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Conserved domains on  [gi|1631970684|ref|NP_780450|]
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protein SPO16 homolog isoform 2 [Mus musculus]

Protein Classification

DUF4580 domain-containing protein( domain architecture ID 10633517)

DUF4580 domain-containing protein similar to Homo sapiens protein C1orf146

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCRE pfam15162
Protein SPO16 homolog; This entry represents the Protein SPO16 homolog (SPO16, also known as ...
 10-171 4.49e-106

Protein SPO16 homolog; This entry represents the Protein SPO16 homolog (SPO16, also known as Synaptonemal complex reinforcing element SCRE), including the mammalian orthologue of budding yeast Spo16. It plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC), resulting in the SC stabilization which ensures the progression of meiotic prophase I in male and female germ cells. It promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1. It is also required for the localization of TEX11 and MSH4 to recombination intermediates.


:

Pssm-ID: 464538  Cd Length: 162  Bit Score: 300.47  E-value: 4.49e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631970684  10 VQWTTTIIISSSLKSYEIATALENRSHKVRYSDTLESGSIVFSLSGVAFLLMDAKECMTSAEEIFVTKIEKFINIHQNSF 89
Cdd:pfam15162   1 SKWTTTVIISSSLQSHEIATALQAQQHRVRYSDSVEEGSIIFSLSGVAFLLVDAQDLFKSAEEGFFERIEKFIQIHRNSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631970684  90 LVLFAPLHGPEEWSLMFRIHQRFLGSNLRILPVHNTVNALDLMCTIAKTTSKPHIDSICYRMITTKAYIIEQSPVWRTLQ 169
Cdd:pfam15162  81 LLLSAALHGPREWEVMFRIQQRFLGSNLRILPVHNTAEIVKLMLTIAKATSKPHVDSIRYRMALAKAQIIEQSPVWEMLQ 160


                  ..
gi 1631970684 170 KI 171
Cdd:pfam15162 161 KL 162
 
Name Accession Description Interval E-value
SCRE pfam15162
Protein SPO16 homolog; This entry represents the Protein SPO16 homolog (SPO16, also known as ...
 10-171 4.49e-106

Protein SPO16 homolog; This entry represents the Protein SPO16 homolog (SPO16, also known as Synaptonemal complex reinforcing element SCRE), including the mammalian orthologue of budding yeast Spo16. It plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC), resulting in the SC stabilization which ensures the progression of meiotic prophase I in male and female germ cells. It promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1. It is also required for the localization of TEX11 and MSH4 to recombination intermediates.


Pssm-ID: 464538  Cd Length: 162  Bit Score: 300.47  E-value: 4.49e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631970684  10 VQWTTTIIISSSLKSYEIATALENRSHKVRYSDTLESGSIVFSLSGVAFLLMDAKECMTSAEEIFVTKIEKFINIHQNSF 89
Cdd:pfam15162   1 SKWTTTVIISSSLQSHEIATALQAQQHRVRYSDSVEEGSIIFSLSGVAFLLVDAQDLFKSAEEGFFERIEKFIQIHRNSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631970684  90 LVLFAPLHGPEEWSLMFRIHQRFLGSNLRILPVHNTVNALDLMCTIAKTTSKPHIDSICYRMITTKAYIIEQSPVWRTLQ 169
Cdd:pfam15162  81 LLLSAALHGPREWEVMFRIQQRFLGSNLRILPVHNTAEIVKLMLTIAKATSKPHVDSIRYRMALAKAQIIEQSPVWEMLQ 160


                  ..
gi 1631970684 170 KI 171
Cdd:pfam15162 161 KL 162
 
Name Accession Description Interval E-value
SCRE pfam15162
Protein SPO16 homolog; This entry represents the Protein SPO16 homolog (SPO16, also known as ...
 10-171 4.49e-106

Protein SPO16 homolog; This entry represents the Protein SPO16 homolog (SPO16, also known as Synaptonemal complex reinforcing element SCRE), including the mammalian orthologue of budding yeast Spo16. It plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC), resulting in the SC stabilization which ensures the progression of meiotic prophase I in male and female germ cells. It promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1. It is also required for the localization of TEX11 and MSH4 to recombination intermediates.


Pssm-ID: 464538  Cd Length: 162  Bit Score: 300.47  E-value: 4.49e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631970684  10 VQWTTTIIISSSLKSYEIATALENRSHKVRYSDTLESGSIVFSLSGVAFLLMDAKECMTSAEEIFVTKIEKFINIHQNSF 89
Cdd:pfam15162   1 SKWTTTVIISSSLQSHEIATALQAQQHRVRYSDSVEEGSIIFSLSGVAFLLVDAQDLFKSAEEGFFERIEKFIQIHRNSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631970684  90 LVLFAPLHGPEEWSLMFRIHQRFLGSNLRILPVHNTVNALDLMCTIAKTTSKPHIDSICYRMITTKAYIIEQSPVWRTLQ 169
Cdd:pfam15162  81 LLLSAALHGPREWEVMFRIQQRFLGSNLRILPVHNTAEIVKLMLTIAKATSKPHVDSIRYRMALAKAQIIEQSPVWEMLQ 160


                  ..
gi 1631970684 170 KI 171
Cdd:pfam15162 161 KL 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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