP---------------AALCNIATVFKDEETDCWKAHGDPTEIALQVFATKF-----DMGKNALTKGGS 400
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 470 ACNTVIKqlmrkEFTleFSRDRKSMSVYCTPTRphptGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKI 549
Cdd:cd02086 401 AQFQHVA-----EFP--FDSTVKRMSVVYYNNQ----AGDYYAYMKGAVERVLECCSSMYGKDGIIPLDDEFRKTIIKNV 469
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 550 RDWGSgsDTLRCLALATRDAPPR-KEDMELDDC-SKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGD 627
Cdd:cd02086 470 ESLAS--QGLRVLAFASRSFTKAqFNDDQLKNItLSRADAESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGD 547
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 628 NKGTAVAICRRLGIF------GDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMT 701
Cdd:cd02086 548 HPGTAKAIAREVGILppnsyhYSQEIMDSMVMTASQFDGLSDEEVDALPVLPLVIARCSPQTKVRMIEALHRRKKFCAMT 627
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 702 GDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVvcIFLTAI 780
Cdd:cd02086 628 GDGVNDSPSLKMADVGIAMGlNGSDVAKDASDIVLTDDNFASIVNAIEEGRRMFDNIQKFVLHLLAENVAQV--ILLLIG 705
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 781 LGLPEA-------LIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAat 853
Cdd:cd02086 706 LAFKDEdglsvfpLSPVEILWINMVTSSFPAMGLGLEKASPDVMQRPPHDLKVGIFTRELIIDTFVYGTFMGVLCLAS-- 783
                       890       900       910       920       930       940       950       960
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 854 wwFVYDAEGphINFYQLrnflkcsednplfaGIDCE---------VFESRFPTTMALSVLVTIemcNALNSVSENQSLLR 924
Cdd:cd02086 784 --FTLVIYG--IGNGDL--------------GSDCNesynsscedVFRARAAVFATLTWCALI---LAWEVVDMRRSFFN 842
                       970       980       990      1000      1010      1020      1030
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28373113 925 MPP-------------WMNPWLLVAVAMSMALHFLILLV-PPLPLIFQVTPLsGRQWVVVLQISLPVILLDEALKYLSR 989
Cdd:cd02086 843 MHPdtdspvksffktlWKNKFLFWSVVLGFVSVFPTLYIpVINDDVFKHTGI-GWEWGLVIACTVAFFAGVELWKAGKR 920
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
93-807 4.59e-162

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 487.59  E-value: 4.59e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    93 VIMLILVANAIVGVWQERNAESAIEALKEYEpEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIeikSTT 172
Cdd:TIGR01494   1 FILFLVLLFVLLEVKQKLKAEDALRSLKDSL-VNTATVLVLRNGWKEISSKDLVPGDVVLVKSGDTVPADGVLL---SGS 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   173 LRVDQSILTGESVSVTKHTEaipdpravnqDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRK 252
Cdd:TIGR01494  77 AFVDESSLTGESLPVLKTAL----------PDGDAVFAGTINFGGTLIVKVTATGILTTVGKIAVVVYTGFSTKTPLQSK 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   253 LDEFGRQL-SHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAValavaaiPEGLPAVITTCLALGTRRMARKNA 331
Cdd:TIGR01494 147 ADKFENFIfILFLLLLALAVFLLLPIGGWDGNSIYKAILRALAVLVIAI-------PCALPLAVSVALAVGDARMAKKGI 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   332 IVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVvaeadagscllheftisgttytpegevrqgdqpvrcgqfDGLV 411
Cdd:TIGR01494 220 LVKNLNALEELGKVDVICFDKTGTLTTNKMTLQKVII---------------------------------------IGGV 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   412 ELATIcalcndsaLDYNEAKGVYEKVGEATETALTCLVEKMNVFDtdlqalsrveragacntVIKQLMRKEFTLEFSRDR 491
Cdd:TIGR01494 261 EEASL--------ALALLAASLEYLSGHPLERAIVKSAEGVIKSD-----------------EINVEYKILDVFPFSSVL 315
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   492 KSMSVYCtptrpHPTGQGSKMFVKGAPESVIERCSSVrvgsrtapltptsrEQILAKIRDWGSgsDTLRCLALATRDAPP 571
Cdd:TIGR01494 316 KRMGVIV-----EGANGSDLLFVKGAPEFVLERCNNE--------------NDYDEKVDEYAR--QGLRVLAFASKKLPD 374
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   572 rkedmelddcskfvqyetDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFgdtedvagk 651
Cdd:TIGR01494 375 ------------------DLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKELGID--------- 427
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   652 aytgrefddlspeqqrqacrtarCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGtAVAKSAA 731
Cdd:TIGR01494 428 -----------------------VFARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKADVGIAMGSG-DVAKAAA 483
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28373113   732 EMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAIlglpealipvqllwVNLVTDGLPATAL 807
Cdd:TIGR01494 484 DIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIV--------------IILLPPLLAALAL 545
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
35-807 5.03e-139

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 430.68  E-value: 5.03e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  35 RYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVlawfeegeetTTAFVEPLVIMLILVANAIVGVWQERNAES 114
Cdd:cd07539  14 LPARNLALETATRSGILAVAAQLELPPVALLGLAAGASAS----------TGGGVDAVLIVGVLTVNAVIGGVQRLRAER 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 115 AIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTGESVSVTKHTEAI 194
Cdd:cd07539  84 ALAALLAQQQQPARVVRAPAGRTQTVPAESLVPGDVIELRAGEVVPADARLLE--ADDLEVDESALTGESLPVDKQVAPT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 195 PdpRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPErTPLQRKLDEFGRQLSHAISVICVAVWvi 274
Cdd:cd07539 162 P--GAPLADRACMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVAPVETA-TGVQAQLRELTSQLLPLSLGGGAAVT-- 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 275 nighfadpahGGSWLRGA--VYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDK 352
Cdd:cd07539 237 ----------GLGLLRGAplRQAVADGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDK 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 353 TGTLTTNQMSVcrmfvvaeadagscllheftisGTTYTPEGEVrqgdqPVRCGQfdglvelaticalcndsaldyNEAKG 432
Cdd:cd07539 307 TGTLTENRLRV----------------------VQVRPPLAEL-----PFESSR---------------------GYAAA 338
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 433 VYEKVGEATETAltclvekmnvfdtdlqalsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphptgqgskm 512
Cdd:cd07539 339 IGRTGGGIPLLA-------------------------------------------------------------------- 350
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 513 fVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDwgSGSDTLRCLALATRDAPPRKEDMeLDDCskfvqyETDLT 592
Cdd:cd07539 351 -VKGAPEVVLPRCDRRMTGGQVVPLTEADRQAIEEVNEL--LAGQGLRVLAVAYRTLDAGTTHA-VEAV------VDDLE 420
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 593 FVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVagkayTGREFDDLSPEQQRQACRT 672
Cdd:cd07539 421 LLGLLGLADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGLPRDAEVV-----TGAELDALDEEALTGLVAD 495
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 673 ARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSAAEMVLSDDNFASIVAAVEEGR 751
Cdd:cd07539 496 IDVFARVSPEQKLQIVQALQAAGRVVAMTGDGANDAAAIRAADVGIGVGArGSDAAREAADLVLTDDDLETLLDAVVEGR 575
                       730       740       750       760       770
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28373113 752 AIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATAL 807
Cdd:cd07539 576 TMWQNVRDAVHVLLGGNLGEVMFTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALAL 631
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
23-861 3.00e-134

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 426.77  E-value: 3.00e-134
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEETttafvEP--------LVI 94
Cdd:cd02608   1 GLTSARAAEILARDGPNALTPPPTTPEWVKFCKQLFGGFSMLLWIGAILCFLAYGIQAATEE-----EPsndnlylgIVL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  95 MLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSttLR 174
Cdd:cd02608  76 AAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEK--MQINAEELVVGDLVEVKGGDRIPADIRIISAHG--CK 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 175 VDQSILTGESVSVTKHTEAIPDpravNQ-DKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKL 253
Cdd:cd02608 152 VDNSSLTGESEPQTRSPEFTHE----NPlETKNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGKTPIAREI 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 254 DEFgrqlSHAISVicVAVWvINIGHFA-DPAHGGSWLRGAVYYFkiavALAVAAIPEGLPAVITTCLALGTRRMARKNAI 332
Cdd:cd02608 228 EHF----IHIITG--VAVF-LGVSFFIlSLILGYTWLEAVIFLI----GIIVANVPEGLLATVTVCLTLTAKRMARKNCL 296
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 333 VRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFV---VAEADAGScllhefTISGTTYTPEGevrqgdqpvrcgqfDG 409
Cdd:cd02608 297 VKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFdnqIHEADTTE------DQSGASFDKSS--------------AT 356
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 410 LVELATICALCNDSALDYNEAKGVYEK---VGEATETALTCLVEkMNVFDTDLqalsrveragacntvIKQLMRKEFTLE 486
Cdd:cd02608 357 WLALSRIAGLCNRAEFKAGQENVPILKrdvNGDASESALLKCIE-LSCGSVME---------------MRERNPKVAEIP 420
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 487 F-SRDRKSMSVYctpTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDtlRCLALA 565
Cdd:cd02608 421 FnSTNKYQLSIH---ENEDPGDPRYLLVMKGAPERILDRCSTILINGKEQPLDEEMKEAFQNAYLELGGLGE--RVLGFC 495
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 566 trdapprkeDMEL--DDCSKFVQYETD--------LTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI 635
Cdd:cd02608 496 ---------HLYLpdDKFPEGFKFDTDevnfptenLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAI 566
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 636 CRRLGIFgdtedvagkaytgrefddlspeqqrqacrtarCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAE 715
Cdd:cd02608 567 AKGVGII--------------------------------VFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKAD 614
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 716 IGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLW 794
Cdd:cd02608 615 IGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILC 694
                       810       820       830       840       850       860       870
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28373113 795 VNLVTDGLPATALGFNPPDLDIMEKLPRSPR------EALISgwlfFRYLAIGVyvgLATVAAATWWFVYDAE 861
Cdd:cd02608 695 IDLGTDMVPAISLAYEKAESDIMKRQPRNPKtdklvnERLIS----MAYGQIGM---IQALAGFFTYFVIMAE 760
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
5-861 9.13e-134

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 428.06  E-value: 9.13e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113     5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEET 84
Cdd:TIGR01106  18 HKLSLDELERKYGTDLSKGLSAARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQASTEE 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    85 TTAFVE---PLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPA 161
Cdd:TIGR01106  98 EPQNDNlylGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRDGEK--MSINAEQVVVGDLVEVKGGDRIPA 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   162 DLRLIEIKSttLRVDQSILTGESVsvtkhteaiPDPRAVN------QDKKNMLFSGTNITSGKAVGVAVATGLHTELGKI 235
Cdd:TIGR01106 176 DLRIISAQG--CKVDNSSLTGESE---------PQTRSPEfthenpLETRNIAFFSTNCVEGTARGIVVNTGDRTVMGRI 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   236 RSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfadpAHGGSWLRGAVYYFkiavALAVAAIPEGLPAVI 315
Cdd:TIGR01106 245 ASLASGLENGKTPIAIEIEHFIHIITGVAVFLGVSFFILSL------ILGYTWLEAVIFLI----GIIVANVPEGLLATV 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   316 TTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFV---VAEADAGScllhefTISGTTYtpe 392
Cdd:TIGR01106 315 TVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFdnqIHEADTTE------DQSGVSF--- 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   393 gevrqgDQPVRcgqfdGLVELATICALCNDSALDYN-EAKGVYEK--VGEATETALTCLVEKmnvfdtdlqalsrverag 469
Cdd:TIGR01106 386 ------DKSSA-----TWLALSRIAGLCNRAVFKAGqENVPILKRavAGDASESALLKCIEL------------------ 436
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   470 ACNTVIKqlMRKEFT----LEF-SRDRKSMSVYctpTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQ 544
Cdd:TIGR01106 437 CLGSVME--MRERNPkvveIPFnSTNKYQLSIH---ENEDPRDPRHLLVMKGAPERILERCSSILIHGKEQPLDEELKEA 511
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   545 I-LAKIRDWGSGSDTLR-CLALATRDAPPRKEDMELDDcskfVQYETD-LTFVGCVGMLDPPRPEVAACITRCYQAGIRV 621
Cdd:TIGR01106 512 FqNAYLELGGLGERVLGfCHLYLPDEQFPEGFQFDTDD----VNFPTDnLCFVGLISMIDPPRAAVPDAVGKCRSAGIKV 587
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   622 VMITGDNKGTAVAICRRLGIFGD----TEDVA--------------GKA--YTGREFDDLSPEQQRQACR--TARCFARV 679
Cdd:TIGR01106 588 IMVTGDHPITAKAIAKGVGIISEgnetVEDIAarlnipvsqvnprdAKAcvVHGSDLKDMTSEQLDEILKyhTEIVFART 667
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   680 EPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMK 758
Cdd:TIGR01106 668 SPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGiAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLK 747
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   759 QFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPR------EALISgw 832
Cdd:TIGR01106 748 KSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPKtdklvnERLIS-- 825
                         890       900
                  ....*....|....*....|....*....
gi 28373113   833 lfFRYLAIGVyvgLATVAAATWWFVYDAE 861
Cdd:TIGR01106 826 --MAYGQIGM---IQALGGFFTYFVILAE 849
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
23-842 8.31e-133

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 415.30  E-value: 8.31e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGeetttafveplVIMLILVANA 102
Cdd:cd07538   1 GLTEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVLGDPREG-----------LILLIFVVVI 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 103 IV-GVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILT 181
Cdd:cd07538  70 IAiEVVQEWRTERALEALKNLSSPRATVIRDGRE--RRIPSRELVPGDLLILGEGERIPADGRLLE--NDDLGVDESTLT 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 182 GESVSVTKhTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLS 261
Cdd:cd07538 146 GESVPVWK-RIDGKAMSAPGGWDKNFCYAGTLVVRGRGVAKVEATGSRTELGKIGKSLAEMDDEPTPLQKQTGRLVKLCA 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 262 HAISVIC---VAVWVINIGHFADPAHGGSWLRGAVyyfkiavalavaaIPEGLPAVITTCLALGTRRMARKNAIVRSLPS 338
Cdd:cd07538 225 LAALVFCaliVAVYGVTRGDWIQAILAGITLAMAM-------------IPEEFPVILTVFMAMGAWRLAKKNVLVRRAAA 291
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 339 VETLGCTSVICSDKTGTLTTNQMSVCRMFVvaeadagscLLHEFTisgttYTPEgevrqgdqpvrcgqfdglvelatica 418
Cdd:cd07538 292 VETLGSITVLCVDKTGTLTKNQMEVVELTS---------LVREYP-----LRPE-------------------------- 331
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 419 lcndsaldyneaKGVYEKVGEATETALTCLvekmnvfdtdlqalsrveragacntvikqlmrkeftlefsrdrksmsvyc 498
Cdd:cd07538 332 ------------LRMMGQVWKRPEGAFAAA-------------------------------------------------- 349
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 499 tptrphptgqgskmfvKGAPESVIERCSsvrvgsrtapLTPTSREQILAKIRDWGSgsDTLRCLALATRDAPPRKEDMEL 578
Cdd:cd07538 350 ----------------KGSPEAIIRLCR----------LNPDEKAAIEDAVSEMAG--EGLRVLAVAACRIDESFLPDDL 401
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 579 DDCSkfvqyetdLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdteDVAGKAYTGREF 658
Cdd:cd07538 402 EDAV--------FIFVGLIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAKQIGL-----DNTDNVITGQEL 468
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 659 DDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSAAEMVLSD 737
Cdd:cd07538 469 DAMSDEELAEKVRDVNIFARVVPEQKLRIVQAFKANGEIVAMTGDGVNDAPALKAAHIGIAMGKrGTDVAREASDIVLLD 548
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 738 DNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDglPATALGF--NPPDLD 815
Cdd:cd07538 549 DNFSSIVSTIRLGRRIYDNLKKAITYVFAIHVPIAGLALLPPLLGLPPLLFPVHVVLLELIID--PTCSIVFeaEPAERD 626
                       810       820
                ....*....|....*....|....*..
gi 28373113 816 IMEKLPRSPREALISGWLFFRYLAIGV 842
Cdd:cd07538 627 IMRRPPRPPDEPLFGPRLVIKAILQGA 653
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
24-980 4.76e-132

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 422.65  E-value: 4.76e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    24 LSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWF-----EEGEETTTAFVEPLVIML-I 97
Cdd:TIGR01517  62 LSSSTLERREKVYGKNELPEKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYvpsvgEDKADTETGWIEGVAILVsV 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    98 LVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLrlIEIKSTTLRVDQ 177
Cdd:TIGR01517 142 ILVVLVTAVNDYKKELQFRQLNREKSAQKIAVIRGGQ--EQQISIHDIVVGDIVSLSTGDVVPADG--VFISGLSLEIDE 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   178 SILTGESvsvtkhteaipDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFG 257
Cdd:TIGR01517 218 SSITGES-----------DPIKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAGEEETPLQEKLSELA 286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   258 RQLSHA---ISVICVAV----WVINI----GHFADPAHGGSWLrgaVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRM 326
Cdd:TIGR01517 287 GLIGKFgmgSAVLLFLVlslrYVFRIirgdGRFEDTEEDAQTF---LDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKM 363
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   327 ARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFvvaeadagscllheftISGTTYTPEGEVRQGDQPvrcgq 406
Cdd:TIGR01517 364 MKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGY----------------IGEQRFNVRDEIVLRNLP----- 422
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   407 fDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERagacntVIKqlmrkefTLE 486
Cdd:TIGR01517 423 -AAVRNILVEGISLNSSSEEVVDRGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEK------VVK-------IYP 488
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   487 FSRDRKSMSVYCTptrpHPTGQgSKMFVKGAPESVIERCSSVRVGSRTA-PLTPTSREQILAKIRdwGSGSDTLRCLALA 565
Cdd:TIGR01517 489 FNSERKFMSVVVK----HSGGK-YREFRKGASEIVLKPCRKRLDSNGEAtPISEDDKDRCADVIE--PLASDALRTICLA 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   566 TRDAPPRKEDmelddcskFVQY-ETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD 644
Cdd:TIGR01517 562 YRDFAPEEFP--------RKDYpNKGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTF 633
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   645 TedvaGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SG 723
Cdd:TIGR01517 634 G----GLAMEGKEFRSLVYEEMDPILPKLRVLARSSPLDKQLLVLMLKDMGEVVAVTGDGTNDAPALKLADVGFSMGiSG 709
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   724 TAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEA--LIPVQLLWVNLVTDG 801
Cdd:TIGR01517 710 TEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISSSHTspLTAVQLLWVNLIMDT 789
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   802 LPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAaatwwfvydaegphINFYQLRNFLKCSEDN- 880
Cdd:TIGR01517 790 LAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFI--------------LLFAGGSIFDVSGPDEi 855
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   881 PLFAGIDCEvfesrfptTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVaMSMALHFLILLVPPLPLIFQVT 960
Cdd:TIGR01517 856 TSHQQGELN--------TIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTI-MGFTFGFQVIIVEFGGSFFSTV 926
                         970       980
                  ....*....|....*....|...
gi 28373113   961 PLSGRQW---VVVLQISLPVILL 980
Cdd:TIGR01517 927 SLSIEQWigcVLLGMLSLIFGVL 949
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
10-854 1.14e-131

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 424.04  E-value: 1.14e-131
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113     10 ADVLRHFSVTA-EGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFvlawfeegeeTTTAF 88
Cdd:TIGR01523   12 ADEAAEFIGTSiPEGLTHDEAQHRLKEVGENRLEADSGIDAKAMLLHQVCNAMCMVLIIAAAISF----------AMHDW 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113     89 VEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEI 168
Cdd:TIGR01523   82 IEGGVISAIIALNILIGFIQEYKAEKTMDSLKNLASPMAHVIRNGKS--DAIDSHDLVPGDICLLKTGDTIPADLRLIET 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    169 KSttLRVDQSILTGESVSVTKHTEAI--PDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIR---------- 236
Cdd:TIGR01523  160 KN--FDTDEALLTGESLPVIKDAHATfgKEEDTPIGDRINLAFSSSAVTKGRAKGICIATALNSEIGAIAaglqgdgglf 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    237 SQMAAVEPER-------------------------TPLQRKLDEFgrqlshAISVICVAVWVINIGHFADPAHGGSwlRG 291
Cdd:TIGR01523  238 QRPEKDDPNKrrklnkwilkvtkkvtgaflglnvgTPLHRKLSKL------AVILFCIAIIFAIIVMAAHKFDVDK--EV 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    292 AVYyfkiAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFV--- 368
Cdd:TIGR01523  310 AIY----AICLAISIIPESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWIprf 385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    369 ----VAEAD-------AGSCLLHEFTISGTTYTPEG----------EVRQGDQP--VRCGQFDGLVElatICALCNDSAL 425
Cdd:TIGR01523  386 gtisIDNSDdafnpneGNVSGIPRFSPYEYSHNEAAdqdilkefkdELKEIDLPedIDMDLFIKLLE---TAALANIATV 462
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    426 DYNEAKGVYEKVGEATETALTCLVEKMNVFDTDL-------QALSRVERAGACNTVIKQLMRKEFTLEFSRDR--KSMSV 496
Cdd:TIGR01523  463 FKDDATDCWKAHGDPTEIAIHVFAKKFDLPHNALtgeedllKSNENDQSSLSQHNEKPGSAQFEFIAEFPFDSeiKRMAS 542
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    497 YCTPTRphptGQGSKMFVKGAPESVIERCSSV--RVGSRTAPLTPTSREQILAKIrdWGSGSDTLRCLALATR--DAPPR 572
Cdd:TIGR01523  543 IYEDNH----GETYNIYAKGAFERIIECCSSSngKDGVKISPLEDCDRELIIANM--ESLAAEGLRVLAFASKsfDKADN 616
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    573 KEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDT------E 646
Cdd:TIGR01523  617 NDDQLKNETLNRATAESDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIIPPNfihdrdE 696
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    647 DVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTA 725
Cdd:TIGR01523  697 IMDSMVMTGSQFDALSDEEVDDLKALCLVIARCAPQTKVKMIEALHRRKAFCAMTGDGVNDSPSLKMANVGIAMGiNGSD 776
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    726 VAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIfltaILGL-----------PeaLIPVQLLW 794
Cdd:TIGR01523  777 VAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLAENVAEAILL----IIGLafrdengksvfP--LSPVEILW 850
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    795 VNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLatVAAATW 854
Cdd:TIGR01523  851 CIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVGIFQKELIIDMFAYGFFLGG--SCLASF 908
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
23-800 5.00e-116

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 374.66  E-value: 5.00e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  23 GLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEETTtaFVEPLVIMLILVANA 102
Cdd:cd02077   1 GLTNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFD--LVGALIILLMVLISG 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 103 IVGVWQERNAESAIEALKEYEPEMGKVIRsDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTG 182
Cdd:cd02077  79 LLDFIQEIRSLKAAEKLKKMVKNTATVIR-DGSKYMEIPIDELVPGDIVYLSAGDMIPADVRIIQ--SKDLFVSQSSLTG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 183 ESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPErTPLQRKLDEFGRQLSH 262
Cdd:cd02077 156 ESEPVEKHATAKKTKDESILELENICFMGTNVVSGSALAVVIATGNDTYFGSIAKSITEKRPE-TSFDKGINKVSKLLIR 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 263 AISVICVAVWVINIghfadpAHGGSWLRGAVYyfkiAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETL 342
Cdd:cd02077 235 FMLVMVPVVFLING------LTKGDWLEALLF----ALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNAIQNF 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 343 GCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISgttYTPEGevrqgdqpvrcgqFDGLVELATICALCND 422
Cdd:cd02077 305 GAMDILCTDKTGTLTQDKIVLERHLDVNGKESERVLRLAYLNS---YFQTG-------------LKNLLDKAIIDHAEEA 368
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 423 SaldYNEAKGVYEKVGEatetaltclvekmnvfdtdlqalsrveragacntvikqlmrkeftLEFSRDRKSMSVYCTPTR 502
Cdd:cd02077 369 N---ANGLIQDYTKIDE---------------------------------------------IPFDFERRRMSVVVKDND 400
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 503 phptgQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDwgSGSDTLRCLALATRDAPPRKEDMELDDcs 582
Cdd:cd02077 401 -----GKHLLITKGAVEEILNVCTHVEVNGEVVPLTDTLREKILAQVEE--LNREGLRVLAIAYKKLPAPEGEYSVKD-- 471
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 583 kfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgDTEDVagkaYTGREFDDLS 662
Cdd:cd02077 472 -----EKELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQVGL--DINRV----LTGSEIEALS 540
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 663 PEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFAS 742
Cdd:cd02077 541 DEELAKIVEETNIFAKLSPLQKARIIQALKKNGHVVGFMGDGINDAPALRQADVGISVDSAVDIAKEAADIILLEKDLMV 620
                       730       740       750       760       770
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 28373113 743 IVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILgLP-EALIPVQLLWVNLVTD 800
Cdd:cd02077 621 LEEGVIEGRKTFGNILKYIKMTASSNFGNVFSVLVASAF-LPfLPMLPIQLLLQNLLYD 678
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
23-793 5.46e-107

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 350.76  E-value: 5.46e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  23 GLSPAQVTGARERYGPNELPSEEgKSLWELVLEQFEDLLVRILLLAALVSFVLA-WfeegeetttafVEPLVIMLILVAN 101
Cdd:cd02076   1 GLTSEEAAKRLKEYGPNELPEKK-ENPILKFLSFFWGPIPWMLEAAAILAAALGdW-----------VDFAIILLLLLIN 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 102 AIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKstTLRVDQSILT 181
Cdd:cd02076  69 AGIGFIEERQAGNAVAALKKSLAPKARVLRDGQ--WQEIDAKELVPGDIVSLKIGDIVPADARLLTGD--ALQVDQSALT 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 182 GESVSVTKHTEAipdpravnqdkknMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPeRTPLQRKLDEFGRQLS 261
Cdd:cd02076 145 GESLPVTKHPGD-------------EAYSGSIVKQGEMLAVVTATGSNTFFGKTAALVASAEE-QGHLQKVLNKIGNFLI 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 262 HAISVICVAVWVINIGHFADPAHGgswLRGAVYYFkiavalaVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVET 341
Cdd:cd02076 211 LLALILVLIIVIVALYRHDPFLEI---LQFVLVLL-------IASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEE 280
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 342 LGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHeftisgttytpegevrqgdqpvrcgqfdglvelatiCALCN 421
Cdd:cd02076 281 LAGVDILCSDKTGTLTLNKLSLDEPYSLEGDGKDELLLL------------------------------------AALAS 324
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 422 DsaldyneakgvyEKVGEATETALtclvekmnvfdtdLQALSRVERAGACntvIKQLMRKEFTLEfsrDRKSMSVYCTPT 501
Cdd:cd02076 325 D------------TENPDAIDTAI-------------LNALDDYKPDLAG---YKQLKFTPFDPV---DKRTEATVEDPD 373
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 502 rphptgqGSKMFV-KGAPESVIERCSsvrvgsrtapLTPTSREQILAKIRDWGS-GsdtLRCLALAtrdappRKEDMELD 579
Cdd:cd02076 374 -------GERFKVtKGAPQVILELVG----------NDEAIRQAVEEKIDELASrG---YRSLGVA------RKEDGGRW 427
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 580 DcskfvqyetdltFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfGDTEDVAGKAYTGREFD 659
Cdd:cd02076 428 E------------LLGLLPLFDPPRPDSKATIARAKELGVRVKMITGDQLAIAKETARQLGM-GTNILSAERLKLGGGGG 494
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 660 DLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDN 739
Cdd:cd02076 495 GMPGSELIEFIEDADGFAEVFPEHKYRIVEALQQRGHLVGMTGDGVNDAPALKKADVGIAVSGATDAARAAADIVLTAPG 574
                       730       740       750       760       770
                ....*....|....*....|....*....|....*....|....*....|....
gi 28373113 740 FASIVAAVEEGRAIYSNMKQFIRYLISSNVgEVVCIFLTAILGLPEALIPVQLL 793
Cdd:cd02076 575 LSVIIDAIKTSRQIFQRMKSYVIYRIAETL-RILVFFTLGILILNFYPLPLIMI 627
ATPase-IIIA_H TIGR01647
plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton ...
23-874 6.14e-105

plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton efflux P-type ATPase found in plants, fungi, protozoa, slime molds and archaea. The best studied representative is from yeast.


Pssm-ID: 273731 [Multi-domain]  Cd Length: 754  Bit Score: 344.70  E-value: 6.14e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    23 GLSPAQVTGARERYGPNELPsEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGeetttafvepLVIMLILVANA 102
Cdd:TIGR01647   1 GLTSAEAKKRLAKYGPNELP-EKKVSPLLKFLGFFWNPLSWVMEAAAIIAIALENWVDF----------VIILGLLLLNA 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   103 IVGVWQERNAESAIEALKEYEPEMGKVIRsDRKGVQrIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQSILTG 182
Cdd:TIGR01647  70 TIGFIEENKAGNAVEALKQSLAPKARVLR-DGKWQE-IPASELVPGDVVRLKIGDIVPADCRLFE--GDYIQVDQAALTG 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   183 ESVSVTKHTEAIPdpravnqdkknmlFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSH 262
Cdd:TIGR01647 146 ESLPVTKKTGDIA-------------YSGSTVKQGEAEAVVTATGMNTFFGKAAALVQSTETGSGHLQKILSKIGLFLIV 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   263 AISVICVAVWVINIGHFadpahGGSWLRGAVYyfkiAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETL 342
Cdd:TIGR01647 213 LIGVLVLIELVVLFFGR-----GESFREGLQF----ALVLLVGGIPIAMPAVLSVTMAVGAAELAKKKAIVTRLTAIEEL 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   343 GCTSVICSDKTGTLTTNQMSvcrmfvvaeadagsclLHEFTISGTTYTPEgevrqgdqpvrcgqfDGLVELATICALCND 422
Cdd:TIGR01647 284 AGMDILCSDKTGTLTLNKLS----------------IDEILPFFNGFDKD---------------DVLLYAALASREEDQ 332
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   423 SALDyneaKGVYEKVGEATETALTCLVEKMNVFDtdlqalsrveragacnTVIKqlmRKEFTLEFSRDRKSMSVyctptr 502
Cdd:TIGR01647 333 DAID----TAVLGSAKDLKEARDGYKVLEFVPFD----------------PVDK---RTEATVEDPETGKRFKV------ 383
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   503 phptgqgskmfVKGAPESVIERCSSVRvgsrtapltpTSREQILAKIRDWGSGSdtLRCLALATRDAPPRKEdmelddcs 582
Cdd:TIGR01647 384 -----------TKGAPQVILDLCDNKK----------EIEEKVEEKVDELASRG--YRALGVARTDEEGRWH-------- 432
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   583 kfvqyetdltFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD--TEDVAGKAYTGrefdD 660
Cdd:TIGR01647 433 ----------FLGLLPLFDPPRHDTKETIERARHLGVEVKMVTGDHLAIAKETARRLGLGTNiyTADVLLKGDNR----D 498
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   661 LSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNF 740
Cdd:TIGR01647 499 DLPSGLGEMVEDADGFAEVFPEHKYEIVEILQKRGHLVGMTGDGVNDAPALKKADVGIAVAGATDAARSAADIVLTEPGL 578
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   741 ASIVAAVEEGRAIYSNMKQFIRYLISSNVgEVVCIFLTAILGLPEALIPVQLLWVNLVTDGlPATALGFN---PPDLDIM 817
Cdd:TIGR01647 579 SVIVDAILESRKIFQRMKSYVIYRIAETI-RIVFFFGLLILILNFYFPPIMVVIIAILNDG-TIMTIAYDnvkPSKLPQR 656
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 28373113   818 EKLPRSPREALISGWlffrYLAIGVYVGLATVAAATWWfvYDAEGPHINFYQLRNFL 874
Cdd:TIGR01647 657 WNLREVFTMSTVLGI----YLVISTFLLLAIALDTTFF--IDKFGLQLLHGNLQSFI 707
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
483-807 3.71e-103

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 325.18  E-value: 3.71e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 483 FTLEFSRDRKSMSVYCTPTRPHptgqgsKMFVKGAPESVIERCSSvrvgsrtaPLTPTSREQILAKIRDWGSgsDTLRCL 562
Cdd:cd01431  23 EEIPFNSTRKRMSVVVRLPGRY------RAIVKGAPETILSRCSH--------ALTEEDRNKIEKAQEESAR--EGLRVL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 563 ALATRdapprkedmELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIF 642
Cdd:cd01431  87 ALAYR---------EFDPETSKEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLTAIAIAREIGID 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 643 GDTEDVagkaYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGS 722
Cdd:cd01431 158 TKASGV----ILGEEADEMSEEELLDLIAKVAVFARVTPEQKLRIVKALQARGEVVAMTGDGVNDAPALKQADVGIAMGS 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 723 -GTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDG 801
Cdd:cd01431 234 tGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIALALFLGGPLPLLAFQILWINLVTDL 313

                ....*.
gi 28373113 802 LPATAL 807
Cdd:cd01431 314 IPALAL 319
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
7-863 1.34e-97

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 328.57  E-value: 1.34e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    7 LPAADVLRHFSvTAEGGLSPAQVTGARERYGPNELPSEEG----KSLWELVLEQFeDLLVRILllaALVSFVLawfeegE 82
Cdd:PRK10517  52 MPEEELWKTFD-THPEGLNEAEVESAREQHGENELPAQKPlpwwVHLWVCYRNPF-NILLTIL---GAISYAT------E 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   83 ETTTAfvepLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSD----RKGVQRIRARDIVPGDIVEVAVGDK 158
Cdd:PRK10517 121 DLFAA----GVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRVIndkgENGWLEIPIDQLVPGDIIKLAAGDM 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  159 VPADLRLIEIKSttLRVDQSILTGESVSVtkhtEAIPDPRAVNQ----DKKNMLFSGTNITSGKAVGVAVATGLHTELGK 234
Cdd:PRK10517 197 IPADLRILQARD--LFVAQASLTGESLPV----EKFATTRQPEHsnplECDTLCFMGTNVVSGTAQAVVIATGANTWFGQ 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  235 IRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINighfadpahG---GSWLRGAVYyfkiAVALAVAAIPEGL 311
Cdd:PRK10517 271 LAGRVSEQDSEPNAFQQGISRVSWLLIRFMLVMAPVVLLIN---------GytkGDWWEAALF----ALSVAVGLTPEML 337
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  312 PAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNqmsvcRMFVVAEADagscllheftISGTTytp 391
Cdd:PRK10517 338 PMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQD-----KIVLENHTD----------ISGKT--- 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  392 egevrqgdqpvrcgqfdglvelaticalcNDSALDYNEAKGVYEkvgeateTALTCLVekmnvfdtDLQALSRVERAGAC 471
Cdd:PRK10517 400 -----------------------------SERVLHSAWLNSHYQ-------TGLKNLL--------DTAVLEGVDEESAR 435
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  472 NtvIKQLMRKEFTLEFSRDRKSMSVYC-TPTRPHptgqgsKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIR 550
Cdd:PRK10517 436 S--LASRWQKIDEIPFDFERRRMSVVVaENTEHH------QLICKGALEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTD 507
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  551 DWGSgsDTLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKG 630
Cdd:PRK10517 508 TLNR--QGLRVVAVATKYLPAREGDYQRAD-------ESDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSEL 578
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  631 TAVAICRRLGIfgdtedVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPA 710
Cdd:PRK10517 579 VAAKVCHEVGL------DAGEVLIGSDIETLSDDELANLAERTTLFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPA 652
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  711 LKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFL-TAILG-LPeaLI 788
Cdd:PRK10517 653 LRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNFGNVFSVLVaSAFLPfLP--ML 730
                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28373113  789 PVQLLWVNLVTDgLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRylAIGVYVGLATVAAAtwWFVYDAEGP 863
Cdd:PRK10517 731 PLHLLIQNLLYD-VSQVAIPFDNVDDEQIQKPQRWNPADLGRFMVFFG--PISSIFDILTFCLM--WWVFHANTP 800
ATPase-IIIB_Mg TIGR01524
magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ...
1-863 1.98e-91

magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ATPase found in a limited number of bacterial species and best described in Salmonella typhimurium, which contains two isoforms. These transporters are active in low external Mg2+ concentrations and pump the ion into the cytoplasm. The magnesium ATPases have been classified as type IIIB by a phylogenetic analysis. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130587 [Multi-domain]  Cd Length: 867  Bit Score: 310.64  E-value: 1.98e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113     1 MEAAHLlPAADVLRHFSVTAEGgLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVlawfee 80
Cdd:TIGR01524  13 LKESQM-GKETLLRKLGVHETG-LTNVEVTERLAEFGPNQTVEEKKVPNLRLLIRAFNNPFIYILAMLMGVSYL------ 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    81 geetTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIR---SDRKGVQRIRARD-IVPGDIVEVAVG 156
Cdd:TIGR01524  85 ----TDDLEATVIIALMVLASGLLGFIQESRAERAAYALKNMVKNTATVLRvinENGNGSMDEVPIDaLVPGDLIELAAG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   157 DKVPADLRLIEikSTTLRVDQSILTGESVSVTKHTEaIPDPRAVNQ-DKKNMLFSGTNITSGKAVGVAVATGLHTELGKI 235
Cdd:TIGR01524 161 DIIPADARVIS--ARDLFINQSALTGESLPVEKFVE-DKRARDPEIlERENLCFMGTNVLSGHAQAVVLATGSSTWFGSL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   236 rSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINiGHFAdpahgGSWLRGAVYyfkiAVALAVAAIPEGLPAVI 315
Cdd:TIGR01524 238 -AIAATERRGQTAFDKGVKSVSKLLIRFMLVMVPVVLMIN-GLMK-----GDWLEAFLF----ALAVAVGLTPEMLPMIV 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   316 TTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSvcrmfvvaeadagscLLHEFTISGTTytpegev 395
Cdd:TIGR01524 307 SSNLAKGAINMSKKKVIVKELSAIQNFGAMDILCTDKTGTLTQDKIE---------------LEKHIDSSGET------- 364
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   396 rqgdqpvrcgqfdglVELATICALCNDSaldyneakgvyekvgeaTETALTclvekmNVFDTDLqaLSRVERAGACNTVI 475
Cdd:TIGR01524 365 ---------------SERVLKMAWLNSY-----------------FQTGWK------NVLDHAV--LAKLDESAARQTAS 404
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   476 KQLMRKEFTLEFSRDRKSMSVyctPTRPHPTgqgsKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSG 555
Cdd:TIGR01524 405 RWKKVDEIPFDFDRRRLSVVV---ENRAEVT----RLICKGAVEEMLTVCTHKRFGGAVVTLSESEKSELQDMTAEMNRQ 477
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   556 SdtLRCLALATRDAPPRKEDMELDDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI 635
Cdd:TIGR01524 478 G--IRVIAVATKTLKVGEADFTKTD-------EEQLIIEGFLGFLDPPKESTKEAIAALFKNGINVKVLTGDNEIVTARI 548
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   636 CRRLGIfgDTEDVagkaYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAE 715
Cdd:TIGR01524 549 CQEVGI--DANDF----LLGADIEELSDEELARELRKYHIFARLTPMQKSRIIGLLKKAGHTVGFLGDGINDAPALRKAD 622
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   716 IGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTA--ILGLPeaLIPVQLL 793
Cdd:TIGR01524 623 VGISVDTAADIAKEASDIILLEKSLMVLEEGVIEGRNTFGNILKYLKMTASSNFGNVFSVLVASafIPFLP--MLSLHLL 700
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28373113   794 WVNLVTDgLPATALGFNPPDLDIMEKlprsPREALISGWLFFrYLAIGVYVGLATVAA-ATWWFVYDAEGP 863
Cdd:TIGR01524 701 IQNLLYD-FSQLTLPWDKMDREFLKK----PHQWEQKGMGRF-MLCIGPVSSIFDIATfLLMWFVFSANTV 765
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
23-813 4.21e-80

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 274.54  E-value: 4.21e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  23 GLSPAQVTGARERYGPNELPSEEGKSLWELVleqFEDLLVRI----LLLAALVSFVLAWfeegeetttafvEPLVIMLIL 98
Cdd:cd02609   1 GLTTKEVEERQAEGKVNDQVEPVSRSVWQIV---RENVFTLFnlinFVIAVLLILVGSY------------SNLAFLGVI 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  99 VANAIVGVWQERNAESAIEALKEYEPEMGKVIRsDRKgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEikSTTLRVDQS 178
Cdd:cd02609  66 IVNTVIGIVQEIRAKRQLDKLSILNAPKVTVIR-DGQ-EVKIPPEELVLDDILILKPGEQIPADGEVVE--GGGLEVDES 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 179 ILTGESVSVTKhteaipdpravnqDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGR 258
Cdd:cd02609 142 LLTGESDLIPK-------------KAGDKLLSGSFVVSGAAYARVTAVGAESYAAKLTLEAKKHKLINSELLNSINKILK 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 259 QLSHAISVICVAVWVINIghfadPAHGGSWLRGAVyyfkIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPS 338
Cdd:cd02609 209 FTSFIIIPLGLLLFVEAL-----FRRGGGWRQAVV----STVAALLGMIPEGLVLLTSVALAVGAIRLAKKKVLVQELYS 279
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 339 VETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAgscllheftisgttytpegevrqgdqpvrcgqfdglvelatica 418
Cdd:cd02609 280 IETLARVDVLCLDKTGTITEGKMKVERVEPLDEANE-------------------------------------------- 315
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 419 lcndsaldyneakgvyekvgEATETALTCLVEKMNVFDTDLQALsrverAGACNTVIKQLMRKEftLEFSRDRKSMSVyc 498
Cdd:cd02609 316 --------------------AEAAAALAAFVAASEDNNATMQAI-----RAAFFGNNRFEVTSI--IPFSSARKWSAV-- 366
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 499 tptrphpTGQGSKMFVKGAPESVIercssvrvgsRTAPltptsrEQILAKIRDwgSGSDTLRCLALATRDAPPRKEdmel 578
Cdd:cd02609 367 -------EFRDGGTWVLGAPEVLL----------GDLP------SEVLSRVNE--LAAQGYRVLLLARSAGALTHE---- 417
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 579 ddcskfvQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGRef 658
Cdd:cd02609 418 -------QLPVGLEPLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAGLEGAESYIDASTLTTD-- 488
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 659 ddlspEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDD 738
Cdd:cd02609 489 -----EELAEAVENYTVFGRVTPEQKRQLVQALQALGHTVAMTGDGVNDVLALKEADCSIAMASGSDATRQVAQVVLLDS 563
                       730       740       750       760       770       780       790
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28373113 739 NFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPD 813
Cdd:cd02609 564 DFSALPDVVFEGRRVVNNIERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNK 638
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
19-800 2.23e-78

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 274.98  E-value: 2.23e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   19 TAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVL-AWF--EEGEETTTAFVEPLVIM 95
Cdd:PRK15122  41 THRQGLTEEDAAERLQRYGPNEVAHEKPPHALVQLLQAFNNPFIYVLMVLAAISFFTdYWLplRRGEETDLTGVIIILTM 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   96 LILvaNAIVGVWQERNAESAIEALKEYEPEMGKVIR---SDRKGVQR-IRARDIVPGDIVEVAVGDKVPADLRLIEikST 171
Cdd:PRK15122 121 VLL--SGLLRFWQEFRSNKAAEALKAMVRTTATVLRrghAGAEPVRReIPMRELVPGDIVHLSAGDMIPADVRLIE--SR 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  172 TLRVDQSILTGESVSVTK-------HTEAIPDPRAVNQ---DKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAA 241
Cdd:PRK15122 197 DLFISQAVLTGEALPVEKydtlgavAGKSADALADDEGsllDLPNICFMGTNVVSGTATAVVVATGSRTYFGSLAKSIVG 276
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  242 VEPErTPLQRKLDEFGRQLSHAISVICVAVWVINighfadpahG---GSWLRGAVYyfkiAVALAVAAIPEGLPAVITTC 318
Cdd:PRK15122 277 TRAQ-TAFDRGVNSVSWLLIRFMLVMVPVVLLIN---------GftkGDWLEALLF----ALAVAVGLTPEMLPMIVSSN 342
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  319 LALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMsvcrmfvvaeadagsCLLHEFTISGttytpegevrQG 398
Cdd:PRK15122 343 LAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDRI---------------ILEHHLDVSG----------RK 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  399 DQPVrcgqfdglVELATicalcndsaLDYNEAKGVyekvgeatetaltclvekMNVFDtdlQA-LSRVERAGAcnTVIKQ 477
Cdd:PRK15122 398 DERV--------LQLAW---------LNSFHQSGM------------------KNLMD---QAvVAFAEGNPE--IVKPA 437
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  478 LMRK--EFTLEFSRDRKSMSVyctptrpHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWgsG 555
Cdd:PRK15122 438 GYRKvdELPFDFVRRRLSVVV-------EDAQGQHLLICKGAVEEMLAVATHVRDGDTVRPLDEARRERLLALAEAY--N 508
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  556 SDTLRCLALATRDAPPRKEDMEL--DDcskfvqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAV 633
Cdd:PRK15122 509 ADGFRVLLVATREIPGGESRAQYstAD-------ERDLVIRGFLTFLDPPKESAAPAIAALRENGVAVKVLTGDNPIVTA 581
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  634 AICRRLGIfgdtedVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKK 713
Cdd:PRK15122 582 KICREVGL------EPGEPLLGTEIEAMDDAALAREVEERTVFAKLTPLQKSRVLKALQANGHTVGFLGDGINDAPALRD 655
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  714 AEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMkqfIRYL---ISSNVGEVVCIfLTAILGLP-EALIP 789
Cdd:PRK15122 656 ADVGISVDSGADIAKESADIILLEKSLMVLEEGVIKGRETFGNI---IKYLnmtASSNFGNVFSV-LVASAFIPfLPMLA 731
                        810
                 ....*....|.
gi 28373113  790 VQLLWVNLVTD 800
Cdd:PRK15122 732 IHLLLQNLMYD 742
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
59-759 3.57e-57

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 210.77  E-value: 3.57e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  59 DLLVrilLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVAnaiVGVWQE----RNAESAIEALKEYEPEMGKVIRSDR 134
Cdd:COG2217 149 DVLV---ALGTLAAFLYSLYATLFGAGHVYFEAAAMIIFLLL---LGRYLEarakGRARAAIRALLSLQPKTARVLRDGE 222
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 135 kgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTEAIpdpravnqdkknmLFSGTNI 214
Cdd:COG2217 223 --EVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS---VDESMLTGESLPVEKTPGDE-------------VFAGTIN 284
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 215 TSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQL---SHAISVICVAVWVINIGHFADpahggsWLRG 291
Cdd:COG2217 285 LDGSLRVRVTKVGSDTTLARIIRLVEEAQSSKAPIQRLADRIARYFvpaVLAIAALTFLVWLLFGGDFST------ALYR 358
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 292 AVyyfkiavalavaaipeglpAV-ITTC---LAL--------GTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTN 359
Cdd:COG2217 359 AV-------------------AVlVIACpcaLGLatptaimvGTGRAARRGILIKGGEALERLAKVDTVVFDKTGTLTEG 419
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 360 QMSVCRMFVVAEADAgscllheftisgttytpegevrqgdqpvrcgqfDGLVELATicalcndSALDYNE---AKGVYEK 436
Cdd:COG2217 420 KPEVTDVVPLDGLDE---------------------------------DELLALAA-------ALEQGSEhplARAIVAA 459
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 437 VGEATETALTClvekmnvfdTDLQALsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphpTGQGSKMFVKG 516
Cdd:COG2217 460 AKERGLELPEV---------EDFEAI-------------------------------------------PGKGVEATVDG 487
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 517 ApesviercsSVRVGSRT--APLTPTSREQILAKIRDWGSGSDTLRCLALATRdapprkedmelddcskfvqyetdltFV 594
Cdd:COG2217 488 K---------RVLVGSPRllEEEGIDLPEALEERAEELEAEGKTVVYVAVDGR-------------------------LL 533
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 595 GCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdtedvagkaytgrefddlspeqqrqacrtAR 674
Cdd:COG2217 534 GLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELGI-------------------------------DE 582
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 675 CFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIY 754
Cdd:COG2217 583 VRAEVLPEDKAAAVRELQAQGKKVAMVGDGINDAPALAAADVGIAMGSGTDVAIEAADIVLMRDDLRGVPDAIRLSRATM 662

                ....*
gi 28373113 755 SNMKQ 759
Cdd:COG2217 663 RIIRQ 667
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
59-788 1.89e-55

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 202.09  E-value: 1.89e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    59 DLLVrilLLAALVSFVLAWFEEGeetttafvepLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKgVQ 138
Cdd:TIGR01525   2 DTLM---ALAAIAAYAMGLVLEG----------ALLLFLFLLGETLEERAKSRASDALSALLALAPSTARVLQGDGS-EE 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   139 RIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTeaipdpravnQDKknmLFSGTNITSGK 218
Cdd:TIGR01525  68 EVPVEELQVGDIVIVRPGERIPVDGVVISGESE---VDESALTGESMPVEKKE----------GDE---VFAGTINGDGS 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   219 AVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVInighfadPAHGGSWLRGAVYYFki 298
Cdd:TIGR01525 132 LTIRVTKLGEDSTLAQIVELVEEAQSSKAPIQRLADRIASYYVPAVLAIALLTFVV-------WLALGALWREALYRA-- 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   299 aVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRmFVVAEADAGSCL 378
Cdd:TIGR01525 203 -LTVLVVACPCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVD-IEPLDDASEEEL 280
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   379 LHeftisgttytpegevrqgdqpvrcgqfdglvelatiCALCNDSALDYNEAKGVYEKVGEATETALTclvekmnvfdTD 458
Cdd:TIGR01525 281 LA------------------------------------LAAALEQSSSHPLARAIVRYAKERGLELPP----------ED 314
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   459 LQALSrveragacntvikqlmrkeftlefsrdrksmsvyctptrphptGQGSKMFVKGAPESVIERCSSvrVGSRTAPLT 538
Cdd:TIGR01525 315 VEEVP-------------------------------------------GKGVEATVDGGREVRIGNPRF--LGNRELAIE 349
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   539 PTSREQILakIRDWGSGSDTLRCLALatrdapprkedmelddcskfvqyetDLTFVGCVGMLDPPRPEVAACITRCYQAG 618
Cdd:TIGR01525 350 PISASPDL--LNEGESQGKTVVFVAV-------------------------DGELLGVIALRDQLRPEAKEAIAALKRAG 402
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   619 -IRVVMITGDNKGTAVAICRRLGIfgdTEDVagkaytgrefddlspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEI 697
Cdd:TIGR01525 403 gIKLVMLTGDNRSAAEAVAAELGI---DDEV---------------------------HAELLPEDKLAIVKKLQEEGGP 452
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   698 TAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVcIFL 777
Cdd:TIGR01525 453 VAMVGDGINDAPALAAADVGIAMGSGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALGYNLVAIP-LAA 531
                         730
                  ....*....|.
gi 28373113   778 TAILGLPEALI 788
Cdd:TIGR01525 532 GGLLPLWLAVL 542
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
59-788 7.18e-48

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 181.26  E-value: 7.18e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  59 DLLVrilLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEmgKVIRSDRKGVQ 138
Cdd:cd02079  62 DVLV---SLAAIGAFVASLLTPLLGGIGYFEEAAMLLFLFLLGRYLEERARSRARSALKALLSLAPE--TATVLEDGSTE 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 139 RIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTEAipdprAVnqdkknmlFSGTNITSGK 218
Cdd:cd02079 137 EVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS---VDESSLTGESLPVEKGAGD-----TV--------FAGTINLNGP 200
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 219 AVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHggsWLRGAVyyfki 298
Cdd:cd02079 201 LTIEVTKTGEDTTLAKIIRLVEEAQSSKPPLQRLADRFARYFTPAVLVLAALVFLFWPLVGGPPSL---ALYRAL----- 272
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 299 avalavaaipeglpAV-ITTC---LAL--------GTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRM 366
Cdd:cd02079 273 --------------AVlVVACpcaLGLatptaivaGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVTEI 338
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 367 FVVAEADAgscllheftisgttytpegevrqgdqpvrcgqfdglvelaticalcndsaldyneakgvyekvgeatetalt 446
Cdd:cd02079 339 EPLEGFSE------------------------------------------------------------------------ 346
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 447 clvekmnvfDTDLQALSRVERAgacntvikqlmrkeftlefsrdrksmsvyctptRPHPTGQGskmFVKGAPESVIErcs 526
Cdd:cd02079 347 ---------DELLALAAALEQH---------------------------------SEHPLARA---IVEAAEEKGLP--- 378
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 527 svrvgsrtaPLTPTSREQILAK-IRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSK--FVQYETDLTFVGCVGMLDPP 603
Cdd:cd02079 379 ---------PLEVEDVEEIPGKgISGEVDGREVLIGSLSFAEEEGLVEAADALSDAGKtsAVYVGRDGKLVGLFALEDQL 449
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 604 RPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAH 683
Cdd:cd02079 450 RPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGI-------------------------------DEVHAGLLPED 498
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 684 KSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRY 763
Cdd:cd02079 499 KLAIVKALQAEGGPVAMVGDGINDAPALAQADVGIAMGSGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKQNLAW 578
                       730       740
                ....*....|....*....|....*
gi 28373113 764 LISSNvgeVVCIFLtAILGLPEALI 788
Cdd:cd02079 579 ALGYN---AIALPL-AALGLLTPWI 599
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
23-857 2.01e-47

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 184.11  E-value: 2.01e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113     23 GLSPAQVTGARERYGPNEL----PSEEgKSLWELVLEQFEDLLVRILLLAALVSFVlawfeegeetttafVEPLVIMLIL 98
Cdd:TIGR01657  139 GLTTGDIAQRKAKYGKNEIeipvPSFL-ELLKEEVLHPFYVFQVFSVILWLLDEYY--------------YYSLCIVFMS 203
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113     99 VANAIVGVWQERNAESAIEALKeYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAV--GDKVPADLRLIeikSTTLRVD 176
Cdd:TIGR01657  204 STSISLSVYQIRKQMQRLRDMV-HKPQSVIVIRNGKW--VTIASDELVPGDIVSIPRpeEKTMPCDSVLL---SGSCIVN 277
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    177 QSILTGESVSVTKhtEAIPDPRAVNQD-------KKNMLFSGTNI-------TSGKAVGVAVATGLHTELGKIRSQMaaV 242
Cdd:TIGR01657  278 ESMLTGESVPVLK--FPIPDNGDDDEDlflyetsKKHVLFGGTKIlqirpypGDTGCLAIVVRTGFSTSKGQLVRSI--L 353
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    243 EPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHfadpahggswLRGAVYYFKIAVALA--VAAIPEGLPAVITTCLA 320
Cdd:TIGR01657  354 YPKPRVFKFYKDSFKFILFLAVLALIGFIYTIIELI----------KDGRPLGKIILRSLDiiTIVVPPALPAELSIGIN 423
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    321 LGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrMFVVAEADAGSCLLHEFTISGTTytpegevrqgdq 400
Cdd:TIGR01657  424 NSLARLKKKGIFCTSPFRINFAGKIDVCCFDKTGTLTEDGLDL--RGVQGLSGNQEFLKIVTEDSSLK------------ 489
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    401 pvrcgqfdgLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQlmr 480
Cdd:TIGR01657  490 ---------PSITHKALATCHSLTKLEGKLVGDPLDKKMFEATGWTLEEDDESAEPTSILAVVRTDDPPQELSIIRR--- 557
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    481 keftLEFSRDRKSMSVYCTptrpHPTGQGSKMFVKGAPESVIERCSSVRVgsrtapltPTSREQILAKIRDWGSgsdtlR 560
Cdd:TIGR01657  558 ----FQFSSALQRMSVIVS----TNDERSPDAFVKGAPETIQSLCSPETV--------PSDYQEVLKSYTREGY-----R 616
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    561 CLALATRDAPPRKEDmELDDCSKfVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLG 640
Cdd:TIGR01657  617 VLALAYKELPKLTLQ-KAQDLSR-DAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECG 694
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    641 I-----------FGDTEDVAGK--------------------------------------AYTGREFDDL---SPEQQRQ 668
Cdd:TIGR01657  695 IvnpsntlilaeAEPPESGKPNqikfevidsipfastqveipyplgqdsvedllasryhlAMSGKAFAVLqahSPELLLR 774
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    669 ACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAksAAEMVLSDDNFASIVAAVE 748
Cdd:TIGR01657  775 LLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVGISLSEAEASV--AAPFTSKLASISCVPNVIR 852
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    749 EGRA-------IYSNMKQ---------FIRYLISSNVGEvvcifltailglpealipVQLLWVNLVTDGLPATALGFNPP 812
Cdd:TIGR01657  853 EGRCalvtsfqMFKYMALysliqfysvSILYLIGSNLGD------------------GQFLTIDLLLIFPVALLMSRNKP 914
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|.
gi 28373113    813 dldiMEKLPRS-PREALISGWLFFR-----YLAIGVYVGLATVAAATWWFV 857
Cdd:TIGR01657  915 ----LKKLSKErPPSNLFSVYILTSvliqfVLHILSQVYLVFELHAQPWYK 961
E1-E2_ATPase pfam00122
E1-E2 ATPase;
121-329 1.28e-46

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 165.05  E-value: 1.28e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   121 EYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEiksTTLRVDQSILTGESVSVTKHteaipdprav 200
Cdd:pfam00122   1 SLLPPTATVLRDG--TEEEVPADELVPGDIVLLKPGERVPADGRIVE---GSASVDESLLTGESLPVEKK---------- 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   201 nqdKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIghfa 280
Cdd:pfam00122  66 ---KGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWL---- 138
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 28373113   281 dpahggSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARK 329
Cdd:pfam00122 139 ------FVGGPPLRALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
66-759 3.66e-45

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 172.07  E-value: 3.66e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    66 LLAALVSFVLAWFEEGEETTTAFVEPLVIMLILvanaIVGVWQERNAES----AIEALKEYEPEMGKVIRSDrKGVQRIR 141
Cdd:TIGR01511  32 YGYSLVALLANQVLTGLHVHTFFDASAMLITFI----LLGRWLEMLAKGrasdALSKLAKLQPSTATLLTKD-GSIEEVP 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   142 ARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTeaipdpravnQDKknmLFSGTNITSGKAVG 221
Cdd:TIGR01511 107 VALLQPGDIVKVLPGEKIPVDGTVIEGESE---VDESLVTGESLPVPKKV----------GDP---VIAGTVNGTGSLVV 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   222 VAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLS---HAISVICVAVWVinighFAdpahggswLRGAVYYFki 298
Cdd:TIGR01511 171 RATATGEDTTLAQIVRLVRQAQQSKAPIQRLADKVAGYFVpvvIAIALITFVIWL-----FA--------LEFAVTVL-- 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   299 avalaVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscl 378
Cdd:TIGR01511 236 -----IIACPCALGLATPTVIAVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTV--------------- 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   379 lheftisgTTYTPEGEVRQGDQpvrcgqfdglveLATICALCNDSalDYNEAKGVYEKVGEATETALTClvekmnvfdTD 458
Cdd:TIGR01511 296 --------TDVHVFGDRDRTEL------------LALAAALEAGS--EHPLAKAIVSYAKEKGITLVTV---------SD 344
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   459 LQALsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphpTGQGSKMFVKGApesviercsSVRVGSrtaplt 538
Cdd:TIGR01511 345 FKAI-------------------------------------------PGIGVEGTVEGT---------KIQLGN------ 366
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   539 ptsreqilakiRDWgsgsdtlrCLALATRDAPPRKEDMElddcSKFVQYETDLTFVGCVGmlDPPRPEVAACITRCYQAG 618
Cdd:TIGR01511 367 -----------EKL--------LGENAIKIDGKAGQGST----VVLVAVNGELAGVFALE--DQLRPEAKEVIQALKRRG 421
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   619 IRVVMITGDNKGTAVAICRRLGIfgdteDVagkaytgrefddlspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEIT 698
Cdd:TIGR01511 422 IEPVMLTGDNRKTAKAVAKELGI-----DV---------------------------RAEVLPDDKAALIKKLQEKGPVV 469
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28373113   699 AMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:TIGR01511 470 AMVGDGINDAPALAQADVGIAIGAGTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRIKQ 530
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
784-987 6.19e-45

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 159.71  E-value: 6.19e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   784 PEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGP 863
Cdd:pfam00689   1 PLPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   864 HINFYqlrnflkcsednplfagidcevfesrfptTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMAL 943
Cdd:pfam00689  81 SQNAQ-----------------------------TMAFNTLVLSQLFNALNARSLRRSLFKIGLFSNKLLLLAILLSLLL 131
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 28373113   944 HFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYL 987
Cdd:pfam00689 132 QLLIIYVPPLQAVFGTTPLSLEQWLIVLLLALVVLLVVELRKLL 175
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
33-770 1.14e-44

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 173.59  E-value: 1.14e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  33 RERYGPNELPSEEgKSLWEL----VLEQFedllvrilLLAALVSfVLAWFEEGeetttaFVE-PLVIMLILVANAIVGVW 107
Cdd:cd07542   7 RLIYGPNEIDVPL-KSILKLlfkeVLNPF--------YVFQLFS-VILWSSDD------YYYyAACIVIISVISIFLSLY 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 108 QERNAESAIEALKEYePEMGKVIRsdRKGVQRIRARDIVPGDIVEVAVGDKV-PADLRLIeikSTTLRVDQSILTGESVS 186
Cdd:cd07542  71 ETRKQSKRLREMVHF-TCPVRVIR--DGEWQTISSSELVPGDILVIPDNGTLlPCDAILL---SGSCIVNESMLTGESVP 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 187 VTK-----HTEAIPDPRAVNQD-KKNMLFSGTNI------TSGKAVGVAVATGLHTELGK-IRSQMAavePERTPLQRKL 253
Cdd:cd07542 145 VTKtplpdESNDSLWSIYSIEDhSKHTLFCGTKViqtrayEGKPVLAVVVRTGFNTTKGQlVRSILY---PKPVDFKFYR 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 254 DefgrqlshAISVICVAVWVINIGHFADpahggswlrgAVYYFKIAVALAVA----------AIPEGLPAVITTCLALGT 323
Cdd:cd07542 222 D--------SMKFILFLAIIALIGFIYT----------LIILILNGESLGEIiiraldiitiVVPPALPAALTVGIIYAQ 283
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 324 RRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagSCLLhefTISGTtytpegevRQGDQPVr 403
Cdd:cd07542 284 SRLKKKGIFCISPQRINICGKINLVCFDKTGTLTEDGLDL------------WGVR---PVSGN--------NFGDLEV- 339
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 404 cgqfdglvelaTICALCNDSALDYneakgvyekvGEATETALTC----LVEkmNVFDTDLQALSRVERAGACNTVIKQLm 479
Cdd:cd07542 340 -----------FSLDLDLDSSLPN----------GPLLRAMATChsltLID--GELVGDPLDLKMFEFTGWSLEILRQF- 395
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 480 rkeftlEFSRDRKSMSVYCTptrpHPTGQGSKMFVKGAPESVIERC--SSVrvgsrtapltPTSREQILAKIRDWGsgsd 557
Cdd:cd07542 396 ------PFSSALQRMSVIVK----TPGDDSMMAFTKGAPEMIASLCkpETV----------PSNFQEVLNEYTKQG---- 451
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 558 tLRCLALATRDAPprKEDMELDDCSKfVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICR 637
Cdd:cd07542 452 -FRVIALAYKALE--SKTWLLQKLSR-EEVESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAISVAR 527
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 638 RLGIFGDTEdvagKAYTGR---EFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKA 714
Cdd:cd07542 528 ECGMISPSK----KVILIEavkPEDDDSASLTWTLLLKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGALKAA 603
                       730       740       750       760       770       780       790
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28373113 715 EIGIAMGSgtAVAKSAAEMVLSDDNFASIVAAVEEGRA-------------IYSnMKQFIR----YLISSNVG 770
Cdd:cd07542 604 DVGISLSE--AEASVAAPFTSKVPDISCVPTVIKEGRAalvtsfscfkymaLYS-LIQFISvlilYSINSNLG 673
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
58-788 3.30e-44

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 169.04  E-value: 3.30e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    58 EDLLVRILLLAALvsFVLAWFEEgeetttafvepLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDrkGV 137
Cdd:TIGR01512   1 VDLLMALAALGAV--AIGEYLEG-----------ALLLLLFSIGETLEEYASGRARRALKALMELAPDTARRLQGD--SL 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   138 QRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHTEaipdpravnqDKknmLFSGTNITSG 217
Cdd:TIGR01512  66 EEVAVEELKVGDVVVVKPGERVPVDGEVLSGTSS---VDESALTGESVPVEKAPG----------DE---VFAGAINLDG 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   218 KAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINighfadPAHGGSWLRGAVYYFk 297
Cdd:TIGR01512 130 VLTIEVTKLPADSTIAKIVNLVEEAQSRKAPTQRFIDRFARYYTPAVLAIALAAALVP------PLLGAGPFLEWIYRA- 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   298 iaVALAVAAIPEGLpaVITTCLAL--GTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRmFVVAEADAG 375
Cdd:TIGR01512 203 --LVLLVVASPCAL--VISAPAAYlsAISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTD-VHPADGHSE 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   376 SCLLHEFTISGTTYTpegevrqgdQPVrcgqfdglvelaticalcNDSALDYNEAKGVYEKVGEATEtaltclvekmnvf 455
Cdd:TIGR01512 278 SEVLRLAAAAEQGST---------HPL------------------ARAIVDYARARELAPPVEDVEE------------- 317
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   456 dtdlqalsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphPTGQGSKMFVKGApesviercsSVRVGSRTA 535
Cdd:TIGR01512 318 -------------------------------------------------VPGEGVRAVVDGG---------EVRIGNPRS 339
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   536 pltptSREQILAKIRDWGSGSDTlrcLALATRDApprkedmelddcskfvqyetdlTFVGCVGMLDPPRPEVAACITRCY 615
Cdd:TIGR01512 340 -----LSEAVGASIAVPESAGKT---IVLVARDG----------------------TLLGYIALSDELRPDAAEAIAELK 389
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   616 QAGI-RVVMITGDNKGTAVAICRRLGIfgdTEDVAgkaytgrefdDLSPEQqrqacrtarcfarvepahKSRIVENLQSF 694
Cdd:TIGR01512 390 ALGIkRLVMLTGDRRAVAEAVARELGI---DEVHA----------ELLPED------------------KLEIVKELREK 438
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   695 NEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGeVV 773
Cdd:TIGR01512 439 AGPVAMVGDGINDAPALAAADVGIAMGaSGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVIALGIILV-LI 517
                         730
                  ....*....|....*
gi 28373113   774 CIFLTAILGLPEALI 788
Cdd:TIGR01512 518 LLALFGVLPLWLAVL 532
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
92-759 3.05e-41

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 161.88  E-value: 3.05e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  92 LVIMLILVanaivGVWQE----RNAESAIEALKEYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIE 167
Cdd:cd02094 107 VIITFILL-----GKYLEarakGKTSEAIKKLLGLQPKTARVIRDG--KEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVE 179
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 168 IKSTtlrVDQSILTGESVSVTKHTEaipdpravnqDKknmLFSGTNITSGKAVGVAVATGLHTELGKIrsqMAAVEpE-- 245
Cdd:cd02094 180 GESS---VDESMLTGESLPVEKKPG----------DK---VIGGTINGNGSLLVRATRVGADTTLAQI---IRLVE-Eaq 239
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 246 --RTPLQRKLDefgrQLS-------HAISVICVAVWVInIGHFADPAHGgswLRGAVyyfkiavalavaaipeglpAV-I 315
Cdd:cd02094 240 gsKAPIQRLAD----RVSgvfvpvvIAIAILTFLVWLL-LGPEPALTFA---LVAAV-------------------AVlV 292
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 316 TTC---LAL--------GTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGscllhefti 384
Cdd:cd02094 293 IACpcaLGLatptaimvGTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVTDVVPLPGDDED--------- 363
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 385 sgttytpegevrqgdqpvrcgqfdglvELATICAlcndSALDYNE---AKGVYEKVGEATETALTClvekmnvfdTDLQA 461
Cdd:cd02094 364 ---------------------------ELLRLAA----SLEQGSEhplAKAIVAAAKEKGLELPEV---------EDFEA 403
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 462 LsrveragacntvikqlmrkeftlefsrdrksmsvyctptrphpTGQGskmfVKGAPESViercsSVRVGSRtapltpts 541
Cdd:cd02094 404 I-------------------------------------------PGKG----VRGTVDGR-----RVLVGNR-------- 423
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 542 reqilAKIRDWG--SGSDTLRCLALATRDAPPrkedmelddcskfVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGI 619
Cdd:cd02094 424 -----RLMEENGidLSALEAEALALEEEGKTV-------------VLVAVDGELAGLIAVADPLKPDAAEAIEALKKMGI 485
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 620 RVVMITGDNKGTAVAICRRLGIfgdtEDVagkaytgrefddlspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEITA 699
Cdd:cd02094 486 KVVMLTGDNRRTARAIAKELGI----DEV---------------------------IAEVLPEDKAEKVKKLQAQGKKVA 534
                       650       660       670       680       690       700
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 700 MTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:cd02094 535 MVGDGINDAPALAQADVGIAIGSGTDVAIESADIVLMRGDLRGVVTAIDLSRATMRNIKQ 594
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
92-846 5.93e-38

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 153.13  E-value: 5.93e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  92 LVIMLILVANAIVGVWQERNAESAIEALKeYEPEMGKVIRSDRKgVQRIRARDIVPGDIVEVAV-GDKVPADLRLIEiks 170
Cdd:cd02082  54 ITVVFMTTINSLSCIYIRGVMQKELKDAC-LNNTSVIVQRHGYQ-EITIASNMIVPGDIVLIKRrEVTLPCDCVLLE--- 128
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 171 TTLRVDQSILTGESVSVTKhtEAIPDP----RAVNQD--KKNMLFSGTNI------TSGKAVGVAVATGLHTELGKIRsq 238
Cdd:cd02082 129 GSCIVTEAMLTGESVPIGK--CQIPTDshddVLFKYEssKSHTLFQGTQVmqiippEDDILKAIVVRTGFGTSKGQLI-- 204
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 239 maavepeRTPLQRKLDEFGRQLSHAISVICVAVwvinighFADPAHGGSWLRG------AVYYFKIAVALAVAAIPEGLP 312
Cdd:cd02082 205 -------RAILYPKPFNKKFQQQAVKFTLLLAT-------LALIGFLYTLIRLldielpPLFIAFEFLDILTYSVPPGLP 270
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 313 AVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEAdagscllHEFTisgttytpe 392
Cdd:cd02082 271 MLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKLDLIGYQLKGQN-------QTFD--------- 334
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 393 gevrqgdqPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTclvekmnvFDTDLQALSRVERAGACN 472
Cdd:cd02082 335 --------PIQCQDPNNISIEHKLFAICHSLTKINGKLLGDPLDVKMAEASTWD--------LDYDHEAKQHYSKSGTKR 398
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 473 TVIKQlmrkefTLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVrvgsrtapltPTSREQILAKIRDW 552
Cdd:cd02082 399 FYIIQ------VFQFHSALQRMSVVAKEVDMITKDFKHYAFIKGAPEKIQSLFSHV----------PSDEKAQLSTLINE 462
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 553 GSgsdtlRCLALATRDAPPRKEDMELDdcSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTA 632
Cdd:cd02082 463 GY-----RVLALGYKELPQSEIDAFLD--LSREAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTA 535
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 633 VAICRRLGIFGdtedvagKAYTGREFDDLSPEQQRQACRTAR------CFARVEPAHKSRIVENLQSFNEITAMTGDGVN 706
Cdd:cd02082 536 LKVAQELEIIN-------RKNPTIIIHLLIPEIQKDNSTQWIliihtnVFARTAPEQKQTIIRLLKESDYIVCMCGDGAN 608
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 707 DAPALKKAEIGIAMGSGTavAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEA 786
Cdd:cd02082 609 DCGALKEADVGISLAEAD--ASFASPFTSKSTSISCVKRVILEGRVNLSTSVEIFKGYALVALIRYLSFLTLYYFYSSYS 686
                       730       740       750       760       770       780
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28373113 787 LIPVQLLWVNLVTDGLPATALGFNPPdLDIMEKLPR---SPREALISGWLFFRYLA-IGVYVGL 846
Cdd:cd02082 687 SSGQMDWQLLAAGYFLVYLRLGCNTP-LKKLEKDDNlfsIYNVTSVLFGFTLHILSiVGCVESL 749
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
124-720 4.51e-37

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 150.61  E-value: 4.51e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 124 PEMGKVIRsDRKGVQrIRARDIVPGDIVEV---AVGDKVPADLRLIeikSTTLRVDQSILTGESVSVTKHT-EAIPDPRA 199
Cdd:cd07543  85 PYTIQVYR-DGKWVP-ISSDELLPGDLVSIgrsAEDNLVPCDLLLL---RGSCIVNEAMLTGESVPLMKEPiEDRDPEDV 159
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 200 V---NQDKKNMLFSGTNI-------------TSGKAVGVAVATGLHTELGK-IRSQMAAVEpERTPLQRKldefgrqlsh 262
Cdd:cd07543 160 LdddGDDKLHVLFGGTKVvqhtppgkgglkpPDGGCLAYVLRTGFETSQGKlLRTILFSTE-RVTANNLE---------- 228
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 263 aiSVICVAVWVInighFADPAHGGSWLRGA----VYY--FKIAVALAVAAIPEGLPavittclalgtrrMARKNAIVRSL 336
Cdd:cd07543 229 --TFIFILFLLV----FAIAAAAYVWIEGTkdgrSRYklFLECTLILTSVVPPELP-------------MELSLAVNTSL 289
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 337 PSVETLG--CT-----------SVICSDKTGTLTTNQMSVcrmfvvaeadAGscllheftISGTTYTPEGEVRQGDQPVR 403
Cdd:cd07543 290 IALAKLYifCTepfripfagkvDICCFDKTGTLTSDDLVV----------EG--------VAGLNDGKEVIPVSSIEPVE 351
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 404 CGQfdglvelatICALCNdSALDYNEAKGVYEKVGEATETALTCLVEKMNVFdtdlqalsrVERAGACNTVikQLMRKef 483
Cdd:cd07543 352 TIL---------VLASCH-SLVKLDDGKLVGDPLEKATLEAVDWTLTKDEKV---------FPRSKKTKGL--KIIQR-- 408
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 484 tLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVrvgsrtapltPTSREQILAKIRDWGSgsdtlRCLA 563
Cdd:cd07543 409 -FHFSSALKRMSVVASYKDPGSTDLKYIVAVKGAPETLKSMLSDV----------PADYDEVYKEYTRQGS-----RVLA 472
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 564 LATRD----APPRKEDMELDDcskfvqYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRL 639
Cdd:cd07543 473 LGYKElghlTKQQARDYKRED------VESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLTACHVAKEL 546
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 640 GIfgdtedvAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIA 719
Cdd:cd07543 547 GI-------VDKPVLILILSEEGKSNEWKLIPHVKVFARVAPKQKEFIITTLKELGYVTLMCGDGTNDVGALKHAHVGVA 619

                .
gi 28373113 720 M 720
Cdd:cd07543 620 L 620
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
50-783 1.42e-35

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 143.93  E-value: 1.42e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  50 WELVLEQFEDLL------VRIL-LLAALVSFVLAWFEEGeetttafvePLVIMLILVANAIVGVWQERnAESAIEALKEY 122
Cdd:cd07551  40 YASAKEGIEATLrkktlnVDLLmILAAIGAAAIGYWAEG---------ALLIFIFSLSHALEDYAMGR-SKRAITALMQL 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 123 EPEMGKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrVDQSILTGESVSVTKHteaIPDPravnq 202
Cdd:cd07551 110 APETARRIQRD-GEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSSS---IDEASITGESIPVEKT---PGDE----- 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 203 dkknmLFSGTnITSGKAVGVAVaTGLHTE--LGKIRSQMAAVEPERTPLQRKLDEFGRQlsHAISVICVAVWVINIGHFA 280
Cdd:cd07551 178 -----VFAGT-INGSGALTVRV-TKLSSDtvFAKIVQLVEEAQSEKSPTQSFIERFERI--YVKGVLLAVLLLLLLPPFL 248
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 281 DpahGGSW----LRGAVYyfkiavalAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTL 356
Cdd:cd07551 249 L---GWTWadsfYRAMVF--------LVVASPCALVASTPPATLSAIANAARQGVLFKGGVHLENLGSVKAIAFDKTGTL 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 357 TTNQMSVcrmfvvaeadagscllheftisgTTYTPEGEVRQgdqpvrcgqfdglvelaticalcndsaldyneakgvyEK 436
Cdd:cd07551 318 TEGKPRV-----------------------TDVIPAEGVDE-------------------------------------EE 337
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 437 VgeatetaltclvekmnvfdtdLQALSRVERAGacNTVIKQLMRKEFTLEFSRDRKSMSVyctptrPHPTGQGSKMFVKG 516
Cdd:cd07551 338 L---------------------LQVAAAAESQS--EHPLAQAIVRYAEERGIPRLPAIEV------EAVTGKGVTATVDG 388
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 517 ApesviercsSVRVGSrtapltPTSREQILakirdwgsgsDTLRCLALATRDAPPRKEDMelddcskFVQyeTDLTFVGC 596
Cdd:cd07551 389 Q---------TYRIGK------PGFFGEVG----------IPSEAAALAAELESEGKTVV-------YVA--RDDQVVGL 434
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 597 VGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdTEDVAGkaytgrefddLSPEQqrqacrtarcf 676
Cdd:cd07551 435 IALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELGI---DEVVAN----------LLPED----------- 490
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 677 arvepahKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRaiysN 756
Cdd:cd07551 491 -------KVAIIRELQQEYGTVAMVGDGINDAPALANADVGIAMGAGTDVALETADVVLMKDDLSKLPYAIRLSR----K 559
                       730       740
                ....*....|....*....|....*..
gi 28373113 757 MKQFIRYLISSNVGEVVCIFLTAILGL 783
Cdd:cd07551 560 MRRIIKQNLIFALAVIALLIVANLFGL 586
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
92-807 6.61e-33

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 135.61  E-value: 6.61e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  92 LVIMLILVANAIVGVWQERnAESAIEALKEYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKST 171
Cdd:cd07546  67 MVLLLFLVGELLEGYAASR-ARSGVKALMALVPETALREENG--ERREVPADSLRPGDVIEVAPGGRLPADGELLSGFAS 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 172 tlrVDQSILTGESVSVTKhteaipdpravnqDKKNMLFSGTNITSGKA-VGVAVATGLHTeLGKIRSQMAAVEPERTPLQ 250
Cdd:cd07546 144 ---FDESALTGESIPVEK-------------AAGDKVFAGSINVDGVLrIRVTSAPGDNA-IDRILHLIEEAEERRAPIE 206
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 251 RKLDEFGRQLSHAISVICVAVWVInighfadP--AHGGSW----LRGavyyfkiaVALAVAAIPEGL----PAVITTCLA 320
Cdd:cd07546 207 RFIDRFSRWYTPAIMAVALLVIVV-------PplLFGADWqtwiYRG--------LALLLIGCPCALvistPAAITSGLA 271
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 321 LGTRRmarkNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISGTTYTPegevrqgdq 400
Cdd:cd07546 272 AAARR----GALIKGGAALEQLGRVTTVAFDKTGTLTRGKPVVTDVVPLTGISEAELLALAAAVEMGSSHP--------- 338
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 401 pvrcgqfdglveLATicALcndsaldyneakgvyekVGEATETALtclvekmnvfdTDLQALSRVERAgacntvikqlmr 480
Cdd:cd07546 339 ------------LAQ--AI-----------------VARAQAAGL-----------TIPPAEEARALV------------ 364
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 481 keftlefsrdrksmsvyctptrphptGQGSKMFVKGAPesvIERCSSVRVGSRtapLTPTSREQILAkIRDWGsgsdtlR 560
Cdd:cd07546 365 --------------------------GRGIEGQVDGER---VLIGAPKFAADR---GTLEVQGRIAA-LEQAG------K 405
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 561 CLALATRDAPPrkedmelddcskfvqyetdltfVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLG 640
Cdd:cd07546 406 TVVVVLANGRV----------------------LGLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELG 463
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 641 IfgdtedvagkaytgrEFDdlspeqqrqacrtarcfARVEPAHKSRIVENLQSfNEITAMTGDGVNDAPALKKAEIGIAM 720
Cdd:cd07546 464 L---------------DFR-----------------AGLLPEDKVKAVRELAQ-HGPVAMVGDGINDAPAMKAASIGIAM 510
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 721 GSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISsnvgeVVCIFL-TAILGLPEalipvqlLWVNLVT 799
Cdd:cd07546 511 GSGTDVALETADAALTHNRLGGVAAMIELSRATLANIRQNITIALG-----LKAVFLvTTLLGITG-------LWLAVLA 578

                ....*...
gi 28373113 800 DGlPATAL 807
Cdd:cd07546 579 DT-GATVL 585
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
92-800 4.77e-29

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 123.68  E-value: 4.77e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  92 LVIMLILVANAIVGVWQERnAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKST 171
Cdd:cd07545  64 MVVFLFAISEALEAYSMDR-ARRSIRSLMDIAPKTALVRRDGQE--REVPVAEVAVGDRMIVRPGERIAMDGIIVRGESS 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 172 tlrVDQSILTGESVSVTKhteaipdpravnqDKKNMLFSGTNITSGkAVGVAV-ATGLHTELGKIRSQMAAVEPERTPLQ 250
Cdd:cd07545 141 ---VNQAAITGESLPVEK-------------GVGDEVFAGTLNGEG-ALEVRVtKPAEDSTIARIIHLVEEAQAERAPTQ 203
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 251 RKLDEFGRQLSHAISVICVAVWVINIGHFadpahGGSWLrGAVYyfkIAVALAVAAIPEGLpaVITTCL----ALGTrrM 326
Cdd:cd07545 204 AFVDRFARYYTPVVMAIAALVAIVPPLFF-----GGAWF-TWIY---RGLALLVVACPCAL--VISTPVsivsAIGN--A 270
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 327 ARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADagscllheftisgttytpEGEVrqgdqpvrcgq 406
Cdd:cd07545 271 ARKGVLIKGGVYLEELGRLKTVAFDKTGTLTKGKPVVTDVVVLGGQT------------------EKEL----------- 321
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 407 fdglveLATICALcnDSALDYNEAKGVyekVGEATETALTclvekmnvfdtdlqaLSRVEragacntvikqlmrkEFTle 486
Cdd:cd07545 322 ------LAIAAAL--EYRSEHPLASAI---VKKAEQRGLT---------------LSAVE---------------EFT-- 358
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 487 fsrdrkSMsvyctptrphpTGQGSKMFVKGapesviercSSVRVGSR------TAPLTPTSREQILAkIRDWGSGSdtlr 560
Cdd:cd07545 359 ------AL-----------TGRGVRGVVNG---------TTYYIGSPrlfeelNLSESPALEAKLDA-LQNQGKTV---- 407
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 561 cLALATRDapprkedmelddcskfvqyetdlTFVGCVGMLDPPRPEVAACITRCYQAGI-RVVMITGDNKGTAVAICRRL 639
Cdd:cd07545 408 -MILGDGE-----------------------RILGVIAVADQVRPSSRNAIAALHQLGIkQTVMLTGDNPQTAQAIAAQV 463
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 640 GIfgdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIA 719
Cdd:cd07545 464 GV-------------------------------SDIRAELLPQDKLDAIEALQAEGGRVAMVGDGVNDAPALAAADVGIA 512
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 720 MGS-GTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQfirylissNVGEVVCIFLTAILglpeALIPVQL-LWVNL 797
Cdd:cd07545 513 MGAaGTDTALETADIALMGDDLRKLPFAVRLSRKTLAIIKQ--------NIAFALGIKLIALL----LVIPGWLtLWMAV 580

                ...
gi 28373113 798 VTD 800
Cdd:cd07545 581 FAD 583
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
93-759 3.25e-28

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 121.26  E-value: 3.25e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  93 VIMLIlvanaivGVWQERN----AESAIEALKEYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEI 168
Cdd:cd07552 102 VIMLL-------GHWIEMKavmgAGDALKKLAELLPKTAHLVTDG--SIEDVPVSELKVGDVVLVRAGEKIPADGTILEG 172
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 169 KSttlRVDQSILTGESvsvtkhteaipdpRAVNQDKKNMLFSGTnITSGKAVGVAV-ATGLHTELGKIRSQMAAVEPERT 247
Cdd:cd07552 173 ES---SVNESMVTGES-------------KPVEKKPGDEVIGGS-VNGNGTLEVKVtKTGEDSYLSQVMELVAQAQASKS 235
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 248 PLQRKLDEFGRQLSHA---ISVICVAVWVInIGHFADPahggswLRGAVYYFkiavalaVAAIPEGLPAVITTCLALGTR 324
Cdd:cd07552 236 RAENLADKVAGWLFYIalgVGIIAFIIWLI-LGDLAFA------LERAVTVL-------VIACPHALGLAIPLVVARSTS 301
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 325 RMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTnqmsvcrmfvvaeadagscllheftisgttytpegevrqgdqpvrc 404
Cdd:cd07552 302 IAAKNGLLIRNREALERARDIDVVLFDKTGTLTE---------------------------------------------- 335
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 405 GQFdGLVELATICALCNDSALDYNEAkgvyekvgeatetaltclvekmnvfdtdLQALSRVERAGACNTVIKQlmrKEFT 484
Cdd:cd07552 336 GKF-GVTDVITFDEYDEDEILSLAAA----------------------------LEAGSEHPLAQAIVSAAKE---KGIR 383
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 485 LEFSRDRKSMSvyctptrphptGQGSKMFVKGapesviercSSVRVGSR--TAPLTPTSREQILAKIRDWGSgsdTLrcl 562
Cdd:cd07552 384 PVEVENFENIP-----------GVGVEGTVNG---------KRYQVVSPkyLKELGLKYDEELVKRLAQQGN---TV--- 437
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 563 alatrdapprkedmelddcsKFVQYETDLtfVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIf 642
Cdd:cd07552 438 --------------------SFLIQDGEV--IGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGI- 494
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 643 gdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGS 722
Cdd:cd07552 495 ------------------------------DEYFAEVLPEDKAKKVKELQAEGKKVAMVGDGVNDAPALAQADVGIAIGA 544
                       650       660       670
                ....*....|....*....|....*....|....*..
gi 28373113 723 GTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:cd07552 545 GTDVAIESADVVLVKSDPRDIVDFLELAKATYRKMKQ 581
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
418-528 3.75e-28

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 108.85  E-value: 3.75e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   418 ALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMnvfdtdlqalsrveraGACNTVIKQLMRKEFTLEFSRDRKSMSVY 497
Cdd:pfam13246   1 ALCNSAAFDENEEKGKWEIVGDPTESALLVFAEKM----------------GIDVEELRKDYPRVAEIPFNSDRKRMSTV 64
                          90       100       110
                  ....*....|....*....|....*....|.
gi 28373113   498 CTPtrphPTGQGSKMFVKGAPESVIERCSSV 528
Cdd:pfam13246  65 HKL----PDDGKYRLFVKGAPEIILDRCTTI 91
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
84-787 3.94e-28

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 120.84  E-value: 3.94e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  84 TTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRkgVQRIRARDIVPGDIVEVAVGDKVPADL 163
Cdd:cd07550  59 LTGDYLAANTIAFLLELGELLEDYTARKSEKALLDLLSPQERTVWVERDGV--EVEVPADEVQPGDTVVVGAGDVIPVDG 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 164 RLIEIKSTtlrVDQSILTGESVSVTKhteaipdpravnqDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVE 243
Cdd:cd07550 137 TVLSGEAL---IDQASLTGESLPVEK-------------REGDLVFASTVVEEGQLVIRAERVGRETRAARIAELIEQSP 200
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 244 PERTPLQRKLDEFGRQLSHAISVICVAVWVINighfadpahgGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTClalgt 323
Cdd:cd07550 201 SLKARIQNYAERLADRLVPPTLGLAGLVYALT----------GDISRAAAVLLVDFSCGIRLSTPVAVLSALNHA----- 265
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 324 rrmARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscllheftisgttytpegevrqgdQPVR 403
Cdd:cd07550 266 ---ARHGILVKGGRALELLAKVDTVVFDKTGTLTEGEPEV------------------------------------TAII 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 404 CgqFDGLVELATICALcndsaldyneAKGVYEKVGEATETALtclvekmnvfdtdlqaLSRVERAGacntvIKQLMRKEf 483
Cdd:cd07550 307 T--FDGRLSEEDLLYL----------AASAEEHFPHPVARAI----------------VREAEERG-----IEHPEHEE- 352
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 484 tLEFSrdrksmsvyctptrphpTGQGSKMFVKGAPesviercssVRVGSR------TAPLTPTsreqILAKIRDWGSGSD 557
Cdd:cd07550 353 -VEYI-----------------VGHGIASTVDGKR---------IRVGSRhfmeeeEIILIPE----VDELIEDLHAEGK 401
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 558 TLRCLALATRdapprkedmelddcskfvqyetdltFVGCVGMLDPPRPEVAACITRCYQAG-IRVVMITGDNKGTAVAIC 636
Cdd:cd07550 402 SLLYVAIDGR-------------------------LIGVIGLSDPLRPEAAEVIARLRALGgKRIIMLTGDHEQRARALA 456
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 637 RRLGIfgdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEI 716
Cdd:cd07550 457 EQLGI-------------------------------DRYHAEALPEDKAEIVEKLQAEGRTVAFVGDGINDSPALSYADV 505
                       650       660       670       680       690       700       710
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28373113 717 GIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGevvCIFLTAILGLPEAL 787
Cdd:cd07550 506 GISMRGGTDIARETADVVLLEDDLRGLAEAIELARETMALIKRNIALVVGPNTA---VLAGGVFGLLSPIL 573
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
128-728 1.37e-26

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 117.27  E-value: 1.37e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 128 KVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRL-----------IEIKS----TTLRVDQSILTGESVSVTKHTE 192
Cdd:cd02073  84 PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLlsssepdglcyVETANldgeTNLKIRQALPETALLLSEEDLA 163
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 193 A----------------------IPDPRAVNQDKKNMLFSGTNI-TSGKAVGVAVATGLHTEL----GKIRSQmaavepe 245
Cdd:cd02073 164 RfsgeieceqpnndlytfngtleLNGGRELPLSPDNLLLRGCTLrNTEWVYGVVVYTGHETKLmlnsGGTPLK------- 236
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 246 RTPLQRKLDE-----FGRQLSHA-ISVICVAVWVINIGHFA---DPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVIT 316
Cdd:cd02073 237 RSSIEKKMNRfiiaiFCILIVMClISAIGKGIWLSKHGRDLwylLPKEERSPALEFFFDFLTFIILYNNLIPISLYVTIE 316
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 317 TCLALGTRRMA----------RKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSvcrmFVvaeadagscllhEFTISG 386
Cdd:cd02073 317 VVKFLQSFFINwdldmydeetDTPAEARTSNLNEELGQVEYIFSDKTGTLTENIME----FK------------KCSING 380
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 387 TTYtpegevrqgdqpvrcgQFdgLVELAticaLCNdsaldyneakgvyekvgeatetalTCLVEKMNVFDTDL-QALSRV 465
Cdd:cd02073 381 VDY----------------GF--FLALA----LCH------------------------TVVPEKDDHPGQLVyQASSPD 414
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 466 ERA---GACN-----------TVIKQLM--RKEF----TLEFSRDRKSMSVYCTptrpHPTGQgSKMFVKGAPESVIERC 525
Cdd:cd02073 415 EAAlveAARDlgfvflsrtpdTVTINALgeEEEYeilhILEFNSDRKRMSVIVR----DPDGR-ILLYCKGADSVIFERL 489
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 526 SSvrvgsRTAPLtptsREQILAKIRDWGSgsDTLRCLALATRDAPP-------------------RKEdmELDDCSKFVq 586
Cdd:cd02073 490 SP-----SSLEL----VEKTQEHLEDFAS--EGLRTLCLAYREISEeeyeewnekydeastalqnREE--LLDEVAEEI- 555
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 587 yETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAIC------------RRLGIFGDTEDVAGKAYT 654
Cdd:cd02073 556 -EKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGyscrllsedmenLALVIDGKTLTYALDPEL 634
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 655 GREFDDLSpeqqrQACRTARCfARVEPAHKSRIVENLQSF-NEITAMTGDGVNDAPALKKAEIGI----------AMGSG 723
Cdd:cd02073 635 ERLFLELA-----LKCKAVIC-CRVSPLQKALVVKLVKKSkKAVTLAIGDGANDVSMIQEAHVGVgisgqegmqaARASD 708

                ....*
gi 28373113 724 TAVAK 728
Cdd:cd02073 709 YAIAQ 713
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
92-807 4.63e-25

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 112.01  E-value: 4.63e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   92 LVIMLILVANAIVGvWQERNAESAIEALKEYEPEMGKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIeikST 171
Cdd:PRK11033 211 MVLLLFLIGERLEG-YAASRARRGVSALMALVPETATRLRDGER--EEVAIADLRPGDVIEVAAGGRLPADGKLL---SP 284
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  172 TLRVDQSILTGESVSVTKHT-EAIPdPRAVNQDKKNMLfsgtNITSGKAvgvavatglHTELGKIRSQMAAVEPERTPLQ 250
Cdd:PRK11033 285 FASFDESALTGESIPVERATgEKVP-AGATSVDRLVTL----EVLSEPG---------ASAIDRILHLIEEAEERRAPIE 350
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  251 RKLDEFGRQLSHAISVICVAVWVINIGHFADPahggsWLrGAVYyfkiavalavaaipEGL---------------PAVI 315
Cdd:PRK11033 351 RFIDRFSRIYTPAIMLVALLVILVPPLLFAAP-----WQ-EWIY--------------RGLtllligcpcalvistPAAI 410
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  316 TTCLALGTRRmarkNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEadagscllheftisgttytpegev 395
Cdd:PRK11033 411 TSGLAAAARR----GALIKGGAALEQLGRVTTVAFDKTGTLTEGKPQVTDIHPATG------------------------ 462
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  396 rqgdqpvrcgqfdglvelaticalcndsaldyneakgvyekVGEATETALTCLVEkmnVFDTDLQALSRVERAGAcntvi 475
Cdd:PRK11033 463 -----------------------------------------ISESELLALAAAVE---QGSTHPLAQAIVREAQV----- 493
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  476 kqlmrKEFTLEFSRDRKSMSvyctptrphptGQGSKMFVKGapeSVIERCSSvrvgSRTAPLTPtsreQILAKIRDWGSG 555
Cdd:PRK11033 494 -----RGLAIPEAESQRALA-----------GSGIEGQVNG---ERVLICAP----GKLPPLAD----AFAGQINELESA 546
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  556 SDTLrclALATRDApprkedmelddcskfvqyetdlTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI 635
Cdd:PRK11033 547 GKTV---VLVLRND----------------------DVLGLIALQDTLRADARQAISELKALGIKGVMLTGDNPRAAAAI 601
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  636 CRRLGIfgdtedvagkaytgrEFDdlspeqqrqacrtarcfARVEPAHKSRIVENLQSfNEITAMTGDGVNDAPALKKAE 715
Cdd:PRK11033 602 AGELGI---------------DFR-----------------AGLLPEDKVKAVTELNQ-HAPLAMVGDGINDAPAMKAAS 648
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  716 IGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNmkqfIRYLISSNVGeVVCIFL-TAILGLPEalipvqlLW 794
Cdd:PRK11033 649 IGIAMGSGTDVALETADAALTHNRLRGLAQMIELSRATHAN----IRQNITIALG-LKAIFLvTTLLGITG-------LW 716
                        730
                 ....*....|...
gi 28373113  795 VNLVTDGlPATAL 807
Cdd:PRK11033 717 LAVLADS-GATAL 728
copA PRK10671
copper-exporting P-type ATPase CopA;
601-759 7.29e-22

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 102.13  E-value: 7.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  601 DPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdTEDVAGkaytgrefddlspeqqrqacrtarcfarVE 680
Cdd:PRK10671 649 DPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGI---DEVIAG----------------------------VL 697
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28373113  681 PAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:PRK10671 698 PDGKAEAIKRLQSQGRQVAMVGDGINDAPALAQADVGIAMGGGSDVAIETAAITLMRHSLMGVADALAISRATLRNMKQ 776
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
117-753 1.56e-21

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 100.41  E-value: 1.56e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 117 EALKEYEPE-MGKVIRSDRKgVQRIRARDIVPGDIVEVAVGDKVPADLRLIE-IKSttlrVDQSILTGESVSVTKhtEAI 194
Cdd:cd02078  86 DSLRKTKTEtQAKRLRNDGK-IEKVPATDLKKGDIVLVEAGDIIPADGEVIEgVAS----VDESAITGESAPVIR--ESG 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 195 PDPRAVNqdkknmlfSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVI 274
Cdd:cd02078 159 GDRSSVT--------GGTKVLSDRIKVRITANPGETFLDRMIALVEGASRQKTPNEIALTILLVGLTLIFLIVVATLPPF 230
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 275 nighfadpahggswlrgAVYYfkiavalavaaipeGLPAVITTCLAL-------------------GTRRMARKNAIVRS 335
Cdd:cd02078 231 -----------------AEYS--------------GAPVSVTVLVALlvclipttiggllsaigiaGMDRLLRFNVIAKS 279
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 336 LPSVETLGCTSVICSDKTGTLTT-NQMSvcrmfvvaeadagscllheftisgTTYTPEGEVRqgdqpvrcgqfdgLVELA 414
Cdd:cd02078 280 GRAVEAAGDVDTLLLDKTGTITLgNRQA------------------------TEFIPVGGVD-------------EKELA 322
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 415 TICALCndSALDYN-EAKGVYEkvgeatetaltcLVEKMNVFDTDLQalsrveRAGAcntvikqlmrkEFtLEFSRDRKs 493
Cdd:cd02078 323 DAAQLA--SLADETpEGRSIVI------------LAKQLGGTERDLD------LSGA-----------EF-IPFSAETR- 369
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 494 MSVYCTPtrphptgqGSKMFVKGAPESVIERCSSvRVGSrtaplTPTSREQILAKIRDWGSGSdtlrcLALATRDapprk 573
Cdd:cd02078 370 MSGVDLP--------DGTEIRKGAVDAIRKYVRS-LGGS-----IPEELEAIVEEISKQGGTP-----LVVAEDD----- 425
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 574 edmelddcskfvqyetdlTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdtedvagkay 653
Cdd:cd02078 426 ------------------RVLGVIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV------------ 475
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 654 tgrefDDLspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEM 733
Cdd:cd02078 476 -----DDF--------------LAEAKPEDKLELIRKEQAKGKLVAMTGDGTNDAPALAQADVGVAMNSGTQAAKEAGNM 536
                       650       660
                ....*....|....*....|
gi 28373113 734 VLSDDNFASIVAAVEEGRAI 753
Cdd:cd02078 537 VDLDSDPTKLIEVVEIGKQL 556
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
110-794 1.57e-20

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 97.01  E-value: 1.57e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 110 RNAESAIEALKEYEPEMGKVIRSDrkGVQRIRARDIVPGDIVEVAVGDKVPADLRLIeikSTTLRVDQSILTGESVSVTK 189
Cdd:cd07544  95 RRASRELTALLDRAPRIAHRLVGG--QLEEVPVEEVTVGDRLLVRPGEVVPVDGEVV---SGTATLDESSLTGESKPVSK 169
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 190 HteaipdpravnqdkknmlfSGTNITSGKAVG------VAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHA 263
Cdd:cd07544 170 R-------------------PGDRVMSGAVNGdsaltmVATKLAADSQYAGIVRLVKEAQANPAPFVRLADRYAVPFTLL 230
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 264 ISVICVAVWVINighfADPAHGGSWLRGAvyyfkiavalavaaIPegLPAVITTCLAL--GTRRMARKNAIVRSLPSVET 341
Cdd:cd07544 231 ALAIAGVAWAVS----GDPVRFAAVLVVA--------------TP--CPLILAAPVAIvsGMSRSSRRGILVKDGGVLEK 290
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 342 LGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAgscllheftisgttytpegevrqgdqpvrcgqfDGLVELAticalcn 421
Cdd:cd07544 291 LARAKTVAFDKTGTLTYGQPKVVDVVPAPGVDA---------------------------------DEVLRLA------- 330
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 422 dSALDYNEAKGVYEKVGEATETALTclvekmnvfdtDLQALSRVERagacntvikqlmrkeftlefsrdrksmsvyctpt 501
Cdd:cd07544 331 -ASVEQYSSHVLARAIVAAAREREL-----------QLSAVTELTE---------------------------------- 364
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 502 rphPTGQGSKMFVKGApesviercsSVRVGSRTapltptsreqiLAKIRDWGSgsdtlrclalatrdapPRKEDMELDDC 581
Cdd:cd07544 365 ---VPGAGVTGTVDGH---------EVKVGKLK-----------FVLARGAWA----------------PDIRNRPLGGT 405
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 582 SKFVQyeTDLTFVGCVGMLDPPRPEVAACITRCYQAGI-RVVMITGDNKGTAVAICRRLGIfgdtEDVAGkaytgrefdD 660
Cdd:cd07544 406 AVYVS--VDGKYAGAITLRDEVRPEAKETLAHLRKAGVeRLVMLTGDRRSVAEYIASEVGI----DEVRA---------E 470
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 661 LSPEQqrqacrtarcfarvepahKSRIVENLQSfNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKS-AAEMVLSDDN 739
Cdd:cd07544 471 LLPED------------------KLAAVKEAPK-AGPTIMVGDGVNDAPALAAADVGIAMGARGSTAASeAADVVILVDD 531
                       650       660       670       680       690       700
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28373113 740 FASIVAAVeegrAIYSNMKQFIryLISSNVGEVVCI---------FLTAILG--LPEALIPVQLLW 794
Cdd:cd07544 532 LDRVVDAV----AIARRTRRIA--LQSVLIGMALSIigmliaafgLIPPVAGalLQEVIDVVSILN 591
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
4-71 2.83e-19

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 82.61  E-value: 2.83e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28373113     4 AHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALV 71
Cdd:pfam00690   1 WHALSVEEVLKKLGTDLEKGLTEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
97-751 1.91e-18

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 90.71  E-value: 1.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    97 ILVANAIVGVWQERNAESAiEALKEYEPE-MGKVIRSDRKgVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTtlrV 175
Cdd:TIGR01497  77 VLFANFAEAVAEGRGKAQA-DSLKGTKKTtFAKLLRDDGA-IDKVPADQLKKGDIVLVEAGDVIPCDGEVIEGVAS---V 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   176 DQSILTGESVSVTKhtEAIPDPRAVNqdkknmlfSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDE 255
Cdd:TIGR01497 152 DESAITGESAPVIK--ESGGDFASVT--------GGTRILSDWLVVECTANPGETFLDRMIALVEGAQRRKTPNEIALTI 221
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   256 FGRQLSHAISVICVAVWVinighFAdpAHGGSWLRGAVyyfkiAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRS 335
Cdd:TIGR01497 222 LLIALTLVFLLVTATLWP-----FA--AYGGNAISVTV-----LVALLVCLIPTTIGGLLSAIGIAGMDRVLGFNVIATS 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   336 LPSVETLGCTSVICSDKTGTLTTnqmsvcrmfvvaeadaGSCLLHEFTisgttytpegevrqgdqPVRCGQFDGLVELAT 415
Cdd:TIGR01497 290 GRAVEACGDVDTLLLDKTGTITL----------------GNRLASEFI-----------------PAQGVDEKTLADAAQ 336
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   416 ICALCNDSAldynEAKGVYEkvgeatetaltcLVEKMNVFDTDLQALSrveragacntvikqlmrKEFtLEFSRDRKsMS 495
Cdd:TIGR01497 337 LASLADDTP----EGKSIVI------------LAKQLGIREDDVQSLH-----------------ATF-VEFTAQTR-MS 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   496 VYCTPtrphptgqGSKMFVKGAPESvIERcssvRVGSRTAPLtPTSREQILAKIRDWGsGSDTLRCLalatrdapprked 575
Cdd:TIGR01497 382 GINLD--------NGRMIRKGAVDA-IKR----HVEANGGHI-PTDLDQAVDQVARQG-GTPLVVCE------------- 433
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   576 melddcskfvqyetDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdtedvagkaytg 655
Cdd:TIGR01497 434 --------------DNRIYGVIYLKDIVKGGIKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGV-------------- 485
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   656 refDDLspeqqrqacrtarcFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVL 735
Cdd:TIGR01497 486 ---DDF--------------IAEATPEDKIALIRQEQAEGKLVAMTGDGTNDAPALAQADVGVAMNSGTQAAKEAANMVD 548
                         650
                  ....*....|....*.
gi 28373113   736 SDDNFASIVAAVEEGR 751
Cdd:TIGR01497 549 LDSDPTKLIEVVHIGK 564
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
110-759 5.56e-18

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 88.95  E-value: 5.56e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 110 RNAESAIEALKEYEPEMGKVIRSDrkGVQR-IRARDIVPGDIVEVAVGDKVPADLRLIeikSTTLRVDQSILTGESVSVT 188
Cdd:cd02092 111 GRARSAAEELAALEARGAQRLQAD--GSREyVPVAEIRPGDRVLVAAGERIPVDGTVV---SGTSELDRSLLTGESAPVT 185
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 189 KHTEAipdpravnqdkknMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLS---HAIS 265
Cdd:cd02092 186 VAPGD-------------LVQAGAMNLSGPLRLRATAAGDDTLLAEIARLMEAAEQGRSRYVRLADRAARLYApvvHLLA 252
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 266 VICVAVWVInighfadpaHGGSWlRGAVyyfkiavalavaaipegLPAV---ITTC-LALG----------TRRMARKNA 331
Cdd:cd02092 253 LLTFVGWVA---------AGGDW-RHAL-----------------LIAVavlIITCpCALGlavpavqvvaSGRLFRRGV 305
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 332 IVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscllheftISGTTYTPEgevrqgdqpvrcgqfdglv 411
Cdd:cd02092 306 LVKDGTALERLAEVDTVVFDKTGTLTLGSPRL--------------------VGAHAISAD------------------- 346
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 412 ELATICALCNDSAldyneakgvyekvgeatetaltclvekmnvfdtdlQALSR--VERAGACNTVIKQLmrKEftlefsr 489
Cdd:cd02092 347 LLALAAALAQASR-----------------------------------HPLSRalAAAAGARPVELDDA--RE------- 382
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 490 drksmsvycTPtrphptGQGSKMFVKGAPesviercssVRVGSR----TAPLTPTSREqilakirdwgsgsdtlrcLALA 565
Cdd:cd02092 383 ---------VP------GRGVEGRIDGAR---------VRLGRPawlgASAGVSTASE------------------LALS 420
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 566 TRDAPPrkedmelddcskfvqyetdltfvGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIfgdt 645
Cdd:cd02092 421 KGGEEA-----------------------ARFPFEDRPRPDAREAISALRALGLSVEILSGDREPAVRALARALGI---- 473
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 646 edvagkaytgrefDDLSpeqqrqacrtarcfARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTA 725
Cdd:cd02092 474 -------------EDWR--------------AGLTPAEKVARIEELKAQGRRVLMVGDGLNDAPALAAAHVSMAPASAVD 526
                       650       660       670
                ....*....|....*....|....*....|....
gi 28373113 726 VAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQ 759
Cdd:cd02092 527 ASRSAADIVFLGDSLAPVPEAIEIARRARRLIRQ 560
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
67-743 1.75e-17

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 87.18  E-value: 1.75e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  67 LAALVSFVLAWFEEGEETTTAFVEPL--VIMLILVANAIVGVWQERNAEsaiEALKEYEPEMGKVIRSDRKGVQRIRARD 144
Cdd:cd07553  69 LGIVIGFVVSWYGLIKGDGLVYFDSLsvLVFLMLVGRWLQVVTQERNRN---RLADSRLEAPITEIETGSGSRIKTRADQ 145
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 145 IVPGDIVEVAVGDKVPADLRLIeikSTTLRVDQSILTGESVSVTKHteaipdpravnqdKKNMLFSGTNITSGKAVGVAV 224
Cdd:cd07553 146 IKSGDVYLVASGQRVPVDGKLL---SEQASIDMSWLTGESLPRIVE-------------RGDKVPAGTSLENQAFEIRVE 209
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 225 ATGLHTELGKIRSQMAAVEPERTPLqrklDEFGRQLSHAISVICVAVWVinighfadpAHGGSWLR-GAVYYFKIAVALA 303
Cdd:cd07553 210 HSLAESWSGSILQKVEAQEARKTPR----DLLADKIIHYFTVIALLIAV---------AGFGVWLAiDLSIALKVFTSVL 276
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 304 VAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVcrmfvvaeadagscllheft 383
Cdd:cd07553 277 IVACPCALALATPFTDEIALARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRGKSSF-------------------- 336
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 384 isgTTYTPEGEVRQgdqpvrcgqfdGLVELATICALCNdsaldyneakgvyekvgeatetaltclvekmnvfdtdlQALS 463
Cdd:cd07553 337 ---VMVNPEGIDRL-----------ALRAISAIEAHSR--------------------------------------HPIS 364
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 464 RveragacnTVIKQLMRKEFTLEFSRDRKSMsvyctptrphpTGQGSKMFVKGapesviercSSVRVGSrtapltptsre 543
Cdd:cd07553 365 R--------AIREHLMAKGLIKAGASELVEI-----------VGKGVSGNSSG---------SLWKLGS----------- 405
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 544 qilakirdwgsgsdtlrclalatrdapprkedmELDDC---SKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIR 620
Cdd:cd07553 406 ---------------------------------APDACgiqESGVVIARDGRQLLDLSFNDLLRPDSNREIEELKKGGLS 452
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 621 VVMITGDNKGTAVAICRRLGIfGDTEDVAGkaytgrefddLSPEQqrqacrtarcfarvepahKSRIVENLQSFNeiTAM 700
Cdd:cd07553 453 IAILSGDNEEKVRLVGDSLGL-DPRQLFGN----------LSPEE------------------KLAWIESHSPEN--TLM 501
                       650       660       670       680
                ....*....|....*....|....*....|....*....|...
gi 28373113 701 TGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASI 743
Cdd:cd07553 502 VGDGANDALALASAFVGIAVAGEVGVSLEAADIYYAGNGIGGI 544
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
5-75 3.27e-17

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 76.85  E-value: 3.27e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28373113      5 HLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVL 75
Cdd:smart00831   5 HALSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
92-776 6.73e-17

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 85.52  E-value: 6.73e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   92 LVIMLILVANAIVGVWQERNAESAIEALKEYEPEM-GKVIRSDrKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKS 170
Cdd:PRK14010  70 IILLLTLVFANFSEALAEGRGKAQANALRQTQTEMkARRIKQD-GSYEMIDASDLKKGHIVRVATGEQIPNDGKVIKGLA 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  171 TtlrVDQSILTGESVSVTKHTEAipdpravnqdKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQ 250
Cdd:PRK14010 149 T---VDESAITGESAPVIKESGG----------DFDNVIGGTSVASDWLEVEITSEPGHSFLDKMIGLVEGATRKKTPNE 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  251 RKLdeFGRQLSHAISVICVAVWVINIGHFadpahggswlrgavYYFKIAVALAVAAIPEGLPAVITTCLAL----GTRRM 326
Cdd:PRK14010 216 IAL--FTLLMTLTIIFLVVILTMYPLAKF--------------LNFNLSIAMLIALAVCLIPTTIGGLLSAigiaGMDRV 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  327 ARKNAIVRSLPSVETLGCTSVICSDKTGTLTTnqmsvcrmfvvaeadaGSCLLHEFTisgttytpegevrqgdqPVRCGQ 406
Cdd:PRK14010 280 TQFNILAKSGRSVETCGDVNVLILDKTGTITY----------------GNRMADAFI-----------------PVKSSS 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  407 FDGLVELATICALCNDSALdyneakgvyekvgeatetaltclvekmnvfdtdlqalsrveragacNTVIKQLMRKEFtLE 486
Cdd:PRK14010 327 FERLVKAAYESSIADDTPE----------------------------------------------GRSIVKLAYKQH-ID 359
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  487 FSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERcssvrvgsrtapltptsreqilakIRDWGSGSdtlrclalat 566
Cdd:PRK14010 360 LPQEVGEYIPFTAETRMSGVKFTTREVYKGAPNSMVKR------------------------VKEAGGHI---------- 405
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  567 rdapPRKEDMELDDCSK-----FVQYETDLtFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGI 641
Cdd:PRK14010 406 ----PVDLDALVKGVSKkggtpLVVLEDNE-ILGVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGV 480
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  642 fgdtedvagkaytgrefddlspeqqrqacrtARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG 721
Cdd:PRK14010 481 -------------------------------DRFVAECKPEDKINVIREEQAKGHIVAMTGDGTNDAPALAEANVGLAMN 529
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 28373113  722 SGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIF 776
Cdd:PRK14010 530 SGTMSAKEAANLIDLDSNPTKLMEVVLIGKQLLMTRGSLTTFSIANDIAKYFAIL 584
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
590-751 2.43e-15

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 80.36  E-value: 2.43e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 590 DLTFVGCVGMLDPPRPEVAACITRCYQAGI-RVVMITGDNKGTAVAICRRLGIfgdtedvaGKAYTgrefdDLSPEQQRQ 668
Cdd:cd07548 417 DGKYVGYIVISDEIKEDAKEAIKGLKELGIkNLVMLTGDRKSVAEKVAKKLGI--------DEVYA-----ELLPEDKVE 483
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 669 AcrtarcFARVEPAHKSRIvenlqsfneitAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSAAEMVLSDDNFASIVAAV 747
Cdd:cd07548 484 K------VEELKAESKGKV-----------AFVGDGINDAPVLARADVGIAMGGlGSDAAIEAADVVLMNDEPSKVAEAI 546

                ....
gi 28373113 748 EEGR 751
Cdd:cd07548 547 KIAR 550
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
47-718 3.54e-14

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 77.42  E-value: 3.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113     47 KSLWElvleQFEDLLVRILLLAALVSFVLAWFEEGEETTTAfvePLVIMLILVAnaivgvwqernAESAIEALK------ 120
Cdd:TIGR01652   19 KNLFE----QFKRFANLYFLVVALLQQVPILSPTYRGTSIV---PLAFVLIVTA-----------IKEAIEDIRrrrrdk 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    121 EYEPEMGKVIRSDRKGVqRIRARDIVPGDIVEVAVGDKVPADLRL-----------IEIKS----TTLRVDQSI------ 179
Cdd:TIGR01652   81 EVNNRLTEVLEGHGQFV-EIPWKDLRVGDIVKVKKDERIPADLLLlsssepdgvcyVETANldgeTNLKLRQALeetqkm 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    180 --------LTGESVSVTKH--------TEAIPDPRAVNQDKKNMLFSGTNITSGK-AVGVAVATGLHTELGKIRSQmaav 242
Cdd:TIGR01652  160 ldeddiknFSGEIECEQPNaslysfqgNMTINGDRQYPLSPDNILLRGCTLRNTDwVIGVVVYTGHDTKLMRNATQ---- 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    243 eperTPLQRKLDEfgRQLSHAISVICVAVWVINI-----GHFADPAHGGSwlrgaVYYFKIAVALAVAAIPEGLPavITT 317
Cdd:TIGR01652  236 ----APSKRSRLE--KELNFLIIILFCLLFVLCLissvgAGIWNDAHGKD-----LWYIRLDVSERNAAANGFFS--FLT 302
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    318 CLAL-------------------------GTRRMARKN----AIVRSLPSVETLGCTSVICSDKTGTLTTNQMSvcrmFV 368
Cdd:TIGR01652  303 FLILfsslipislyvslelvksvqayfinSDLQMYHEKtdtpASVRTSNLNEELGQVEYIFSDKTGTLTQNIME----FK 378
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    369 VAeadagscllhefTISGTTYTpEGEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVY--EKVGEATETALT 446
Cdd:TIGR01652  379 KC------------SIAGVSYG-DGFTEIKDGIRERLGSYVENENSMLVESKGFTFVDPRLVDLLKtnKPNAKRINEFFL 445
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    447 CL---------VEKMNVFDTDLQALSRVERA-------------GACNTVIKQLMR-----KEF----TLEFSRDRKSMS 495
Cdd:TIGR01652  446 ALalchtvvpeFNDDGPEEITYQAASPDEAAlvkaardvgfvffERTPKSISLLIEmhgetKEYeilnVLEFNSDRKRMS 525
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    496 VYCTptrpHPTGQgSKMFVKGAPESVIERCSSVRVGSRTApltpTSREqiLAKIrdwgsGSDTLRCLALATRDAPP---- 571
Cdd:TIGR01652  526 VIVR----NPDGR-IKLLCKGADTVIFKRLSSGGNQVNEE----TKEH--LENY-----ASEGLRTLCIAYRELSEeeye 589
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    572 -------------RKEDMELDDCSKFVqyETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI--- 635
Cdd:TIGR01652  590 ewneeyneastalTDREEKLDVVAESI--EKDLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTGDKVETAINIgys 667
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113    636 CRRLGI-----------FGDTEDVA-----GKAYTGREFDD-------------------LSPEQQRQ------ACRTAR 674
Cdd:TIGR01652  668 CRLLSRnmeqivitsdsLDATRSVEaaikfGLEGTSEEFNNlgdsgnvalvidgkslgyaLDEELEKEflqlalKCKAVI 747
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*
gi 28373113    675 CfARVEPAHKSRIVENLQ-SFNEITAMTGDGVNDAPALKKAEIGI 718
Cdd:TIGR01652  748 C-CRVSPSQKADVVRLVKkSTGKTTLAIGDGANDVSMIQEADVGV 791
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
47-720 1.67e-11

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 68.40  E-value: 1.67e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113  47 KSLWElvleQFEDLLVRILLLAALVSFVLAWFEEGEETTTAfvePLVImlILVANAIVGVWQERNAESAIEALKEYEPem 126
Cdd:cd07536  17 GVLYE----QFKRFLNLYFLVIACLQFVPALKPGYLYTTWA---PLIF--ILAVTMTKEAIDDFRRFQRDKEVNKKQL-- 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 127 gKVIRSDRKgvQRIRARDIVPGDIVEVAVGDKVPADLRLIEI--KSTTLRVDQSILTGES-------VSVTKHTEAI--- 194
Cdd:cd07536  86 -YSKLTGRK--VQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTsePQGSCYVETAQLDGETdlklrvaVSCTQQLPALgdl 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 195 -----------PD-----------------PRAVNQDKKNMLFSGTNI-TSGKAVGVAVATGLHTELGKIRSQmaaVEPE 245
Cdd:cd07536 163 mkisayvecqkPQmdihsfegnftledsdpPIHESLSIENTLLRASTLrNTGWVIGVVVYTGKETKLVMNTSN---AKNK 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 246 RTPLQRKLDefgrQLSHAISVICVAVWVINI--GHFADPAHG-GSW----LRGAVYYFKIAVALAVAAIPEGLPAVITTC 318
Cdd:cd07536 240 VGLLDLELN----RLTKALFLALVVLSLVMVtlQGFWGPWYGeKNWyikkMDTTSDNFGRNLLRFLLLFSYIIPISLRVN 315
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 319 LAL--------------------GTRRMARKNAIVrslpsvETLGCTSVICSDKTGTLTTNQMSVCRMfvvaeadagscl 378
Cdd:cd07536 316 LDMvkavyawfimwdenmyyignDTGTVARTSTIP------EELGQVVYLLTDKTGTLTQNEMIFKRC------------ 377
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 379 lhefTISGTTYtpegevrqGDQPVRCGqfdglvelaticalcndsaldyneakgvyekvgeatetaltclvekmnvfdtd 458
Cdd:cd07536 378 ----HIGGVSY--------GGQVLSFC----------------------------------------------------- 392
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 459 lqalsrveragacntvIKQLmrkeftLEFSRDRKSMSVYctpTRPHPTGQgSKMFVKGAPESVIERcssVRVGSRTaplt 538
Cdd:cd07536 393 ----------------ILQL------LEFTSDRKRMSVI---VRDESTGE-ITLYMKGADVAISPI---VSKDSYM---- 439
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 539 ptsrEQILAKIRDWGSgsDTLRCLALATRDApprKEDMELDDCSKFVQ------------------YETDLTFVGCVGML 600
Cdd:cd07536 440 ----EQYNDWLEEECG--EGLRTLCVAKKAL---TENEYQEWESRYTEaslslhdrslrvaevvesLERELELLGLTAIE 510
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 601 DPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAI-------------------------------CRRLGI-FGDTEDV 648
Cdd:cd07536 511 DRLQAGVPETIETLRKAGIKIWMLTGDKQETAICIakschlvsrtqdihllrqdtsrgeraaitqhAHLELNaFRRKHDV 590
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 649 A----GKA------YTGREFDDLSPEqqrqaCRTARCfARVEPAHKSRIVENLQSFNE-ITAMTGDGVNDAPALKKAEIG 717
Cdd:cd07536 591 AlvidGDSlevalkYYRHEFVELACQ-----CPAVIC-CRVSPTQKARIVTLLKQHTGrRTLAIGDGGNDVSMIQAADCG 664

                ...
gi 28373113 718 IAM 720
Cdd:cd07536 665 VGI 667
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
601-714 4.26e-11

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 62.99  E-value: 4.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   601 DPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGrefddlspeqqrqacrtarcFARVE 680
Cdd:pfam00702  97 LKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDVG--------------------VGKPK 156
                          90       100       110
                  ....*....|....*....|....*....|....
gi 28373113   681 PAHKSRIVENLQSFNEITAMTGDGVNDAPALKKA 714
Cdd:pfam00702 157 PEIYLAALERLGVKPEEVLMVGDGVNDIPAAKAA 190
PLN03190 PLN03190
aminophospholipid translocase; Provisional
334-720 2.25e-08

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 58.37  E-value: 2.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   334 RSLPSVETLGCTSVICSDKTGTLTTNQMSvcrmFVVAeadagscllhefTISGTTYTPEGEVRQGDQPVRCGQFDGL--- 410
Cdd:PLN03190  442 RALNINEDLGQIKYVFSDKTGTLTENKME----FQCA------------SIWGVDYSDGRTPTQNDHAGYSVEVDGKilr 505
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   411 ----VELATICALCNDSALDYNEAKGVYE--KVGEATETALTCLVEK-----MNVFD-----TDLQALSR---------V 465
Cdd:PLN03190  506 pkmkVKVDPQLLELSKSGKDTEEAKHVHDffLALAACNTIVPIVVDDtsdptVKLMDyqgesPDEQALVYaaaaygfmlI 585
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   466 ERAGACNTVIKQLMRKEFTL----EFSRDRKSMSVY--CtptrPHPTgqgSKMFVKGAPES---VIERCSSVRV------ 530
Cdd:PLN03190  586 ERTSGHIVIDIHGERQRFNVlglhEFDSDRKRMSVIlgC----PDKT---VKVFVKGADTSmfsVIDRSLNMNViratea 658
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   531 --------GSRTapLTPTSREQILAKIRDWGSGSDTLRClALATRDAPPRKEDMELddcskfvqyETDLTFVGCVGMLDP 602
Cdd:PLN03190  659 hlhtysslGLRT--LVVGMRELNDSEFEQWHFSFEAAST-ALIGRAALLRKVASNV---------ENNLTILGASAIEDK 726
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   603 PRPEVAACITRCYQAGIRVVMITGDNKGTAVAI-----------------------CRR-----------LGIFGDTEDV 648
Cdd:PLN03190  727 LQQGVPEAIESLRTAGIKVWVLTGDKQETAISIgyssklltnkmtqiiinsnskesCRKsledalvmskkLTTVSGISQN 806
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   649 AGKAYTGRE---------------FDDLSPEQQRQ---ACRTARCfARVEPAHKSRIVENLQS-FNEITAMTGDGVNDAP 709
Cdd:PLN03190  807 TGGSSAAASdpvaliidgtslvyvLDSELEEQLFQlasKCSVVLC-CRVAPLQKAGIVALVKNrTSDMTLAIGDGANDVS 885
                         490
                  ....*....|.
gi 28373113   710 ALKKAEIGIAM 720
Cdd:PLN03190  886 MIQMADVGVGI 896
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
685-734 2.90e-05

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 46.88  E-value: 2.90e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28373113   685 SRIVENLQ-SFNEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMV 734
Cdd:TIGR00099 194 QSLAEALGiSLEDVIAF-GDGMNDIEMLEAAGYGVAMGNADEELKALADYV 243
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
589-749 9.05e-05

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 44.36  E-value: 9.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 589 TDL--TFVGCVGMLDPprpEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGD--------TEDVAGKAYTGRef 658
Cdd:COG0561   7 LDLdgTLLNDDGEISP---RTKEALRRLREKGIKVVIATGRPLRSALPLLEELGLDDPlitsngalIYDPDGEVLYER-- 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 659 dDLSPEQQRQACRTAR-------CFARVEP---------AHKSRIVENLQ-----SFNEITAMtGDGVNDAPALKKAEIG 717
Cdd:COG0561  82 -PLDPEDVREILELLRehglhlqVVVRSGPgfleilpkgVSKGSALKKLAerlgiPPEEVIAF-GDSGNDLEMLEAAGLG 159
                       170       180       190
                ....*....|....*....|....*....|..
gi 28373113 718 IAMGSGTAVAKSAAEMVLSDDNFASIVAAVEE 749
Cdd:COG0561 160 VAMGNAPPEVKAAADYVTGSNDEDGVAEALEK 191
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
685-743 1.62e-04

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 44.54  E-value: 1.62e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   685 SRIVENLQ-SFNEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASI 743
Cdd:pfam08282 193 KALAKHLNiSLEEVIAF-GDGENDIEMLEAAGLGVAMGNASPEVKAAADYVTDSNNEDGV 251
COG4087 COG4087
Soluble P-type ATPase [General function prediction only];
619-737 6.07e-04

Soluble P-type ATPase [General function prediction only];


Pssm-ID: 443263 [Multi-domain]  Cd Length: 156  Bit Score: 41.30  E-value: 6.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 619 IRVVMITGDNKGTAVAICRRLGIfgdtedvagkaytgrEFDDLSPEQQRQAcrtarcfarvepahKSRIVENLQSfnEIT 698
Cdd:COG4087  46 LEIHVLTADTFGTVAKELAGLPV---------------ELHILPSGDQAEE--------------KLEFVEKLGA--ETT 94
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 28373113 699 AMTGDGVNDAPALKKAEIGIA-MGS-GTAV-AKSAAEMVLSD 737
Cdd:COG4087  95 VAIGNGRNDVLMLKEAALGIAvIGPeGASVkALLAADIVVKS 136
HAD pfam12710
haloacid dehalogenase-like hydrolase;
604-712 6.72e-04

haloacid dehalogenase-like hydrolase;


Pssm-ID: 432733 [Multi-domain]  Cd Length: 188  Bit Score: 41.75  E-value: 6.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113   604 RPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLG---IFGDTEDVAGKAYTGREFDDLSPEQQRQACR--TARCFAR 678
Cdd:pfam12710  86 HPGALELLAAHRAAGDRVVVVTGGLRPLVEPVLAELGfdeVLATELEVDDGRFTGELRLIGPPCAGEGKVRrlRAWLAAR 165
                          90       100       110
                  ....*....|....*....|....*....|....
gi 28373113   679 VEPAHKSRIVenlqsfneitAMtGDGVNDAPALK 712
Cdd:pfam12710 166 GLGLDLADSV----------AY-GDSPSDLPMLR 188
SerB COG0560
Phosphoserine phosphatase [Amino acid transport and metabolism]; Phosphoserine phosphatase is ...
604-719 1.26e-03

Phosphoserine phosphatase [Amino acid transport and metabolism]; Phosphoserine phosphatase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 440326 [Multi-domain]  Cd Length: 221  Bit Score: 41.36  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373113 604 RPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGI---FGDTEDVAGKAYTGREFDDLspeqqrqacrtarcfarVE 680
Cdd:COG0560  90 YPGARELIAEHRAAGHKVAIVSGGFTFFVEPIAERLGIdhvIANELEVEDGRLTGEVVGPI-----------------VD 152
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 28373113 681 PAHKSRIVENL-----QSFNEITAMtGDGVNDAPALKKAEIGIA 719
Cdd:COG0560 153 GEGKAEALRELaaelgIDLEQSYAY-GDSANDLPMLEAAGLPVA 195
HAD_HPP cd07517
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate ...
702-760 2.27e-03

phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily; Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319819 [Multi-domain]  Cd Length: 213  Bit Score: 40.67  E-value: 2.27e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 28373113 702 GDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVlSDDNFasivaavEEGraIYSNMKQF 760
Cdd:cd07517 164 GDGLNDIEMLEAVGIGIAMGNAHEELKEIADYV-TKDVD-------EDG--ILKALKHF 212
HAD_Pase cd07516
phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the ...
695-749 6.63e-03

phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily; Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319818 [Multi-domain]  Cd Length: 253  Bit Score: 39.50  E-value: 6.63e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28373113 695 NEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEmVLSDDNFASIVA-AVEE 749
Cdd:cd07516 200 EEVIAF-GDNENDLSMLEYAGLGVAMGNAIDEVKEAAD-YVTLTNNEDGVAkAIEK 253
HAD_Pase cd07514
phosphatase, similar to Thermoplasma acidophilum TA0175 phosphoglycolate phosphatase (PCPase), ...
695-748 7.10e-03

phosphatase, similar to Thermoplasma acidophilum TA0175 phosphoglycolate phosphatase (PCPase), and Pyrococcus horikoshii PH1421, a magnesium-dependent phosphatase; belongs to the haloacid dehalogenase-like superfamily; Thermoplasma acidophilum TA0175 phosphoglycolate phosphatase (PGPase) catalyzes the magnesium-dependent dephosphorylation of phosphoglycolate. This family also includes Pyrococcus horikoshii OT3 PH1421, a magnesium-dependent phosphatase. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319816 [Multi-domain]  Cd Length: 139  Bit Score: 37.95  E-value: 7.10e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 28373113 695 NEITAMtGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVE 748
Cdd:cd07514  84 EEVLAI-GDSENDIEMFKVAGFKVAVANADEELKEAADYVTDASYGDGVLEAID 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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