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Conserved domains on  [gi|665399496|ref|NP_788284|]
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LDL receptor protein 1, isoform G [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2784-2818 9.74e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 62.22  E-value: 9.74e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 2784 CDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINC 2818
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3637-3671 2.30e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.07  E-value: 2.30e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3637 CDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNC 3671
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2449-2491 3.23e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 3.23e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665399496   2449 EVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNR 2491
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3186-3228 1.46e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.15  E-value: 1.46e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665399496   3186 QTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYR 3228
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1451-1495 1.93e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 1.93e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 665399496   1451 RTLIAGNMESPRAIALDPREGLLFWTDWDdnSPRIERASMSGDGR 1495
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2052-2086 4.14e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 4.14e-10
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 665399496   2052 DWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHR 2086
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3750-3782 7.55e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 7.55e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 665399496   3750 TCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDE 3782
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1408-1450 9.99e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 9.99e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665399496   1408 EAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFR 1450
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3556-3590 1.76e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.76e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3556 CKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDEANC 3590
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4082-4124 4.73e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 4.73e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665399496   4082 KSLVERDVGWPISLSMDYPTGRLYWADYRKGTIETCRLNGKDR 4124
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3595-3626 1.18e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.18e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3595 CGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDE 3626
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3676-3710 1.55e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 1.55e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3676 CSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINC 3710
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3473-3507 2.26e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 2.26e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3473 CEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNC 3507
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3834-3868 2.52e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 2.52e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3834 CRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNC 3868
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3249-3288 2.80e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.55  E-value: 2.80e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 665399496  3249 QHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTI 3288
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAV 40
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2645-2676 3.55e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 3.55e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 2645 CPETHFMCQNHRCIPKEHKCDGEQQCGDGSDE 2676
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 61-92 9.75e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 9.75e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496     61 CPASYFTCNDGFCIPMRWKCDSKADCPDMSDE 92
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2822-2852 1.93e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 1.93e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 2822 CRHNQFAC-DKTCIPASWQCDGKSDCEDGSDE 2852
Cdd:cd00112     1 CPPNEFRCaNGRCIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3273-3314 2.16e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 2.16e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 665399496   3273 KMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNH 3314
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2701-2733 4.07e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 4.07e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 665399496 2701 PDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMC 2733
Cdd:cd00112     3 PNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3004-3035 7.61e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.36  E-value: 7.61e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 3004 DDFRCKNGACIHADLLCDRRNDCADFSDEELC 3035
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 100-137 8.32e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.97  E-value: 8.32e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 665399496  100 CNEGQFRCGvSRHCIPNNWLCDGEFDCgkGDISDELNC 137
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDC--GDGSDEENC 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
3909-4122 1.26e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.77  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 3909 LASGPDQILLLASEQEFRFILPAKQEGTTVVGFFQTDSLKIDVFDILIRPKDTLLFWIDSHHGKVHTMKIATPHVEGTgv 3988
Cdd:COG3391    28 LGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVAT-- 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 3989 rvrrdlkeltafnIPELDDPKSLAVDWISQRVYIIDSRHNQILATDIEGKKYISLVSTGMNPTDIVLEPESRIMIWSTLE 4068
Cdd:COG3391   106 -------------IPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSG 172

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 665399496 4069 NG---ILVASLDGSNKKSLVERDVG-WPISLSMDYPTGRLYWADYRKGTieTCRLNGK 4122
Cdd:COG3391   173 SNtvsVIVSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT--SNGGSNT 228
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1507-1541 2.48e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 2.48e-06
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 665399496   1507 GWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEH 1541
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 791-826 2.98e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 2.98e-06
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 665399496    791 MQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGR 826
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
3077-3115 3.79e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 3.79e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 665399496   3077 DIDECDEQQPCSQ--TCINTYGSYKCLCAKGYalVDHHTCK 3115
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY--TDGRNCE 39
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3432-3464 5.05e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 5.05e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 665399496 3432 CTAAHFECVNtYKCIPFYWRCDTQDDCGDGSDE 3464
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2963-2989 9.84e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.93  E-value: 9.84e-06
                            10        20
                    ....*....|....*....|....*..
gi 665399496   2963 HQCQDGLCIFKNQTCDGKPDCGDGSDE 2989
Cdd:smart00192    7 FQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2747-2776 1.48e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.50  E-value: 1.48e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 665399496 2747 HCGNSTiCIMPRWRCDGDPDCPDGTDELDC 2776
Cdd:cd00112     7 RCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2912-2943 1.54e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.55  E-value: 1.54e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   2912 CPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDE 2943
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 446-487 2.69e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 2.69e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 665399496    446 VLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDYEGRNR 487
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2861-2890 3.32e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.39  E-value: 3.32e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 665399496   2861 CRPHLFQCKSsGRCIPQKWVCDGEKDCPSG 2890
Cdd:smart00192    2 CPPGEFQCDN-GRCIPSSWVCDGVDDCGDG 30
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1263-1291 3.68e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.39  E-value: 3.68e-05
                           10        20
                   ....*....|....*....|....*....
gi 665399496  1263 CSHRCHNTPEGYICSCPDHLYLQPNGKRC 1291
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2604-2635 4.16e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 4.16e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 2604 CGLSQYNCHSGECIPLELTCDNVTHCADGSDE 2635
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3792-3823 4.63e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 4.63e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3792 CHANAFKCRNQLCVRNSALCDGINDCGENEDE 3823
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-257 5.26e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 5.26e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 665399496    220 DYDECSEPGTCDQ--VCRNTPGSYECSCVSGYakTKGNRC 257
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY--TDGRNC 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1542-1585 1.74e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.82  E-value: 1.74e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 665399496   1542 HVVLRNKeiLSHP--FAISVFENYVYWTDWRtTSVIRANKWNGSDV 1585
Cdd:smart00135    1 RTLLSSG--LGHPngLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1031-1066 1.83e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 1.83e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 665399496   1031 TCNSNEFTChKSGRCIQLTWVNDGVVDCGpdDDSDE 1066
Cdd:smart00192    1 TCPPGEFQC-DNGRCIPSSWVCDGVDDCG--DGSDE 33
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 2056-2126 3.18e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14962:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 271  Bit Score: 46.04  E-value: 3.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 2056 GIAIDwVAGNIYWSDTKRNIIEVARLDGSHRYVVVSNLE--KPTALAVDPLQGLLFYV-TQQH-----------IGRVGL 2121
Cdd:cd14962    61 GVAID-ANGNLYVSDAELGKVFVFDRDGKFLRAIGAGALfkRPTGIAVDPAGKRLYVVdTLAHkvkvfdldgrlLFDIGK 139


                  ....*
gi 665399496 2122 DGSQP 2126
Cdd:cd14962   140 RGSGP 144
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2243-2277 5.27e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 5.27e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 665399496  2243 CAHSNGACEQLCLFNGTSAVCACA-HSRLASDGYSC 2277
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPeGYELQDDGRTC 36
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 423-461 1.21e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.45  E-value: 1.21e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 665399496   423 GFMFYTDWT--PSLSRSLLDGSNRTVLVTDQVYHPSSVTLD 461
Cdd:pfam00058    1 GRLYWTDSSlrASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1768-1812 1.63e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.12  E-value: 1.63e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 665399496   1768 IIHEDLNMVDSIVLDPANGKMYWihsaSDGSMSQLEQSNLDGSSR 1812
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYW----TDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1078-1108 1.86e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 38.73  E-value: 1.86e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 665399496 1078 EFDCNNGRCRQFADVCDGIDNCGNNADEMEC 1108
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3328-3363 2.20e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 2.20e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 665399496   3328 NLHHIFAIAV--WEGHIYWSDWETKSIEYCSIfNGQNC 3363
Cdd:smart00135    7 GLGHPNGLAVdwIEGRLYWTDWGLDVIEVANL-DGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2404-2445 2.33e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 2.33e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 665399496   2404 KVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSpcIQRSYLTG 2445
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDV--IEVANLDG 40
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4389-4424 2.39e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 2.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 665399496 4389 IDECADF--CKNGGSCvISTKGQRQCKCPSGYFGEHCE 4424
Cdd:cd00054     2 IDECASGnpCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1613-1650 3.77e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.99  E-value: 3.77e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 665399496  1613 CGENNGGCSHLCLLSGrGTFKCECPHVMRLDPaNERNC 1650
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQD-DGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4360-4388 4.15e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 4.15e-03
                          10        20
                  ....*....|....*....|....*....
gi 665399496 4360 CENGGICRETLtGTPQCECPDGFTGKRCE 4388
Cdd:cd00054    11 CQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
3036-3065 4.48e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 4.48e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3036 NVNECLIPDICEH--ECEDKVVGYQCHCRPGY 3065
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1725-1763 7.67e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.20  E-value: 7.67e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 665399496   1725 IINTNIEKPYGFAVDWIARNMYFSSgQIKCNILASNLKG 1763
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTD-WGLDVIEVANLDG 40
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1165-1200 8.23e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 36.80  E-value: 8.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 665399496 1165 CAPLEFACMfPFECIPDFLRCDGISHCFDKTDEFNC 1200
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2784-2818 9.74e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 62.22  E-value: 9.74e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 2784 CDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINC 2818
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3637-3671 2.30e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.07  E-value: 2.30e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3637 CDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNC 3671
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2449-2491 3.23e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 3.23e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665399496   2449 EVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNR 2491
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3186-3228 1.46e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.15  E-value: 1.46e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665399496   3186 QTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYR 3228
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1451-1495 1.93e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 1.93e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 665399496   1451 RTLIAGNMESPRAIALDPREGLLFWTDWDdnSPRIERASMSGDGR 1495
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2052-2086 4.14e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 4.14e-10
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 665399496   2052 DWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHR 2086
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2784-2815 4.37e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.26  E-value: 4.37e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   2784 CDPGQFRCASGNCIAGSWHCDGEKDCPDGSDE 2815
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3636-3668 4.45e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.26  E-value: 4.45e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 665399496   3636 TCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDE 3668
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3636-3671 4.90e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 4.90e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 665399496  3636 TCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNC 3671
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3750-3782 7.55e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 7.55e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 665399496   3750 TCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDE 3782
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1408-1450 9.99e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 9.99e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665399496   1408 EAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFR 1450
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2784-2818 1.23e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.10  E-value: 1.23e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 665399496  2784 CDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINC 2818
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3556-3590 1.76e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.76e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3556 CKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDEANC 3590
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3751-3782 1.89e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.89e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 3751 CHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDE 3782
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4082-4124 4.73e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 4.73e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665399496   4082 KSLVERDVGWPISLSMDYPTGRLYWADYRKGTIETCRLNGKDR 4124
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3595-3626 1.18e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.18e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3595 CGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDE 3626
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3676-3710 1.55e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 1.55e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3676 CSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINC 3710
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3556-3590 1.87e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 1.87e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 665399496  3556 CKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDEANC 3590
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3593-3626 1.90e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 1.90e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 665399496  3593 VSCGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDE 3626
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3473-3507 2.26e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 2.26e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3473 CEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNC 3507
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3595-3626 2.45e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 2.45e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 3595 CGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDE 3626
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3834-3868 2.52e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 2.52e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3834 CRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNC 3868
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3249-3288 2.80e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.55  E-value: 2.80e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 665399496  3249 QHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTI 3288
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAV 40
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1429-1468 3.37e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.16  E-value: 3.37e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 665399496  1429 NLYWIDSNLDQ-IEVAKLNGSFRRTLIAGNMESPRAIALDP 1468
Cdd:pfam00058    2 RLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2645-2676 3.55e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 3.55e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 2645 CPETHFMCQNHRCIPKEHKCDGEQQCGDGSDE 2676
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3556-3587 3.81e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 3.81e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3556 CKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDE 3587
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2644-2676 4.91e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.48  E-value: 4.91e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 665399496   2644 QCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDE 2676
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3229-3271 6.09e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 6.09e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665399496   3229 KVLINEYLREPRGIALHPYQQHIFWSDWGdSPHIGKAGMDGSN 3271
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTN 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 61-92 9.75e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 9.75e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496     61 CPASYFTCNDGFCIPMRWKCDSKADCPDMSDE 92
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 61-92 1.44e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.44e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496   61 CPASYFTCNDGFCIPMRWKCDSKADCPDMSDE 92
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3750-3782 1.62e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 1.62e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 665399496  3750 TCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDE 3782
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2822-2852 1.93e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 1.93e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 2822 CRHNQFAC-DKTCIPASWQCDGKSDCEDGSDE 2852
Cdd:cd00112     1 CPPNEFRCaNGRCIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3273-3314 2.16e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 2.16e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 665399496   3273 KMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNH 3314
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3674-3710 3.59e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 3.59e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 665399496  3674 RNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINC 3710
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2064-2103 3.68e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 3.68e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 665399496  2064 GNIYWSDTK-RNIIEVARLDGSHRYVVVS-NLEKPTALAVDP 2103
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTdDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2821-2852 3.80e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 3.80e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 665399496   2821 ECRHNQFAC-DKTCIPASWQCDGKSDCEDGSDE 2852
Cdd:smart00192    1 TCPPGEFQCdNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2701-2733 4.07e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 4.07e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 665399496 2701 PDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMC 2733
Cdd:cd00112     3 PNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3004-3035 7.61e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.36  E-value: 7.61e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 3004 DDFRCKNGACIHADLLCDRRNDCADFSDEELC 3035
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3676-3707 7.93e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 7.93e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3676 CSESEFRCGTGKCIKHNYRCDGEIHCDDNSDE 3707
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 100-137 8.32e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.97  E-value: 8.32e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 665399496  100 CNEGQFRCGvSRHCIPNNWLCDGEFDCgkGDISDELNC 137
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDC--GDGSDEENC 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
3909-4122 1.26e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.77  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 3909 LASGPDQILLLASEQEFRFILPAKQEGTTVVGFFQTDSLKIDVFDILIRPKDTLLFWIDSHHGKVHTMKIATPHVEGTgv 3988
Cdd:COG3391    28 LGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVAT-- 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 3989 rvrrdlkeltafnIPELDDPKSLAVDWISQRVYIIDSRHNQILATDIEGKKYISLVSTGMNPTDIVLEPESRIMIWSTLE 4068
Cdd:COG3391   106 -------------IPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSG 172

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 665399496 4069 NG---ILVASLDGSNKKSLVERDVG-WPISLSMDYPTGRLYWADYRKGTieTCRLNGK 4122
Cdd:COG3391   173 SNtvsVIVSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT--SNGGSNT 228
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2700-2733 1.46e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.63  E-value: 1.46e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 665399496  2700 MPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMC 2733
Cdd:pfam00057    4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3473-3504 1.64e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 1.64e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3473 CEPGQYQCANKKCTHPSNLCDGINQCGDGSDE 3504
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1507-1541 2.48e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 2.48e-06
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 665399496   1507 GWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEH 1541
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3833-3865 2.52e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.86  E-value: 2.52e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 665399496   3833 KCRHDQFQCENDDCISKAFRCDGQYNCVDGSDE 3865
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 791-826 2.98e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 2.98e-06
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 665399496    791 MQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGR 826
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3833-3868 3.19e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.47  E-value: 3.19e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 665399496  3833 KCRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNC 3868
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
3077-3115 3.79e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 3.79e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 665399496   3077 DIDECDEQQPCSQ--TCINTYGSYKCLCAKGYalVDHHTCK 3115
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY--TDGRNCE 39
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3432-3464 5.05e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 5.05e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 665399496 3432 CTAAHFECVNtYKCIPFYWRCDTQDDCGDGSDE 3464
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3432-3464 5.91e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 5.91e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 665399496   3432 CTAAHFECVNTyKCIPFYWRCDTQDDCGDGSDE 3464
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1427-1588 6.35e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.85  E-value: 6.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 1427 GKNLYWIDSNLDQIEVAKL-NGSFRRTLIAGnmESPRAIALDPREGLLFWTDWDDNSPRIerasMSGDGRRMISTswqLS 1505
Cdd:COG3391    79 GRRLYVANSGSGRVSVIDLaTGKVVATIPVG--GGPRGLAVDPDGGRLYVADSGNGRVSV----IDTATGKVVAT---IP 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 1506 AG-WPNGLTLDYTQKRVYWVDAKSDSISS--TMYDGSEHHVVLRNKeILSHPFAISV--FENYVYWTDWRTTsviRANKW 1580
Cdd:COG3391   150 VGaGPHGIAVDPDGKRLYVANSGSNTVSVivSVIDTATGKVVATIP-VGGGPVGVAVspDGRRLYVANRGSN---TSNGG 225


                  ....*...
gi 665399496 1581 NGsDVQVL 1588
Cdd:COG3391   226 SN-TVSVI 232
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2963-2989 9.84e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.93  E-value: 9.84e-06
                            10        20
                    ....*....|....*....|....*..
gi 665399496   2963 HQCQDGLCIFKNQTCDGKPDCGDGSDE 2989
Cdd:smart00192    7 FQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3473-3507 1.18e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.93  E-value: 1.18e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 665399496  3473 CEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNC 3507
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2822-2852 1.34e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.93  E-value: 1.34e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665399496  2822 CRHNQFAC-DKTCIPASWQCDGKSDCEDGSDE 2852
Cdd:pfam00057    3 CSPNEFQCgSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3077-3106 1.35e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 1.35e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 3077 DIDECDEQQPCS--QTCINTYGSYKCLCAKGY 3106
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGY 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2747-2776 1.48e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.50  E-value: 1.48e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 665399496 2747 HCGNSTiCIMPRWRCDGDPDCPDGTDELDC 2776
Cdd:cd00112     7 RCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2912-2943 1.54e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.55  E-value: 1.54e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   2912 CPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDE 2943
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
60-92 1.66e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 1.66e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 665399496    60 PCPASYFTCNDGFCIPMRWKCDSKADCPDMSDE 92
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2963-2989 1.82e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.50  E-value: 1.82e-05
                          10        20
                  ....*....|....*....|....*..
gi 665399496 2963 HQCQDGLCIFKNQTCDGKPDCGDGSDE 2989
Cdd:cd00112     6 FRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 99-134 1.82e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.16  E-value: 1.82e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 665399496     99 KCNEGQFRCGvSRHCIPNNWLCDGEFDCGKGdiSDE 134
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDG--SDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2701-2730 2.47e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.78  E-value: 2.47e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 665399496   2701 PDMFRCGSGECIPRKFLCDSLKDCRDFSDE 2730
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 446-487 2.69e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 2.69e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 665399496    446 VLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDYEGRNR 487
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2861-2890 3.32e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.39  E-value: 3.32e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 665399496   2861 CRPHLFQCKSsGRCIPQKWVCDGEKDCPSG 2890
Cdd:smart00192    2 CPPGEFQCDN-GRCIPSSWVCDGVDDCGDG 30
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1263-1291 3.68e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.39  E-value: 3.68e-05
                           10        20
                   ....*....|....*....|....*....
gi 665399496  1263 CSHRCHNTPEGYICSCPDHLYLQPNGKRC 1291
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2604-2635 4.16e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 4.16e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 2604 CGLSQYNCHSGECIPLELTCDNVTHCADGSDE 2635
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2861-2890 4.20e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 4.20e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 665399496 2861 CRPHLFQCKSsGRCIPQKWVCDGEKDCPSG 2890
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDG 29
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2859-2890 4.56e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.39  E-value: 4.56e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665399496  2859 RPCRPHLFQCKSsGRCIPQKWVCDGEKDCPSG 2890
Cdd:pfam00057    1 STCSPNEFQCGS-GECIPRSWVCDGDPDCGDG 31
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3792-3823 4.63e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 4.63e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3792 CHANAFKCRNQLCVRNSALCDGINDCGENEDE 3823
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2604-2635 4.68e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 4.68e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   2604 CGLSQYNCHSGECIPLELTCDNVTHCADGSDE 2635
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3207-3246 4.82e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 43.30  E-value: 4.82e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 665399496  3207 NLYWCDKGLD-TIEVSQLDGKYRKVLINEYLREPRGIALHP 3246
Cdd:pfam00058    2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3002-3032 5.16e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 5.16e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 665399496   3002 GTDDFRCKNGACIHADLLCDRRNDCADFSDE 3032
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-257 5.26e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 5.26e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 665399496    220 DYDECSEPGTCDQ--VCRNTPGSYECSCVSGYakTKGNRC 257
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY--TDGRNC 38
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3004-3035 7.90e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.62  E-value: 7.90e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665399496  3004 DDFRCKNGACIHADLLCDRRNDCADFSDEELC 3035
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
99-137 1.06e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.24  E-value: 1.06e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 665399496    99 KCNEGQFRCGvSRHCIPNNWLCDGEFDCGKGdiSDELNC 137
Cdd:pfam00057    2 TCSPNEFQCG-SGECIPRSWVCDGDPDCGDG--SDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2912-2943 1.35e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.35e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 2912 CPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDE 2943
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2747-2776 1.37e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.85  E-value: 1.37e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 665399496  2747 HCGNSTiCIMPRWRCDGDPDCPDGTDELDC 2776
Cdd:pfam00057    9 QCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3792-3825 1.43e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.43e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 665399496 3792 CHANAFKCRNQLCVRNSALCDGINDCGENEDESD 3825
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1542-1585 1.74e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.82  E-value: 1.74e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 665399496   1542 HVVLRNKeiLSHP--FAISVFENYVYWTDWRtTSVIRANKWNGSDV 1585
Cdd:smart00135    1 RTLLSSG--LGHPngLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1031-1066 1.83e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 1.83e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 665399496   1031 TCNSNEFTChKSGRCIQLTWVNDGVVDCGpdDDSDE 1066
Cdd:smart00192    1 TCPPGEFQC-DNGRCIPSSWVCDGVDDCG--DGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2643-2676 2.35e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.08  E-value: 2.35e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 665399496  2643 RQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDE 2676
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 2056-2126 3.18e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 46.04  E-value: 3.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 2056 GIAIDwVAGNIYWSDTKRNIIEVARLDGSHRYVVVSNLE--KPTALAVDPLQGLLFYV-TQQH-----------IGRVGL 2121
Cdd:cd14962    61 GVAID-ANGNLYVSDAELGKVFVFDRDGKFLRAIGAGALfkRPTGIAVDPAGKRLYVVdTLAHkvkvfdldgrlLFDIGK 139


                  ....*
gi 665399496 2122 DGSQP 2126
Cdd:cd14962   140 RGSGP 144
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 220-257 3.73e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 3.73e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 665399496  220 DYDECSEPGTCD--QVCRNTPGSYECSCVSGYaktKGNRC 257
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGY---TGRNC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2747-2773 3.82e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.69  E-value: 3.82e-04
                            10        20
                    ....*....|....*....|....*..
gi 665399496   2747 HCGNSTiCIMPRWRCDGDPDCPDGTDE 2773
Cdd:smart00192    8 QCDNGR-CIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2243-2277 5.27e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 5.27e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 665399496  2243 CAHSNGACEQLCLFNGTSAVCACA-HSRLASDGYSC 2277
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPeGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1471-1516 1.03e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.45  E-value: 1.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 665399496  1471 GLLFWTDWdDNSPRIERASMSGDGRRMISTSwqlSAGWPNGLTLDY 1516
Cdd:pfam00058    1 GRLYWTDS-SLRASISSADLNGSDRKTLFTD---DLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3432-3466 1.15e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.15  E-value: 1.15e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 665399496  3432 CTAAHFECVNTyKCIPFYWRCDTQDDCGDGSDEPE 3466
Cdd:pfam00057    3 CSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEEN 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 423-461 1.21e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.45  E-value: 1.21e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 665399496   423 GFMFYTDWT--PSLSRSLLDGSNRTVLVTDQVYHPSSVTLD 461
Cdd:pfam00058    1 GRLYWTDSSlrASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1768-1812 1.63e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.12  E-value: 1.63e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 665399496   1768 IIHEDLNMVDSIVLDPANGKMYWihsaSDGSMSQLEQSNLDGSSR 1812
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYW----TDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1078-1108 1.86e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 38.73  E-value: 1.86e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 665399496 1078 EFDCNNGRCRQFADVCDGIDNCGNNADEMEC 1108
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3328-3363 2.20e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 2.20e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 665399496   3328 NLHHIFAIAV--WEGHIYWSDWETKSIEYCSIfNGQNC 3363
Cdd:smart00135    7 GLGHPNGLAVdwIEGRLYWTDWGLDVIEVANL-DGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2404-2445 2.33e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 2.33e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 665399496   2404 KVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSpcIQRSYLTG 2445
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDV--IEVANLDG 40
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4389-4424 2.39e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 2.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 665399496 4389 IDECADF--CKNGGSCvISTKGQRQCKCPSGYFGEHCE 4424
Cdd:cd00054     2 IDECASGnpCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4005-4038 2.87e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 2.87e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 665399496   4005 LDDPKSLAVDWISQRVYIIDSRHNQILATDIEGK 4038
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1076-1105 3.07e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 38.00  E-value: 3.07e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 665399496   1076 CPEFDCNNGRCRQFADVCDGIDNCGNNADE 1105
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 404-444 3.16e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 3.16e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 665399496    404 RVILQQVDPLSSLDLDPTKGFMFYTDW-TPSLSRSLLDGSNR 444
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWgLDVIEVANLDGTNR 43
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 4003-4132 3.38e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 42.66  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 4003 PELDDPKSLAVDWisQRVYIIDSRHNQILATDIEGKKYISLVSTGMN------PTDIVLEPESRIMIWSTLENGILVASL 4076
Cdd:cd14963     7 DPLNKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGpgefkyPYGIAVDSDGNIYVADLYNGRIQVFDP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 665399496 4077 DGSNKKSLVERDVGWPIS--LSMDYPTGRLYWADYRKGTIETCRLNGKdrnVVRRFGN 4132
Cdd:cd14963    85 DGKFLKYFPEKKDRVKLIspAGLAIDDGKLYVSDVKKHKVIVFDLEGK---LLLEFGK 139
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3087-3114 3.77e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.99  E-value: 3.77e-03
                           10        20
                   ....*....|....*....|....*....
gi 665399496  3087 CSQTCINTYGSYKCLCAKGYALV-DHHTC 3114
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1613-1650 3.77e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.99  E-value: 3.77e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 665399496  1613 CGENNGGCSHLCLLSGrGTFKCECPHVMRLDPaNERNC 1650
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQD-DGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4360-4388 4.15e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 4.15e-03
                          10        20
                  ....*....|....*....|....*....
gi 665399496 4360 CENGGICRETLtGTPQCECPDGFTGKRCE 4388
Cdd:cd00054    11 CQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2086-2125 4.17e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.97  E-value: 4.17e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 665399496   2086 RYVVVSNLEKPTALAVDPLQGLLFYV--TQQHIGRVGLDGSQ 2125
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTdwGLDVIEVANLDGTN 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
3036-3065 4.48e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 4.48e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3036 NVNECLIPDICEH--ECEDKVVGYQCHCRPGY 3065
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2963-2989 5.31e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.61  E-value: 5.31e-03
                           10        20
                   ....*....|....*....|....*..
gi 665399496  2963 HQCQDGLCIFKNQTCDGKPDCGDGSDE 2989
Cdd:pfam00057    8 FQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2911-2947 5.86e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.23  E-value: 5.86e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 665399496  2911 DCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEyEGC 2947
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE-ENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2602-2635 6.03e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.23  E-value: 6.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 665399496  2602 TSCGLSQYNCHSGECIPLELTCDNVTHCADGSDE 2635
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1032-1066 6.31e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.19  E-value: 6.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 1032 CNSNEFTChKSGRCIQLTWVNDGVVDCGpdDDSDE 1066
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCG--DGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1725-1763 7.67e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.20  E-value: 7.67e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 665399496   1725 IINTNIEKPYGFAVDWIARNMYFSSgQIKCNILASNLKG 1763
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTD-WGLDVIEVANLDG 40
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4355-4386 8.10e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 8.10e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665399496  4355 CRNLTCENGGICRETLtGTPQCECPDGFTGKR 4386
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1165-1200 8.23e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 36.80  E-value: 8.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 665399496 1165 CAPLEFACMfPFECIPDFLRCDGISHCFDKTDEFNC 1200
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2784-2818 9.74e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 62.22  E-value: 9.74e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 2784 CDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINC 2818
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3637-3671 2.30e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.07  E-value: 2.30e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3637 CDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNC 3671
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2449-2491 3.23e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 3.23e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665399496   2449 EVIIKTDIKMPNALTLDLEQQKLYWADARLDKIERTNYDGSNR 2491
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3186-3228 1.46e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.15  E-value: 1.46e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665399496   3186 QTLHQAMLKNPDGLAVDWVAKNLYWCDKGLDTIEVSQLDGKYR 3228
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1451-1495 1.93e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 1.93e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 665399496   1451 RTLIAGNMESPRAIALDPREGLLFWTDWDdnSPRIERASMSGDGR 1495
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG--LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2052-2086 4.14e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 4.14e-10
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 665399496   2052 DWLGGIAIDWVAGNIYWSDTKRNIIEVARLDGSHR 2086
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2784-2815 4.37e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.26  E-value: 4.37e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   2784 CDPGQFRCASGNCIAGSWHCDGEKDCPDGSDE 2815
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3636-3668 4.45e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 57.26  E-value: 4.45e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 665399496   3636 TCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDE 3668
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3636-3671 4.90e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.26  E-value: 4.90e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 665399496  3636 TCDPTYFKCNNSKCIPGRWRCDYENDCGDGSDELNC 3671
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3750-3782 7.55e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 7.55e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 665399496   3750 TCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDE 3782
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1408-1450 9.99e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.46  E-value: 9.99e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665399496   1408 EAVIHSGLSTTEGLAVDWVGKNLYWIDSNLDQIEVAKLNGSFR 1450
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2784-2818 1.23e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.10  E-value: 1.23e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 665399496  2784 CDPGQFRCASGNCIAGSWHCDGEKDCPDGSDEINC 2818
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3556-3590 1.76e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.76e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3556 CKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDEANC 3590
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3751-3782 1.89e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 1.89e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 3751 CHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDE 3782
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4082-4124 4.73e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 4.73e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665399496   4082 KSLVERDVGWPISLSMDYPTGRLYWADYRKGTIETCRLNGKDR 4124
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3595-3626 1.18e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.41  E-value: 1.18e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3595 CGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDE 3626
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3676-3710 1.55e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 1.55e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3676 CSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINC 3710
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3556-3590 1.87e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 1.87e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 665399496  3556 CKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDEANC 3590
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3593-3626 1.90e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 1.90e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 665399496  3593 VSCGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDE 3626
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3473-3507 2.26e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 2.26e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3473 CEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNC 3507
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3595-3626 2.45e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 2.45e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 3595 CGPNDFQCDSGRCIPLAWRCDDDHDCPNGEDE 3626
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3834-3868 2.52e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 2.52e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 3834 CRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNC 3868
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3249-3288 2.80e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.55  E-value: 2.80e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 665399496  3249 QHIFWSDWGDSPHIGKAGMDGSNPKMIIRDGLGWPNALTI 3288
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAV 40
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1429-1468 3.37e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 52.16  E-value: 3.37e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 665399496  1429 NLYWIDSNLDQ-IEVAKLNGSFRRTLIAGNMESPRAIALDP 1468
Cdd:pfam00058    2 RLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2645-2676 3.55e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 3.55e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 2645 CPETHFMCQNHRCIPKEHKCDGEQQCGDGSDE 2676
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3556-3587 3.81e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 3.81e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3556 CKKDQFQCGNNRCMPFVWVCDGDIDCPDKSDE 3587
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2644-2676 4.91e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.48  E-value: 4.91e-08
                            10        20        30
                    ....*....|....*....|....*....|...
gi 665399496   2644 QCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDE 2676
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3229-3271 6.09e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 6.09e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665399496   3229 KVLINEYLREPRGIALHPYQQHIFWSDWGdSPHIGKAGMDGSN 3271
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTN 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 61-92 9.75e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 9.75e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496     61 CPASYFTCNDGFCIPMRWKCDSKADCPDMSDE 92
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 61-92 1.44e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.44e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496   61 CPASYFTCNDGFCIPMRWKCDSKADCPDMSDE 92
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3750-3782 1.62e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 1.62e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 665399496  3750 TCHSDHFSCGNGKCIMSRWKCDGWDDCLDGSDE 3782
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2822-2852 1.93e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 1.93e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 2822 CRHNQFAC-DKTCIPASWQCDGKSDCEDGSDE 2852
Cdd:cd00112     1 CPPNEFRCaNGRCIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3273-3314 2.16e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 2.16e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 665399496   3273 KMIIRDGLGWPNALTISFETQQLFWGDAREDTISVSDLDGNH 3314
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3674-3710 3.59e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 3.59e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 665399496  3674 RNCSESEFRCGTGKCIKHNYRCDGEIHCDDNSDEINC 3710
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2064-2103 3.68e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 3.68e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 665399496  2064 GNIYWSDTK-RNIIEVARLDGSHRYVVVS-NLEKPTALAVDP 2103
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTdDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2821-2852 3.80e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.17  E-value: 3.80e-07
                            10        20        30
                    ....*....|....*....|....*....|...
gi 665399496   2821 ECRHNQFAC-DKTCIPASWQCDGKSDCEDGSDE 2852
Cdd:smart00192    1 TCPPGEFQCdNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2701-2733 4.07e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.13  E-value: 4.07e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 665399496 2701 PDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMC 2733
Cdd:cd00112     3 PNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3004-3035 7.61e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 48.36  E-value: 7.61e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 3004 DDFRCKNGACIHADLLCDRRNDCADFSDEELC 3035
Cdd:cd00112     4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3676-3707 7.93e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 7.93e-07
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3676 CSESEFRCGTGKCIKHNYRCDGEIHCDDNSDE 3707
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 100-137 8.32e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.97  E-value: 8.32e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 665399496  100 CNEGQFRCGvSRHCIPNNWLCDGEFDCgkGDISDELNC 137
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDC--GDGSDEENC 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
3909-4122 1.26e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.77  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 3909 LASGPDQILLLASEQEFRFILPAKQEGTTVVGFFQTDSLKIDVFDILIRPKDTLLFWIDSHHGKVHTMKIATPHVEGTgv 3988
Cdd:COG3391    28 LGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVAT-- 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 3989 rvrrdlkeltafnIPELDDPKSLAVDWISQRVYIIDSRHNQILATDIEGKKYISLVSTGMNPTDIVLEPESRIMIWSTLE 4068
Cdd:COG3391   106 -------------IPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSG 172

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 665399496 4069 NG---ILVASLDGSNKKSLVERDVG-WPISLSMDYPTGRLYWADYRKGTieTCRLNGK 4122
Cdd:COG3391   173 SNtvsVIVSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT--SNGGSNT 228
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2700-2733 1.46e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.63  E-value: 1.46e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 665399496  2700 MPDMFRCGSGECIPRKFLCDSLKDCRDFSDEKMC 2733
Cdd:pfam00057    4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3473-3504 1.64e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 47.24  E-value: 1.64e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3473 CEPGQYQCANKKCTHPSNLCDGINQCGDGSDE 3504
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1507-1541 2.48e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 2.48e-06
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 665399496   1507 GWPNGLTLDYTQKRVYWVDAKSDSISSTMYDGSEH 1541
Cdd:smart00135    9 GHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3833-3865 2.52e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.86  E-value: 2.52e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 665399496   3833 KCRHDQFQCENDDCISKAFRCDGQYNCVDGSDE 3865
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 791-826 2.98e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 2.98e-06
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 665399496    791 MQWPRSLDVDRRTKELYWCDIRLSTIELMRLDGTGR 826
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3833-3868 3.19e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.47  E-value: 3.19e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 665399496  3833 KCRHDQFQCENDDCISKAFRCDGQYNCVDGSDEMNC 3868
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
3077-3115 3.79e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 3.79e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 665399496   3077 DIDECDEQQPCSQ--TCINTYGSYKCLCAKGYalVDHHTCK 3115
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY--TDGRNCE 39
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3432-3464 5.05e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 5.05e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 665399496 3432 CTAAHFECVNtYKCIPFYWRCDTQDDCGDGSDE 3464
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3432-3464 5.91e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 5.91e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 665399496   3432 CTAAHFECVNTyKCIPFYWRCDTQDDCGDGSDE 3464
Cdd:smart00192    2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1427-1588 6.35e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.85  E-value: 6.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 1427 GKNLYWIDSNLDQIEVAKL-NGSFRRTLIAGnmESPRAIALDPREGLLFWTDWDDNSPRIerasMSGDGRRMISTswqLS 1505
Cdd:COG3391    79 GRRLYVANSGSGRVSVIDLaTGKVVATIPVG--GGPRGLAVDPDGGRLYVADSGNGRVSV----IDTATGKVVAT---IP 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 1506 AG-WPNGLTLDYTQKRVYWVDAKSDSISS--TMYDGSEHHVVLRNKeILSHPFAISV--FENYVYWTDWRTTsviRANKW 1580
Cdd:COG3391   150 VGaGPHGIAVDPDGKRLYVANSGSNTVSVivSVIDTATGKVVATIP-VGGGPVGVAVspDGRRLYVANRGSN---TSNGG 225


                  ....*...
gi 665399496 1581 NGsDVQVL 1588
Cdd:COG3391   226 SN-TVSVI 232
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2963-2989 9.84e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.93  E-value: 9.84e-06
                            10        20
                    ....*....|....*....|....*..
gi 665399496   2963 HQCQDGLCIFKNQTCDGKPDCGDGSDE 2989
Cdd:smart00192    7 FQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3473-3507 1.18e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.93  E-value: 1.18e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 665399496  3473 CEPGQYQCANKKCTHPSNLCDGINQCGDGSDELNC 3507
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2822-2852 1.34e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.93  E-value: 1.34e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665399496  2822 CRHNQFAC-DKTCIPASWQCDGKSDCEDGSDE 2852
Cdd:pfam00057    3 CSPNEFQCgSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3077-3106 1.35e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 1.35e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 3077 DIDECDEQQPCS--QTCINTYGSYKCLCAKGY 3106
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGY 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2747-2776 1.48e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.50  E-value: 1.48e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 665399496 2747 HCGNSTiCIMPRWRCDGDPDCPDGTDELDC 2776
Cdd:cd00112     7 RCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2912-2943 1.54e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.55  E-value: 1.54e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   2912 CPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDE 2943
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
60-92 1.66e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 1.66e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 665399496    60 PCPASYFTCNDGFCIPMRWKCDSKADCPDMSDE 92
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2963-2989 1.82e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 44.50  E-value: 1.82e-05
                          10        20
                  ....*....|....*....|....*..
gi 665399496 2963 HQCQDGLCIFKNQTCDGKPDCGDGSDE 2989
Cdd:cd00112     6 FRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 99-134 1.82e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.16  E-value: 1.82e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 665399496     99 KCNEGQFRCGvSRHCIPNNWLCDGEFDCGKGdiSDE 134
Cdd:smart00192    1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDG--SDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2701-2730 2.47e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.78  E-value: 2.47e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 665399496   2701 PDMFRCGSGECIPRKFLCDSLKDCRDFSDE 2730
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 446-487 2.69e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 2.69e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 665399496    446 VLVTDQVYHPSSVTLDLANELVYWIDIYKDEVNRVDYEGRNR 487
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2861-2890 3.32e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.39  E-value: 3.32e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 665399496   2861 CRPHLFQCKSsGRCIPQKWVCDGEKDCPSG 2890
Cdd:smart00192    2 CPPGEFQCDN-GRCIPSSWVCDGVDDCGDG 30
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1263-1291 3.68e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.39  E-value: 3.68e-05
                           10        20
                   ....*....|....*....|....*....
gi 665399496  1263 CSHRCHNTPEGYICSCPDHLYLQPNGKRC 1291
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2604-2635 4.16e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 4.16e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 2604 CGLSQYNCHSGECIPLELTCDNVTHCADGSDE 2635
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2861-2890 4.20e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 4.20e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 665399496 2861 CRPHLFQCKSsGRCIPQKWVCDGEKDCPSG 2890
Cdd:cd00112     1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDG 29
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2859-2890 4.56e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.39  E-value: 4.56e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665399496  2859 RPCRPHLFQCKSsGRCIPQKWVCDGEKDCPSG 2890
Cdd:pfam00057    1 STCSPNEFQCGS-GECIPRSWVCDGDPDCGDG 31
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3792-3823 4.63e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 4.63e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3792 CHANAFKCRNQLCVRNSALCDGINDCGENEDE 3823
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2604-2635 4.68e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 4.68e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   2604 CGLSQYNCHSGECIPLELTCDNVTHCADGSDE 2635
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 3207-3246 4.82e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 43.30  E-value: 4.82e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 665399496  3207 NLYWCDKGLD-TIEVSQLDGKYRKVLINEYLREPRGIALHP 3246
Cdd:pfam00058    2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3002-3032 5.16e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.01  E-value: 5.16e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 665399496   3002 GTDDFRCKNGACIHADLLCDRRNDCADFSDE 3032
Cdd:smart00192    3 PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-257 5.26e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 5.26e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 665399496    220 DYDECSEPGTCDQ--VCRNTPGSYECSCVSGYakTKGNRC 257
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY--TDGRNC 38
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1384-1530 7.49e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.77  E-value: 7.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 1384 IYWTDVIDDKIYRGHLVGeslRNVEAVIHSGlSTTEGLAVDWVGKNLYWIDSNLDQI-EVAKLNGSFRRTLIAGNmeSPR 1462
Cdd:COG3391    82 LYVANSGSGRVSVIDLAT---GKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVsVIDTATGKVVATIPVGA--GPH 155

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665399496 1463 AIALDPREGLLFWTDWDDNspRIER--ASMSGDGRRMISTswqLSAG-WPNGLTLDYTQKRVYWVDAKSDS 1530
Cdd:COG3391   156 GIAVDPDGKRLYVANSGSN--TVSVivSVIDTATGKVVAT---IPVGgGPVGVAVSPDGRRLYVANRGSNT 221
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3004-3035 7.90e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.62  E-value: 7.90e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665399496  3004 DDFRCKNGACIHADLLCDRRNDCADFSDEELC 3035
Cdd:pfam00057    6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
99-137 1.06e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 42.24  E-value: 1.06e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 665399496    99 KCNEGQFRCGvSRHCIPNNWLCDGEFDCGKGdiSDELNC 137
Cdd:pfam00057    2 TCSPNEFQCG-SGECIPRSWVCDGDPDCGDG--SDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2912-2943 1.35e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.35e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 665399496 2912 CPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDE 2943
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2747-2776 1.37e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.85  E-value: 1.37e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 665399496  2747 HCGNSTiCIMPRWRCDGDPDCPDGTDELDC 2776
Cdd:pfam00057    9 QCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 3792-3825 1.43e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.43e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 665399496 3792 CHANAFKCRNQLCVRNSALCDGINDCGENEDESD 3825
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1542-1585 1.74e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.82  E-value: 1.74e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 665399496   1542 HVVLRNKeiLSHP--FAISVFENYVYWTDWRtTSVIRANKWNGSDV 1585
Cdd:smart00135    1 RTLLSSG--LGHPngLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1031-1066 1.83e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 1.83e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 665399496   1031 TCNSNEFTChKSGRCIQLTWVNDGVVDCGpdDDSDE 1066
Cdd:smart00192    1 TCPPGEFQC-DNGRCIPSSWVCDGVDDCG--DGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2643-2676 2.35e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.08  E-value: 2.35e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 665399496  2643 RQCPETHFMCQNHRCIPKEHKCDGEQQCGDGSDE 2676
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 2056-2126 3.18e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 46.04  E-value: 3.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 2056 GIAIDwVAGNIYWSDTKRNIIEVARLDGSHRYVVVSNLE--KPTALAVDPLQGLLFYV-TQQH-----------IGRVGL 2121
Cdd:cd14962    61 GVAID-ANGNLYVSDAELGKVFVFDRDGKFLRAIGAGALfkRPTGIAVDPAGKRLYVVdTLAHkvkvfdldgrlLFDIGK 139


                  ....*
gi 665399496 2122 DGSQP 2126
Cdd:cd14962   140 RGSGP 144
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 220-257 3.73e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 3.73e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 665399496  220 DYDECSEPGTCD--QVCRNTPGSYECSCVSGYaktKGNRC 257
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGY---TGRNC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 2747-2773 3.82e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.69  E-value: 3.82e-04
                            10        20
                    ....*....|....*....|....*..
gi 665399496   2747 HCGNSTiCIMPRWRCDGDPDCPDGTDE 2773
Cdd:smart00192    8 QCDNGR-CIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2243-2277 5.27e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 5.27e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 665399496  2243 CAHSNGACEQLCLFNGTSAVCACA-HSRLASDGYSC 2277
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPeGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1471-1516 1.03e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.45  E-value: 1.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 665399496  1471 GLLFWTDWdDNSPRIERASMSGDGRRMISTSwqlSAGWPNGLTLDY 1516
Cdd:pfam00058    1 GRLYWTDS-SLRASISSADLNGSDRKTLFTD---DLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
3432-3466 1.15e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.15  E-value: 1.15e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 665399496  3432 CTAAHFECVNTyKCIPFYWRCDTQDDCGDGSDEPE 3466
Cdd:pfam00057    3 CSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDEEN 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 423-461 1.21e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.45  E-value: 1.21e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 665399496   423 GFMFYTDWT--PSLSRSLLDGSNRTVLVTDQVYHPSSVTLD 461
Cdd:pfam00058    1 GRLYWTDSSlrASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1768-1812 1.63e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.12  E-value: 1.63e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 665399496   1768 IIHEDLNMVDSIVLDPANGKMYWihsaSDGSMSQLEQSNLDGSSR 1812
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYW----TDWGLDVIEVANLDGTNR 43
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 218-250 1.84e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.14  E-value: 1.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 665399496  218 CVDYDECSE-PGTCDQVCRNTPGSYECSCVSGYA 250
Cdd:cd01475   184 CVVPDLCATlSHVCQQVCISTPGSYLCACTEGYA 217
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1078-1108 1.86e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 38.73  E-value: 1.86e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 665399496 1078 EFDCNNGRCRQFADVCDGIDNCGNNADEMEC 1108
Cdd:cd00112     5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 3328-3363 2.20e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 2.20e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 665399496   3328 NLHHIFAIAV--WEGHIYWSDWETKSIEYCSIfNGQNC 3363
Cdd:smart00135    7 GLGHPNGLAVdwIEGRLYWTDWGLDVIEVANL-DGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2404-2445 2.33e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.74  E-value: 2.33e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 665399496   2404 KVLSLREDDKPRGIAVEPCLGMIYWTNWNEGSpcIQRSYLTG 2445
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDV--IEVANLDG 40
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4389-4424 2.39e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 2.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 665399496 4389 IDECADF--CKNGGSCvISTKGQRQCKCPSGYFGEHCE 4424
Cdd:cd00054     2 IDECASGnpCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 4005-4038 2.87e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 2.87e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 665399496   4005 LDDPKSLAVDWISQRVYIIDSRHNQILATDIEGK 4038
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1076-1105 3.07e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 38.00  E-value: 3.07e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 665399496   1076 CPEFDCNNGRCRQFADVCDGIDNCGNNADE 1105
Cdd:smart00192    4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 404-444 3.16e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 3.16e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 665399496    404 RVILQQVDPLSSLDLDPTKGFMFYTDW-TPSLSRSLLDGSNR 444
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWgLDVIEVANLDGTNR 43
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 4003-4132 3.38e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 42.66  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 4003 PELDDPKSLAVDWisQRVYIIDSRHNQILATDIEGKKYISLVSTGMN------PTDIVLEPESRIMIWSTLENGILVASL 4076
Cdd:cd14963     7 DPLNKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGpgefkyPYGIAVDSDGNIYVADLYNGRIQVFDP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 665399496 4077 DGSNKKSLVERDVGWPIS--LSMDYPTGRLYWADYRKGTIETCRLNGKdrnVVRRFGN 4132
Cdd:cd14963    85 DGKFLKYFPEKKDRVKLIspAGLAIDDGKLYVSDVKKHKVIVFDLEGK---LLLEFGK 139
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 3087-3114 3.77e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.99  E-value: 3.77e-03
                           10        20
                   ....*....|....*....|....*....
gi 665399496  3087 CSQTCINTYGSYKCLCAKGYALV-DHHTC 3114
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1613-1650 3.77e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.99  E-value: 3.77e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 665399496  1613 CGENNGGCSHLCLLSGrGTFKCECPHVMRLDPaNERNC 1650
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQD-DGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4360-4388 4.15e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 4.15e-03
                          10        20
                  ....*....|....*....|....*....
gi 665399496 4360 CENGGICRETLtGTPQCECPDGFTGKRCE 4388
Cdd:cd00054    11 CQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 2086-2125 4.17e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.97  E-value: 4.17e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 665399496   2086 RYVVVSNLEKPTALAVDPLQGLLFYV--TQQHIGRVGLDGSQ 2125
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTdwGLDVIEVANLDGTN 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
3036-3065 4.48e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 4.48e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 665399496   3036 NVNECLIPDICEH--ECEDKVVGYQCHCRPGY 3065
Cdd:smart00179    1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2963-2989 5.31e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.61  E-value: 5.31e-03
                           10        20
                   ....*....|....*....|....*..
gi 665399496  2963 HQCQDGLCIFKNQTCDGKPDCGDGSDE 2989
Cdd:pfam00057    8 FQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2911-2947 5.86e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.23  E-value: 5.86e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 665399496  2911 DCPPPAHLCTSGLCIDSHYVCDGDEDCPGGDDEyEGC 2947
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE-ENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
2602-2635 6.03e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 37.23  E-value: 6.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 665399496  2602 TSCGLSQYNCHSGECIPLELTCDNVTHCADGSDE 2635
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA pfam07645
Calcium-binding EGF domain;
3077-3105 6.16e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 6.16e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665399496  3077 DIDEC-DEQQPCSQ--TCINTYGSYKCLCAKG 3105
Cdd:pfam07645    1 DVDECaTGTHNCPAntVCVNTIGSFECRCPDG 32
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1032-1066 6.31e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 37.19  E-value: 6.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665399496 1032 CNSNEFTChKSGRCIQLTWVNDGVVDCGpdDDSDE 1066
Cdd:cd00112     1 CPPNEFRC-ANGRCIPSSWVCDGEDDCG--DGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1725-1763 7.67e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.20  E-value: 7.67e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 665399496   1725 IINTNIEKPYGFAVDWIARNMYFSSgQIKCNILASNLKG 1763
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTD-WGLDVIEVANLDG 40
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4355-4386 8.10e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 8.10e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 665399496  4355 CRNLTCENGGICRETLtGTPQCECPDGFTGKR 4386
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 4004-4132 8.10e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.54  E-value: 8.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 4004 ELDDPKSLAVDwISQRVYIIDSRHNQILATDIEGKKYISLVSTG------MNPTDIVLEPESRIMIWSTLENGILVASLD 4077
Cdd:cd05819    53 QFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGGSGdgdgefNGPRGIAVDSSGNIYVADTGNHRIQKFDPD 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399496 4078 GSNKKSLVERDVGW-----PISLSMDyPTGRLYWADYRKGTIEtcRLNgKDRNVVRRFGN 4132
Cdd:cd05819   132 GEFLTTFGSGGSGPgqfngPTGVAVD-SDGNIYVADTGNHRIQ--VFD-PDGNFLTTFGS 187
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1165-1200 8.23e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 36.80  E-value: 8.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 665399496 1165 CAPLEFACMfPFECIPDFLRCDGISHCFDKTDEFNC 1200
Cdd:cd00112     1 CPPNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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