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Conserved domains on  [gi|28574581|ref|NP_787994|]
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uncharacterized protein Dmel_CG7102, isoform A [Drosophila melanogaster]

Protein Classification

BTB/POZ and TLD domain-containing protein( domain architecture ID 13031927)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and TLD (TBC and LysM) domain-containing protein

Gene Ontology:  GO:0005515
PubMed:  27521773|17120193|15544948

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
303-477 1.57e-46

domain in TBC and LysM domain containing proteins;


:

Pssm-ID: 214733  Cd Length: 165  Bit Score: 159.79  E-value: 1.57e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581    303 SQILKNDNLALQTVLNNWVGVGKQsWRLVFRASTHGYDSGAFHRYCDGV-APCMVIGLGSHGEISGGYTDVAWAKTSRkg 381
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYP-WTLLYSSSQHGYSLNTLYRKVEGYrPPTLLIIKDTDGEVFGAYASQAWRVSDH-- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581    382 GYVQSERaFLFALNPangeQPVKFDIVKKP--YAICYHPDCGPIFGAGADLLISSNCNTNMDSYSnlpHSYDGTNAAHLT 459
Cdd:smart00584  78 FYGTGES-FLFQLNP----KFVVYDWTGKNkyYYINGTPDSLPIGGGGGGFGLWIDEDLNHGSSS---HCKTFGNPPLST 149

                          170
                   ....*....|....*...
gi 28574581    460 LfgDYNFTITDYEVYTLS 477
Cdd:smart00584 150 K--QEDFLILDIEVWGFG 165
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 143-255 1.18e-15

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


:

Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 72.37  E-value: 1.18e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581    143 VMDIHEKAGAKCAASFMERCIIYIGENANECVKTNAFLTLTKDAIIKIISSDYFCL-EEEEVWRCVLSWAKYQagvtqpt 221
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVsSEEEVFEAVLRWVKHD------- 73

                           90       100       110
                   ....*....|....*....|....*....|....
gi 28574581    222 ahwtEEERarvCQHLSGVMGHVRLLLIDSQVFAE 255
Cdd:smart00875  74 ----PEKR---REHLPELLEHVRLPLLSPDYLLE 100
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-112 1.64e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 68.73  E-value: 1.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  20 ADVVFICGrDERIYAHRLMLMARCKSFKTAKRGEvcripgctvspaaPGASTPTTIRLPHVNPELFRQFILYVYTAKLVL 99
Cdd:cd18186   2 CDVTLVVG-GREFPAHRAVLAARSPYFRAMFSSG-------------MKESSSSEIELDDVSPEAFEALLDYIYTGELEL 67

                        90
                ....*....|...
gi 28574581 100 QDSQVFQMMILAQ 112
Cdd:cd18186  68 SEENVEELLAAAD 80
 
Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
303-477 1.57e-46

domain in TBC and LysM domain containing proteins;


Pssm-ID: 214733  Cd Length: 165  Bit Score: 159.79  E-value: 1.57e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581    303 SQILKNDNLALQTVLNNWVGVGKQsWRLVFRASTHGYDSGAFHRYCDGV-APCMVIGLGSHGEISGGYTDVAWAKTSRkg 381
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYP-WTLLYSSSQHGYSLNTLYRKVEGYrPPTLLIIKDTDGEVFGAYASQAWRVSDH-- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581    382 GYVQSERaFLFALNPangeQPVKFDIVKKP--YAICYHPDCGPIFGAGADLLISSNCNTNMDSYSnlpHSYDGTNAAHLT 459
Cdd:smart00584  78 FYGTGES-FLFQLNP----KFVVYDWTGKNkyYYINGTPDSLPIGGGGGGFGLWIDEDLNHGSSS---HCKTFGNPPLST 149

                          170
                   ....*....|....*...
gi 28574581    460 LfgDYNFTITDYEVYTLS 477
Cdd:smart00584 150 K--QEDFLILDIEVWGFG 165
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
 330-476 9.39e-17

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


Pssm-ID: 429519  Cd Length: 139  Bit Score: 76.88  E-value: 9.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   330 LVFRASTHGYDSGAFHRYCDGVAPCMVIGLGSHGEISGGYTDVAWAKTSRKggYVQSERAFLFALNPangeqpvKFDIVK 409
Cdd:pfam07534   1 LLYSTSRDGSSYQTFLEKIDNKGPTLLIIKDNDGYIFGAFASQPWKVSGKK--FYGDGESFLFSLSP-------QFDPYK 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28574581   410 ---KPYAICYHPDCGPIFGAG---ADLLISSNCNTnmdSYSNLPHSYDGTnaaHLTLFGDYNFTITDYEVYTL 476
Cdd:pfam07534  72 wtgKNNAYFNCTSDGLGFGGGqpkFDLWIDSDLEF---GYSRHCETFGNG---QLSGSGQERFKIDDVEVWGL 138
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 143-255 1.18e-15

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 72.37  E-value: 1.18e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581    143 VMDIHEKAGAKCAASFMERCIIYIGENANECVKTNAFLTLTKDAIIKIISSDYFCL-EEEEVWRCVLSWAKYQagvtqpt 221
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVsSEEEVFEAVLRWVKHD------- 73

                           90       100       110
                   ....*....|....*....|....*....|....
gi 28574581    222 ahwtEEERarvCQHLSGVMGHVRLLLIDSQVFAE 255
Cdd:smart00875  74 ----PEKR---REHLPELLEHVRLPLLSPDYLLE 100
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-112 1.64e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 68.73  E-value: 1.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  20 ADVVFICGrDERIYAHRLMLMARCKSFKTAKRGEvcripgctvspaaPGASTPTTIRLPHVNPELFRQFILYVYTAKLVL 99
Cdd:cd18186   2 CDVTLVVG-GREFPAHRAVLAARSPYFRAMFSSG-------------MKESSSSEIELDDVSPEAFEALLDYIYTGELEL 67

                        90
                ....*....|...
gi 28574581 100 QDSQVFQMMILAQ 112
Cdd:cd18186  68 SEENVEELLAAAD 80
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 159-258 1.46e-13

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 66.80  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   159 MERCIIYIGENANECVKTNAFLTLTKDAIIKIISSDYFCLE-EEEVWRCVLSWAKYQagvtqptahwtEEERArvcQHLS 237
Cdd:pfam07707  17 AEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPsEEEVFEAVIRWVKHD-----------VERRK---KHLP 82

                          90       100
                  ....*....|....*....|.
gi 28574581   238 GVMGHVRLLLIDSQVFAEEVE 258
Cdd:pfam07707  83 ELLSAVRLPLLSPQYLLNLVE 103
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 21-131 1.09e-11

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 61.17  E-value: 1.09e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581     21 DVVFICGrDERIYAHRLMLMARCKSFKTAKRGEVCRipgctvspaapgaSTPTTIRLPHVNPELFRQFILYVYTAKLVLQ 100
Cdd:smart00225   1 DVTLVVG-GKKFHAHKAVLAAHSPYFKALFSSDFKE-------------SDKSEIYLDDVSPEDFRALLNFLYTGKLDLP 66

                           90       100       110
                   ....*....|....*....|....*....|.
gi 28574581    101 DSQVFQMMILAQDIGVVELRTACEDHVISTL 131
Cdd:smart00225  67 EENVEELLELADYLQIPGLVELCEEFLLKLL 97
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 131-213 1.68e-11

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 60.70  E-value: 1.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 131 LSVDNACtfltavmDIHEKAGAKCAASFMERCIIYIGENANECVKTNAFLTLTKDAIIKIISSDYFCLEEEEVWRCVLSW 210
Cdd:cd14822   1 LNIRNVC-------LIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRW 73


                ...
gi 28574581 211 AKY 213
Cdd:cd14822  74 CEH 76
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 10-131 6.56e-10

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 56.50  E-value: 6.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581    10 LQRLSEDQDSADVVFICGrDERIYAHRLMLMARCKSFKTAKRGEVCripgctvspaapgASTPTTIRLPHVNPELFRQFI 89
Cdd:pfam00651   1 LNELREQGELCDVTLVVG-DKEFRAHKAVLAACSPYFKALFSGQES-------------ESSVSEITLDDVSPEDFEALL 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 28574581    90 LYVYTAKLVlQDSQVFQMMILAQDIGVVELRTACEDHVISTL 131
Cdd:pfam00651  67 EFMYTGKLI-SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
PHA03098 PHA03098
kelch-like protein; Provisional
 21-214 2.46e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.60  E-value: 2.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   21 DVVFICGRDERIYAHRLMLMARCKSFKTAKRGEvcripgctvspaapgaSTPTTIRLPHvNPELFRQFILYVYTAKLVLQ 100
Cdd:PHA03098  12 ESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNN----------------FKENEINLNI-DYDSFNEVIKYIYTGKINIT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  101 DSQVFQMMILAQDIGVVELRTACEDHVISTLSVDNACTFLTavmdIHEKAGAKCAASFMercIIYIGENANECVKTNAFL 180
Cdd:PHA03098  75 SNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYR----FSFFYGCKKLYSAA---YNYIRNNIELIYNDPDFI 147

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 28574581  181 TLTKDAIIKIISSDYFCLEEEEVWRCVL-SWAKYQ 214
Cdd:PHA03098 148 YLSKNELIKILSDDKLNVSSEDVVLEIIiKWLTSK 182
 
Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
303-477 1.57e-46

domain in TBC and LysM domain containing proteins;


Pssm-ID: 214733  Cd Length: 165  Bit Score: 159.79  E-value: 1.57e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581    303 SQILKNDNLALQTVLNNWVGVGKQsWRLVFRASTHGYDSGAFHRYCDGV-APCMVIGLGSHGEISGGYTDVAWAKTSRkg 381
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYP-WTLLYSSSQHGYSLNTLYRKVEGYrPPTLLIIKDTDGEVFGAYASQAWRVSDH-- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581    382 GYVQSERaFLFALNPangeQPVKFDIVKKP--YAICYHPDCGPIFGAGADLLISSNCNTNMDSYSnlpHSYDGTNAAHLT 459
Cdd:smart00584  78 FYGTGES-FLFQLNP----KFVVYDWTGKNkyYYINGTPDSLPIGGGGGGFGLWIDEDLNHGSSS---HCKTFGNPPLST 149

                          170
                   ....*....|....*...
gi 28574581    460 LfgDYNFTITDYEVYTLS 477
Cdd:smart00584 150 K--QEDFLILDIEVWGFG 165
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
 330-476 9.39e-17

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


Pssm-ID: 429519  Cd Length: 139  Bit Score: 76.88  E-value: 9.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   330 LVFRASTHGYDSGAFHRYCDGVAPCMVIGLGSHGEISGGYTDVAWAKTSRKggYVQSERAFLFALNPangeqpvKFDIVK 409
Cdd:pfam07534   1 LLYSTSRDGSSYQTFLEKIDNKGPTLLIIKDNDGYIFGAFASQPWKVSGKK--FYGDGESFLFSLSP-------QFDPYK 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28574581   410 ---KPYAICYHPDCGPIFGAG---ADLLISSNCNTnmdSYSNLPHSYDGTnaaHLTLFGDYNFTITDYEVYTL 476
Cdd:pfam07534  72 wtgKNNAYFNCTSDGLGFGGGqpkFDLWIDSDLEF---GYSRHCETFGNG---QLSGSGQERFKIDDVEVWGL 138
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 143-255 1.18e-15

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 72.37  E-value: 1.18e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581    143 VMDIHEKAGAKCAASFMERCIIYIGENANECVKTNAFLTLTKDAIIKIISSDYFCL-EEEEVWRCVLSWAKYQagvtqpt 221
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVsSEEEVFEAVLRWVKHD------- 73

                           90       100       110
                   ....*....|....*....|....*....|....
gi 28574581    222 ahwtEEERarvCQHLSGVMGHVRLLLIDSQVFAE 255
Cdd:smart00875  74 ----PEKR---REHLPELLEHVRLPLLSPDYLLE 100
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-112 1.64e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 68.73  E-value: 1.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  20 ADVVFICGrDERIYAHRLMLMARCKSFKTAKRGEvcripgctvspaaPGASTPTTIRLPHVNPELFRQFILYVYTAKLVL 99
Cdd:cd18186   2 CDVTLVVG-GREFPAHRAVLAARSPYFRAMFSSG-------------MKESSSSEIELDDVSPEAFEALLDYIYTGELEL 67

                        90
                ....*....|...
gi 28574581 100 QDSQVFQMMILAQ 112
Cdd:cd18186  68 SEENVEELLAAAD 80
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-124 1.09e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 67.27  E-value: 1.09e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   6 LIEDLQRLSEDQDSADVVFICGrDER--IYAHRLMLMARCKSFKTakrgevcripgcTVSPAAPGASTPTTIRLPHVNPE 83
Cdd:cd18294   1 FAADMKSLINNPEFSDVKFLVG-PERqeIFAHKCILAARCEVFRA------------MFLTGPQKESTQSPLVLSDIEPE 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 28574581  84 LFRQFILYVYTAKLVLQDSQVFQMMILAQDIGVVELRTACE 124
Cdd:cd18294  68 VFRAVLEFIYTNCVTLSNHTVIEVLAAAVEYGLDELRKLCE 108
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 159-258 1.46e-13

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 66.80  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   159 MERCIIYIGENANECVKTNAFLTLTKDAIIKIISSDYFCLE-EEEVWRCVLSWAKYQagvtqptahwtEEERArvcQHLS 237
Cdd:pfam07707  17 AEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPsEEEVFEAVIRWVKHD-----------VERRK---KHLP 82

                          90       100
                  ....*....|....*....|.
gi 28574581   238 GVMGHVRLLLIDSQVFAEEVE 258
Cdd:pfam07707  83 ELLSAVRLPLLSPQYLLNLVE 103
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 8-124 2.55e-13

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 66.08  E-value: 2.55e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   8 EDLQRLSEDQDSADVVFICGRDERIYAHRLMLMARCKSFktakrgevCRIpgctvspaapgASTPTTIRL-PHVNPELFR 86
Cdd:cd18299   1 EDLRNLLHSPSCADVVFILQGGVRIFAHRIVLAAASSVF--------ADL-----------FLMMTVVTLdSDITPEAFR 61

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 28574581  87 QFILYVYTAKLVLQDSQVFQMMILAQDIGVVELRTACE 124
Cdd:cd18299  62 RVLEFLYTGVLDENEDDLKELKDAAELLELFDLVMMCT 99
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 21-131 1.09e-11

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 61.17  E-value: 1.09e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581     21 DVVFICGrDERIYAHRLMLMARCKSFKTAKRGEVCRipgctvspaapgaSTPTTIRLPHVNPELFRQFILYVYTAKLVLQ 100
Cdd:smart00225   1 DVTLVVG-GKKFHAHKAVLAAHSPYFKALFSSDFKE-------------SDKSEIYLDDVSPEDFRALLNFLYTGKLDLP 66

                           90       100       110
                   ....*....|....*....|....*....|.
gi 28574581    101 DSQVFQMMILAQDIGVVELRTACEDHVISTL 131
Cdd:smart00225  67 EENVEELLELADYLQIPGLVELCEEFLLKLL 97
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 131-213 1.68e-11

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 60.70  E-value: 1.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 131 LSVDNACtfltavmDIHEKAGAKCAASFMERCIIYIGENANECVKTNAFLTLTKDAIIKIISSDYFCLEEEEVWRCVLSW 210
Cdd:cd14822   1 LNIRNVC-------LIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRW 73


                ...
gi 28574581 211 AKY 213
Cdd:cd14822  74 CEH 76
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 10-131 6.56e-10

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 56.50  E-value: 6.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581    10 LQRLSEDQDSADVVFICGrDERIYAHRLMLMARCKSFKTAKRGEVCripgctvspaapgASTPTTIRLPHVNPELFRQFI 89
Cdd:pfam00651   1 LNELREQGELCDVTLVVG-DKEFRAHKAVLAACSPYFKALFSGQES-------------ESSVSEITLDDVSPEDFEALL 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 28574581    90 LYVYTAKLVlQDSQVFQMMILAQDIGVVELRTACEDHVISTL 131
Cdd:pfam00651  67 EFMYTGKLI-SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 165-259 2.42e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 54.93  E-value: 2.42e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 165 YIGENANECVKTNAFLTLTKDAIIKIISSDYFCLE-EEEVWRCVLSWAKYQAgvtqptahwteEERArvcQHLSGVMGHV 243
Cdd:cd18445  28 YTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPsEEKVFEAVMSWVNHDP-----------ENRK---EHLAELLEHV 93

                        90
                ....*....|....*.
gi 28574581 244 RLLLIDSQVFAEEVEP 259
Cdd:cd18445  94 RLPLLSPEYLVQRVEE 109
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 132-211 3.22e-09

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 53.47  E-value: 3.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 132 SVDNACTFLTAvmdihekAGAKCAASFMERCIIYIGENANECVKTNAFLTLTKDAIIKIISSDYFCLEEEEVWRCVLSWA 211
Cdd:cd18494   1 SVETACEALQA-------AVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREWA 73
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-126 6.63e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 53.78  E-value: 6.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   6 LIEDLQRLSEDQDSADVVFICGrDERIYAHRLMLMARCKSFKTAKRGEVCRipgctvspaapgaSTPTTIRLPHVNPELF 85
Cdd:cd18287   9 LSEDIGALFLNEEYSDVTFVVE-EKRFPAHRVILAARSEYFRALLYGGMRE-------------SQQSEIELKDTNAEAF 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 28574581  86 RQFILYVYTAKLVLQDSQ---VFQMMILAQDIGVVELRTACEDH 126
Cdd:cd18287  75 KALLKYIYTGRLTLTDLKedvLLDVLGLAHQYGFEELEAAISDY 118
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 20-131 8.29e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 53.40  E-value: 8.29e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  20 ADVVFICgRDERIYAHRLMLMARCK--------SFKTAKRGEVCripgctvspaapgastpttirLPHVNPELFRQFILY 91
Cdd:cd18300  10 SDVTFIV-EDGTIPAHKALLVARCDvmaamfggNFRESSAKEVE---------------------LPGVSKETFLALLEY 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 28574581  92 VYTAKL-VLQDSQVFQMMILAQDIGVVELRTACEDHVISTL 131
Cdd:cd18300  68 LYTDQApILEDGDCVGLIVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 15-123 9.43e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 52.73  E-value: 9.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  15 EDQDSADVVFICGrDERIYAHRLMLMARCKSFKTAKRGEVCRipgctvspaapgaSTPTTIRLPHVNPELFRQFILYVYT 94
Cdd:cd18314   2 NDSEFSDVVLCVG-DRKFFAHRIVLCARSPVFRSMLTGSMIE-------------SNLKEVTLEDVEPEIFETVLKYMYT 67

                        90       100
                ....*....|....*....|....*....
gi 28574581  95 AKLVLQDSQVFQMMILAQDIGVVELRTAC 123
Cdd:cd18314  68 GQVTLSEENVLDLLMLASKYQVPDLEKLC 96
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 150-258 1.66e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 52.47  E-value: 1.66e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 150 AGAKCAASFMERCIIYIGENANECVKTNAFLTLTKDAIIKIISSD-YFCLEEEEVWRCVLSWAKYQagvtqptahwtEEE 228
Cdd:cd18446  13 ADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDdLYVTEEEQVFETVMRWVRYK-----------ESE 81

                        90       100       110
                ....*....|....*....|....*....|
gi 28574581 229 RArvcQHLSGVMGHVRLLLIDSQVFAEEVE 258
Cdd:cd18446  82 RL---PLLPRVLENVRLPLLDPWYFVETVE 108
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-136 1.89e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 52.65  E-value: 1.89e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  10 LQRLSEDQDSA---DVVFICGRDErIYAHRLMLMarCKS------FKTAKRGEVCRipgctvspaapgastptTIRLPHV 80
Cdd:cd18306   6 LAKLNALRKNRqfcDVILQVGGHE-IPAHRAVLA--CASpylfelFSSDSDGESIL-----------------TVKLDGL 65

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28574581  81 NPELFRQFILYVYTAKLVLQDSQVFQMMILAQDIGVVELRTACEDHVISTLSVDNA 136
Cdd:cd18306  66 DPDAVEVLVNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNC 121
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-135 2.44e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 52.15  E-value: 2.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   5 QLIEDLQRLSEDQDSADVVFICGRDErIYAHRLMLMARCKSFKTAKRGEVcripgctvspaapGASTPTTIRLPHVNPEL 84
Cdd:cd18279   4 RLAEDLGNLWENSRFTDCCLCVGGQE-FQAHKAILAARSPVFSAMFEHEM-------------EESKKNRVEINDVDPEV 69

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 28574581  85 FRQFILYVYTAKLVLQDSQVFQMMILAQDIGVVELRTACEDHVISTLSVDN 135
Cdd:cd18279  70 FKEMMRFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-125 1.72e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 49.59  E-value: 1.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   4 PQLIEDLQRLSEDQDSADVVFICGrDERIYAHRLMLmarcksfktAKRGEVCRipgCTVSPAAPGASTPTTIRLpHVNPE 83
Cdd:cd18292   2 REFLQDIAQLYNNEELSDIVLRVG-GKVFHAHRLIL---------AKSSDVFR---VMLSNDWWSESKQSEIEL-VEDPE 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 28574581  84 ---LFRQFILYVYTAKLVLQDSQVFQMMILAQDIGVVELRTACED 125
Cdd:cd18292  68 caaVFEKFLRYLYTGQISVNLETALPLLMLADKYNVTDLKQLCVD 112
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 144-255 8.11e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 47.71  E-value: 8.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 144 MDIHEKAGAKCAASFMERCIIYIGENANECVKTNAFLTLTKDAIIKIISSDYFCL-EEEEVWRCVLSWAKYqagvtqpta 222
Cdd:cd18509   8 LGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVpDEETIFHALMMWVKY--------- 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 28574581 223 hwteeERARVCQHLSGVMGHVRLLLIDSQVFAE 255
Cdd:cd18509  79 -----DMQRRCSDLSMLLAYIRLPLLPPQLLAD 106
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 8-111 1.12e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 47.63  E-value: 1.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   8 EDLQRLSEDQDSADVVF-ICGrdERIYAHRLMLMARCK----SFKTAKRGEVCripgctVSpaapgastpttIRLPHVNP 82
Cdd:cd18295   8 EFLRRLLEQGSYSDVTFnVHG--ESFPAHRCILSARSPyfaeMFETKWKDKRE------IN-----------LKHPLVNP 68

                        90       100
                ....*....|....*....|....*....
gi 28574581  83 ELFRQFILYVYTAKLVLQDSQVFQMMILA 111
Cdd:cd18295  69 DAFRALLQYLYTGRLEIHVDDVEDCKRLA 97
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 146-213 1.43e-06

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 45.86  E-value: 1.43e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28574581 146 IHEKAGAKCAASFMERCIIYIGENANECVKTNAFLTLTKDAIIKIISSDYFCL-EEEEVWRCVLSWAKY 213
Cdd:cd18508   8 IHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVpSEERVYEAAVAWLKH 76
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 2-97 1.90e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 47.76  E-value: 1.90e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   2 SLPQ--LIEDLQRLSEDQDSADVVFICGRDE-RIYAHRLMLMARCKSFKT----------AKRGEVCRIPGCTVSPAAPG 68
Cdd:cd18308   4 SYPKctLHDDFGRLLESRQFCDVEFIVGEEEeRIPAHIAFVAARSKWLRNkilqarerqkQKAEQEVEDEGSEADSSSAS 83

                        90       100       110
                ....*....|....*....|....*....|.
gi 28574581  69 A--STPTTIRLPHVNPELFRQFILYVYTAKL 97
Cdd:cd18308  84 KndSPMLEVRLPEADPEAFELILSFIYTDKI 114
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 156-257 5.69e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 44.99  E-value: 5.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 156 ASFMERCIIYIGENANECVKTNAFLTLTKDAIIKIISSDYFCLE-EEEVWRCVLSWAKYQagvtqptahwtEEERarvCQ 234
Cdd:cd18457  19 SSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKsEEQVFEAALAWVKYD-----------RENR---EE 84

                        90       100
                ....*....|....*....|...
gi 28574581 235 HLSGVMGHVRLLLIDSQVFAEEV 257
Cdd:cd18457  85 YLPELLSKVRLPLLRPQFLTDRV 107
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 137-258 6.30e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 45.83  E-value: 6.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 137 CTFLTAVMDIH------EKAGAKCAASFMErciIYIGENanecvktnaFLTLTKDAIIKIISSDYFCLE-EEEVWRCVLS 209
Cdd:cd18513   6 CLGIRAFADVHtctellQQANAYAEQHFPE---VMLGEE---------FLSLSLDQVCSLISSDKLTVSsEEKVFEAVIS 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 28574581 210 WAKYqagvtqptahwteEERARVcQHLSGVMGHVRLLLIDSQVFAEEVE 258
Cdd:cd18513  74 WIKY-------------DKEARL-EHMAKLMEHVRLPLLPRDYLVQTVE 108
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-127 7.62e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 44.94  E-value: 7.62e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   8 EDLQRLSEDQDSADVVFICGrDERIYAHRLMLMARCKSFKTAKRGEVcripgctvspaapGASTPTTIRLPHVNPELFRQ 87
Cdd:cd18298   1 DSLRKAFNDPRTSDLKFRVD-GKYIYVHKAILKIRCEYFRSMFQSHW-------------NEDDKNVIEIDQYSYPVYYA 66

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 28574581  88 FILYVYTAKLVLQDSQVFQMMILAQDIGVVELRTACEDHV 127
Cdd:cd18298  67 FLRYLYTDQVDLPPEDAIGLLDLANSYCEERLKKLCEDII 106
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 137-258 8.30e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 45.41  E-value: 8.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 137 CTFLTAVMDIHekagakCAASFMERCIIYIGENANECVKTNAFLTLTKDAIIKIISSDYFCL-EEEEVWRCVLSWAKYQA 215
Cdd:cd18512   6 CLGIRAFADMH------ACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTIsSEEKVFEAVIAWVNHDK 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 28574581 216 GVTQptahwteeerarvcQHLSGVMGHVRLLLIDSQVFAEEVE 258
Cdd:cd18512  80 EVRQ--------------EHMAHLMEHVRLPLLSREYLVQRVE 108
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-135 1.04e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 45.00  E-value: 1.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   5 QLIEDLQRLSEDQDSADVVFICGRDErIYAHRLMLMARCKSFKTAKRGEVcripgctvspaapGASTPTTIRLPHVNPEL 84
Cdd:cd18343   7 RLAEDLGNLWENSRFTDCSLFVGGQE-FKAHKSILAARSPVFNAMFEHEM-------------EESKKNRVEINDVDPEV 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 28574581  85 FRQFILYVYTAKLVLQDSQVFQMMILAQDIGVVELRTACEDHVISTLSVDN 135
Cdd:cd18343  73 FKEMMRFIYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-135 1.10e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 44.73  E-value: 1.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  20 ADVVFICGRD---ERIYAHRLMLMARCKSFKTAKRGevcripgctvspaaPGASTPTTIRLPHVNPELFRQFILYVYTAK 96
Cdd:cd18281  23 SDVHFIVGKGdneQRIPAHKFVLSIGSAVFDAMFNG--------------GMATTSAEIELPDVEPAAFLALLRFLYSDE 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 28574581  97 LVLQDSQVFQMMILAQDIGVVELRTACEDHVISTLSVDN 135
Cdd:cd18281  89 VQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 132-193 2.21e-05

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 41.88  E-value: 2.21e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28574581 132 SVDNACtfltavmDIHEKAGAKCAASFMERCIIYIGENANECVKTNAFLTLTKDAIIKIISS 193
Cdd:cd14733   1 DPENCL-------GILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_BTBD12_SLX4 cd18288
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-124 3.84e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349597 [Multi-domain]  Cd Length: 116  Bit Score: 43.22  E-value: 3.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   2 SLPQLIEDLQRLSEDQDSADVVFICGRDERIYAHRLMLMARCKSFKTAKRGEvcripgctvSPAAPGASTPTTIR--LPH 79
Cdd:cd18288   1 SLGKLAADFSAMVNNPHLSDVQFQTDSGEVLYAHSFVLYARCPLLIQMVHSE---------GFSVEEEGGVTTRRvlLGD 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 28574581  80 VNPELFRQFILYVYTAKLVLQDSQVFQMMILAQDIGVVELRTACE 124
Cdd:cd18288  72 VSGEAARCFLQYLYTADTGLPPGLSPHVSELADRFGVSELVHLCE 116
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-102 5.93e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 42.57  E-value: 5.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   3 LPQLIEdlQRLseDQDSADVVFICGrDERIYAHRLMLMARCKSFKTAKRGEVCrIPGCTVSPAAPGA-STPTTIRLPHVN 81
Cdd:cd18195   6 LLQLNE--QRL--RGLFCDVTLIAG-DTKFRAHRSVLAASSPYFRELLSSPLP-LGAAAVAAAPGATqSPERVLELPGVK 79

                        90       100
                ....*....|....*....|.
gi 28574581  82 PELFRQFILYVYTAKLVLQDS 102
Cdd:cd18195  80 AGVFSDVLNFIYSSRVALPGS 100
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-135 6.27e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 42.89  E-value: 6.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  20 ADVVFICGRDERIYAHRLMLMARCKSFK---TAKRGEvcripgctvspaapgaSTPTTIRLPHVNPELFRQFILYVYTAK 96
Cdd:cd18252  22 TDITLQCASGQIFHCHKAALAACSSYFKvmfTADMKE----------------KSNNVIKLSGIDHDILEALVNYVYTSQ 85

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 28574581  97 LVLQDSQVFQMMILAQDIGVVELRTACEDHVISTLSVDN 135
Cdd:cd18252  86 ICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDN 124
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 169-248 7.59e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 41.65  E-value: 7.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 169 NANECVKTNAFLTLTKDAIIKIISSDYF-CLEEEEVWRCVLSWAKYQAGvtqptahwteEERarvcQHLSGVMGHVRLLL 247
Cdd:cd18459  33 NFQEVMESEEFMLLPVNQLIDIISSDELnVRSEEQVFNAVMAWVKYNIQ----------ERR----PHLPQVLQHVRLPL 98


                .
gi 28574581 248 I 248
Cdd:cd18459  99 L 99
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-136 1.20e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 41.87  E-value: 1.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   6 LIEDLQRLSEDQDSADVVFICGRDErIYAHRLMLMARCKSFKTAKRGEVcripgctvspaapGASTPTTIRLPHVNPELF 85
Cdd:cd18344  10 LTDDLGELWENSLFTDCCLLVAGHE-FRAHKAILAARSPVFRAMFEHEM-------------EERLKNPIEIHDLDPQVF 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 28574581  86 RQFILYVYTAKL--VLQDSQVFQMMILAQDIGVVELRTACEDHVISTLSVDNA 136
Cdd:cd18344  76 KEMMGFIYTGKAphLHSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVENA 128
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-136 1.32e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 41.63  E-value: 1.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   5 QLIEDLQRLSEDQDSADVVfICGRDERIYAHRLMLMARCKSFKTAKRGEVcripgctvspaapGASTPTTIRLPHVNPEL 84
Cdd:cd18342   8 RLADELGGLWENSRFTDCC-LCVAGQEFQAHKAILAARSPVFSAMFEHEM-------------EESKKNRVEINDVEPEV 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 28574581  85 FRQFILYVYTAKLVLQDSQVFQMMILAQDIGVVELRTACEDHVISTLSVDNA 136
Cdd:cd18342  74 FKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENA 125
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 5-95 1.50e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 41.18  E-value: 1.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   5 QLIEDLQRLSEDQDSADVVFICGrDERIYAHRLMLMARCKSFKTAkrgevcripgctVSPAAPGASTPTTIRLPHVNPEL 84
Cdd:cd18285   1 HLSQDLLRLLREELHTDVTFYVG-STLFKAHKAILLARVPEFFSH------------IIGKLSSLEDQEPINIENLEASE 67

                        90
                ....*....|.
gi 28574581  85 FRQFILYVYTA 95
Cdd:cd18285  68 FKTFLRQVYTS 78
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-135 2.10e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 40.81  E-value: 2.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  21 DVVFICGrDERIYAHRLMLMARCKSFKTAKRGEVCRipgctvspaapgaSTPTTIRLPHVNPELFRQFILYVYTAKLVLQ 100
Cdd:cd18234   3 DVILIAG-DRRIPAHRLVLSAVSDYFAAMFTNDVRE-------------ATEEEIKLKDVDPDALWTLVQYCYTGRLELK 68

                        90       100       110
                ....*....|....*....|....*....|....*
gi 28574581 101 DSQVFQMMILAQDIGVVELRTACEDHVISTLSVDN 135
Cdd:cd18234  69 EDNVESLLATACLLQLSEVVEACCGFLMKQLHPSN 103
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 178-245 2.18e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 40.42  E-value: 2.18e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28574581 178 AFLTLTKDAIIKIISSDYFCLEEEEVWR-CVLSWAKYQAgvtqptahwteEERArvcQHLSGVMGHVRL 245
Cdd:cd18479  41 AFMQLSHDLLIDILSSDNLNVEKEETVReAAMLWLEYNT-----------ESRS---QYLSSVLSQIRI 95
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 6-131 2.21e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 41.09  E-value: 2.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   6 LIEDLQRLSEDQDSADVVFICgRDERIYAHRLMLMARCKSFKTAKRGEVcripgctvspaapGASTPTTIRLPHVNPELF 85
Cdd:cd18286   4 LGKDLLQLFLNGEDSDITIKV-DGKTFKAHRCILCARSSYFAAMLSGSW-------------AESNSSEITLTGVSHAAV 69

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 28574581  86 RQFILYVYTAKLVLQDSQ-VFQMMILAQDIGVVELRTAcedhVISTL 131
Cdd:cd18286  70 SFVLLFIYGGVLDLPDDVnLGELLSLADMYGLDGLKDV----VAYTL 112
PHA03098 PHA03098
kelch-like protein; Provisional
 21-214 2.46e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.60  E-value: 2.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   21 DVVFICGRDERIYAHRLMLMARCKSFKTAKRGEvcripgctvspaapgaSTPTTIRLPHvNPELFRQFILYVYTAKLVLQ 100
Cdd:PHA03098  12 ESIIIVNGGGIIKVHKIILSSSSEYFKKMFKNN----------------FKENEINLNI-DYDSFNEVIKYIYTGKINIT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  101 DSQVFQMMILAQDIGVVELRTACEDHVISTLSVDNACTFLTavmdIHEKAGAKCAASFMercIIYIGENANECVKTNAFL 180
Cdd:PHA03098  75 SNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYR----FSFFYGCKKLYSAA---YNYIRNNIELIYNDPDFI 147

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 28574581  181 TLTKDAIIKIISSDYFCLEEEEVWRCVL-SWAKYQ 214
Cdd:PHA03098 148 YLSKNELIKILSDDKLNVSSEDVVLEIIiKWLTSK 182
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 165-245 2.64e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 39.98  E-value: 2.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 165 YIGENANECVKTNAFLTLTKDAIIKII-SSDYFCLEEEEVWRCVLSWAKYQAgvtqptahwteEERARvcqHLSGVMGHV 243
Cdd:cd18448  29 YACDHFNEVVECEEFVSISAQHLEKLIsSSDLNVESESQVYEAVMKWVKHDP-----------QHRKR---HLDDLLSQV 94


                ..
gi 28574581 244 RL 245
Cdd:cd18448  95 RL 96
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-140 8.30e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 39.62  E-value: 8.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  20 ADVVFICGR---DERIYAHRLMLMARCKSFKTAKRGEVcripgctvspaapgASTPTTIRLPHVNPELFRQFILYVYTAK 96
Cdd:cd18348  22 ADIHFVVGPpggTQRLPGHKYVLAVGSSVFHAMFYGEL--------------AEDKDEIRIPDVEPAAFLAMLKYIYCDE 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 28574581  97 LVLQDSQVFQMMILAQDIGVVELRTACEDHVISTLSVDNACTFL 140
Cdd:cd18348  88 IDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 131
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-131 1.01e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 39.32  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  23 VFICGRDERIYAHRLMLMARCKSFKTAKRGEVCRipgctvspaapgaSTPTTIRLPHVNPELFRQFILYVYTAKLVLQDS 102
Cdd:cd18339  24 VTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSE-------------SKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEE 90

                        90       100
                ....*....|....*....|....*....
gi 28574581 103 QVFQMMILAQDIGVVELRTACEDHVISTL 131
Cdd:cd18339  91 NVQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 165-255 1.02e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 38.89  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 165 YIGENANECVKTNAFLTLTKDAIIKIISSDYFCL-EEEEVWRCVLSWAKyqagvtqptaHWTEEERarvcQHLSGVMGHV 243
Cdd:cd18511  29 YTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIpNEETILNALLSWVR----------HDVEQRR----KDLSKLLAYI 94

                        90
                ....*....|..
gi 28574581 244 RLLLIDSQVFAE 255
Cdd:cd18511  95 RLPLLAPQFLAD 106
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-135 1.03e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 39.27  E-value: 1.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  20 ADVVFICGR---------DERIYAHRLMLMARCKSFKTAKRGEVcripgctvspaapgASTPTTIRLPHVNPELFRQFIL 90
Cdd:cd18346  23 SDVRFVVGKgrprgpgpgAQRIPAHRFVLAAGSAVFDAMFNGGM--------------ATTSAEIELPDVEPAAFLALLR 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 28574581  91 YVYTAKLVLQDSQVFQMMILAQDIGVVELRTACEDHVISTLSVDN 135
Cdd:cd18346  89 FLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-135 2.25e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 38.13  E-value: 2.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   2 SLPQLIEDLQRLSEDQDSADVVFICGRD---ERIYAHRLMLMARCKSFKTAKRGEVcripgctvspaapgASTPTTIRLP 78
Cdd:cd18347   5 TKPTVQERFAFLFNNEVLSDVHFLVGKGlgsQRIPAHRFVLAVGSAVFDAMFNGGM--------------ATTSTEIELP 70

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 28574581  79 HVNPELFRQFILYVYTAKLVLQDSQVFQMMILAQDIGVVELRTACEDHVISTLSVDN 135
Cdd:cd18347  71 DVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 165-255 2.40e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 37.70  E-value: 2.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 165 YIGENANECVKTNAFLTLTKDAIIKIISSDYFCL-EEEEVWRCVLSWAKYQAGvtqptahwteeERarvCQHLSGVMGHV 243
Cdd:cd18444  29 YTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVpSEETIFHALLLWVKHDLP-----------ER---KKHLAKLLALI 94

                        90
                ....*....|..
gi 28574581 244 RLLLIDSQVFAE 255
Cdd:cd18444  95 RLPLLTPQFLAD 106
BACK_GPRS_like cd18507
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched ...
 132-212 4.05e-03

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.


Pssm-ID: 350582  Cd Length: 80  Bit Score: 36.33  E-value: 4.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 132 SVDNACTFLtAVMDIHEKAgaKCAASFMERCIIYIGENANECVKTNAFLTLTKDAIIKIISSDYFCLEEEEVWRCVLSWA 211
Cdd:cd18507   1 NVDTVCALL-ASAERYDQY--KCTKTLVQKVLEFVDKHGTDVLNLPEFLLLPEHVVRLILSRDSLGADEMTKFQAALAWS 77


                .
gi 28574581 212 K 212
Cdd:cd18507  78 R 78
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 20-116 4.30e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 36.37  E-value: 4.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  20 ADVVFICGrDERIYAHRLMLMARCKSFKTAkrgeVCRIPGCTVspaapgastpTTIRLPHVNPELFRQFILYVYTAKLVL 99
Cdd:cd18315   2 VDVTLACE-GGSLKAHKLVLAAASPYFAAL----LKETPPDEH----------PVIILPDVPYSELKALLDFIYTGEVNV 66

                        90
                ....*....|....*..
gi 28574581 100 QDSQVFQMMILAQDIGV 116
Cdd:cd18315  67 SQEQLESLLKLAELLQI 83
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-135 5.36e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 36.92  E-value: 5.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   5 QLIEDLQRLSEDQDSADVVFICGrDERIYAHRLMLMARCKSFKtakrgevcripgctvspAAPGASTpTTIRLPHVNPEL 84
Cdd:cd18303   4 RLLKTVASLFDKELYSDITIKLA-DKSIPAHKFVLAARSEKWS-----------------NENLAST-NELDLSDISYEV 64

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 28574581  85 FRQFILYVYTAKLVLQDSQVFQM--MILAQDIGVVELRTACEDHVISTLSVDN 135
Cdd:cd18303  65 VLALLRWLYTDELDLTLDDEFLLelMKAAKRFQLTDLVERCERALMSSVNVDN 117
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 159-214 5.71e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 36.05  E-value: 5.71e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 28574581 159 MERCIIYIGENANECVKTNA-FLTLTKDAIIKIISSDYFCLEEEE-VWRCVLSWAKYQ 214
Cdd:cd18450  22 ERKAYRYILRNFEEVAKDSEeFLELSCEELEDIIEDDELNVKEEEvVFEAIVKWIDHD 79
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-131 6.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 36.60  E-value: 6.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  20 ADVVFICGRD---ERIYAHRLMLMARCKSFKTAKRGEVcripgctvspaapgASTPTTIRLPHVNPELFRQFILYVYTAK 96
Cdd:cd18282   8 ADVHFIVGPPggtQRIPAHKYVLATGSSVFYAMFYGGL--------------AENKNEIEIPDVEPAAFLNLLRYLYCDE 73

                        90       100       110
                ....*....|....*....|....*....|....*
gi 28574581  97 LVLQDSQVFQMMILAQDIGVVELRTACEDHVISTL 131
Cdd:cd18282  74 IDLEPDTVLATLYAAKKYLVPHLARACVQFLETSL 108
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-145 7.30e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 36.61  E-value: 7.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   6 LIEDLQRLSEDQDSADVVFICGrDERIYAHRLMLMARCKSFKTAKRGEVCRipgctvspaapgaSTPTTIRLPHVNPELF 85
Cdd:cd18256   7 ILAQLNKLRGQHEFCDVQLQVG-MELFSVHRLVLAASSPYFAALFAGGMSE-------------SSKDVVQIHGVEPDIF 72

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  86 RQFILYVYTAKLVLQDSQVFQMMILAQDIGVVELRTACedhvistlsvdnaCTFLTAVMD 145
Cdd:cd18256  73 HILLDFIYTGVVEVTVSNVQELLVAADMLQLTEVVEIC-------------CEFLKGQLH 119
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-125 7.80e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 36.76  E-value: 7.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581  27 GRDERIYAHRLMLMARCKSFKTAKRGEvcRIPGCTVspaapgastpTTIRLPHVNPELFRQFILYVYTAKLVLQDSQVFQ 106
Cdd:cd18211  36 GSKEEFSAHKAVLAASSKYFKEVFLNE--KISDGKN----------TNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQR 103

                        90
                ....*....|....*....
gi 28574581 107 MMILAQDIGVVELRTACED 125
Cdd:cd18211 104 MLEIAEKLKCLDLSETCFQ 122
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 2-111 7.86e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 36.50  E-value: 7.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   2 SLPQLIEDLQRLsedqdsADVVFiCGRDERIYAHRLMLMARCKSFKTAKRGEVCRIPGCtvSPAAPgastptTIRLPHVN 81
Cdd:cd18296   6 ELPFPPEQELSF------PDVCF-QVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEEN--NGSIP------VVTLHDVS 70

                        90       100       110
                ....*....|....*....|....*....|
gi 28574581  82 PELFRQFILYVYTAKLVLQDSQVFQMMILA 111
Cdd:cd18296  71 PEVFAIVLYYIYTDDTDLPPENAYDVLYVA 100
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 160-213 8.24e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 35.45  E-value: 8.24e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 28574581 160 ERCIIYIGENANECVKTNAFLTLTKDAIIKIISSDYFCL-EEEEVWRCVLSWAKY 213
Cdd:cd18463  24 EKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVpKEEEVFEAVMRWVYH 78
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 165-248 8.32e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 36.13  E-value: 8.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581 165 YIGENANECVKTNAFLTLTKDAIIKIISSDYFCL-EEEEVWRCVLSWAKYQAGVTQptahwteeerarvcQHLSGVMGHV 243
Cdd:cd18456  28 YVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVpSEEEVYRAVLSWVKHDVDGRR--------------QHVPRLMKCV 93


                ....*
gi 28574581 244 RLLLI 248
Cdd:cd18456  94 RLPLL 98
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 5-129 9.85e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 36.90  E-value: 9.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28574581   5 QLIEDLQRL--SEDQDSADVVFI--CGRDerIYAHRLMLMARCKSFKT--AKRGEvcripgcTVSPAAPGASTPTTIRLP 78
Cdd:cd18310   2 KLSSDLENLldSPDLFYSDAEIIveGGRP--VPVHRCILAARSPFFRDifASAKA-------EGANTKPKLELRELIPGG 72

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28574581  79 HVNPELFRQFILYVYTAKLVL--------QDSQ------------VFQMMILAQDIGVVELRTACEDHVIS 129
Cdd:cd18310  73 IVGYDAFMLVLSYLYSGRLRLvpkegsacVDSDcwhvacrpavdfALEVLYAASVFQIPELVSLFQRRLLD 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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