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Conserved domains on  [gi|45552027|ref|NP_787963|]
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out at first, isoform D [Drosophila melanogaster]

Protein Classification

OAF domain-containing protein( domain architecture ID 10633103)

OAF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OAF pfam14941
Transcriptional regulator, Out at first; This family of proteins is found in eukaryotes. ...
 80-332 2.36e-153

Transcriptional regulator, Out at first; This family of proteins is found in eukaryotes. Proteins in this family are typically between 198 and 332 amino acids in length. The domains in this family vary in length from 239 to 242 amino acids. The gene, OAF (out at first), which encodes this protein, has a promoter which may help mediate regulation of neighbouring genes. An alternative name for this protein is HCV NS5A-transactivated protein 13 target protein 2, which stands for Hepatitis C virus nonstructural 5A-transactivated protein 13 target protein 2. NS5A inhibits double-stranded-RNA-activated protein kinase (PKR) activity, which is thought to allow Hepatitis C Virus replication to continue in the presence of an alpha interferon (IFN)induced antiviral response.


:

Pssm-ID: 464389  Cd Length: 243  Bit Score: 436.00  E-value: 2.36e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552027    80 SQLLINVQNQGGEVIQESITSNIGEDLITLEFQKTDGTLITQVIDFRNEVQILKALVLGEEERGQSQYQVMCFATKFNKG 159
Cdd:pfam14941   1 SQLLVNVKNQGGDVTQEVLEANSEEDTITLEFQRADGTLITQLADFKNEVQIFRALILGEEERGQSQYQALCFVTHLNKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552027   160 DFISSAAMAKLRQKNPHTIRTPEEDKGRETFTMSSWVQLNRSLPITRHLQGLCAEAMDATYVRDVDLKAWAELPGSSISS 239
Cdd:pfam14941  81 EFISSDAMAKLRQKNPGTIRSAEEDRGTENYTMDVAVNVSRSGQLSPHIHNLCSEARDAVYTREADIKHWADRPGSSFEL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552027   240 LEAATEKFPDTLSTRCNEVSSLWAPCLCNLETCIGWYPCGLKYCKGKGvagadssgaqQQAQPTNYRCGIKTCRKCTQFT 319
Cdd:pfam14941 161 LPQAVSNFPSSLLSRCSDTSDLWKPCICRLELCIEWYPCGLKYCKGKD----------SGGKVSSYRCGIKTCKKCYRFD 230

                         250
                  ....*....|...
gi 45552027   320 YYVRQKQQCLWDE 332
Cdd:pfam14941 231 YYVPQKQLCLWDE 243
 
Name Accession Description Interval E-value
OAF pfam14941
Transcriptional regulator, Out at first; This family of proteins is found in eukaryotes. ...
 80-332 2.36e-153

Transcriptional regulator, Out at first; This family of proteins is found in eukaryotes. Proteins in this family are typically between 198 and 332 amino acids in length. The domains in this family vary in length from 239 to 242 amino acids. The gene, OAF (out at first), which encodes this protein, has a promoter which may help mediate regulation of neighbouring genes. An alternative name for this protein is HCV NS5A-transactivated protein 13 target protein 2, which stands for Hepatitis C virus nonstructural 5A-transactivated protein 13 target protein 2. NS5A inhibits double-stranded-RNA-activated protein kinase (PKR) activity, which is thought to allow Hepatitis C Virus replication to continue in the presence of an alpha interferon (IFN)induced antiviral response.


Pssm-ID: 464389  Cd Length: 243  Bit Score: 436.00  E-value: 2.36e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552027    80 SQLLINVQNQGGEVIQESITSNIGEDLITLEFQKTDGTLITQVIDFRNEVQILKALVLGEEERGQSQYQVMCFATKFNKG 159
Cdd:pfam14941   1 SQLLVNVKNQGGDVTQEVLEANSEEDTITLEFQRADGTLITQLADFKNEVQIFRALILGEEERGQSQYQALCFVTHLNKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552027   160 DFISSAAMAKLRQKNPHTIRTPEEDKGRETFTMSSWVQLNRSLPITRHLQGLCAEAMDATYVRDVDLKAWAELPGSSISS 239
Cdd:pfam14941  81 EFISSDAMAKLRQKNPGTIRSAEEDRGTENYTMDVAVNVSRSGQLSPHIHNLCSEARDAVYTREADIKHWADRPGSSFEL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552027   240 LEAATEKFPDTLSTRCNEVSSLWAPCLCNLETCIGWYPCGLKYCKGKGvagadssgaqQQAQPTNYRCGIKTCRKCTQFT 319
Cdd:pfam14941 161 LPQAVSNFPSSLLSRCSDTSDLWKPCICRLELCIEWYPCGLKYCKGKD----------SGGKVSSYRCGIKTCKKCYRFD 230

                         250
                  ....*....|...
gi 45552027   320 YYVRQKQQCLWDE 332
Cdd:pfam14941 231 YYVPQKQLCLWDE 243
 
Name Accession Description Interval E-value
OAF pfam14941
Transcriptional regulator, Out at first; This family of proteins is found in eukaryotes. ...
 80-332 2.36e-153

Transcriptional regulator, Out at first; This family of proteins is found in eukaryotes. Proteins in this family are typically between 198 and 332 amino acids in length. The domains in this family vary in length from 239 to 242 amino acids. The gene, OAF (out at first), which encodes this protein, has a promoter which may help mediate regulation of neighbouring genes. An alternative name for this protein is HCV NS5A-transactivated protein 13 target protein 2, which stands for Hepatitis C virus nonstructural 5A-transactivated protein 13 target protein 2. NS5A inhibits double-stranded-RNA-activated protein kinase (PKR) activity, which is thought to allow Hepatitis C Virus replication to continue in the presence of an alpha interferon (IFN)induced antiviral response.


Pssm-ID: 464389  Cd Length: 243  Bit Score: 436.00  E-value: 2.36e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552027    80 SQLLINVQNQGGEVIQESITSNIGEDLITLEFQKTDGTLITQVIDFRNEVQILKALVLGEEERGQSQYQVMCFATKFNKG 159
Cdd:pfam14941   1 SQLLVNVKNQGGDVTQEVLEANSEEDTITLEFQRADGTLITQLADFKNEVQIFRALILGEEERGQSQYQALCFVTHLNKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552027   160 DFISSAAMAKLRQKNPHTIRTPEEDKGRETFTMSSWVQLNRSLPITRHLQGLCAEAMDATYVRDVDLKAWAELPGSSISS 239
Cdd:pfam14941  81 EFISSDAMAKLRQKNPGTIRSAEEDRGTENYTMDVAVNVSRSGQLSPHIHNLCSEARDAVYTREADIKHWADRPGSSFEL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552027   240 LEAATEKFPDTLSTRCNEVSSLWAPCLCNLETCIGWYPCGLKYCKGKGvagadssgaqQQAQPTNYRCGIKTCRKCTQFT 319
Cdd:pfam14941 161 LPQAVSNFPSSLLSRCSDTSDLWKPCICRLELCIEWYPCGLKYCKGKD----------SGGKVSSYRCGIKTCKKCYRFD 230

                         250
                  ....*....|...
gi 45552027   320 YYVRQKQQCLWDE 332
Cdd:pfam14941 231 YYVPQKQLCLWDE 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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