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Conserved domains on  [gi|169808405|ref|NP_780372|]
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zinc finger protein 689 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
29-88 3.45e-25

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.05  E-value: 3.45e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405    29 LKFVDVAVYFSSEEWGCLQPAQRTLYRDVMRETYGLLGALGCAGPKPALISWLERNTDDW 88
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-466 2.48e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 2.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 171 QNLKKPYPCPDCGRRFSYPSLLVSHRRAHSGECPYVC--DQCGKRFSQRKNLSQHQVIHTGEKPY-HCPDCGRCFRRSRS 247
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 248 LANHRTTHT---GEKPHQCPSCGRRFaYPSLLAIHQRTHTGEKP-YTCLECSRRFRQRTALV------------------ 305
Cdd:COG5048  108 SSLSSSSSNsndNNLLSSHSLPPSSR-DPQLPDLLSISNLRNNPlPGNNSSSVNTPQSNSLHpplpanslskdpssnlsl 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 306 -IHQRIHTGEKPYPCPDCERRFSSSSRLVSHRRVHSGERPYACENCEARFSQRSTLLQHQLLHTGEKPYPCPDCGRAFRR 384
Cdd:COG5048  187 lISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 385 SGSLAIHRSTHTEE-------KLHACDDCGRRFAYPSLLASHRR--VHSGE--RPYACD--LCSKRFAQWSHLSQHQLLH 451
Cdd:COG5048  267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLH 346

                        330
                 ....*....|....*
gi 169808405 452 TGEKPFPCLECGRCF 466
Cdd:COG5048  347 TSISPAKEKLLNSSS 361
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
29-88 3.45e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.05  E-value: 3.45e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405    29 LKFVDVAVYFSSEEWGCLQPAQRTLYRDVMRETYGLLGALGCAGPKPALISWLERNTDDW 88
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 31-69 7.62e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 76.74  E-value: 7.62e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 169808405   31 FVDVAVYFSSEEWGCLQPAQRTLYRDVMRETYGLLGALG 69
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 29-68 1.73e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.27  E-value: 1.73e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 169808405  29 LKFVDVAVYFSSEEWGCLQPAQRTLYRDVMRETYGLLGAL 68
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-466 2.48e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 2.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 171 QNLKKPYPCPDCGRRFSYPSLLVSHRRAHSGECPYVC--DQCGKRFSQRKNLSQHQVIHTGEKPY-HCPDCGRCFRRSRS 247
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 248 LANHRTTHT---GEKPHQCPSCGRRFaYPSLLAIHQRTHTGEKP-YTCLECSRRFRQRTALV------------------ 305
Cdd:COG5048  108 SSLSSSSSNsndNNLLSSHSLPPSSR-DPQLPDLLSISNLRNNPlPGNNSSSVNTPQSNSLHpplpanslskdpssnlsl 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 306 -IHQRIHTGEKPYPCPDCERRFSSSSRLVSHRRVHSGERPYACENCEARFSQRSTLLQHQLLHTGEKPYPCPDCGRAFRR 384
Cdd:COG5048  187 lISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 385 SGSLAIHRSTHTEE-------KLHACDDCGRRFAYPSLLASHRR--VHSGE--RPYACD--LCSKRFAQWSHLSQHQLLH 451
Cdd:COG5048  267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLH 346

                        330
                 ....*....|....*
gi 169808405 452 TGEKPFPCLECGRCF 466
Cdd:COG5048  347 TSISPAKEKLLNSSS 361
zf-H2C2_2 pfam13465
Zinc-finger double domain;
219-244 4.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.50e-04
                          10        20
                  ....*....|....*....|....*.
gi 169808405  219 NLSQHQVIHTGEKPYHCPDCGRCFRR 244
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 204-251 7.29e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 7.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 169808405 204 PYVCDQCGKRFSQRKNLSQHqvIHTGEKPYHCPDCGRCFRRSRSLANH 251
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
29-88 3.45e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.05  E-value: 3.45e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405    29 LKFVDVAVYFSSEEWGCLQPAQRTLYRDVMRETYGLLGALGCAGPKPALISWLERNTDDW 88
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 31-69 7.62e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 76.74  E-value: 7.62e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 169808405   31 FVDVAVYFSSEEWGCLQPAQRTLYRDVMRETYGLLGALG 69
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 29-68 1.73e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 70.27  E-value: 1.73e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 169808405  29 LKFVDVAVYFSSEEWGCLQPAQRTLYRDVMRETYGLLGAL 68
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-466 2.48e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 2.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 171 QNLKKPYPCPDCGRRFSYPSLLVSHRRAHSGECPYVC--DQCGKRFSQRKNLSQHQVIHTGEKPY-HCPDCGRCFRRSRS 247
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 248 LANHRTTHT---GEKPHQCPSCGRRFaYPSLLAIHQRTHTGEKP-YTCLECSRRFRQRTALV------------------ 305
Cdd:COG5048  108 SSLSSSSSNsndNNLLSSHSLPPSSR-DPQLPDLLSISNLRNNPlPGNNSSSVNTPQSNSLHpplpanslskdpssnlsl 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 306 -IHQRIHTGEKPYPCPDCERRFSSSSRLVSHRRVHSGERPYACENCEARFSQRSTLLQHQLLHTGEKPYPCPDCGRAFRR 384
Cdd:COG5048  187 lISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 385 SGSLAIHRSTHTEE-------KLHACDDCGRRFAYPSLLASHRR--VHSGE--RPYACD--LCSKRFAQWSHLSQHQLLH 451
Cdd:COG5048  267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLH 346

                        330
                 ....*....|....*
gi 169808405 452 TGEKPFPCLECGRCF 466
Cdd:COG5048  347 TSISPAKEKLLNSSS 361
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
159-335 1.20e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 159 PDHLALESHKcaqNLKKPYPCPDCGRRFSYPSLLVSHRRA--HSGEC--PYVCD--QCGKRFSQRKNLSQHQVIHTGEKP 232
Cdd:COG5048  275 PNESDSSSEK---GFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESlkPFSCPysLCGKLFSRNDALKRHILLHTSISP 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 233 YHCPDCGRCF-------RRSRSLANHRTTHTGEKPHQC--PSCGRRFAYPSLLAIHQRTHTGEKP--YTCLECSRRFRQR 301
Cdd:COG5048  352 AKEKLLNSSSkfspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                        170       180       190
                 ....*....|....*....|....*....|....
gi 169808405 302 TALVIHQRIHTgEKPYPCPDCERRFSSSSRLVSH 335
Cdd:COG5048  432 YNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-408 3.59e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 3.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 176 PYPCPDCGRRFSYPSLLVSHRRAHSGEcPYVCDQCGKRFSQRKNLSQHQVIHTGEKPYHCPDCGRCFRRSRSLANHRTTH 255
Cdd:COG5048  199 SSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNE 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 256 TGE-------KPHQCPSCGRRFAYPSLLAIHQRT--HTGEKPYTCLE----CSRRFRQRTALVIHQRIHTGEKPYPCPDC 322
Cdd:COG5048  278 SDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEKLL 357

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 323 ERRFSSSSRL-------VSHRRVHSGERPYACE--NCEARFSQRSTLLQHQLLHTGEKPY--PCPDCGRAFRRSGSLAIH 391
Cdd:COG5048  358 NSSSKFSPLLnneppqsLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPH 437

                        250
                 ....*....|....*..
gi 169808405 392 RSTHTEEKLHACDDCGR 408
Cdd:COG5048  438 KKIHTNHAPLLCSILKS 454
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 313-396 1.04e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 313 GEKPYPCP--DCERRFSSSSRLVSHRRvHSGERPYACENCEArfsqrstlLQHQLLHTGEKPYPCPDCGRAFRRSGSLAI 390
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 169808405 391 HRsTHT 396
Cdd:COG5189  417 HR-KHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-469 1.10e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 259 KPHQCPSCGRRFAYPSLLAIHQRTHTGEKPYTCLECSRRFRQRT--ALVIHQRIHTGEKPYPCPDCERRFSSSSRLVSHR 336
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 337 RVHSGE-RPYACENCEARFSQRSTLLQHQLLHTGEKPYPCPDCGRAFR-RSGSLAIHRSTHTEEKLHacddcgrRFAYPS 414
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQSNSLHPPLPANSLSK-------DPSSNL 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 169808405 415 LLASHRRVHSGERPYACDLCSKRFAQWSHLSQHQLLHTGEKPFPCLECGRCFRQR 469
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS 239
zf-H2C2_2 pfam13465
Zinc-finger double domain;
219-244 4.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.50e-04
                          10        20
                  ....*....|....*....|....*.
gi 169808405  219 NLSQHQVIHTGEKPYHCPDCGRCFRR 244
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
303-328 5.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.16e-04
                          10        20
                  ....*....|....*....|....*.
gi 169808405  303 ALVIHQRIHTGEKPYPCPDCERRFSS 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
247-272 9.04e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.04e-04
                          10        20
                  ....*....|....*....|....*.
gi 169808405  247 SLANHRTTHTGEKPHQCPSCGRRFAY 272
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 369-447 9.57e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 9.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169808405 369 GEKPYPCP--DCGRAFRRSGSLAIHR-STHTEEKLHACDDcgrrfayPSllaSHRRVHSGERPYACDLCSKRFAQWSHLS 445
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMlHGHQNQKLHENPS-------PE---KMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ..
gi 169808405 446 QH 447
Cdd:COG5189  416 YH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
416-440 2.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.37e-03
                          10        20
                  ....*....|....*....|....*
gi 169808405  416 LASHRRVHSGERPYACDLCSKRFAQ 440
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
360-384 2.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.58e-03
                          10        20
                  ....*....|....*....|....*
gi 169808405  360 LLQHQLLHTGEKPYPCPDCGRAFRR 384
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
276-300 2.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.88e-03
                          10        20
                  ....*....|....*....|....*
gi 169808405  276 LAIHQRTHTGEKPYTCLECSRRFRQ 300
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
443-468 7.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 169808405  443 HLSQHQLLHTGEKPFPCLECGRCFRQ 468
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 204-251 7.29e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 7.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 169808405 204 PYVCDQCGKRFSQRKNLSQHqvIHTGEKPYHCPDCGRCFRRSRSLANH 251
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDH 118
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 233-255 8.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.95e-03
                          10        20
                  ....*....|....*....|...
gi 169808405  233 YHCPDCGRCFRRSRSLANHRTTH 255
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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