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Conserved domains on  [gi|40254307|ref|NP_795926|]
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probable tRNA methyltransferase 9B isoform 1 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 26-143 6.41e-26

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 102.38  E-value: 6.41e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307  26 DLQSKAWPRVRQFLQ--DQKPGSLVADIGCGTGKYLK--VNSQVHTLGCDYCGPLVEIARNR------GCEVMVCDNLNL 95
Cdd:COG2226   2 DRVAARYDGREALLAalGLRPGARVLDLGCGTGRLALalAERGARVTGVDISPEMLELARERaaeaglNVEFVVGDAEDL 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 40254307  96 PFRDQGFDAIISIGVIHHFstkERRIRAIKEMARVLAPGGQLMIYVWA 143
Cdd:COG2226  82 PFPDGSFDLVISSFVLHHL---PDPERALAEIARVLKPGGRLVVVDFS 126
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 26-143 6.41e-26

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 102.38  E-value: 6.41e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307  26 DLQSKAWPRVRQFLQ--DQKPGSLVADIGCGTGKYLK--VNSQVHTLGCDYCGPLVEIARNR------GCEVMVCDNLNL 95
Cdd:COG2226   2 DRVAARYDGREALLAalGLRPGARVLDLGCGTGRLALalAERGARVTGVDISPEMLELARERaaeaglNVEFVVGDAEDL 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 40254307  96 PFRDQGFDAIISIGVIHHFstkERRIRAIKEMARVLAPGGQLMIYVWA 143
Cdd:COG2226  82 PFPDGSFDLVISSFVLHHL---PDPERALAEIARVLKPGGRLVVVDFS 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-135 1.73e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 94.17  E-value: 1.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307    48 VADIGCGTGKYL-----KVNSQVHtlGCDYCGPLVEIARNRG------CEVMVCDNLNLPFRDQGFDAIISIGVIHHFST 116
Cdd:pfam13649   1 VLDLGCGTGRLTlalarRGGARVT--GVDLSPEMLERARERAaeaglnVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPD 78

                          90
                  ....*....|....*....
gi 40254307   117 KERRiRAIKEMARVLAPGG 135
Cdd:pfam13649  79 PDLE-AALREIARVLKPGG 96
PRK08317 PRK08317
hypothetical protein; Provisional
 22-139 3.15e-15

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 74.97  E-value: 3.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307   22 PYFTDLQSkawpRVRQFLQDQkPGSLVADIGCGTG---KYLK--VNSQVHTLGCDYCGPLVEIARNRGC------EVMVC 90
Cdd:PRK08317   2 PDFRRYRA----RTFELLAVQ-PGDRVLDVGCGPGndaRELArrVGPEGRVVGIDRSEAMLALAKERAAglgpnvEFVRG 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 40254307   91 DNLNLPFRDQGFDAIISIGVIHHFSTKERrirAIKEMARVLAPGGQLMI 139
Cdd:PRK08317  77 DADGLPFPDGSFDAVRSDRVLQHLEDPAR---ALAEIARVLRPGGRVVV 122
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 48-139 8.25e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 61.68  E-value: 8.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307  48 VADIGCGTGKY---LKVNSQVHTLGCDYCGPLVEIARNR-------GCEVMVCDNLNLPF-RDQGFDAIISIGVIHHFst 116
Cdd:cd02440   2 VLDLGCGTGALalaLASGPGARVTGVDISPVALELARKAaaalladNVEVLKGDAEELPPeADESFDVIISDPPLHHL-- 79

                        90       100
                ....*....|....*....|...
gi 40254307 117 KERRIRAIKEMARVLAPGGQLMI 139
Cdd:cd02440  80 VEDLARFLEEARRLLKPGGVLVL 102
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 13-139 1.90e-11

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 63.44  E-value: 1.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307    13 VHSVYENTAPYFTDL-------QSKAWprvRQFLQDQ---KPGSLVADIGCGTG----KYLKVNSQV-HTLGCDYCGPLV 77
Cdd:TIGR01934   1 VQEMFDRIAPKYDLLndllsfgLHRLW---RRRAVKLigvFKGQKVLDVACGTGdlaiELAKSAPDRgKVTGVDFSSEML 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 40254307    78 EIARNRGC-----EVMVCDNLNLPFRDQGFDAI-ISIGvIHHFStkeRRIRAIKEMARVLAPGGQLMI 139
Cdd:TIGR01934  78 EVAKKKSElplniEFIQADAEALPFEDNSFDAVtIAFG-LRNVT---DIQKALREMYRVLKPGGRLVI 141
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 26-143 6.41e-26

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 102.38  E-value: 6.41e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307  26 DLQSKAWPRVRQFLQ--DQKPGSLVADIGCGTGKYLK--VNSQVHTLGCDYCGPLVEIARNR------GCEVMVCDNLNL 95
Cdd:COG2226   2 DRVAARYDGREALLAalGLRPGARVLDLGCGTGRLALalAERGARVTGVDISPEMLELARERaaeaglNVEFVVGDAEDL 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 40254307  96 PFRDQGFDAIISIGVIHHFstkERRIRAIKEMARVLAPGGQLMIYVWA 143
Cdd:COG2226  82 PFPDGSFDLVISSFVLHHL---PDPERALAEIARVLKPGGRLVVVDFS 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-135 1.73e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 94.17  E-value: 1.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307    48 VADIGCGTGKYL-----KVNSQVHtlGCDYCGPLVEIARNRG------CEVMVCDNLNLPFRDQGFDAIISIGVIHHFST 116
Cdd:pfam13649   1 VLDLGCGTGRLTlalarRGGARVT--GVDLSPEMLERARERAaeaglnVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPD 78

                          90
                  ....*....|....*....
gi 40254307   117 KERRiRAIKEMARVLAPGG 135
Cdd:pfam13649  79 PDLE-AALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 50-139 2.94e-20

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 85.02  E-value: 2.94e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307    50 DIGCGTGKYLKVNSQV--HTLGCDYCGPLVEIAR----NRGCEVMVCDNLNLPFRDQGFDAIISIGVIHHFstkERRIRA 123
Cdd:pfam08241   2 DVGCGTGLLTELLARLgaRVTGVDISPEMLELARekapREGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHV---EDPERA 78

                          90
                  ....*....|....*.
gi 40254307   124 IKEMARVLAPGGQLMI 139
Cdd:pfam08241  79 LREIARVLKPGGILII 94
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 25-139 4.74e-19

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 82.76  E-value: 4.74e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307  25 TDLQSKAW-PRVRQFLQDQ-KPGSLVADIGCGTGKYLKV----NSQVHtlGCDYCGPLVEIARNR----GCEVMVCDNLN 94
Cdd:COG2227   3 DPDARDFWdRRLAALLARLlPAGGRVLDVGCGTGRLALAlarrGADVT--GVDISPEALEIARERaaelNVDFVQGDLED 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 40254307  95 LPFRDQGFDAIISIGVIHHFstkERRIRAIKEMARVLAPGGQLMI 139
Cdd:COG2227  81 LPLEDGSFDLVICSEVLEHL---PDPAALLRELARLLKPGGLLLL 122
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 23-152 5.46e-19

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 84.97  E-value: 5.46e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307  23 YFTDLQSKAWPRVRQFLQDQKPGSLVADIGCGTGKYL-----KVNSQVhtLGCDYCGPLVEIARNR-------GCEVMVC 90
Cdd:COG0500   5 YYSDELLPGLAALLALLERLPKGGRVLDLGCGTGRNLlalaaRFGGRV--IGIDLSPEAIALARARaakaglgNVEFLVA 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 40254307  91 DNLNL-PFRDQGFDAIISIGVIHHFStKERRIRAIKEMARVLAPGGQLMIYVWAMEQKNRRFE 152
Cdd:COG0500  83 DLAELdPLPAESFDLVVAFGVLHHLP-PEEREALLRELARALKPGGVLLLSASDAAAALSLAR 144
PRK08317 PRK08317
hypothetical protein; Provisional
 22-139 3.15e-15

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 74.97  E-value: 3.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307   22 PYFTDLQSkawpRVRQFLQDQkPGSLVADIGCGTG---KYLK--VNSQVHTLGCDYCGPLVEIARNRGC------EVMVC 90
Cdd:PRK08317   2 PDFRRYRA----RTFELLAVQ-PGDRVLDVGCGPGndaRELArrVGPEGRVVGIDRSEAMLALAKERAAglgpnvEFVRG 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 40254307   91 DNLNLPFRDQGFDAIISIGVIHHFSTKERrirAIKEMARVLAPGGQLMI 139
Cdd:PRK08317  77 DADGLPFPDGSFDAVRSDRVLQHLEDPAR---ALAEIARVLRPGGRVVV 122
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 13-139 4.00e-15

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 74.42  E-value: 4.00e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307   13 VHSVYENTAP-YftDL--------QSKAWprvRQFLQDQ---KPGSLVADIGCGTGKYL-----KVNSQVHTLGCDYCGP 75
Cdd:PRK00216  13 VAEMFDSIAPkY--DLmndllsfgLHRVW---RRKTIKWlgvRPGDKVLDLACGTGDLAialakAVGKTGEVVGLDFSEG 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 40254307   76 LVEIARNR--------GCEVMVCDNLNLPFRDQGFDAI-ISIG---VIHhfstkerRIRAIKEMARVLAPGGQLMI 139
Cdd:PRK00216  88 MLAVGREKlrdlglsgNVEFVQGDAEALPFPDNSFDAVtIAFGlrnVPD-------IDKALREMYRVLKPGGRLVI 156
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 43-141 1.80e-14

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 70.73  E-value: 1.80e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307  43 KPGSLVADIGCGTG---KYLKVNSQVHTLGCDYCGPLVEIARNR--------GCEVMVCDNLNLPFrDQGFDAIISIGVI 111
Cdd:COG2230  50 KPGMRVLDIGCGWGglaLYLARRYGVRVTGVTLSPEQLEYARERaaeagladRVEVRLADYRDLPA-DGQFDAIVSIGMF 128

                        90       100       110
                ....*....|....*....|....*....|
gi 40254307 112 HHFSTKERRiRAIKEMARVLAPGGQLMIYV 141
Cdd:COG2230 129 EHVGPENYP-AYFAKVARLLKPGGRLLLHT 157
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
44-141 9.13e-14

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 66.77  E-value: 9.13e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307  44 PGSLVADIGCGTGKYLKV----NSQVHTLGCDYCGPLVEIARNR--GCEVMVCDNLNLPFrDQGFDAIISIGVIHHFstk 117
Cdd:COG4106   1 PPRRVLDLGCGTGRLTALlaerFPGARVTGVDLSPEMLARARARlpNVRFVVADLRDLDP-PEPFDLVVSNAALHWL--- 76

                        90       100
                ....*....|....*....|....
gi 40254307 118 ERRIRAIKEMARVLAPGGQLMIYV 141
Cdd:COG4106  77 PDHAALLARLAAALAPGGVLAVQV 100
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
10-155 9.78e-14

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 69.26  E-value: 9.78e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307  10 KRHVHSVYENTAPYF-----TDLQSKAWPRVRQFLQDQ---KPGSLVADIGCGTG---KYLKvNSQVHTLGCDYCGPLVE 78
Cdd:COG4976   4 DAYVEALFDQYADSYdaalvEDLGYEAPALLAEELLARlppGPFGRVLDLGCGTGllgEALR-PRGYRLTGVDLSEEMLA 82

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 40254307  79 IARNRGC--EVMVCDNLNLPFRDQGFDAIISIGVIHHFstkERRIRAIKEMARVLAPGGQLMIYVWAMEQKNRRFEKQD 155
Cdd:COG4976  83 KAREKGVydRLLVADLADLAEPDGRFDLIVAADVLTYL---GDLAAVFAGVARALKPGGLFIFSVEDADGSGRYAHSLD 158
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 50-137 6.10e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 61.61  E-value: 6.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307    50 DIGCGTG----KYLKVNSQVHTLGCDYCGPLVEIARNR--GCEVMVCDNLNLPFRD------QGFDAIISIGVIHHFSTK 117
Cdd:pfam08242   2 EIGCGTGtllrALLEALPGLEYTGLDISPAALEAARERlaALGLLNAVRVELFQLDlgeldpGSFDVVVASNVLHHLADP 81

                          90       100
                  ....*....|....*....|
gi 40254307   118 ErriRAIKEMARVLAPGGQL 137
Cdd:pfam08242  82 R---AVLRNIRRLLKPGGVL 98
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 48-139 8.25e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 61.68  E-value: 8.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307  48 VADIGCGTGKY---LKVNSQVHTLGCDYCGPLVEIARNR-------GCEVMVCDNLNLPF-RDQGFDAIISIGVIHHFst 116
Cdd:cd02440   2 VLDLGCGTGALalaLASGPGARVTGVDISPVALELARKAaaalladNVEVLKGDAEELPPeADESFDVIISDPPLHHL-- 79

                        90       100
                ....*....|....*....|...
gi 40254307 117 KERRIRAIKEMARVLAPGGQLMI 139
Cdd:cd02440  80 VEDLARFLEEARRLLKPGGVLVL 102
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 13-139 1.90e-11

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 63.44  E-value: 1.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307    13 VHSVYENTAPYFTDL-------QSKAWprvRQFLQDQ---KPGSLVADIGCGTG----KYLKVNSQV-HTLGCDYCGPLV 77
Cdd:TIGR01934   1 VQEMFDRIAPKYDLLndllsfgLHRLW---RRRAVKLigvFKGQKVLDVACGTGdlaiELAKSAPDRgKVTGVDFSSEML 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 40254307    78 EIARNRGC-----EVMVCDNLNLPFRDQGFDAI-ISIGvIHHFStkeRRIRAIKEMARVLAPGGQLMI 139
Cdd:TIGR01934  78 EVAKKKSElplniEFIQADAEALPFEDNSFDAVtIAFG-LRNVT---DIQKALREMYRVLKPGGRLVI 141
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 43-139 7.76e-11

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 60.12  E-value: 7.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307    43 KPGSLVADIGCGTGKYL-----KVNSQVHTLGCDYCGPLVEIARNR-------GCEVMVCDNLNLP--FRDQGFDAIISI 108
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSfelaeELGPNAEVVGIDISEEAIEKARENaqklgfdNVEFEQGDIEELPelLEDDKFDVVISN 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 40254307   109 GVIHHFSTKErriRAIKEMARVLAPGGQLMI 139
Cdd:pfam13847  82 CVLNHIPDPD---KVLQEILRVLKPGGRLII 109
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 48-138 6.48e-08

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 53.44  E-value: 6.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307    48 VADIGCGTG----KYLKVNSQVHTLGCDYCGPLVEIARNRGCEVM--VCDNL-NLPFRDQGFDAIISIGVIHHFSTKErr 120
Cdd:TIGR02072  38 VLDIGCGTGyltrALLKRFPQAEFIALDISAGMLAQAKTKLSENVqfICGDAeKLPLEDSSFDLIVSNLALQWCDDLS-- 115

                          90
                  ....*....|....*...
gi 40254307   121 iRAIKEMARVLAPGGQLM 138
Cdd:TIGR02072 116 -QALSELARVLKPGGLLA 132
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
59-141 3.26e-07

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 49.86  E-value: 3.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307  59 LKVNsqvhtLGC--DYCGPLVEIARNRGCEVMVCDNLN--LPFRDQGFDAIISIGVIHHFsTKERRIRAIKEMARVLAPG 134
Cdd:COG4627   5 LKLN-----IGCgpKRLPGWLNVDIVPAPGVDIVGDLTdpLPFPDNSVDAIYSSHVLEHL-DYEEAPLALKECYRVLKPG 78


                ....*..
gi 40254307 135 GQLMIYV 141
Cdd:COG4627  79 GILRIVV 85
PLN02244 PLN02244
tocopherol O-methyltransferase
 41-168 3.62e-07

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 51.67  E-value: 3.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307   41 DQKPGSLVADIGCGTG---KYL--KVNSQVH--TLGCDYCGPLVEIARNRG----CEVMVCDNLNLPFRDQGFDAIISIG 109
Cdd:PLN02244 115 DEKRPKRIVDVGCGIGgssRYLarKYGANVKgiTLSPVQAARANALAAAQGlsdkVSFQVADALNQPFEDGQFDLVWSME 194

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307  110 VIHHFSTKERrirAIKEMARVLAPGGQLMIYVWAmeqkNRRFEK-QDVLVPWNRALCSRL 168
Cdd:PLN02244 195 SGEHMPDKRK---FVQELARVAAPGGRIIIVTWC----HRDLEPgETSLKPDEQKLLDKI 247
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 36-150 5.36e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 49.35  E-value: 5.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307    36 RQFLQDQKPGSLVaDIGCGTGKYLKVNSQVhtlGCDYCGplVEIARNRGCEVMVC------DNLNLPFRDQGFDAIISIG 109
Cdd:pfam13489  15 RLLPKLPSPGRVL-DFGCGTGIFLRLLRAQ---GFSVTG--VDPSPIAIERALLNvrfdqfDEQEAAVPAGKFDVIVARE 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 40254307   110 VIHHFSTKerrIRAIKEMARVLAPGGQLMIYVWAMEQKNRR 150
Cdd:pfam13489  89 VLEHVPDP---PALLRQIAALLKPGGLLLLSTPLASDEADR 126
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 43-135 1.57e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 48.02  E-value: 1.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307  43 KPGSLVADIGCGTG------KYLKVNSqvhtLGCDYCGPLVEIAR-------NRGCEVMVCDNLNLPFRDQGFDAIIS-- 107
Cdd:COG1041  25 KEGDTVLDPFCGTGtilieaGLLGRRV----IGSDIDPKMVEGARenlehygYEDADVIRGDARDLPLADESVDAIVTdp 100

                        90       100       110
                ....*....|....*....|....*....|..
gi 40254307 108 -IGVIHHFSTKERRI---RAIKEMARVLAPGG 135
Cdd:COG1041 101 pYGRSSKISGEELLElyeKALEEAARVLKPGG 132
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 16-139 9.04e-06

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 47.19  E-value: 9.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307   16 VYENTAPYFTDLQSKAWPRVRQFLQDQKPGSLVADIGCGTGK--YL---KVNSQVHTLGCDYCGPLVEIA------RNRG 84
Cdd:PLN02233  45 VYDNLNDLLSLGQHRIWKRMAVSWSGAKMGDRVLDLCCGSGDlaFLlseKVGSDGKVMGLDFSSEQLAVAasrqelKAKS 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 40254307   85 C----EVMVCDNLNLPFRDQGFDAIiSIGviHHFSTKERRIRAIKEMARVLAPGGQLMI 139
Cdd:PLN02233 125 CykniEWIEGDATDLPFDDCYFDAI-TMG--YGLRNVVDRLKAMQEMYRVLKPGSRVSI 180
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
28-137 1.11e-05

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 46.28  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307    28 QSKAWPRVRQFLQDQKPGSLVADIGCGTG----KYLK-VNSQVHTLGCDYCGPLVEIARNRGCEV------MVCDN-LNL 95
Cdd:pfam01209  26 IHRLWKDFTMKCMGVKRGNKFLDVAGGTGdwtfGLSDsAGSSGKVVGLDINENMLKEGEKKAKEEgkynieFLQGNaEEL 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 40254307    96 PFRDQGFDAI-ISIGvIHHFSTkerRIRAIKEMARVLAPGGQL 137
Cdd:pfam01209 106 PFEDDSFDIVtISFG-LRNFPD---YLKVLKEAFRVLKPGGRV 144
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 41-139 3.48e-05

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 45.90  E-value: 3.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307   41 DQKPGSLVADIGCGTGK---YLKVNSQVHTLGCDYCGPLVEIA------RNRGCEVMVCDNLNLPFRDQGFDAIISIGVI 111
Cdd:PLN02336 263 DLKPGQKVLDVGCGIGGgdfYMAENFDVHVVGIDLSVNMISFAleraigRKCSVEFEVADCTKKTYPDNSFDVIYSRDTI 342

                         90       100
                 ....*....|....*....|....*...
gi 40254307  112 HHFSTKERRIRAikeMARVLAPGGQLMI 139
Cdd:PLN02336 343 LHIQDKPALFRS---FFKWLKPGGKVLI 367
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 44-139 1.00e-04

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 43.81  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307   44 PGSLVADIGCGTG---KYLKVNSQVHTLGCDYCGPLVEIA--RNRG---CEVMVCDNLNLPFRDQGFDAIISIGVIHHFS 115
Cdd:PTZ00098  52 ENSKVLDIGSGLGggcKYINEKYGAHVHGVDICEKMVNIAklRNSDknkIEFEANDILKKDFPENTFDMIYSRDAILHLS 131

                         90       100
                 ....*....|....*....|....
gi 40254307  116 TKERRiRAIKEMARVLAPGGQLMI 139
Cdd:PTZ00098 132 YADKK-KLFEKCYKWLKPNGILLI 154
arsM PRK11873
arsenite methyltransferase;
43-139 7.46e-04

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 41.09  E-value: 7.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307   43 KPGSLVADIGCGTGK--YL---KVNSQVHTLGCDYCGPLVEIARN----RG---CEVMVCDNLNLPFRDQGFDAIISIGV 110
Cdd:PRK11873  76 KPGETVLDLGSGGGFdcFLaarRVGPTGKVIGVDMTPEMLAKARAnarkAGytnVEFRLGEIEALPVADNSVDVIISNCV 155

                         90       100
                 ....*....|....*....|....*....
gi 40254307  111 IHHFSTKErriRAIKEMARVLAPGGQLMI 139
Cdd:PRK11873 156 INLSPDKE---RVFKEAFRVLKPGGRFAI 181
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 37-139 7.80e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 40.56  E-value: 7.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307  37 QFLQDQKPGSlVADIGCGTG----KYLKVNSQVHTLGCDYCGPLVEIAR-N------RGCEVMVCDNLNlPFRDQGFDAI 105
Cdd:COG2813  43 EHLPEPLGGR-VLDLGCGYGviglALAKRNPEARVTLVDVNARAVELARaNaaanglENVEVLWSDGLS-GVPDGSFDLI 120

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 40254307 106 IS-----IGVIHHFSTKERRIRAIkemARVLAPGGQLMI 139
Cdd:COG2813 121 LSnppfhAGRAVDKEVAHALIADA---ARHLRPGGELWL 156
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 34-137 8.44e-04

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 41.05  E-value: 8.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307   34 RVRQFLQDQKPGS--LVADIGCGTGKY----LKVNSQVHTL---GCDYCGPLVEIARNR--GCEVMVCDNLNLPFRDQGF 102
Cdd:PRK11088  73 AVANLLAERLDEKatALLDIGCGEGYYthalADALPEITTMqlfGLDISKVAIKYAAKRypQVTFCVASSHRLPFADQSL 152

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 40254307  103 DAIIsigvihhfstkerRIRA---IKEMARVLAPGGQL 137
Cdd:PRK11088 153 DAII-------------RIYApckAEELARVVKPGGIV 177
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 43-139 1.52e-03

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 40.39  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307    43 KPGSLVADIGCGTG---KYLKVNSQVHTLGC-------DYCGPLV-EIARNRGCEVMVCDNLNLpfrDQGFDAIISIGVI 111
Cdd:pfam02353  60 KPGMTLLDIGCGWGglmRRAAERYDVNVVGLtlsknqyKLARKRVaAEGLARKVEVLLQDYRDF---DEPFDRIVSVGMF 136

                          90       100
                  ....*....|....*....|....*...
gi 40254307   112 HHFStKERRIRAIKEMARVLAPGGQLMI 139
Cdd:pfam02353 137 EHVG-HENYDTFFKKLYNLLPPGGLMLL 163
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 91-139 6.79e-03

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 37.36  E-value: 6.79e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 40254307   91 DNLNLPFRDQGFDAIiSIGviHHFSTKERRIRAIKEMARVLAPGGQLMI 139
Cdd:PLN02232  34 DAIDLPFDDCEFDAV-TMG--YGLRNVVDRLRAMKEMYRVLKPGSRVSI 79
PRK05785 PRK05785
hypothetical protein; Provisional
 11-130 6.99e-03

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 37.74  E-value: 6.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307   11 RHVHSVYENTAPYFTDLQSKAWPR--VRQFLQ-DQKPGsLVADIGCGTGK---YLKVNSQVHTLGCDYCGPLVEIARNRG 84
Cdd:PRK05785  16 NKIPKAYDRANRFISFNQDVRWRAelVKTILKyCGRPK-KVLDVAAGKGElsyHFKKVFKYYVVALDYAENMLKMNLVAD 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 40254307   85 CEVmVCDNLNLPFRDQGFDAIISIGVIHHFSTKErriRAIKEMARV 130
Cdd:PRK05785  95 DKV-VGSFEALPFRDKSFDVVMSSFALHASDNIE---KVIAEFTRV 136
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
37-137 7.38e-03

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 37.82  E-value: 7.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40254307   37 QFLQDQ-KPGSLVADIGCGTG------KYLKVNsqvHTLGCDYcGPL-VE-----IARNRgcevmVCDNLNLPFRDQGFD 103
Cdd:PRK00517 111 EALEKLvLPGKTVLDVGCGSGilaiaaAKLGAK---KVLAVDI-DPQaVEaarenAELNG-----VELNVYLPQGDLKAD 181

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 40254307  104 AIIS-I--GVIhhfstkerrIRAIKEMARVLAPGGQL 137
Cdd:PRK00517 182 VIVAnIlaNPL---------LELAPDLARLLKPGGRL 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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