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Conserved domains on  [gi|30425338|ref|NP_780761|]
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WD repeat-containing protein 3 isoform 1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455513)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 406-702 1.62e-70

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 235.69  E-value: 1.62e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 406 SRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMpCEYALCSF---FVPGDRQVVIGTKTGNLQLYD 481
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDgTIKVWDLETGELLRTL-KGHTGPVRdvaASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 482 LASGTLLETIAAHDGALWSMSLSPDQRGFVTGGADKAVKFWDFElvtdknstqkrlSVKQTRTLQL-DEDVLCVSYSPNQ 560
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE------------TGKCLTTLRGhTDWVNSVAFSPDG 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 561 KLLAVSLLDCTVKVFYVDTLKFFLSLYGHKLPVLCMDISHDGALIATGSADRNVKIWGLDFGDCHRSLFAHDDSVMYLRF 640
Cdd:cd00200 148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30425338 641 VPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSASHDKSLRLWE 702
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
49-620 2.61e-46

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.63  E-value: 2.61e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  49 IWDLRKGEKILILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFSLLSGEGNITFNGHKAAVTSLKYDQLGGRLASGSKD 128
Cdd:COG2319  62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 129 TDVIIWDVINESGLYRLKGHKDAVTQALFLRERNLLVTSGKDTMVKWWDLDNQHCFKTMVGHRTEVWGLVLVSEEKRLIT 208
Cdd:COG2319 142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 209 GAADSELRAWDIDylqeiddpeepepkkikecpgiqdtpesedstleaddeksedrilscskagsimregrdrvvnlavd 288
Cdd:COG2319 222 GSADGTVRLWDLA------------------------------------------------------------------- 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 289 kTGRILAchgtdsvlevfcilskaevqkkmdkklkkarkkarlnsaneeedpetsvsmtlqdeilrvakiktsakiksfd 368
Cdd:COG2319 235 -TGKLLR------------------------------------------------------------------------- 240

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 369 lihspqgelkavfllqnnlvelyslnaslpapqpvrtsriTIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWnrstlqc 447
Cdd:COG2319 241 ----------------------------------------TLTGHSGSVRSVAFSPDGRLLASGSADgTVRLW------- 273

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 448 irtmpceyalcsffvpgdrqvvigtktgnlqlyDLASGTLLETIAAHDGALWSMSLSPDQRGFVTGGADKAVKFWDFElv 527
Cdd:COG2319 274 ---------------------------------DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-- 318

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 528 tdknstqkrlSVKQTRTLQ-LDEDVLCVSYSPNQKLLAVSLLDCTVKVFYVDTLKFFLSLYGHKLPVLCMDISHDGALIA 606
Cdd:COG2319 319 ----------TGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                       570
                ....*....|....
gi 30425338 607 TGSADRNVKIWGLD 620
Cdd:COG2319 389 SGSADGTVRLWDLA 402
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 803-906 3.82e-18

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


:

Pssm-ID: 461125  Cd Length: 106  Bit Score: 80.67  E-value: 3.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338   803 PSAYVLET-FKGIRSSELEEALLVLPFSYVPDVLTLFNEFIQT-GLDVELLCRCLFFLLRIHFGQITSNQMLVPVIEKLK 880
Cdd:pfam04003   1 NDEYLLESvLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAErSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 30425338   881 ETTISKVRQVQDAIGFNMAGLDYLKR 906
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLLS 106
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 406-702 1.62e-70

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 235.69  E-value: 1.62e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 406 SRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMpCEYALCSF---FVPGDRQVVIGTKTGNLQLYD 481
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDgTIKVWDLETGELLRTL-KGHTGPVRdvaASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 482 LASGTLLETIAAHDGALWSMSLSPDQRGFVTGGADKAVKFWDFElvtdknstqkrlSVKQTRTLQL-DEDVLCVSYSPNQ 560
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE------------TGKCLTTLRGhTDWVNSVAFSPDG 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 561 KLLAVSLLDCTVKVFYVDTLKFFLSLYGHKLPVLCMDISHDGALIATGSADRNVKIWGLDFGDCHRSLFAHDDSVMYLRF 640
Cdd:cd00200 148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30425338 641 VPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSASHDKSLRLWE 702
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
369-709 2.11e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 225.56  E-value: 2.11e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 369 LIHSPQGELKAVFLLQNNLVELYSLNASLPAPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQC 447
Cdd:COG2319  33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADgTVRLWDLATGLL 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 448 IRTMPCE----YALCsfFVPGDRQVVIGTKTGNLQLYDLASGTLLETIAAHDGALWSMSLSPDQRGFVTGGADKAVKFWD 523
Cdd:COG2319 113 LRTLTGHtgavRSVA--FSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 524 FElvtdknstqkrlSVKQTRTLQLDED-VLCVSYSPNQKLLAVSLLDCTVKVFYVDTLKFFLSLYGHKLPVLCMDISHDG 602
Cdd:COG2319 191 LA------------TGKLLRTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG 258

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 603 ALIATGSADRNVKIWGLDFGDCHRSLFAHDDSVMYLRFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAV 682
Cdd:COG2319 259 RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                       330       340
                ....*....|....*....|....*..
gi 30425338 683 SPSGDYVVSASHDKSLRLWERTREPLI 709
Cdd:COG2319 339 SPDGKTLASGSDDGTVRLWDLATGELL 365
WD40 COG2319
WD40 repeat [General function prediction only];
49-620 2.61e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.63  E-value: 2.61e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  49 IWDLRKGEKILILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFSLLSGEGNITFNGHKAAVTSLKYDQLGGRLASGSKD 128
Cdd:COG2319  62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 129 TDVIIWDVINESGLYRLKGHKDAVTQALFLRERNLLVTSGKDTMVKWWDLDNQHCFKTMVGHRTEVWGLVLVSEEKRLIT 208
Cdd:COG2319 142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 209 GAADSELRAWDIDylqeiddpeepepkkikecpgiqdtpesedstleaddeksedrilscskagsimregrdrvvnlavd 288
Cdd:COG2319 222 GSADGTVRLWDLA------------------------------------------------------------------- 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 289 kTGRILAchgtdsvlevfcilskaevqkkmdkklkkarkkarlnsaneeedpetsvsmtlqdeilrvakiktsakiksfd 368
Cdd:COG2319 235 -TGKLLR------------------------------------------------------------------------- 240

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 369 lihspqgelkavfllqnnlvelyslnaslpapqpvrtsriTIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWnrstlqc 447
Cdd:COG2319 241 ----------------------------------------TLTGHSGSVRSVAFSPDGRLLASGSADgTVRLW------- 273

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 448 irtmpceyalcsffvpgdrqvvigtktgnlqlyDLASGTLLETIAAHDGALWSMSLSPDQRGFVTGGADKAVKFWDFElv 527
Cdd:COG2319 274 ---------------------------------DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-- 318

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 528 tdknstqkrlSVKQTRTLQ-LDEDVLCVSYSPNQKLLAVSLLDCTVKVFYVDTLKFFLSLYGHKLPVLCMDISHDGALIA 606
Cdd:COG2319 319 ----------TGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                       570
                ....*....|....
gi 30425338 607 TGSADRNVKIWGLD 620
Cdd:COG2319 389 SGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-523 1.07e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 145.94  E-value: 1.07e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 102 TFNGHKAAVTSLKYDQLGGRLASGSKDTDVIIWDVINESGLYRLKGHKDAVTQALFLRERNLLVTSGKDTMVKWWDLDNQ 181
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 182 HCFKTMVGHRTEVWGLVLVSEEKRLITGAADSELRAWDIdylqeiddpeePEPKKIKECPGIQDTpesedstleaddeks 261
Cdd:cd00200  84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-----------ETGKCLTTLRGHTDW--------------- 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 262 edrilscskagsimregrdrVVNLAVDKTGRILACHGTDSvlevfcilskaevqkkmdkklkkarkkarlnsaneeedpe 341
Cdd:cd00200 138 --------------------VNSVAFSPDGTFVASSSQDG---------------------------------------- 157

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 342 tsvsmtlqdeilrvakiktsaKIKSFDLihsPQGELKAVFLlqnnlvelyslnaslpapqpvrtsritigGHRSDVRTLS 421
Cdd:cd00200 158 ---------------------TIKLWDL---RTGKCVATLT-----------------------------GHTGEVNSVA 184

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 422 FSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMP-CEYALCSFFVPGDRQVVI-GTKTGNLQLYDLASGTLLETIAAHDGAL 498
Cdd:cd00200 185 FSPDGEKLLSSSSDgTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLAsGSEDGTIRVWDLRTGECVQTLSGHTNSV 264

                       410       420
                ....*....|....*....|....*
gi 30425338 499 WSMSLSPDQRGFVTGGADKAVKFWD 523
Cdd:cd00200 265 TSLAWSPDGKRLASGSADGTIRIWD 289
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 803-906 3.82e-18

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 80.67  E-value: 3.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338   803 PSAYVLET-FKGIRSSELEEALLVLPFSYVPDVLTLFNEFIQT-GLDVELLCRCLFFLLRIHFGQITSNQMLVPVIEKLK 880
Cdd:pfam04003   1 NDEYLLESvLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAErSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 30425338   881 ETTISKVRQVQDAIGFNMAGLDYLKR 906
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 663-702 1.55e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 1.55e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30425338    663 KFEHIQTLEGHHQEIWCLAVSPSGDYVVSASHDKSLRLWE 702
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
664-702 4.26e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 4.26e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30425338   664 FEHIQTLEGHHQEIWCLAVSPSGDYVVSASHDKSLRLWE 702
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 54-113 1.59e-07

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 49.97  E-value: 1.59e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30425338    54 KGEKI--LILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFSLLSGEGNITFNGHKAAVTSL 113
Cdd:pfam12894  25 NWQRVwtLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 47-215 9.02e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.78  E-value: 9.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338   47 VFIWDLRKGEKILILQGNKQEVTCL-CPSPDGLHLAVGYEDGAIRIFSLLSGEGNITFNGhKAAVTSLKYDQLGGR-LAS 124
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIdYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRsLAF 635

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  125 GSKDTDVIIWDVINES-GLYRLKGHKDAVTQALFLrERNLLVTSGKDTMVKWWDLD------NQHCFKTMVGHrTEVWGL 197
Cdd:PLN00181 636 GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGH-TNVKNF 713

                        170
                 ....*....|....*....
gi 30425338  198 VLVS-EEKRLITGAADSEL 215
Cdd:PLN00181 714 VGLSvSDGYIATGSETNEV 732
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-135 2.95e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.95e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 30425338    102 TFNGHKAAVTSLKYDQLGGRLASGSKDTDVIIWD 135
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 481-702 9.39e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 9.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  481 DLASGTLLETiaahDGALWSMSLSPDQRGFVTGGADKAVKFWDFELVTDKNSTQKRLSVKQTRTLQLDEdvLCV-SYSPN 559
Cdd:PLN00181 473 DLKQGDLLNS----SNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELASRSKLSG--ICWnSYIKS 546

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  560 QklLAVSLLDCTVKVFYVDTLKFFLSLYGHKLPVLCMDISH-DGALIATGSADRNVKIWGLDFGdCHRSLFAHDDSVMYL 638
Cdd:PLN00181 547 Q--VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQG-VSIGTIKTKANICCV 623

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30425338  639 RFVPKSHLFFTAGK-DHKIKQWDADKFE-HIQTLEGHHQEIWCLAVSPSGDyVVSASHDKSLRLWE 702
Cdd:PLN00181 624 QFPSESGRSLAFGSaDHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWD 688
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 406-702 1.62e-70

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 235.69  E-value: 1.62e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 406 SRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMpCEYALCSF---FVPGDRQVVIGTKTGNLQLYD 481
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDgTIKVWDLETGELLRTL-KGHTGPVRdvaASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 482 LASGTLLETIAAHDGALWSMSLSPDQRGFVTGGADKAVKFWDFElvtdknstqkrlSVKQTRTLQL-DEDVLCVSYSPNQ 560
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE------------TGKCLTTLRGhTDWVNSVAFSPDG 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 561 KLLAVSLLDCTVKVFYVDTLKFFLSLYGHKLPVLCMDISHDGALIATGSADRNVKIWGLDFGDCHRSLFAHDDSVMYLRF 640
Cdd:cd00200 148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30425338 641 VPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSASHDKSLRLWE 702
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
369-709 2.11e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 225.56  E-value: 2.11e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 369 LIHSPQGELKAVFLLQNNLVELYSLNASLPAPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQC 447
Cdd:COG2319  33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADgTVRLWDLATGLL 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 448 IRTMPCE----YALCsfFVPGDRQVVIGTKTGNLQLYDLASGTLLETIAAHDGALWSMSLSPDQRGFVTGGADKAVKFWD 523
Cdd:COG2319 113 LRTLTGHtgavRSVA--FSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 524 FElvtdknstqkrlSVKQTRTLQLDED-VLCVSYSPNQKLLAVSLLDCTVKVFYVDTLKFFLSLYGHKLPVLCMDISHDG 602
Cdd:COG2319 191 LA------------TGKLLRTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG 258

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 603 ALIATGSADRNVKIWGLDFGDCHRSLFAHDDSVMYLRFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAV 682
Cdd:COG2319 259 RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                       330       340
                ....*....|....*....|....*..
gi 30425338 683 SPSGDYVVSASHDKSLRLWERTREPLI 709
Cdd:COG2319 339 SPDGKTLASGSDDGTVRLWDLATGELL 365
WD40 COG2319
WD40 repeat [General function prediction only];
409-701 2.92e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 222.48  E-value: 2.92e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 409 TIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMPCE----YALCsfFVPGDRQVVIGTKTGNLQLYDLA 483
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADgTVRLWDLATGKLLRTLTGHsgavTSVA--FSPDGKLLASGSDDGTVRLWDLA 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 484 SGTLLETIAAHDGALWSMSLSPDQRGFVTGGADKAVKFWDFElvtdknstqkrlSVKQTRTLQLDED-VLCVSYSPNQKL 562
Cdd:COG2319 193 TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA------------TGKLLRTLTGHSGsVRSVAFSPDGRL 260

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 563 LAVSLLDCTVKVFYVDTLKFFLSLYGHKLPVLCMDISHDGALIATGSADRNVKIWGLDFGDCHRSLFAHDDSVMYLRFVP 642
Cdd:COG2319 261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 340

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 30425338 643 KSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSASHDKSLRLW 701
Cdd:COG2319 341 DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
428-708 1.37e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.18  E-value: 1.37e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 428 AVLSAAADSIKIWNRSTLQCIRTMPCEYALCSFFVPGDRQVVIGTKTGNLQLYDLASGTLLETIAAHDGALWSMSLSPDQ 507
Cdd:COG2319  11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 508 RGFVTGGADKAVKFWDFelvtdknSTQKRLSVKQTRTlqldEDVLCVSYSPNQKLLAVSLLDCTVKVFYVDTLKFFLSLY 587
Cdd:COG2319  91 RLLASASADGTVRLWDL-------ATGLLLRTLTGHT----GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 588 GHKLPVLCMDISHDGALIATGSADRNVKIWGLDFGDCHRSLFAHDDSVMYLRFVPKSHLFFTAGKDHKIKQWDADKFEHI 667
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 30425338 668 QTLEGHHQEIWCLAVSPSGDYVVSASHDKSLRLWE-RTREPL 708
Cdd:COG2319 240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlATGELL 281
WD40 COG2319
WD40 repeat [General function prediction only];
49-620 2.61e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.63  E-value: 2.61e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  49 IWDLRKGEKILILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFSLLSGEGNITFNGHKAAVTSLKYDQLGGRLASGSKD 128
Cdd:COG2319  62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 129 TDVIIWDVINESGLYRLKGHKDAVTQALFLRERNLLVTSGKDTMVKWWDLDNQHCFKTMVGHRTEVWGLVLVSEEKRLIT 208
Cdd:COG2319 142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 209 GAADSELRAWDIDylqeiddpeepepkkikecpgiqdtpesedstleaddeksedrilscskagsimregrdrvvnlavd 288
Cdd:COG2319 222 GSADGTVRLWDLA------------------------------------------------------------------- 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 289 kTGRILAchgtdsvlevfcilskaevqkkmdkklkkarkkarlnsaneeedpetsvsmtlqdeilrvakiktsakiksfd 368
Cdd:COG2319 235 -TGKLLR------------------------------------------------------------------------- 240

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 369 lihspqgelkavfllqnnlvelyslnaslpapqpvrtsriTIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWnrstlqc 447
Cdd:COG2319 241 ----------------------------------------TLTGHSGSVRSVAFSPDGRLLASGSADgTVRLW------- 273

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 448 irtmpceyalcsffvpgdrqvvigtktgnlqlyDLASGTLLETIAAHDGALWSMSLSPDQRGFVTGGADKAVKFWDFElv 527
Cdd:COG2319 274 ---------------------------------DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-- 318

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 528 tdknstqkrlSVKQTRTLQ-LDEDVLCVSYSPNQKLLAVSLLDCTVKVFYVDTLKFFLSLYGHKLPVLCMDISHDGALIA 606
Cdd:COG2319 319 ----------TGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                       570
                ....*....|....
gi 30425338 607 TGSADRNVKIWGLD 620
Cdd:COG2319 389 SGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-523 1.07e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 145.94  E-value: 1.07e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 102 TFNGHKAAVTSLKYDQLGGRLASGSKDTDVIIWDVINESGLYRLKGHKDAVTQALFLRERNLLVTSGKDTMVKWWDLDNQ 181
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 182 HCFKTMVGHRTEVWGLVLVSEEKRLITGAADSELRAWDIdylqeiddpeePEPKKIKECPGIQDTpesedstleaddeks 261
Cdd:cd00200  84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-----------ETGKCLTTLRGHTDW--------------- 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 262 edrilscskagsimregrdrVVNLAVDKTGRILACHGTDSvlevfcilskaevqkkmdkklkkarkkarlnsaneeedpe 341
Cdd:cd00200 138 --------------------VNSVAFSPDGTFVASSSQDG---------------------------------------- 157

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 342 tsvsmtlqdeilrvakiktsaKIKSFDLihsPQGELKAVFLlqnnlvelyslnaslpapqpvrtsritigGHRSDVRTLS 421
Cdd:cd00200 158 ---------------------TIKLWDL---RTGKCVATLT-----------------------------GHTGEVNSVA 184

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 422 FSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMP-CEYALCSFFVPGDRQVVI-GTKTGNLQLYDLASGTLLETIAAHDGAL 498
Cdd:cd00200 185 FSPDGEKLLSSSSDgTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDGYLLAsGSEDGTIRVWDLRTGECVQTLSGHTNSV 264

                       410       420
                ....*....|....*....|....*
gi 30425338 499 WSMSLSPDQRGFVTGGADKAVKFWD 523
Cdd:cd00200 265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
47-226 3.96e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 147.75  E-value: 3.96e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  47 VFIWDLRKGEKILILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFSLLSGEGNITFNGHKAAVTSLKYDQLGGRLASGS 126
Cdd:COG2319 186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 127 KDTDVIIWDVINESGLYRLKGHKDAVTQALFLRERNLLVTSGKDTMVKWWDLDNQHCFKTMVGHRTEVWGLVLVSEEKRL 206
Cdd:COG2319 266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL 345

                       170       180
                ....*....|....*....|
gi 30425338 207 ITGAADSELRAWDIDYLQEI 226
Cdd:COG2319 346 ASGSDDGTVRLWDLATGELL 365
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-306 9.33e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 9.33e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  47 VFIWDLRKGEKILILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFSLLSGEGNITFNGHKAAVTSLKYDQLGGRLASGS 126
Cdd:cd00200  33 IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 127 KDTDVIIWDVINESGLYRLKGHKDAVTQALFLRERNLLVTSGKDTMVKWWDLDNQHCFKTMVGHRTEVWGLVLVSEEKRL 206
Cdd:cd00200 113 RDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKL 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 207 ITGAADSELRAWDIDYLQEIDDPEEPEpkkiKECPGIQDTPE-------SEDSTLEADDEKSEDRILSCSkagsimrEGR 279
Cdd:cd00200 193 LSSSSDGTIKLWDLSTGKCLGTLRGHE----NGVNSVAFSPDgyllasgSEDGTIRVWDLRTGECVQTLS-------GHT 261

                       250       260
                ....*....|....*....|....*..
gi 30425338 280 DRVVNLAVDKTGRILACHGTDSVLEVF 306
Cdd:cd00200 262 NSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
36-221 1.58e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 1.58e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  36 GRYVAVPACEH-VFIWDLRKGEKILILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFSLLSGEGNITFNGHKAAVTSLK 114
Cdd:COG2319 132 GKTLASGSADGtVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 211

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 115 YDQLGGRLASGSKDTDVIIWDVINESGLYRLKGHKDAVTQALFLRERNLLVTSGKDTMVKWWDLDNQHCFKTMVGHRTEV 194
Cdd:COG2319 212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291

                       170       180
                ....*....|....*....|....*..
gi 30425338 195 WGLVLVSEEKRLITGAADSELRAWDID 221
Cdd:COG2319 292 NSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
36-221 3.10e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 3.10e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  36 GRYVAVPACEH-VFIWDLRKGEKILILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFSLLSGEGNITFNGHKAAVTSLK 114
Cdd:COG2319 216 GKLLASGSADGtVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA 295

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 115 YDQLGGRLASGSKDTDVIIWDVINESGLYRLKGHKDAVTQALFLRERNLLVTSGKDTMVKWWDLDNQHCFKTMVGHRTEV 194
Cdd:COG2319 296 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375

                       170       180
                ....*....|....*....|....*..
gi 30425338 195 WGLVLVSEEKRLITGAADSELRAWDID 221
Cdd:COG2319 376 TSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-219 3.03e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.84  E-value: 3.03e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  47 VFIWDLRKGEKILILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFSLLSGEGNITFNGHKAAVTSLKYDQLGGRLASGS 126
Cdd:cd00200 117 IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 127 KDTDVIIWDVINESGLYRLKGHKDAVTQALFLRERNLLVTSGKDTMVKWWDLDNQHCFKTMVGHRTEVWGLVLVSEEKRL 206
Cdd:cd00200 197 SDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL 276

                       170
                ....*....|...
gi 30425338 207 ITGAADSELRAWD 219
Cdd:cd00200 277 ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
502-709 6.66e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.32  E-value: 6.66e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 502 SLSPDQRGFVTGGADKAVKFWDfelvtdknstqKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKVFYVDTLK 581
Cdd:COG2319   1 ALSADGAALAAASADLALALLA-----------AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338 582 FFLSLYGHKLPVLCMDISHDGALIATGSADRNVKIWGLDFGDCHRSLFAHDDSVMYLRFVPKSHLFFTAGKDHKIKQWDA 661
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 30425338 662 DKFEHIQTLEGHHQEIWCLAVSPSGDYVVSASHDKSLRLWERTREPLI 709
Cdd:COG2319 150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 197
WD40 COG2319
WD40 repeat [General function prediction only];
36-180 9.30e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 9.30e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  36 GRYVAVpACEH--VFIWDLRKGEKILILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFSLLSGEGNITFNGHKAAVTSL 113
Cdd:COG2319 258 GRLLAS-GSADgtVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30425338 114 KYDQLGGRLASGSKDTDVIIWDVINESGLYRLKGHKDAVTQALFLRERNLLVTSGKDTMVKWWDLDN 180
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 803-906 3.82e-18

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 80.67  E-value: 3.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338   803 PSAYVLET-FKGIRSSELEEALLVLPFSYVPDVLTLFNEFIQT-GLDVELLCRCLFFLLRIHFGQITSNQMLVPVIEKLK 880
Cdd:pfam04003   1 NDEYLLESvLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAErSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 30425338   881 ETTISKVRQVQDAIGFNMAGLDYLKR 906
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-135 6.28e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 6.28e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  46 HVFIWDLRKGEKILILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFSLLSGEGNITFNGHKAAVTSLKYDQLGGRLASG 125
Cdd:cd00200 200 TIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279

                        90
                ....*....|
gi 30425338 126 SKDTDVIIWD 135
Cdd:cd00200 280 SADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 663-702 1.55e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 1.55e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30425338    663 KFEHIQTLEGHHQEIWCLAVSPSGDYVVSASHDKSLRLWE 702
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
664-702 4.26e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 4.26e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30425338   664 FEHIQTLEGHHQEIWCLAVSPSGDYVVSASHDKSLRLWE 702
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 579-617 1.09e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 1.09e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 30425338    579 TLKFFLSLYGHKLPVLCMDISHDGALIATGSADRNVKIW 617
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 54-113 1.59e-07

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 49.97  E-value: 1.59e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30425338    54 KGEKI--LILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFSLLSGEGNITFNGHKAAVTSL 113
Cdd:pfam12894  25 NWQRVwtLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
WD40 pfam00400
WD domain, G-beta repeat;
585-617 2.50e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 2.50e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 30425338   585 SLYGHKLPVLCMDISHDGALIATGSADRNVKIW 617
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 47-215 9.02e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.78  E-value: 9.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338   47 VFIWDLRKGEKILILQGNKQEVTCL-CPSPDGLHLAVGYEDGAIRIFSLLSGEGNITFNGhKAAVTSLKYDQLGGR-LAS 124
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIdYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRsLAF 635

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  125 GSKDTDVIIWDVINES-GLYRLKGHKDAVTQALFLrERNLLVTSGKDTMVKWWDLD------NQHCFKTMVGHrTEVWGL 197
Cdd:PLN00181 636 GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGH-TNVKNF 713

                        170
                 ....*....|....*....
gi 30425338  198 VLVS-EEKRLITGAADSEL 215
Cdd:PLN00181 714 VGLSvSDGYIATGSETNEV 732
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 484-523 2.92e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.92e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30425338    484 SGTLLETIAAHDGALWSMSLSPDQRGFVTGGADKAVKFWD 523
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-135 2.95e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.95e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 30425338    102 TFNGHKAAVTSLKYDQLGGRLASGSKDTDVIIWD 135
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
485-523 8.80e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 8.80e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30425338   485 GTLLETIAAHDGALWSMSLSPDQRGFVTGGADKAVKFWD 523
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 481-702 9.39e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 9.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  481 DLASGTLLETiaahDGALWSMSLSPDQRGFVTGGADKAVKFWDFELVTDKNSTQKRLSVKQTRTLQLDEdvLCV-SYSPN 559
Cdd:PLN00181 473 DLKQGDLLNS----SNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELASRSKLSG--ICWnSYIKS 546

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  560 QklLAVSLLDCTVKVFYVDTLKFFLSLYGHKLPVLCMDISH-DGALIATGSADRNVKIWGLDFGdCHRSLFAHDDSVMYL 638
Cdd:PLN00181 547 Q--VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQG-VSIGTIKTKANICCV 623

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30425338  639 RFVPKSHLFFTAGK-DHKIKQWDADKFE-HIQTLEGHHQEIWCLAVSPSGDyVVSASHDKSLRLWE 702
Cdd:PLN00181 624 QFPSESGRSLAFGSaDHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 622-660 1.07e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.07e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 30425338    622 GDCHRSLFAHDDSVMYLRFVPKSHLFFTAGKDHKIKQWD 660
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
102-135 1.37e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.37e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 30425338   102 TFNGHKAAVTSLKYDQLGGRLASGSKDTDVIIWD 135
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-93 1.43e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.43e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30425338     54 KGEKILILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFS 93
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
55-93 5.21e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 5.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30425338    55 GEKILILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFS 93
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 467-619 6.44e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 6.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  467 QVVIGTKTGNLQLYDLASGTLLETIAAHDGALWSMSL-SPDQRGFVTGGADKAVKFWdfelvtdknSTQKRLSVKqtrTL 545
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW---------SINQGVSIG---TI 614

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425338  546 QLDEDVLCVSYsPNQKLLAVSLLDCTVKVFYVDtlkfflsLYGHKLPvLCMDISH----------DGALIATGSADRNVK 615
Cdd:PLN00181 615 KTKANICCVQF-PSESGRSLAFGSADHKVYYYD-------LRNPKLP-LCTMIGHsktvsyvrfvDSSTLVSSSTDNTLK 685


                 ....
gi 30425338  616 IWGL 619
Cdd:PLN00181 686 LWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
622-660 6.53e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 6.53e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30425338   622 GDCHRSLFAHDDSVMYLRFVPKSHLFFTAGKDHKIKQWD 660
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-177 1.82e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.82e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 30425338    142 LYRLKGHKDAVTQALFLRERNLLVTSGKDTMVKWWD 177
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
142-177 4.95e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.95e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 30425338   142 LYRLKGHKDAVTQALFLRERNLLVTSGKDTMVKWWD 177
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
409-441 2.10e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 2.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 30425338   409 TIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWN 441
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDgTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 409-441 5.19e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 5.19e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 30425338    409 TIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWN 441
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDgTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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