RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 306 PRIVVDCCDLIEQKYRRstqpIEGIYRQCGDYNKIQTLRFSIDANDYDSLRQpDVDIHTLTGVLKLFLREIKSPLVRVNE 385
Cdd:cd00159   1 PLIIEKCIEYLEKNGLN----TEGIFRVSGSASKIEELKKKFDRGEDIDDLE-DYDVHDVASLLKLYLRELPEPLIPFEL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 386 AKTFIgqpNQWLLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRITKVPLQ-QISAETLSISVTPSIFHtvpqgvHM 464
Cdd:cd00159  76 YDEFI---ELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVnKMTASNLAIVFAPTLLR------PP 146

                       170       180
                ....*....|....*....|...
gi 45552129 465 QDIQQLLREGETLADCVKLMIEY 487
Cdd:cd00159 147 DSDDELLEDIKKLNEIVEFLIEN 169

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 306 PRIVVDCCDLIEQKYRRstqpIEGIYRQCGDYNKIQTLRFSIDANDYDSLRQpDVDIHTLTGVLKLFLREIKSPLVRVNE 385
Cdd:cd00159   1 PLIIEKCIEYLEKNGLN----TEGIFRVSGSASKIEELKKKFDRGEDIDDLE-DYDVHDVASLLKLYLRELPEPLIPFEL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 386 AKTFIgqpNQWLLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRITKVPLQ-QISAETLSISVTPSIFHtvpqgvHM 464
Cdd:cd00159  76 YDEFI---ELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVnKMTASNLAIVFAPTLLR------PP 146

                       170       180
                ....*....|....*....|...
gi 45552129 465 QDIQQLLREGETLADCVKLMIEY 487
Cdd:cd00159 147 DSDDELLEDIKKLNEIVEFLIEN 169

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129    303 RTVPRIVVDCCDLIEQKYRRStqpiEGIYRQCGDYNKIQTLRFSIDANDYDSLRQPDVDIHTLTGVLKLFLREIKSPLVR 382
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDT----EGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLIT 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129    383 VNEAKTFIGQPNqwlLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRITKVPLQ-QISAETLSISVTPSIFHtvPQG 461
Cdd:smart00324  77 YELYEEFIEAAK---LEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEEnKMTARNLAIVFGPTLLR--PPD 151

                          170       180
                   ....*....|....*....|....*..
gi 45552129    462 VHMQDIQQLLRegetLADCVKLMIEYQ 488
Cdd:smart00324 152 GEVASLKDIRH----QNTVIEFLIENA 174

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 306 PRIVVDCCDLIEQKYRRstqpIEGIYRQCGDYNKIQTLRFSIDANDYDSLRQpDVDIHTLTGVLKLFLREIKSPLVRVNE 385
Cdd:cd00159   1 PLIIEKCIEYLEKNGLN----TEGIFRVSGSASKIEELKKKFDRGEDIDDLE-DYDVHDVASLLKLYLRELPEPLIPFEL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 386 AKTFIgqpNQWLLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRITKVPLQ-QISAETLSISVTPSIFHtvpqgvHM 464
Cdd:cd00159  76 YDEFI---ELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVnKMTASNLAIVFAPTLLR------PP 146

                       170       180
                ....*....|....*....|...
gi 45552129 465 QDIQQLLREGETLADCVKLMIEY 487
Cdd:cd00159 147 DSDDELLEDIKKLNEIVEFLIEN 169

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129    303 RTVPRIVVDCCDLIEQKYRRStqpiEGIYRQCGDYNKIQTLRFSIDANDYDSLRQPDVDIHTLTGVLKLFLREIKSPLVR 382
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDT----EGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLIT 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129    383 VNEAKTFIGQPNqwlLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRITKVPLQ-QISAETLSISVTPSIFHtvPQG 461
Cdd:smart00324  77 YELYEEFIEAAK---LEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEEnKMTARNLAIVFGPTLLR--PPD 151

                          170       180
                   ....*....|....*....|....*..
gi 45552129    462 VHMQDIQQLLRegetLADCVKLMIEYQ 488
Cdd:smart00324 152 GEVASLKDIRH----QNTVIEFLIENA 174

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 305 VPRIVVDCCDLIEQkyRRSTQpiEGIYRQCGDYNKIQTLRfsidandyDSLRQ----PD---VDIHTLTGVLKLFLREIK 377
Cdd:cd04382  17 IPALIVHCVNEIEA--RGLTE--EGLYRVSGSEREVKALK--------EKFLRgktvPNlskVDIHVICGCLKDFLRSLK 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 378 SPLVRVNEAKTFIGQPNqwlLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRITKVPLQQISAETLSISVTPSIF-H 456
Cdd:cd04382  85 EPLITFALWKEFMEAAE---ILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQSPECKMDINNLARVFGPTIVgY 161

                ....
gi 45552129 457 TVPQ 460
Cdd:cd04382 162 SVPN 165

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 305 VPRIVVDCCDLIEQKYRRStqpiEGIYRQCGDYNKIQTL--RFSIDANDYdSLRQPDVDIHTLTGVLKLFLREIKSPLVr 382
Cdd:cd04385  15 IPVIVDKCIDFITQHGLMS----EGIYRKNGKNSSVKKLleAFRKDARSV-QLREGEYTVHDVADVLKRFLRDLPDPLL- 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 383 vneakTFIGQPnQWL----LTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRITK-VPLQQISAETLSISVTPSIFHT 457
Cdd:cd04385  89 -----TSELHA-EWIeaaeLENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKhSDENQMSVHNLALVFGPTLFQT 162

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 289 FDTELEMVLKHDQHRTVPRIVVDCCDLIEQKYRRSTqpieGIYRQCGDYNKIQTLRFSIDANDYDSLRQPDV--DIHTLT 366
Cdd:cd04395   2 FGVPLDDCPPSSENPYVPLIVEVCCNIVEARGLETV----GIYRVPGNNAAISALQEELNRGGFDIDLQDPRwrDVNVVS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 367 GVLKLFLREIKSPLVRVNEAKTFIgQPNQwlLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRITK-VPLQQISAET 445
Cdd:cd04395  78 SLLKSFFRKLPEPLFTNELYPDFI-EANR--IEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADnSEVNKMEPRN 154

                       170
                ....*....|..
gi 45552129 446 LSISVTPSIFHT 457
Cdd:cd04395 155 LAIVFGPTLVRT 166

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 289 FDTELEMVL----KHDQHRTVPRIVVDCCDLIEQkyRRSTQPiEGIYRQCGDYNKIQTL--RFSiDANDYDSLRQPDV-D 361
Cdd:cd04400   2 FGSPLEEAVelssHKYNGRDLPSVVYRCIEYLDK--NRAIYE-EGIFRLSGSASVIKQLkeRFN-TEYDVDLFSSSLYpD 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45552129 362 IHTLTGVLKLFLREIKSPLVRVNEAKTFIGQPNqwLLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRI 433
Cdd:cd04400  78 VHTVAGLLKLYLRELPTLILGGELHNDFKRLVE--ENHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKI 147

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 303 RTVPRIVVDCCDLIEQKYRRStqpiEGIYRQCGDYNKIQTL--RFSIDAN-DYDSLrqpDVDIHTLTGVLKLFLREIKSP 379
Cdd:cd04373  13 KPIPIFLEKCVEFIEATGLET----EGIYRVSGNKTHLDSLqkQFDQDHNlDLVSK---DFTVNAVAGALKSFFSELPDP 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 380 LVRVNEAKtfigqpnQWL----LTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRITKV-PLQQISAETLSISVTPSI 454
Cdd:cd04373  86 LIPYSMHL-------ELVeaakINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNsKVNLMTSENLSICFWPTL 158

                .
gi 45552129 455 F 455
Cdd:cd04373 159 M 159

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 289 FDTELEMVLKHDQH---RTVPRIVVDCCDLIEQKYRRStqpiEGIYRQCGDYNKIQTLRFSIDANDYDSLRQpDVDIHTL 365
Cdd:cd04390   3 FGQRLEDTVAYERKfgpRLVPILVEQCVDFIREHGLKE----EGLFRLPGQANLVKQLQDAFDAGERPSFDS-DTDVHTV 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 366 TGVLKLFLREIKSPLVRVNEAKTFIgQPNQWLLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRITK-VPLQQISAE 444
Cdd:cd04390  78 ASLLKLYLRELPEPVIPWAQYEDFL-SCAQLLSKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSnSSVNKMSVQ 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 45552129 445 TLSISVTPSIFHtvPQgvhMQDIQQLLREGETLADCVKLMIEYQGRIF 492
Cdd:cd04390 157 NLATVFGPNILR--PK---VEDPATIMEGTPQIQQLMTVMISKHEPLF 199

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 328 EGIYRQCGDYNKIQTLRFSIDAnDYDSLRQPDVDIHTLTGVLKLFLREIKSPLVrvneakTFiGQPNQWL----LTDLSA 403
Cdd:cd04407  34 EGIYRKSGSANRMKELHQLLQA-DPENVKLENYPIHAITGLLKQWLRELPEPLM------TF-AQYNDFLraveLPEKQE 105

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 45552129 404 KLDSLKRLIRSLPESNRDTMDYIFGHFNRITKVP-LQQISAETLSISVTPSIF 455
Cdd:cd04407 106 QLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEdVNRMSPNALAIVFAPCLL 158

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 305 VPRIVVDCCDLIEQKyrrstQPIEGIYRQCGDYNKIQTLRfsidaNDYDSLRQPDV-------DIHTLTGVLKLFLREIK 377
Cdd:cd04384  18 VPQVLKSCTEFIEKH-----GIVDGIYRLSGIASNIQRLR-----HEFDSEQIPDLtkdvyiqDIHSVSSLCKLYFRELP 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 378 SPLVRVNEAKTFIGQPNQwllTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRITKV-PLQQISAETLSISVTPSIFH 456
Cdd:cd04384  88 NPLLTYQLYEKFSEAVSA---ASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYcSITNMHAKNLAIVWAPNLLR 164

                ...
gi 45552129 457 TVP 459
Cdd:cd04384 165 SKQ 167

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 305 VPRIVVDCCDLIEQKYRRstqpIEGIYRQCGDYNKIQTLRFSIDANDYDSLRqpDVDIHTLTGVLKLFLREIKSPLV--- 381
Cdd:cd04381  20 LPLVFRECIDYVEKHGMK----CEGIYKVSGIKSKVDELKAAYNRRESPNLE--EYEPPTVASLLKQYLRELPEPLLtke 93

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45552129 382 ---RVNEAKTfigqpnqwlLTDLSAKLDSLKRLIRSLPESNRDTMDYIFGHF-NRITKVPLQQISAETLSISVTPSI 454
Cdd:cd04381  94 lmpRFEEACG---------RPTEAEREQELQRLLKELPECNRLLLAWLIVHMdHVIAQELETKMNIQNISIVLSPTV 161

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 329 GIYRQCGDYNKIQTLRFSIDAND----YDSLRQPDVdihtlTGVLKLFLREIKSPLVRVNEAKTFIgQPNQWLLTDLsaK 404
Cdd:cd04375  40 GLFRKSGVKSRIQKLRSMIESSTdnvnYDGQQAYDV-----ADMLKQYFRDLPEPLLTNKLSETFI-AIFQYVPKEQ--R 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 405 LDSLKRLIRSLPESNRDTMDYIFGHFNRITK-VPLQQISAETLSISVTPSIFH-------TVPQGVHMQDIQQL------ 470
Cdd:cd04375 112 LEAVQCAILLLPDENREVLQTLLYFLSDVAAnSQENQMTATNLAVCLAPSLFHlntsrreNSSPARRMQRKKSLgkpdqk 191

                       170       180
                ....*....|....*....|....
gi 45552129 471 -LREGETLADCVKLMIEYQGRIFE 493
Cdd:cd04375 192 eLSENKAAHQCLAYMIEECNTLFM 215

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 301 QHRTVPRIVVDCCDLIEQKYrrSTqpiEGIYRQCGDYNKIQTLRFSID-ANDYDSLRQPdVDIhtlTGVLKLFLREIKSP 379
Cdd:cd04394  16 EYGNVPKFLVDACTFLLDHL--ST---EGLFRKSGSVVRQKELKAKLEgGEACLSSALP-CDV---AGLLKQFFRELPEP 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 380 LVRVNEAKTFIGQpnQWLLTDlSAKLDSLKRLIRSLPESNRDTMDYIFGHFNRIT-KVPLQQISAETLSISVTPSIFHTV 458
Cdd:cd04394  87 LLPYDLHEALLKA--QELPTD-EERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAqRCSENKMDSSNLAVIFAPNLFQSE 163

                       170       180       190
                ....*....|....*....|....*....|....
gi 45552129 459 PQGVHM-QDIQQLLREgetLADCVKLMIEYQGRI 491
Cdd:cd04394 164 EGGEKMsSSTEKRLRL---QAAVVQTLIDNASNI 194

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 305 VPRIVVDCCDLIEQKyrrsTQPIEGIYRQCGDYNKIQTLRFSIDaNDYDSLRQPDVDIHTLTGVLKLFLREIKSPLVRVN 384
Cdd:cd04408  16 VPFVVVRCTAEIENR----ALGVQGIYRISGSKARVEKLCQAFE-NGRDLVDLSGHSPHDITSVLKHFLKELPEPVLPFQ 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 385 EAKTFIGQPNQWL-LTDLSAK--------LDSLKRLIRSLPESNRDTMDYIFGHFNRIT-KVPLQQISAETLSISVTPSI 454
Cdd:cd04408  91 LYDDFIALAKELQrDSEKAAEspsiveniIRSLKELLGRLPVSNYNTLRHLMAHLYRVAeRFEDNKMSPNNLGIVFGPTL 170

                ....*..
gi 45552129 455 FHTVPQG 461
Cdd:cd04408 171 LRPLVGG 177

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 289 FDTELE--MVLKHDQH--RTVPRIVVDCCDLIEQKYRRSTqpiEGIYRQCGDYNKIQTLRFSIDANDYDSlrQPDVDIHT 364
Cdd:cd04389   1 FGSSLEeiMDRQKEKYpeLKLPWILTFLSEKVLALGGFQT---EGIFRVPGDIDEVNELKLRVDQWDYPL--SGLEDPHV 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45552129 365 LTGVLKLFLREIKSPLVRVNEAKTFIgqpnqwlltDLSAKLDSLKRLIRSLPESNRDTMDYI 426
Cdd:cd04389  76 PASLLKLWLRELEEPLIPDALYQQCI---------SASEDPDKAVEIVQKLPIINRLVLCYL 128

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 301 QHRTVPRIVVDCCDLIEQKyrrsTQPIEGIYRQCGDYNKIQTLRFSIDANdydSLRQPDVDIHT---LTGVLKLFLREIK 377
Cdd:cd04397  23 GKLRIPALIDDIISAMRQM----DMSVEGVFRKNGNIRRLKELTEEIDKN---PTEVPDLSKENpvqLAALLKKFLRELP 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 378 SPLVRVNEAKTFIgqpnqwlltdLSAKLDSLKRLIRS-------LPESNRDTMDYIFGHFNRITKvpLQQISAET----- 445
Cdd:cd04397  96 DPLLTFKLYRLWI----------SSQKIEDEEERKRVlhlvyclLPKYHRDTMEVLFSFLKWVSS--FSHIDEETgskmd 163

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 45552129 446 ---LSISVTPSIFHTVPQGVHMQDIQQLLREgetladCVKLMIEYQ 488
Cdd:cd04397 164 ihnLATVITPNILYSKTDNPNTGDEYFLAIE------AVNYLIENN 203

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 305 VPRIVVDCCDLIEQKYRRStqpiEGIYRQCGDYNKIQTLRFSIDANDYDSLRQpDVDIHTLTGVLKLFLREIKSPLVrVN 384
Cdd:cd04404  23 IPPVVRETVEYLQAHALTT----EGIFRRSANTQVVKEVQQKYNMGEPVDFDQ-YEDVHLPAVILKTFLRELPEPLL-TF 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 385 EAKTFIGQPNQWLLTDlsaKLDSLKRLIRSLPESNRDTMDYIFGHFNRITKVP-LQQISAETLSISVTPSIFHTVPQGVH 463
Cdd:cd04404  97 DLYDDIVGFLNVDKEE---RVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSdQNKMTNSNLAVVFGPNLLWAKDASMS 173

                ....*..
gi 45552129 464 MQDIQQL 470
Cdd:cd04404 174 LSAINPI 180

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552129 328 EGIYRQCGDYNKIQTLRFSIDANDyDSLR--QPDVDIHTLTGVLKLFLREIKSPLVRVNEAKTFIGQPNqwlLTDLSAKL 405
Cdd:cd04383  37 QGIFRVSGSQVEVNDIKNAFERGE-DPLAddQNDHDINSVAGVLKLYFRGLENPLFPKERFEDLMSCVK---LENPTERV 112

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45552129 406 DSLKRLIRSLPESNRDTMDYIFGHFNRitkvpLQQISAE------TLSISVTPSIFHtVPQG 461
Cdd:cd04383 113 HQIREILSTLPRSVIIVMRYLFAFLNH-----LSQFSDEnmmdpyNLAICFGPTLMP-VPEG 168