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Conserved domains on  [gi|28571676|ref|NP_788658|]
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uncharacterized protein Dmel_CG33098, isoform C [Drosophila melanogaster]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 1001355)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00183 super family cl33171
centrin; Provisional
 85-170 4.04e-13

centrin; Provisional


The actual alignment was detected with superfamily member PTZ00183:

Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 63.94  E-value: 4.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571676   85 ELKEVFSLFDTDCDGLISKDDLRFTYTALGNEPNEQLLEQMMQEAK----EPLDYEAFVRLMSRRTQELDPEDVLLEAWS 160
Cdd:PTZ00183  18 EIREAFDLFDTDGSGTIDPKELKVAMRSLGFEPKKEEIKQMIADVDkdgsGKIDFEEFLDIMTKKLGERDPREEILKAFR 97

                         90
                 ....*....|
gi 28571676  161 KWDDHGTGKI 170
Cdd:PTZ00183  98 LFDDDKTGKI 107
 
Name Accession Description Interval E-value
PTZ00183 PTZ00183
centrin; Provisional
 85-170 4.04e-13

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 63.94  E-value: 4.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571676   85 ELKEVFSLFDTDCDGLISKDDLRFTYTALGNEPNEQLLEQMMQEAK----EPLDYEAFVRLMSRRTQELDPEDVLLEAWS 160
Cdd:PTZ00183  18 EIREAFDLFDTDGSGTIDPKELKVAMRSLGFEPKKEEIKQMIADVDkdgsGKIDFEEFLDIMTKKLGERDPREEILKAFR 97

                         90
                 ....*....|
gi 28571676  161 KWDDHGTGKI 170
Cdd:PTZ00183  98 LFDDDKTGKI 107
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 85-143 1.97e-08

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 49.08  E-value: 1.97e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28571676  85 ELKEVFSLFDTDCDGLISKDDLRFTYTALGNEPNEQLLEQMMQEAKEP----LDYEAFVRLMS 143
Cdd:cd00051   1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDgdgkIDFEEFLELMA 63
EF-hand_6 pfam13405
EF-hand domain;
85-114 9.80e-05

EF-hand domain;


Pssm-ID: 463869 [Multi-domain]  Cd Length: 30  Bit Score: 38.31  E-value: 9.80e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 28571676    85 ELKEVFSLFDTDCDGLISKDDLRFTYTALG 114
Cdd:pfam13405   1 ELREAFKLFDKDGDGKISLEELRKALRSLG 30
EFh smart00054
EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in ...
 85-107 3.49e-03

EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in pairs. Links between disease states and genes encoding EF-hands, particularly the S100 subclass, are emerging. Each motif consists of a 12 residue loop flanked on either side by a 12 residue alpha-helix. EF-hands undergo a conformational change unpon binding calcium ions.


Pssm-ID: 197492 [Multi-domain]  Cd Length: 29  Bit Score: 33.89  E-value: 3.49e-03
                           10        20
                   ....*....|....*....|...
gi 28571676     85 ELKEVFSLFDTDCDGLISKDDLR 107
Cdd:smart00054   1 ELKEAFRLFDKDGDGKIDFEEFK 23
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
64-142 5.14e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 35.92  E-value: 5.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571676  64 PEEMRAddnVAPHELDIAKLAELKEVFSLFDTDCDGLISKDDLRFTYTALG--NEPNEQLLEQMMQEAKEPLDYEAFVRL 141
Cdd:COG5126  52 REEFVA---GMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGvsEEEADELFARLDTDGDGKISFEEFVAA 128


                .
gi 28571676 142 M 142
Cdd:COG5126 129 V 129
 
Name Accession Description Interval E-value
PTZ00183 PTZ00183
centrin; Provisional
 85-170 4.04e-13

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 63.94  E-value: 4.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571676   85 ELKEVFSLFDTDCDGLISKDDLRFTYTALGNEPNEQLLEQMMQEAK----EPLDYEAFVRLMSRRTQELDPEDVLLEAWS 160
Cdd:PTZ00183  18 EIREAFDLFDTDGSGTIDPKELKVAMRSLGFEPKKEEIKQMIADVDkdgsGKIDFEEFLDIMTKKLGERDPREEILKAFR 97

                         90
                 ....*....|
gi 28571676  161 KWDDHGTGKI 170
Cdd:PTZ00183  98 LFDDDKTGKI 107
PTZ00184 PTZ00184
calmodulin; Provisional
 75-170 1.33e-12

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 62.47  E-value: 1.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571676   75 PHELDIAKLAELKEVFSLFDTDCDGLISKDDLRFTYTALGNEPNEQLLEQMMQEAKE----PLDYEAFVRLMSRRTQELD 150
Cdd:PTZ00184   2 ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDAdgngTIDFPEFLTLMARKMKDTD 81

                         90       100
                 ....*....|....*....|
gi 28571676  151 PEDVLLEAWSKWDDHGTGKI 170
Cdd:PTZ00184  82 SEEEIKEAFKVFDRDGNGFI 101
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 85-143 1.97e-08

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 49.08  E-value: 1.97e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28571676  85 ELKEVFSLFDTDCDGLISKDDLRFTYTALGNEPNEQLLEQMMQEAKEP----LDYEAFVRLMS 143
Cdd:cd00051   1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDgdgkIDFEEFLELMA 63
PTZ00184 PTZ00184
calmodulin; Provisional
 85-145 5.61e-08

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 50.15  E-value: 5.61e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28571676   85 ELKEVFSLFDTDCDGLISKDDLRFTYTALGNEPNEQLLEQMMQEA----KEPLDYEAFVRLMSRR 145
Cdd:PTZ00184  85 EIKEAFKVFDRDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREAdvdgDGQINYEEFVKMMMSK 149
EF-hand_6 pfam13405
EF-hand domain;
85-114 9.80e-05

EF-hand domain;


Pssm-ID: 463869 [Multi-domain]  Cd Length: 30  Bit Score: 38.31  E-value: 9.80e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 28571676    85 ELKEVFSLFDTDCDGLISKDDLRFTYTALG 114
Cdd:pfam13405   1 ELREAFKLFDKDGDGKISLEELRKALRSLG 30
EF-hand_7 pfam13499
EF-hand domain pair;
85-129 5.91e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 36.85  E-value: 5.91e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 28571676    85 ELKEVFSLFDTDCDGLISKDDLRFTYTAL--GNEPNEQLLEQMMQEA 129
Cdd:pfam13499   3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLeeGEPLSDEEVEELFKEF 49
EFh smart00054
EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in ...
 85-107 3.49e-03

EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in pairs. Links between disease states and genes encoding EF-hands, particularly the S100 subclass, are emerging. Each motif consists of a 12 residue loop flanked on either side by a 12 residue alpha-helix. EF-hands undergo a conformational change unpon binding calcium ions.


Pssm-ID: 197492 [Multi-domain]  Cd Length: 29  Bit Score: 33.89  E-value: 3.49e-03
                           10        20
                   ....*....|....*....|...
gi 28571676     85 ELKEVFSLFDTDCDGLISKDDLR 107
Cdd:smart00054   1 ELKEAFRLFDKDGDGKIDFEEFK 23
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
64-142 5.14e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 35.92  E-value: 5.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571676  64 PEEMRAddnVAPHELDIAKLAELKEVFSLFDTDCDGLISKDDLRFTYTALG--NEPNEQLLEQMMQEAKEPLDYEAFVRL 141
Cdd:COG5126  52 REEFVA---GMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGvsEEEADELFARLDTDGDGKISFEEFVAA 128


                .
gi 28571676 142 M 142
Cdd:COG5126 129 V 129
EFh_PEF_CAPN13_14 cd16195
Penta-EF hand, calcium binding motifs, found in calpain-13 (CAPN13), calpain-14 (CAPN14), and ...
 82-144 5.40e-03

Penta-EF hand, calcium binding motifs, found in calpain-13 (CAPN13), calpain-14 (CAPN14), and similar proteins; CAPN13, also termed calcium-activated neutral proteinase 13 (CANP 13), a 63.6 kDa calpain large subunit that exhibits a restricted tissue distribution with low levels of expression detected only in human testis and lung. In calpain family, CAPN13 is most closely related to calpain-14 (CAPN14). CAPN14, also termed calcium-activated neutral proteinase 14 (CANP 14), is a 76.7 kDa calpain large subunit that is most highly expressed in the oesophagus. Its expression and calpain activity can be induced by IL-13. Both CAPN13 and CAPN14 contain a calpain cysteine protease (CysPc) domain, a C2-domain-like (C2L) domain, and a C-terminal Ca2+-binding penta-EF-hand (PEF) domain.


Pssm-ID: 320070 [Multi-domain]  Cd Length: 168  Bit Score: 36.03  E-value: 5.40e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28571676  82 KLAELKEVFSLFDTDCDGLISKDDLRFTYTALGNEPNEQLLEQMM---QEAKEPLDYEAFVRLMSR 144
Cdd:cd16195  71 KLRKYKDIFQKADVSKSGFLSLSELRNAIQAAGIRVSDDLLNLMAlryGDSSGRISFESFICLMLR 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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