Failed axon connections homolog N-terminus; This family represents the N-terminal domain of the failed axon connections homolog (FAXC). This protein is localized to the cellular membranes, thus it is likely that this region anchors it to the plasma membrane. It is thought to play a role in axonal development, being involved in cell-cell interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167234386    1 MHWGVGFASSRPCVVDLSWNQSISFFgwWAGSEEPFSFYGDIIAFPLQDYGGIMAGLGSDPWWKKTLYLTGGALLAAAAY 80
Cdd:pfam19333   1 MYWRVGFASSRSCVVDLGRNQSLSFG--LCGSDEQCSFYGYIVAFPLQDYGGIMSALGSDSWWRKTLYLTGGALLAAAAY 78

                          90       100
                  ....*....|....*....|....*.
gi 167234386   81 LLHELLVIRKQQELDSKDAIILHQFA 106
Cdd:pfam19333  79 LLHELLAIRKEQELDSKDAIILHQFS 104

Glutathione S-transferase, C-terminal domain; This domain is closely related to PF00043.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 167234386  263 MEKDMRSLAGLLGDKKYIMGPKLSTLDATVFGHLAQAMWTLPGTRPERLIKGELINLAMYCERI 326
Cdd:pfam17171   1 AKKDLRALSERLGDKPFFFGDKPTSLDALVFGHLALILYTPLPSPALRIHLKEYPNLVAYCERI 64

Failed axon connections homolog N-terminus; This family represents the N-terminal domain of the failed axon connections homolog (FAXC). This protein is localized to the cellular membranes, thus it is likely that this region anchors it to the plasma membrane. It is thought to play a role in axonal development, being involved in cell-cell interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167234386    1 MHWGVGFASSRPCVVDLSWNQSISFFgwWAGSEEPFSFYGDIIAFPLQDYGGIMAGLGSDPWWKKTLYLTGGALLAAAAY 80
Cdd:pfam19333   1 MYWRVGFASSRSCVVDLGRNQSLSFG--LCGSDEQCSFYGYIVAFPLQDYGGIMSALGSDSWWRKTLYLTGGALLAAAAY 78

                          90       100
                  ....*....|....*....|....*.
gi 167234386   81 LLHELLVIRKQQELDSKDAIILHQFA 106
Cdd:pfam19333  79 LLHELLAIRKEQELDSKDAIILHQFS 104

GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. In humans, alterations in the metaxin gene may be associated with Gaucher disease. One characterized member of this subgroup is a novel GST from Rhodococcus with toluene o-monooxygenase and gamma-glutamylcysteine synthetase activities. Also members are the cadmium-inducible lysosomal protein CDR-1 and its homologs from C. elegans, and the failed axon connections (fax) protein from Drosophila. CDR-1 is an integral membrane protein that functions to protect against cadmium toxicity and may also have a role in osmoregulation to maintain salt balance in C. elegans. The fax gene of Drosophila was identified as a genetic modifier of Abelson (Abl) tyrosine kinase. The fax protein is localized in cellular membranes and is expressed in embryonic mesoderm and axons of the central nervous system.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 167234386  99 AIILHQFaRPNNGVPSLSPFCLKMETYLRMADLPYQNYFGG--KLSAQGKMPWIEYNNEKVSGTEFIIDFLEEKLG 172
Cdd:cd03080    1 MITLYQF-PRAFGVPSLSPFCLKVETFLRMAGIPYENKFGGlaKRSPKGKLPFIELNGEKIADSELIIDHLEEKYG 75

C-terminal, alpha helical domain of Metaxin and related proteins; Glutathione S-transferase (GST) C-terminal domain family, Metaxin subfamily; composed of metaxins and related proteins. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. In humans, alterations in the metaxin gene may be associated with Gaucher disease. Metaxin 2 binds to metaxin 1 and may also play a role in protein translocation into the mitochondria. Genome sequencing shows that a third metaxin gene also exists in zebrafish, Xenopus, chicken, and mammals. Sequence analysis suggests that all three metaxins share a common ancestry and that they possess similarity to GSTs. Also included in the subfamily are uncharacterized proteins with similarity to metaxins, including a novel GST from Rhodococcus with toluene o-monooxygenase and glutamylcysteine synthetase activities. Other members are the cadmium-inducible lysosomal protein CDR-1 and its homologs from C. elegans, and the failed axon connections (fax) protein from Drosophila. CDR-1 is an integral membrane protein that functions to protect against cadmium toxicity and may also have a role in osmoregulation to maintain salt balance in C. elegans. The fax gene of Drosophila was identified as a genetic modifier of Abelson (Abl) tyrosine kinase. The fax protein is localized in cellular membranes and is expressed in embryonic mesoderm and axons of the central nervous system.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167234386 187 SRAVTKMVEEHFYWTLAYcqwvdnlnetrkmlslsgggpfsnllrwvvchitkgivkremhghgigrfseeEIYMLMEKD 266
Cdd:cd03193    1 ARALSRMVETHLYWALRR-----------------------------------------------------EIYELALED 27

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 167234386 267 MRSLAGLLGDKKYIMGPKLSTLDATVFGHLAQAMWTLPGTRPERLIKGELINLAMYCERIR 327
Cdd:cd03193   28 LEALSTLLGDKKFLFGDKPTSVDATVFAHLASILYPPEDSPLLRVLVASSPNLVEYCERIR 88

Failed axon connections homolog N-terminus; This family represents the N-terminal domain of the failed axon connections homolog (FAXC). This protein is localized to the cellular membranes, thus it is likely that this region anchors it to the plasma membrane. It is thought to play a role in axonal development, being involved in cell-cell interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167234386    1 MHWGVGFASSRPCVVDLSWNQSISFFgwWAGSEEPFSFYGDIIAFPLQDYGGIMAGLGSDPWWKKTLYLTGGALLAAAAY 80
Cdd:pfam19333   1 MYWRVGFASSRSCVVDLGRNQSLSFG--LCGSDEQCSFYGYIVAFPLQDYGGIMSALGSDSWWRKTLYLTGGALLAAAAY 78

                          90       100
                  ....*....|....*....|....*.
gi 167234386   81 LLHELLVIRKQQELDSKDAIILHQFA 106
Cdd:pfam19333  79 LLHELLAIRKEQELDSKDAIILHQFS 104

GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. In humans, alterations in the metaxin gene may be associated with Gaucher disease. One characterized member of this subgroup is a novel GST from Rhodococcus with toluene o-monooxygenase and gamma-glutamylcysteine synthetase activities. Also members are the cadmium-inducible lysosomal protein CDR-1 and its homologs from C. elegans, and the failed axon connections (fax) protein from Drosophila. CDR-1 is an integral membrane protein that functions to protect against cadmium toxicity and may also have a role in osmoregulation to maintain salt balance in C. elegans. The fax gene of Drosophila was identified as a genetic modifier of Abelson (Abl) tyrosine kinase. The fax protein is localized in cellular membranes and is expressed in embryonic mesoderm and axons of the central nervous system.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 167234386  99 AIILHQFaRPNNGVPSLSPFCLKMETYLRMADLPYQNYFGG--KLSAQGKMPWIEYNNEKVSGTEFIIDFLEEKLG 172
Cdd:cd03080    1 MITLYQF-PRAFGVPSLSPFCLKVETFLRMAGIPYENKFGGlaKRSPKGKLPFIELNGEKIADSELIIDHLEEKYG 75

Glutathione S-transferase, C-terminal domain; This domain is closely related to PF00043.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 167234386  263 MEKDMRSLAGLLGDKKYIMGPKLSTLDATVFGHLAQAMWTLPGTRPERLIKGELINLAMYCERI 326
Cdd:pfam17171   1 AKKDLRALSERLGDKPFFFGDKPTSLDALVFGHLALILYTPLPSPALRIHLKEYPNLVAYCERI 64

Outer mitochondrial membrane transport complex protein; The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intra-membrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane. It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167234386  119 CLKMETYLRMADLPYQ-------NYFggkLSAQGKMPWIEYNN-EKVSGTEFIIDFLEEK-LGVNLNKSLGPHERAVSRA 189
Cdd:pfam10568   1 CLAAIAYLKLLALPAPfevvpsnNPD---LSPTGELPALIDGDgTWVSGFDSIVEYLRSKgGGYDLDADLSAKQKADSLA 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 167234386  190 VTKMVEEHFYWTLAYCQWVDNLNE---TRKMLS 219
Cdd:pfam10568  78 YISLLESKLYPLLLYSLWVDEENYeevTRPAYS 110

C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins; Glutathione S-transferase (GST) C-terminal domain family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins. Mammalian metaxin (or metaxin 1) is a component of the preprotein import complex of the mitochondrial outer membrane. Metaxin extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. Like the murine gene, the human metaxin gene is located downstream to the glucocerebrosidase (GBA) pseudogene and is convergently transcribed. Inherited deficiency of GBA results in Gaucher disease, which presents many diverse clinical phenotypes. Alterations in the metaxin gene, in addition to GBA mutations, may be associated with Gaucher disease. Genome sequencing shows that a third metaxin gene also exists in zebrafish, Xenopus, chicken, and mammals.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167234386 207 WVD--NLNE-TRKMLSLSGGGPFSnllRWVVCHITKGIVKREMHGHGIGRF-SEEEIYMLMEKDMRS----LAGLLGDKK 278
Cdd:cd03212    8 WVDekNYVEvTRPWYAKALPFPLN---FYYPGRYQRRAKDRLQLLRGLSELdSEEEVEKELYKDAKEclnlLSERLGEKK 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 167234386 279 YIMGPKLSTLDATVFGHLAqAMW--TLPGTRPERLIKGeLINLAMYCERIRRKF 330
Cdd:cd03212   85 FFFGDRPTSLDALVFGYLA-PLLkaPLPNNKLQNHLKG-CPNLVQFVDRILQNY 136

GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins including Tom37 from fungi. Mammalian metaxin (or metaxin 1) and the fungal protein Tom37 are components of preprotein import complexes of the mitochondrial outer membrane. Metaxin extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. Like the murine gene, the human metaxin gene is located downstream to the glucocerebrosidase (GBA) pseudogene and is convergently transcribed. Inherited deficiency of GBA results in Gaucher disease, which presents many diverse clinical phenotypes. Alterations in the metaxin gene, in addition to GBA mutations, may be associated with Gaucher disease. Genome sequencing shows that a third metaxin gene also exists in zebrafish, Xenopus, chicken and mammals.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 167234386 102 LHQFaRPNNGVPSLSPFCLKMETYLRMADLPYQNYFGGK--LSAQGKMPWIEYNNEKVSGTEFIIDFLEEK 170
Cdd:cd03078    3 LHVW-GGDWGLPSVDPECLAVLAYLKFAGAPLKVVPSNNpwRSPTGKLPALLTSGTKISGPEKIIEYLRKQ 72

Glutathione S-transferase, N-terminal domain;

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 167234386  116 SPFCLKMETYLRMADLPYQ----NYFGG-----KLSAQGKMPWIEYNNEKVSGTEFIIDFLEEK 170
Cdd:pfam13417   7 SPYARRVRIALNEKGLPYEfvpiPPGDHppellAKNPLGKVPVLEDDGGILCESLAIIDYLEEL 70