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Conserved domains on  [gi|126116589|ref|NP_803875|]
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fibrocystin-L precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2185-2303 1.95e-43

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 155.46  E-value: 1.95e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  2185 SWGGKSPPEEGSLVVITKGQTILLDQSTPILKMLLIQgGTLIF-DEADIELQAENILITdGGVLQIGTETSPFQHKAVIT 2263
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 126116589  2264 LHG--HLRSPELPVYGAKTLAVRE-GILDLHGVPVPVTWTRLA 2303
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
Cupredoxin_Fibrocystin-L_like cd04217
Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease ...
 1395-1498 4.99e-36

Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease protein; One member of this family is Fibrocystin-L, a homolog of the autosomal recessive polycystic kidney disease protein PKHD1. Human fibrocystin-L is predicted to be a large receptor protein (466 kDa) with a signal peptide, a single transmembrane domain and a short cytoplasmic tail. Fibrocystin-L is widely expressed at a low level in most tissues but is up-regulated specifically in T lymphocytes following activation signals. It may play roles in immunity.


:

Pssm-ID: 259879 [Multi-domain]  Cd Length: 86  Bit Score: 132.68  E-value: 4.99e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1395 TNNGKDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPflrgiGYRIFSVSSPGSVIYDgkgftsgrQKSTSGSFSYQFTSP 1474
Cdd:cd04217     1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                          90       100
                  ....*....|....*....|....
gi 126116589 1475 GIHYYSSGYVDEahsifLQGVINV 1498
Cdd:cd04217    68 GTYYFSVKDVPE-----MKGTINV 86
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 3044-3173 4.69e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.57  E-value: 4.69e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  3044 NNYTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDKynvgaaessyREVVLNATYISLQGGRLIGGWEDNPFK 3123
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDD----------KNITLRARYILVQGGRLIIGSEDCPFQ 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 126116589  3124 GDLKIVLRGNHTTQDwalPEGPNQGAKVLGV--FGELDLHGIPHSIYKTKLS 3173
Cdd:pfam10162   73 GKATITLHGRPELDD---DDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 271-363 1.09e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 83.66  E-value: 1.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  271 EVTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTPPKPhilkTVYPGGRGLKLEVWNNS 350
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAA----TPGEGPVEVTVDGANVS 77

                          90
                  ....*....|...
gi 126116589  351 RPIRLEEILEYNE 363
Cdd:cd00603    78 ARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2091-2178 2.14e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.89  E-value: 2.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 2091 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTLSGWAP--VCVHIRGVGMAK 2168
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPveVTVDGANVSARV 80

                          90
                  ....*....|
gi 126116589 2169 LDNADFLYVD 2178
Cdd:cd00603    81 LSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1659-1745 3.46e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 79.42  E-value: 3.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQ---QLVDVDLLIHGVPAQC 1735
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATpgeGPVEVTVDGANVSARV 80

                          90
                  ....*....|
gi 126116589 1736 QGNCTFSYLE 1745
Cdd:cd00603    81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1831-1910 1.86e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 77.10  E-value: 1.86e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1831 PPVASLSPTSGSIGGGTTLVITGNGFYPG--NTTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNT--IAYPPL 1906
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGggISSSPL 80


                   ....
gi 126116589  1907 LFTY 1910
Cdd:pfam01833   81 TFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1240-1314 1.23e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 74.80  E-value: 1.23e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126116589 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNElTQNMAVYVGGKTCQILHWNFTDIRCLLPKL-SPGKHDIYVEVRNWG 1314
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSG-SPRVRVTVGGVPCKVLNVSSTEIVCRTPAAaTPGEGPVEVTVDGAN 75
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1157-1234 2.65e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 70.95  E-value: 2.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1157 ISHIWPDSGSIAGGTLLTLSGFGFN---ENSKVLVGNETCNVIEGDLNRITCRTPKKTEG-----TVDISVTTNGFQATA 1228
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLGsgsPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                  ....*.
gi 126116589 1229 RDAFSY 1234
Cdd:cd00603    83 NTTFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1067-1154 4.08e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 64.78  E-value: 4.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSA-VTVSVGPVGCSLLSVDEKELKCQIL-NGSAGHAPVAVSmADVGLAQNV 1144
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrVRVTVGGVPCKVLNVSSTEIVCRTPaAATPGEGPVEVT-VDGANVSAR 79

                          90
                  ....*....|
gi 126116589 1145 GGEEFYFVYQ 1154
Cdd:cd00603    80 VLSNTTFTYV 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2000-2085 1.01e-11

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 63.63  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 2000 NIQNINPSQGSFGGGQTMTVTGTGFNP--QNSIILVCGSECAIdrLRSDYTTLLCEIPS-NNGTGAEQACEVSVVNGKDL 2076
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSgsPRVRVTVGGVPCKV--LNVSSTEIVCRTPAaATPGEGPVEVTVDGANVSAR 79


                  ....*....
gi 126116589 2077 SQSMTPFTY 2085
Cdd:cd00603    80 VLSNTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1566-1633 6.34e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 61.31  E-value: 6.34e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1566 PSISNITPSTGTVN--ELITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHIDPQNSMDVGIRETV 1633
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTV 70
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1916-1997 2.26e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 2.26e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1916 PFLRGIIPSRGPP--GTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDHAGGTFPVMMHHKTKGSAMSTV 1993
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ....
gi 126116589  1994 VFEY 1997
Cdd:pfam01833   81 TFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1330-1406 2.41e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 2.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1330 LEVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENVIKCIL--HSTGNI-FRITNNGKDSVHGLG 1406
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTppGTSGLVnVSVTVGGGGISSSPL 80
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 31-139 5.00e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 59.01  E-value: 5.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   31 PKVTEIIPKYGSINGATRLTIRGEGFSQanqfnygvdnaelgNSVQLISSFQSITCDVEKdaSHSTQITCYTRAMPE-DS 109
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGS--------------GSPRVRVTVGGVPCKVLN--VSSTEIVCRTPAAATpGE 64

                          90       100       110
                  ....*....|....*....|....*....|
gi 126116589  110 YTVRVSVDGVPVtenntckGHINSWECTFN 139
Cdd:cd00603    65 GPVEVTVDGANV-------SARVLSNTTFT 87
PA14 super family cl08459
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 341-467 9.21e-07

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


The actual alignment was detected with superfamily member smart00758:

Pssm-ID: 471833 [Multi-domain]  Cd Length: 136  Bit Score: 50.86  E-value: 9.21e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589    341 GLKLEVWNNSRPIRLEEIleynEKTPGYMGASWvDSASYIWLMEQDTFVARFSGFLVAPDSDVYRFYIKGDDRYAIYFSq 420
Cdd:smart00758    2 GLTGYYFENEKFSGLPEI----IDTDPLNTFYW-DSDKFGEGEKADNFSVRWTGYLKPPEDGEYTFSITSDDGARLWID- 75

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*..
gi 126116589    421 tglpeDKVRIAYHSANANsyfssPTQRSDDIHLQKGKEYYIEILLQE 467
Cdd:smart00758   76 -----GKLVIDNWGKHEA-----RPSTSSTLYLLAGGTYPIRIEYFE 112
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 146-255 3.90e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 47.83  E-value: 3.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   146 PTIRSITPLSGTP--GTLITIQGRIFtdvygsnialssnGKNVRILRVYIGGMPCELlIPQSDNlyglkldhpngdmgSM 223
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTV-ISVSST--------------TI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 126116589   224 VCKTTGTFIGHHNVSFILDNDYGRSFPQKMAY 255
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
NosD super family cl34609
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3256-3512 5.47e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG3420:

Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 48.76  E-value: 5.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 3256 ILSRNIKIVGEDYPgwsedsfgarVLVGSFTENMMTFKG-NARISNVEFYHSGqegfRDSTDPRYAvtflnlgqIQEHGS 3334
Cdd:COG3420    49 VIDKPLTLIGEGGA----------VIDGGGKGTVITITAdNVTVRGLTITGSG----DSLTDDDAG--------IYVRGA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 3335 SY--IRGCAFHHGFSpAIGVFGTDGLDIDDNIIH------FTVGEGIRIWG-NANRVRGNLIalsvwpgtYQNRKdlsst 3405
Cdd:COG3420   107 DNavIENNRIENNLF-GIYLEGSDNNVIRNNTISgnrdlrADRGNGIHLWNsPGNVIEGNTI--------SGGRD----- 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 3406 lwhaAIEINRGTNTVLQNNVVAGfGRAGYRIDGepcpGQFNPVEkwfDNEAHGGLYGIY-MNQDGLpgcsLIQGFTIWTC 3484
Cdd:COG3420   173 ----GIYLEFSDNNVIRNNTIRN-LRYGIHYMY----SNDNLVE---GNTFRDNGAGIAlMYSKGN----TVRGNTILGN 236

                         250       260
                  ....*....|....*....|....*...
gi 126116589 3485 WDYGIYFQTTESVHIYNVTLVDNGMAIF 3512
Cdd:COG3420   237 SGYGILLKESSDSVIEGNTISGNGKGIF 264
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1749-1827 1.69e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.20  E-value: 1.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1749 PYITGVFPNS--VIGSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVVVGSKGLALGNL 1826
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   .
gi 126116589  1827 T 1827
Cdd:pfam01833   81 T 81
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2185-2303 1.95e-43

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 155.46  E-value: 1.95e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  2185 SWGGKSPPEEGSLVVITKGQTILLDQSTPILKMLLIQgGTLIF-DEADIELQAENILITdGGVLQIGTETSPFQHKAVIT 2263
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 126116589  2264 LHG--HLRSPELPVYGAKTLAVRE-GILDLHGVPVPVTWTRLA 2303
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
Cupredoxin_Fibrocystin-L_like cd04217
Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease ...
 1395-1498 4.99e-36

Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease protein; One member of this family is Fibrocystin-L, a homolog of the autosomal recessive polycystic kidney disease protein PKHD1. Human fibrocystin-L is predicted to be a large receptor protein (466 kDa) with a signal peptide, a single transmembrane domain and a short cytoplasmic tail. Fibrocystin-L is widely expressed at a low level in most tissues but is up-regulated specifically in T lymphocytes following activation signals. It may play roles in immunity.


Pssm-ID: 259879 [Multi-domain]  Cd Length: 86  Bit Score: 132.68  E-value: 4.99e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1395 TNNGKDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPflrgiGYRIFSVSSPGSVIYDgkgftsgrQKSTSGSFSYQFTSP 1474
Cdd:cd04217     1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                          90       100
                  ....*....|....*....|....
gi 126116589 1475 GIHYYSSGYVDEahsifLQGVINV 1498
Cdd:cd04217    68 GTYYFSVKDVPE-----MKGTINV 86
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 3044-3173 4.69e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.57  E-value: 4.69e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  3044 NNYTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDKynvgaaessyREVVLNATYISLQGGRLIGGWEDNPFK 3123
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDD----------KNITLRARYILVQGGRLIIGSEDCPFQ 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 126116589  3124 GDLKIVLRGNHTTQDwalPEGPNQGAKVLGV--FGELDLHGIPHSIYKTKLS 3173
Cdd:pfam10162   73 GKATITLHGRPELDD---DDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 271-363 1.09e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 83.66  E-value: 1.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  271 EVTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTPPKPhilkTVYPGGRGLKLEVWNNS 350
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAA----TPGEGPVEVTVDGANVS 77

                          90
                  ....*....|...
gi 126116589  351 RPIRLEEILEYNE 363
Cdd:cd00603    78 ARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2091-2178 2.14e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.89  E-value: 2.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 2091 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTLSGWAP--VCVHIRGVGMAK 2168
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPveVTVDGANVSARV 80

                          90
                  ....*....|
gi 126116589 2169 LDNADFLYVD 2178
Cdd:cd00603    81 LSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1659-1745 3.46e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 79.42  E-value: 3.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQ---QLVDVDLLIHGVPAQC 1735
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATpgeGPVEVTVDGANVSARV 80

                          90
                  ....*....|
gi 126116589 1736 QGNCTFSYLE 1745
Cdd:cd00603    81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1831-1910 1.86e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 77.10  E-value: 1.86e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1831 PPVASLSPTSGSIGGGTTLVITGNGFYPG--NTTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNT--IAYPPL 1906
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGggISSSPL 80


                   ....
gi 126116589  1907 LFTY 1910
Cdd:pfam01833   81 TFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1831-1910 2.01e-16

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 77.11  E-value: 2.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPG--NTTVTIGDEPCQIISINPNEVYCRTPAGTTGM---VDVKIF---VNTIA 1902
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGspRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGegpVEVTVDganVSARV 80


                  ....*...
gi 126116589 1903 YPPLLFTY 1910
Cdd:cd00603    81 LSNTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 2091-2176 6.09e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 75.56  E-value: 6.09e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  2091 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTlSGWAPVCVHIRGVGMAkLD 2170
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGT-SGLVNVSVTVGGGGIS-SS 78


                   ....*.
gi 126116589  2171 NADFLY 2176
Cdd:pfam01833   79 PLTFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1240-1314 1.23e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 74.80  E-value: 1.23e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126116589 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNElTQNMAVYVGGKTCQILHWNFTDIRCLLPKL-SPGKHDIYVEVRNWG 1314
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSG-SPRVRVTVGGVPCKVLNVSSTEIVCRTPAAaTPGEGPVEVTVDGAN 75
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1157-1234 2.65e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 70.95  E-value: 2.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1157 ISHIWPDSGSIAGGTLLTLSGFGFN---ENSKVLVGNETCNVIEGDLNRITCRTPKKTEG-----TVDISVTTNGFQATA 1228
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLGsgsPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                  ....*.
gi 126116589 1229 RDAFSY 1234
Cdd:cd00603    83 NTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1659-1743 1.22e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 65.93  E-value: 1.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVDVDLLIHGVpAQCQGN 1738
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGG-GISSSP 79


                   ....*
gi 126116589  1739 CTFSY 1743
Cdd:pfam01833   80 LTFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1067-1154 4.08e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 64.78  E-value: 4.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSA-VTVSVGPVGCSLLSVDEKELKCQIL-NGSAGHAPVAVSmADVGLAQNV 1144
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrVRVTVGGVPCKVLNVSSTEIVCRTPaAATPGEGPVEVT-VDGANVSAR 79

                          90
                  ....*....|
gi 126116589 1145 GGEEFYFVYQ 1154
Cdd:cd00603    80 VLSNTTFTYV 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2000-2085 1.01e-11

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 63.63  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 2000 NIQNINPSQGSFGGGQTMTVTGTGFNP--QNSIILVCGSECAIdrLRSDYTTLLCEIPS-NNGTGAEQACEVSVVNGKDL 2076
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSgsPRVRVTVGGVPCKV--LNVSSTEIVCRTPAaATPGEGPVEVTVDGANVSAR 79


                  ....*....
gi 126116589 2077 SQSMTPFTY 2085
Cdd:cd00603    80 VLSNTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1156-1234 1.57e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.85  E-value: 1.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1156 QISHIWPDSGSIAGGTLLTLSGFGFNENS---KVLVGNETCNVIEGDLNRITCRTPKKTEGTVDISVTTNGFQATARD-A 1231
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPlT 81


                   ...
gi 126116589  1232 FSY 1234
Cdd:pfam01833   82 FTY 84
IPT smart00429
ig-like, plexins, transcription factors;
271-335 4.56e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 61.67  E-value: 4.56e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126116589    271 EVTMIFPSQGSIRGGTTLTISGRFFDQ-TDFPVRVLVGGEPCDILNVTENSICCKTPPKPHILKTV 335
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSV 68
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1566-1633 6.34e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 61.31  E-value: 6.34e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1566 PSISNITPSTGTVN--ELITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHIDPQNSMDVGIRETV 1633
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTV 70
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1916-1997 2.26e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 2.26e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1916 PFLRGIIPSRGPP--GTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDHAGGTFPVMMHHKTKGSAMSTV 1993
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ....
gi 126116589  1994 VFEY 1997
Cdd:pfam01833   81 TFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1330-1406 2.41e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 2.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1330 LEVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENVIKCIL--HSTGNI-FRITNNGKDSVHGLG 1406
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTppGTSGLVnVSVTVGGGGISSSPL 80
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1331-1383 3.22e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 59.39  E-value: 3.22e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 126116589 1331 EVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENVIKC 1383
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVC 54
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 272-327 3.86e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.00  E-value: 3.86e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 126116589   272 VTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTPP 327
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPP 58
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 31-139 5.00e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 59.01  E-value: 5.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   31 PKVTEIIPKYGSINGATRLTIRGEGFSQanqfnygvdnaelgNSVQLISSFQSITCDVEKdaSHSTQITCYTRAMPE-DS 109
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGS--------------GSPRVRVTVGGVPCKVLN--VSSTEIVCRTPAAATpGE 64

                          90       100       110
                  ....*....|....*....|....*....|
gi 126116589  110 YTVRVSVDGVPVtenntckGHINSWECTFN 139
Cdd:cd00603    65 GPVEVTVDGANV-------SARVLSNTTFT 87
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 2001-2085 9.94e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.84  E-value: 9.94e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  2001 IQNINPSQGSFGGGQTMTVTGTGFN--PQNSIILVCGSECAIdrLRSDYTTLLCEIPSNNGTGaeqaCEVSV-VNGKDLS 2077
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGtdSSDLKVTIGGTPCTV--ISVSSTTIVCTTPPGTSGL----VNVSVtVGGGGIS 76


                   ....*...
gi 126116589  2078 QSMTPFTY 2085
Cdd:pfam01833   77 SSPLTFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1916-1997 1.17e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 57.85  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1916 PFLRGIIPSRGPP--GTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDHA-GGTFPVMMHHKTKGSAM-- 1990
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANVSArv 80


                  ....*...
gi 126116589 1991 -STVVFEY 1997
Cdd:cd00603    81 lSNTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1240-1318 2.67e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.69  E-value: 2.67e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126116589  1240 PIITDFSPKVRTILGEVNLTIKGYNFGNElTQNMAVYVGGKTCQILHWNFTDIRCLLPKLSPGKHDIYVEVRNWGFAST 1318
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTD-SSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1067-1143 5.23e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.92  E-value: 5.23e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126116589  1067 PLVLAISPSQGSYEEGTILTIVGSGFSP-SSAVTVSVGPVGCSLLSVDEKELKCQILNGSAGHAPVAVSMADVGLAQN 1143
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTdSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT smart00429
ig-like, plexins, transcription factors;
1831-1896 1.00e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 55.12  E-value: 1.00e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126116589   1831 PPVASLSPTSGSIGGGTTLVITGNGFYPGNT---TVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKI 1896
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPV 70
IPT smart00429
ig-like, plexins, transcription factors;
1157-1225 6.79e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 52.81  E-value: 6.79e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126116589   1157 ISHIWPDSGSIAGGTLLTLSGFGFN----ENSKVLVGNETCNVIEGDLNRITCRTPKKTEGTVDISVTTNGFQ 1225
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCGKNLKsisvVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLR 76
IPT smart00429
ig-like, plexins, transcription factors;
2091-2177 6.47e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 50.11  E-value: 6.47e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   2091 PLITAVSPKRGSTAGGTRLTVVGSGF-SENMEDVHITIAEAKCDVEYSNKTHIICMTDA-HTLSGWAPV-CVHIRGVGmA 2167
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLkSISVVFVEVGVGEAPCTFSPSSSTAIVCKTPPyHNIPGSVPVrTVGLRNGG-V 80

                            90
                    ....*....|
gi 126116589   2168 KLDNADFLYV 2177
Cdd:smart00429   81 PSSPQPFTYV 90
PA14 smart00758
domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, ...
 341-467 9.21e-07

domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins;


Pssm-ID: 214807 [Multi-domain]  Cd Length: 136  Bit Score: 50.86  E-value: 9.21e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589    341 GLKLEVWNNSRPIRLEEIleynEKTPGYMGASWvDSASYIWLMEQDTFVARFSGFLVAPDSDVYRFYIKGDDRYAIYFSq 420
Cdd:smart00758    2 GLTGYYFENEKFSGLPEI----IDTDPLNTFYW-DSDKFGEGEKADNFSVRWTGYLKPPEDGEYTFSITSDDGARLWID- 75

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*..
gi 126116589    421 tglpeDKVRIAYHSANANsyfssPTQRSDDIHLQKGKEYYIEILLQE 467
Cdd:smart00758   76 -----GKLVIDNWGKHEA-----RPSTSSTLYLLAGGTYPIRIEYFE 112
IPT smart00429
ig-like, plexins, transcription factors;
1067-1153 2.51e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 48.57  E-value: 2.51e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSVGPVG--CSLLSVDEKELKCQILNGSAGHAPVAVSMADVGLAqNV 1144
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEapCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRNG-GV 80


                    ....*....
gi 126116589   1145 GGEEFYFVY 1153
Cdd:smart00429   81 PSSPQPFTY 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 146-255 3.90e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 47.83  E-value: 3.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   146 PTIRSITPLSGTP--GTLITIQGRIFtdvygsnialssnGKNVRILRVYIGGMPCELlIPQSDNlyglkldhpngdmgSM 223
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTV-ISVSST--------------TI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 126116589   224 VCKTTGTFIGHHNVSFILDNDYGRSFPQKMAY 255
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 363-467 5.00e-06

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 48.90  E-value: 5.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   363 EKTPGYMGASWvDSASYIWLMEQDTFVARFSGFLVAPDSDVYRFYIKGDDRYAIYFSqtglpeDKVRIAYhsaNANSYFS 442
Cdd:pfam07691   22 IDTDPDNTFYW-DTDVPGFGEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWID------GELVIDN---WGQHPPD 91

                           90       100
                   ....*....|....*....|....*
gi 126116589   443 SPTQRSDDIHLQKGKEYYIEILLQE 467
Cdd:pfam07691   92 ASPEESNTLYLVAGKLYPIRIEYFH 116
IPT smart00429
ig-like, plexins, transcription factors;
1658-1744 5.60e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 47.42  E-value: 5.60e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   1658 LPNIDLVLPNAGSTTGMTSVTIKGSGF-AVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVD-----VDLLIHGV 1731
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLkSISVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSvpvrtVGLRNGGV 80

                            90
                    ....*....|...
gi 126116589   1732 PAQCQgncTFSYL 1744
Cdd:smart00429   81 PSSPQ---PFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
2001-2085 1.42e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 46.26  E-value: 1.42e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   2001 IQNINPSQGSFGGGQTMTVTGTGFNPQNSIIL---VCGSECAIDRLRSdyTTLLCEIPS-NNGTGAEQACEVSVVNGkDL 2076
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCGKNLKSISVVFVevgVGEAPCTFSPSSS--TAIVCKTPPyHNIPGSVPVRTVGLRNG-GV 80


                    ....*....
gi 126116589   2077 SQSMTPFTY 2085
Cdd:smart00429   81 PSSPQPFTY 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1566-1624 1.47e-05

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 46.29  E-value: 1.47e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126116589 1566 PSISNITPSTGTVNE--LITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHIDPQNS 1624
Cdd:cd00603     1 PVITSISPSSGPLSGgtRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAT 61
IPT smart00429
ig-like, plexins, transcription factors;
1330-1383 1.61e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 46.26  E-value: 1.61e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 126116589   1330 LEVTSMFPQRGSLFGGTEITIRGFGFSTIPAEN-TVLLGSIPCNVTSSSENVIKC 1383
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFvEVGVGEAPCTFSPSSSTAIVC 56
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 31-126 2.87e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 45.13  E-value: 2.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589    31 PKVTEIIPKYGSINGATRLTIRGEGFSQanqfnygvdnaelgNSVQLISSFQSITCDVEKDAshSTQITCYTRAMPEDSY 110
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGT--------------DSSDLKVTIGGTPCTVISVS--STTIVCTTPPGTSGLV 64

                           90
                   ....*....|....*.
gi 126116589   111 TVRVSVDGVPVTENNT 126
Cdd:pfam01833   65 NVSVTVGGGGISSSPL 80
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3256-3512 5.47e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 48.76  E-value: 5.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 3256 ILSRNIKIVGEDYPgwsedsfgarVLVGSFTENMMTFKG-NARISNVEFYHSGqegfRDSTDPRYAvtflnlgqIQEHGS 3334
Cdd:COG3420    49 VIDKPLTLIGEGGA----------VIDGGGKGTVITITAdNVTVRGLTITGSG----DSLTDDDAG--------IYVRGA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 3335 SY--IRGCAFHHGFSpAIGVFGTDGLDIDDNIIH------FTVGEGIRIWG-NANRVRGNLIalsvwpgtYQNRKdlsst 3405
Cdd:COG3420   107 DNavIENNRIENNLF-GIYLEGSDNNVIRNNTISgnrdlrADRGNGIHLWNsPGNVIEGNTI--------SGGRD----- 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 3406 lwhaAIEINRGTNTVLQNNVVAGfGRAGYRIDGepcpGQFNPVEkwfDNEAHGGLYGIY-MNQDGLpgcsLIQGFTIWTC 3484
Cdd:COG3420   173 ----GIYLEFSDNNVIRNNTIRN-LRYGIHYMY----SNDNLVE---GNTFRDNGAGIAlMYSKGN----TVRGNTILGN 236

                         250       260
                  ....*....|....*....|....*...
gi 126116589 3485 WDYGIYFQTTESVHIYNVTLVDNGMAIF 3512
Cdd:COG3420   237 SGYGILLKESSDSVIEGNTISGNGKGIF 264
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 146-244 1.01e-04

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 43.98  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  146 PTIRSITPLSGTP--GTLITIqgriftdvYGSNiaLSSNGKNVRilrVYIGGMPCELLipqsdnlyglkldhpNGDMGSM 223
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTI--------TGSN--LGSGSPRVR---VTVGGVPCKVL---------------NVSSTEI 52

                          90       100
                  ....*....|....*....|..
gi 126116589  224 VCKT-TGTFIGHHNVSFILDND 244
Cdd:cd00603    53 VCRTpAAATPGEGPVEVTVDGA 74
IPT smart00429
ig-like, plexins, transcription factors;
31-138 1.28e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 43.56  E-value: 1.28e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589     31 PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAElgnsvqlissfqsITCDVekDASHSTQITCYTRAmpedsy 110
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGE-------------APCTF--SPSSSTAIVCKTPP------ 60

                            90       100
                    ....*....|....*....|....*...
gi 126116589    111 tVRVSVDGVPVTENNTCKGHINSWECTF 138
Cdd:smart00429   61 -YHNIPGSVPVRTVGLRNGGVPSSPQPF 87
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1749-1827 1.69e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.20  E-value: 1.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1749 PYITGVFPNS--VIGSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVVVGSKGLALGNL 1826
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   .
gi 126116589  1827 T 1827
Cdd:pfam01833   81 T 81
PetE COG3794
Plastocyanin [Energy production and conversion];
1407-1479 2.57e-04

Plastocyanin [Energy production and conversion];


Pssm-ID: 443008 [Multi-domain]  Cd Length: 76  Bit Score: 42.29  E-value: 2.57e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126116589 1407 YAWSPPVLNVSVGDTVAWHWQThpflrGIGYRIFSVSSPgsviydGKGFTSGRQKsTSGSFSYQFTSPGIHYY 1479
Cdd:COG3794     1 MAFEPATLTVKPGDTVTWVNTD-----SVPHNVTSDDGP------DGAFDSGLLA-PGETFSVTFDEPGTYDY 61
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3294-3387 7.85e-03

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 40.08  E-value: 7.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  3294 GNARISNVEFYHSGQEGFRDSTDPRyaVTFLN-------LGQIQEHGSSY--IRGCAFHHGFSPAIGVFGTDGLDIDDNI 3364
Cdd:pfam13229   32 SNATIENNTITNNGGDGIEISGSSN--NTISNntisnngGGGIALRGSSNnlIENNTISNNGGAGIYLSDSSNNTIENNI 109

                           90       100
                   ....*....|....*....|....*
gi 126116589  3365 IHFTVGEGIRI--WGNANRVRGNLI 3387
Cdd:pfam13229  110 IHNNGGSGIVIedSSNNVTISNNTV 134
IPT smart00429
ig-like, plexins, transcription factors;
1240-1297 8.95e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 38.17  E-value: 8.95e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 126116589   1240 PIITDFSPKVRTILGEVNLTIKGYNFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLP 1297
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPSSSTAIVCKTP 59
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2185-2303 1.95e-43

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 155.46  E-value: 1.95e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  2185 SWGGKSPPEEGSLVVITKGQTILLDQSTPILKMLLIQgGTLIF-DEADIELQAENILITdGGVLQIGTETSPFQHKAVIT 2263
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 126116589  2264 LHG--HLRSPELPVYGAKTLAVRE-GILDLHGVPVPVTWTRLA 2303
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
Cupredoxin_Fibrocystin-L_like cd04217
Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease ...
 1395-1498 4.99e-36

Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease protein; One member of this family is Fibrocystin-L, a homolog of the autosomal recessive polycystic kidney disease protein PKHD1. Human fibrocystin-L is predicted to be a large receptor protein (466 kDa) with a signal peptide, a single transmembrane domain and a short cytoplasmic tail. Fibrocystin-L is widely expressed at a low level in most tissues but is up-regulated specifically in T lymphocytes following activation signals. It may play roles in immunity.


Pssm-ID: 259879 [Multi-domain]  Cd Length: 86  Bit Score: 132.68  E-value: 4.99e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1395 TNNGKDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPflrgiGYRIFSVSSPGSVIYDgkgftsgrQKSTSGSFSYQFTSP 1474
Cdd:cd04217     1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                          90       100
                  ....*....|....*....|....
gi 126116589 1475 GIHYYSSGYVDEahsifLQGVINV 1498
Cdd:cd04217    68 GTYYFSVKDVPE-----MKGTINV 86
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 3044-3173 4.69e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.57  E-value: 4.69e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  3044 NNYTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDKynvgaaessyREVVLNATYISLQGGRLIGGWEDNPFK 3123
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDD----------KNITLRARYILVQGGRLIIGSEDCPFQ 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 126116589  3124 GDLKIVLRGNHTTQDwalPEGPNQGAKVLGV--FGELDLHGIPHSIYKTKLS 3173
Cdd:pfam10162   73 GKATITLHGRPELDD---DDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 271-363 1.09e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 83.66  E-value: 1.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  271 EVTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTPPKPhilkTVYPGGRGLKLEVWNNS 350
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAA----TPGEGPVEVTVDGANVS 77

                          90
                  ....*....|...
gi 126116589  351 RPIRLEEILEYNE 363
Cdd:cd00603    78 ARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2091-2178 2.14e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.89  E-value: 2.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 2091 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTLSGWAP--VCVHIRGVGMAK 2168
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPveVTVDGANVSARV 80

                          90
                  ....*....|
gi 126116589 2169 LDNADFLYVD 2178
Cdd:cd00603    81 LSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1659-1745 3.46e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 79.42  E-value: 3.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQ---QLVDVDLLIHGVPAQC 1735
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATpgeGPVEVTVDGANVSARV 80

                          90
                  ....*....|
gi 126116589 1736 QGNCTFSYLE 1745
Cdd:cd00603    81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1831-1910 1.86e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 77.10  E-value: 1.86e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1831 PPVASLSPTSGSIGGGTTLVITGNGFYPG--NTTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNT--IAYPPL 1906
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGggISSSPL 80


                   ....
gi 126116589  1907 LFTY 1910
Cdd:pfam01833   81 TFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1831-1910 2.01e-16

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 77.11  E-value: 2.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPG--NTTVTIGDEPCQIISINPNEVYCRTPAGTTGM---VDVKIF---VNTIA 1902
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGspRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGegpVEVTVDganVSARV 80


                  ....*...
gi 126116589 1903 YPPLLFTY 1910
Cdd:cd00603    81 LSNTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 2091-2176 6.09e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 75.56  E-value: 6.09e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  2091 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTlSGWAPVCVHIRGVGMAkLD 2170
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGT-SGLVNVSVTVGGGGIS-SS 78


                   ....*.
gi 126116589  2171 NADFLY 2176
Cdd:pfam01833   79 PLTFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1240-1314 1.23e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 74.80  E-value: 1.23e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126116589 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNElTQNMAVYVGGKTCQILHWNFTDIRCLLPKL-SPGKHDIYVEVRNWG 1314
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSG-SPRVRVTVGGVPCKVLNVSSTEIVCRTPAAaTPGEGPVEVTVDGAN 75
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1831-1910 9.49e-15

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 72.11  E-value: 9.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPG-NTTVTIGDE-PCQIISINPNEVYCRTPAGTTGM-----VDVKIFVNTIAY 1903
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGsNLRVTFGGGvPCSVLSVSSTAIVCTTPPYANPGpgpveVTVDRGNGGITS 80


                  ....*..
gi 126116589 1904 PPLLFTY 1910
Cdd:cd00102    81 SPLTFTY 87
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1157-1234 2.65e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 70.95  E-value: 2.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1157 ISHIWPDSGSIAGGTLLTLSGFGFN---ENSKVLVGNETCNVIEGDLNRITCRTPKKTEG-----TVDISVTTNGFQATA 1228
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLGsgsPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                  ....*.
gi 126116589 1229 RDAFSY 1234
Cdd:cd00603    83 NTTFTY 88
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 2091-2178 3.01e-13

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 67.87  E-value: 3.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 2091 PLITAVSPKRGSTAGGTRLTVVGSGFSENMeDVHITI-AEAKCDVEYSNKTHIICMTDAHTLSGWAPVCVHI-RGVGMAK 2168
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGS-NLRVTFgGGVPCSVLSVSSTAIVCTTPPYANPGPGPVEVTVdRGNGGIT 79

                          90
                  ....*....|
gi 126116589 2169 LDNADFLYVD 2178
Cdd:cd00102    80 SSPLTFTYVP 89
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 271-329 5.79e-13

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 67.10  E-value: 5.79e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  271 EVTMIFPSQGSIRGGTTLTISGRFFDqTDFPVRVLVGGE-PCDILNVTENSICCKTPPKP 329
Cdd:cd00102     2 VITSISPSSGPVSGGTEVTITGSNFG-SGSNLRVTFGGGvPCSVLSVSSTAIVCTTPPYA 60
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1659-1743 1.22e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 65.93  E-value: 1.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVDVDLLIHGVpAQCQGN 1738
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGG-GISSSP 79


                   ....*
gi 126116589  1739 CTFSY 1743
Cdd:pfam01833   80 LTFTY 84
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 272-363 1.23e-12

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 66.09  E-value: 1.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  272 VTMIFPSQGSIRGGTTLTISGRFFDqTDFPVRVLVGGEPCDILNVTENSICCKTPPKPHILKtvypggrgLKLEVWNNSR 351
Cdd:cd01179     3 ITSLSPSYGPQSGGTRLTITGKHLN-AGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGE--------APVKVLIDGA 73

                          90
                  ....*....|..
gi 126116589  352 PIRLEEILEYNE 363
Cdd:cd01179    74 RRLAPLVFTYTE 85
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1831-1910 1.51e-12

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 65.71  E-value: 1.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPGNTT-VTIGDEPCQIISINPNEVYCRTPAGTTGM-VDVKIFV-NTIAYPPLL 1907
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVrVTVGGQPCKILSVSSSQIVCLTPPSASPGeAPVKVLIdGARRLAPLV 80


                  ...
gi 126116589 1908 FTY 1910
Cdd:cd01179    81 FTY 83
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1067-1154 4.08e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 64.78  E-value: 4.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSA-VTVSVGPVGCSLLSVDEKELKCQIL-NGSAGHAPVAVSmADVGLAQNV 1144
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrVRVTVGGVPCKVLNVSSTEIVCRTPaAATPGEGPVEVT-VDGANVSAR 79

                          90
                  ....*....|
gi 126116589 1145 GGEEFYFVYQ 1154
Cdd:cd00603    80 VLSNTTFTYV 89
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1156-1234 4.19e-12

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 64.79  E-value: 4.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1156 QISHIWPDSGSIAGGTLLTLSG--FGFNENSKVLV-GNETCNVIEGDLNRITCRTPK---KTEGTVDISVTT-NGFQATA 1228
Cdd:cd00102     2 VITSISPSSGPVSGGTEVTITGsnFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPyanPGPGPVEVTVDRgNGGITSS 81


                  ....*.
gi 126116589 1229 RDAFSY 1234
Cdd:cd00102    82 PLTFTY 87
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2000-2085 1.01e-11

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 63.63  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 2000 NIQNINPSQGSFGGGQTMTVTGTGFNP--QNSIILVCGSECAIdrLRSDYTTLLCEIPS-NNGTGAEQACEVSVVNGKDL 2076
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSgsPRVRVTVGGVPCKV--LNVSSTEIVCRTPAaATPGEGPVEVTVDGANVSAR 79


                  ....*....
gi 126116589 2077 SQSMTPFTY 2085
Cdd:cd00603    80 VLSNTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1156-1234 1.57e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.85  E-value: 1.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1156 QISHIWPDSGSIAGGTLLTLSGFGFNENS---KVLVGNETCNVIEGDLNRITCRTPKKTEGTVDISVTTNGFQATARD-A 1231
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPlT 81


                   ...
gi 126116589  1232 FSY 1234
Cdd:pfam01833   82 FTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1659-1745 3.91e-11

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 62.09  E-value: 3.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQL-VDVDLLIHGVPAQCQG 1737
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCTTPPYANPGpGPVEVTVDRGNGGITS 80


                  ....*....
gi 126116589 1738 NC-TFSYLE 1745
Cdd:cd00102    81 SPlTFTYVP 89
IPT smart00429
ig-like, plexins, transcription factors;
271-335 4.56e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 61.67  E-value: 4.56e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126116589    271 EVTMIFPSQGSIRGGTTLTISGRFFDQ-TDFPVRVLVGGEPCDILNVTENSICCKTPPKPHILKTV 335
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSV 68
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1566-1633 6.34e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 61.31  E-value: 6.34e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1566 PSISNITPSTGTVN--ELITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHIDPQNSMDVGIRETV 1633
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTV 70
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1916-1997 2.26e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 2.26e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1916 PFLRGIIPSRGPP--GTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDHAGGTFPVMMHHKTKGSAMSTV 1993
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ....
gi 126116589  1994 VFEY 1997
Cdd:pfam01833   81 TFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1330-1406 2.41e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 2.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1330 LEVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENVIKCIL--HSTGNI-FRITNNGKDSVHGLG 1406
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTppGTSGLVnVSVTVGGGGISSSPL 80
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1331-1383 3.22e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 59.39  E-value: 3.22e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 126116589 1331 EVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENVIKC 1383
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVC 54
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1240-1318 3.61e-10

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 59.40  E-value: 3.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNEltQNMAVYVGG-KTCQILHWNFTDIRCLLPKL---SPGKHDIYVEVRNWGF 1315
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSG--SNLRVTFGGgVPCSVLSVSSTAIVCTTPPYanpGPGPVEVTVDRGNGGI 78


                  ...
gi 126116589 1316 AST 1318
Cdd:cd00102    79 TSS 81
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 272-327 3.86e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.00  E-value: 3.86e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 126116589   272 VTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTPP 327
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPP 58
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 31-139 5.00e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 59.01  E-value: 5.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   31 PKVTEIIPKYGSINGATRLTIRGEGFSQanqfnygvdnaelgNSVQLISSFQSITCDVEKdaSHSTQITCYTRAMPE-DS 109
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGS--------------GSPRVRVTVGGVPCKVLN--VSSTEIVCRTPAAATpGE 64

                          90       100       110
                  ....*....|....*....|....*....|
gi 126116589  110 YTVRVSVDGVPVtenntckGHINSWECTFN 139
Cdd:cd00603    65 GPVEVTVDGANV-------SARVLSNTTFT 87
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 2001-2085 9.94e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.84  E-value: 9.94e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  2001 IQNINPSQGSFGGGQTMTVTGTGFN--PQNSIILVCGSECAIdrLRSDYTTLLCEIPSNNGTGaeqaCEVSV-VNGKDLS 2077
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGtdSSDLKVTIGGTPCTV--ISVSSTTIVCTTPPGTSGL----VNVSVtVGGGGIS 76


                   ....*...
gi 126116589  2078 QSMTPFTY 2085
Cdd:pfam01833   77 SSPLTFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1916-1997 1.17e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 57.85  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1916 PFLRGIIPSRGPP--GTEIEITGSNFGFEILEISVMINNIQCNVTMANDSVVQCIVGDHA-GGTFPVMMHHKTKGSAM-- 1990
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANVSArv 80


                  ....*...
gi 126116589 1991 -STVVFEY 1997
Cdd:cd00603    81 lSNTTFTY 88
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1067-1155 1.97e-09

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 57.09  E-value: 1.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSV-GPVGCSLLSVDEKELKCQI---LNGSAGHAPVAVSMADVGLAQ 1142
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTppyANPGPGPVEVTVDRGNGGITS 80

                          90
                  ....*....|...
gi 126116589 1143 NvggeEFYFVYQS 1155
Cdd:cd00102    81 S----PLTFTYVP 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1240-1318 2.67e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.69  E-value: 2.67e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126116589  1240 PIITDFSPKVRTILGEVNLTIKGYNFGNElTQNMAVYVGGKTCQILHWNFTDIRCLLPKLSPGKHDIYVEVRNWGFAST 1318
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTD-SSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1067-1143 5.23e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.92  E-value: 5.23e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126116589  1067 PLVLAISPSQGSYEEGTILTIVGSGFSP-SSAVTVSVGPVGCSLLSVDEKELKCQILNGSAGHAPVAVSMADVGLAQN 1143
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTdSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 2091-2161 8.57e-09

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 55.31  E-value: 8.57e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126116589 2091 PLITAVSPKRGSTAGGTRLTVVG----SGFSenmedVHITIAEAKCDVEYSNKTHIICMTDAHTLSGWAPVCVHI 2161
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGkhlnAGSS-----VRVTVGGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLI 70
IPT smart00429
ig-like, plexins, transcription factors;
1831-1896 1.00e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 55.12  E-value: 1.00e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126116589   1831 PPVASLSPTSGSIGGGTTLVITGNGFYPGNT---TVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKI 1896
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPV 70
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1999-2085 5.28e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 53.23  E-value: 5.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1999 LNIQNINPSQGSFGGGQTMTVTGTGFNP-QNSIILV-CGSECAIdrLRSDYTTLLCEIPSNNGTGAEQAcEVSVVNGKDL 2076
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSgSNLRVTFgGGVPCSV--LSVSSTAIVCTTPPYANPGPGPV-EVTVDRGNGG 77

                          90
                  ....*....|
gi 126116589 2077 S-QSMTPFTY 2085
Cdd:cd00102    78 ItSSPLTFTY 87
IPT smart00429
ig-like, plexins, transcription factors;
1157-1225 6.79e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 52.81  E-value: 6.79e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126116589   1157 ISHIWPDSGSIAGGTLLTLSGFGFN----ENSKVLVGNETCNVIEGDLNRITCRTPKKTEGTVDISVTTNGFQ 1225
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCGKNLKsisvVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLR 76
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 2091-2178 9.97e-08

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 52.32  E-value: 9.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 2091 PLITAVSPKRGSTAGGTRLTVVGS--GFSENMEDVHITIAEAKCDV---EYSNKTHIICMTD-AHTLSGWAPVCVHIRGV 2164
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSnlGLRKNDVRHGVRVGGVPCNPeppEYSSSEKIVCTTGpAGNPVFNGPVEVTVGHG 80

                          90
                  ....*....|....
gi 126116589 2165 GMAKLDNADFLYVD 2178
Cdd:cd01180    81 SFRTESSEGFSFVD 94
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 31-128 2.18e-07

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 51.31  E-value: 2.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   31 PKVTEIIPKYGSINGATRLTIRGEGFSQANqfnygvdnaelgNSVQLIssFQSITCDVEKdaSHSTQITCYTRAMPE-DS 109
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGS------------NLRVTF--GGGVPCSVLS--VSSTAIVCTTPPYANpGP 64

                          90
                  ....*....|....*....
gi 126116589  110 YTVRVSVDGVPVTENNTCK 128
Cdd:cd00102    65 GPVEVTVDRGNGGITSSPL 83
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1157-1234 4.66e-07

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 50.39  E-value: 4.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1157 ISHIWPDSGSIAGGTLLTLSG--FGFNEN---SKVLVGNETCNVIEG---DLNRITCRTPKK----TEGTVDISVTTNGF 1224
Cdd:cd01180     3 ITEFFPLSGPLEGGTRLTICGsnLGLRKNdvrHGVRVGGVPCNPEPPeysSSEKIVCTTGPAgnpvFNGPVEVTVGHGSF 82

                          90
                  ....*....|
gi 126116589 1225 QATARDAFSY 1234
Cdd:cd01180    83 RTESSEGFSF 92
IPT smart00429
ig-like, plexins, transcription factors;
2091-2177 6.47e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 50.11  E-value: 6.47e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   2091 PLITAVSPKRGSTAGGTRLTVVGSGF-SENMEDVHITIAEAKCDVEYSNKTHIICMTDA-HTLSGWAPV-CVHIRGVGmA 2167
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLkSISVVFVEVGVGEAPCTFSPSSSTAIVCKTPPyHNIPGSVPVrTVGLRNGG-V 80

                            90
                    ....*....|
gi 126116589   2168 KLDNADFLYV 2177
Cdd:smart00429   81 PSSPQPFTYV 90
PA14 smart00758
domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, ...
 341-467 9.21e-07

domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins;


Pssm-ID: 214807 [Multi-domain]  Cd Length: 136  Bit Score: 50.86  E-value: 9.21e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589    341 GLKLEVWNNSRPIRLEEIleynEKTPGYMGASWvDSASYIWLMEQDTFVARFSGFLVAPDSDVYRFYIKGDDRYAIYFSq 420
Cdd:smart00758    2 GLTGYYFENEKFSGLPEI----IDTDPLNTFYW-DSDKFGEGEKADNFSVRWTGYLKPPEDGEYTFSITSDDGARLWID- 75

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*..
gi 126116589    421 tglpeDKVRIAYHSANANsyfssPTQRSDDIHLQKGKEYYIEILLQE 467
Cdd:smart00758   76 -----GKLVIDNWGKHEA-----RPSTSSTLYLLAGGTYPIRIEYFE 112
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1157-1234 9.78e-07

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 49.53  E-value: 9.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1157 ISHIWPDSGSIAGGTLLTLSGFGFNENS--KVLVGNETCNVIEGDLNRITCRTPKKTE-GTVDISVTTNGFQATARDAFS 1233
Cdd:cd01179     3 ITSLSPSYGPQSGGTRLTITGKHLNAGSsvRVTVGGQPCKILSVSSSQIVCLTPPSASpGEAPVKVLIDGARRLAPLVFT 82


                  .
gi 126116589 1234 Y 1234
Cdd:cd01179    83 Y 83
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 271-329 1.58e-06

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 49.24  E-value: 1.58e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126116589  271 EVTMIFPSQGSIRGGTTLTISGRFF--DQTDFPVRVLVGGEPCDILN---VTENSICCKTPPKP 329
Cdd:cd01180     2 VITEFFPLSGPLEGGTRLTICGSNLglRKNDVRHGVRVGGVPCNPEPpeySSSEKIVCTTGPAG 65
IPT smart00429
ig-like, plexins, transcription factors;
1067-1153 2.51e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 48.57  E-value: 2.51e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSVGPVG--CSLLSVDEKELKCQILNGSAGHAPVAVSMADVGLAqNV 1144
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEapCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRNG-GV 80


                    ....*....
gi 126116589   1145 GGEEFYFVY 1153
Cdd:smart00429   81 PSSPQPFTY 89
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1331-1390 2.77e-06

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 48.47  E-value: 2.77e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126116589 1331 EVTSMFPQRGSLFGGTEITIRG--FGFSTIPAENTVLLGSIPCNVT---SSSENVIKCILHSTGN 1390
Cdd:cd01180     2 VITEFFPLSGPLEGGTRLTICGsnLGLRKNDVRHGVRVGGVPCNPEppeYSSSEKIVCTTGPAGN 66
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1330-1384 3.13e-06

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 48.23  E-value: 3.13e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 126116589 1330 LEVTSMFPQRGSLFGGTEITIRGFGFSTIPAEnTVLL-GSIPCNVTSSSENVIKCI 1384
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNL-RVTFgGGVPCSVLSVSSTAIVCT 55
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 146-255 3.90e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 47.83  E-value: 3.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   146 PTIRSITPLSGTP--GTLITIQGRIFtdvygsnialssnGKNVRILRVYIGGMPCELlIPQSDNlyglkldhpngdmgSM 223
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTV-ISVSST--------------TI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 126116589   224 VCKTTGTFIGHHNVSFILDNDYGRSFPQKMAY 255
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 363-467 5.00e-06

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 48.90  E-value: 5.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   363 EKTPGYMGASWvDSASYIWLMEQDTFVARFSGFLVAPDSDVYRFYIKGDDRYAIYFSqtglpeDKVRIAYhsaNANSYFS 442
Cdd:pfam07691   22 IDTDPDNTFYW-DTDVPGFGEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWID------GELVIDN---WGQHPPD 91

                           90       100
                   ....*....|....*....|....*
gi 126116589   443 SPTQRSDDIHLQKGKEYYIEILLQE 467
Cdd:pfam07691   92 ASPEESNTLYLVAGKLYPIRIEYFH 116
IPT smart00429
ig-like, plexins, transcription factors;
1658-1744 5.60e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 47.42  E-value: 5.60e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   1658 LPNIDLVLPNAGSTTGMTSVTIKGSGF-AVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVD-----VDLLIHGV 1731
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLkSISVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSvpvrtVGLRNGGV 80

                            90
                    ....*....|...
gi 126116589   1732 PAQCQgncTFSYL 1744
Cdd:smart00429   81 PSSPQ---PFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
2001-2085 1.42e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 46.26  E-value: 1.42e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   2001 IQNINPSQGSFGGGQTMTVTGTGFNPQNSIIL---VCGSECAIDRLRSdyTTLLCEIPS-NNGTGAEQACEVSVVNGkDL 2076
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCGKNLKSISVVFVevgVGEAPCTFSPSSS--TAIVCKTPPyHNIPGSVPVRTVGLRNG-GV 80


                    ....*....
gi 126116589   2077 SQSMTPFTY 2085
Cdd:smart00429   81 PSSPQPFTY 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1566-1624 1.47e-05

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 46.29  E-value: 1.47e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126116589 1566 PSISNITPSTGTVNE--LITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHIDPQNS 1624
Cdd:cd00603     1 PVITSISPSSGPLSGgtRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAT 61
IPT smart00429
ig-like, plexins, transcription factors;
1330-1383 1.61e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 46.26  E-value: 1.61e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 126116589   1330 LEVTSMFPQRGSLFGGTEITIRGFGFSTIPAEN-TVLLGSIPCNVTSSSENVIKC 1383
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFvEVGVGEAPCTFSPSSSTAIVC 56
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 31-126 2.87e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 45.13  E-value: 2.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589    31 PKVTEIIPKYGSINGATRLTIRGEGFSQanqfnygvdnaelgNSVQLISSFQSITCDVEKDAshSTQITCYTRAMPEDSY 110
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGT--------------DSSDLKVTIGGTPCTVISVS--STTIVCTTPPGTSGLV 64

                           90
                   ....*....|....*.
gi 126116589   111 TVRVSVDGVPVTENNT 126
Cdd:pfam01833   65 NVSVTVGGGGISSSPL 80
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1921-1997 2.96e-05

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 45.14  E-value: 2.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1921 IIPSRGPP--GTEIEITGSNFGFEIlEISVMI-NNIQCNVTMANDSVVQCIVG-DHAGGTFPVMMHHKTKGSAM--STVV 1994
Cdd:cd00102     6 ISPSSGPVsgGTEVTITGSNFGSGS-NLRVTFgGGVPCSVLSVSSTAIVCTTPpYANPGPGPVEVTVDRGNGGItsSPLT 84


                  ...
gi 126116589 1995 FEY 1997
Cdd:cd00102    85 FTY 87
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1067-1152 4.06e-05

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 44.91  E-value: 4.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSVGPVGCSLLSVDEKELKCQILNGSAGH-APVAVSmadVGLAQNVG 1145
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGeAPVKVL---IDGARRLA 77


                  ....*..
gi 126116589 1146 GEEFYFV 1152
Cdd:cd01179    78 PLVFTYT 84
Halocyanin cd04220
Halocyanin is an archaea blue (type I) copper redox protein; Halocyanins are blue (type I) ...
 1406-1479 5.37e-05

Halocyanin is an archaea blue (type I) copper redox protein; Halocyanins are blue (type I) copper redox proteins found in halophilic archaea such as Natronomonas pharaonis (Natronobacterium pharaonis). Halocyanin may serve as a mobile electron carrier at a peripheral membrane protein. The copper-binding domain is present only once in some halocyanins and is duplicated in others.


Pssm-ID: 259882 [Multi-domain]  Cd Length: 92  Bit Score: 44.69  E-value: 5.37e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126116589 1406 GYAWSPPVLNVSVGDTVAWHWQTHpflrGIGYRIFSVSSPgsviydGKGFTSGRQKSTSG-SFSYQFTSPGIHYY 1479
Cdd:cd04220    11 GFAFDPAAIRVSPGTTVTWEWTGE----GGGHNVVAYEDP------ITAFDSGSTDSSEGeTYEHTFEETGEYRY 75
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3256-3512 5.47e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 48.76  E-value: 5.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 3256 ILSRNIKIVGEDYPgwsedsfgarVLVGSFTENMMTFKG-NARISNVEFYHSGqegfRDSTDPRYAvtflnlgqIQEHGS 3334
Cdd:COG3420    49 VIDKPLTLIGEGGA----------VIDGGGKGTVITITAdNVTVRGLTITGSG----DSLTDDDAG--------IYVRGA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 3335 SY--IRGCAFHHGFSpAIGVFGTDGLDIDDNIIH------FTVGEGIRIWG-NANRVRGNLIalsvwpgtYQNRKdlsst 3405
Cdd:COG3420   107 DNavIENNRIENNLF-GIYLEGSDNNVIRNNTISgnrdlrADRGNGIHLWNsPGNVIEGNTI--------SGGRD----- 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 3406 lwhaAIEINRGTNTVLQNNVVAGfGRAGYRIDGepcpGQFNPVEkwfDNEAHGGLYGIY-MNQDGLpgcsLIQGFTIWTC 3484
Cdd:COG3420   173 ----GIYLEFSDNNVIRNNTIRN-LRYGIHYMY----SNDNLVE---GNTFRDNGAGIAlMYSKGN----TVRGNTILGN 236

                         250       260
                  ....*....|....*....|....*...
gi 126116589 3485 WDYGIYFQTTESVHIYNVTLVDNGMAIF 3512
Cdd:COG3420   237 SGYGILLKESSDSVIEGNTISGNGKGIF 264
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1659-1745 5.83e-05

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 44.14  E-value: 5.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAgVKVLMGHFPCKVLSVNYTAIECETSPAAQ-QLVDVDLLIHGvpAQCQG 1737
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSS-VRVTVGGQPCKILSVSSSQIVCLTPPSASpGEAPVKVLIDG--ARRLA 77


                  ....*...
gi 126116589 1738 NCTFSYLE 1745
Cdd:cd01179    78 PLVFTYTE 85
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1067-1152 9.58e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 43.84  E-value: 9.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1067 PLVLAISPSQGSYEEGTILTIVGS--GFSPS-SAVTVSVGPVGCSLL---SVDEKELKCQI--LNGSAGHAPVAVSMADv 1138
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSnlGLRKNdVRHGVRVGGVPCNPEppeYSSSEKIVCTTgpAGNPVFNGPVEVTVGH- 79

                          90
                  ....*....|....
gi 126116589 1139 GLAQNVGGEEFYFV 1152
Cdd:cd01180    80 GSFRTESSEGFSFV 93
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 146-244 1.01e-04

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 43.98  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  146 PTIRSITPLSGTP--GTLITIqgriftdvYGSNiaLSSNGKNVRilrVYIGGMPCELLipqsdnlyglkldhpNGDMGSM 223
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTI--------TGSN--LGSGSPRVR---VTVGGVPCKVL---------------NVSSTEI 52

                          90       100
                  ....*....|....*....|..
gi 126116589  224 VCKT-TGTFIGHHNVSFILDND 244
Cdd:cd00603    53 VCRTpAAATPGEGPVEVTVDGA 74
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1831-1897 1.08e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 43.84  E-value: 1.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126116589 1831 PPVASLSPTSGSIGGGTTLVITGNGFY----PGNTTVTIGDEPCQII---SINPNEVYCRTPA----GTTGMVDVKIF 1897
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGlrknDVRHGVRVGGVPCNPEppeYSSSEKIVCTTGPagnpVFNGPVEVTVG 78
IPT smart00429
ig-like, plexins, transcription factors;
31-138 1.28e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 43.56  E-value: 1.28e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589     31 PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNAElgnsvqlissfqsITCDVekDASHSTQITCYTRAmpedsy 110
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGE-------------APCTF--SPSSSTAIVCKTPP------ 60

                            90       100
                    ....*....|....*....|....*...
gi 126116589    111 tVRVSVDGVPVTENNTCKGHINSWECTF 138
Cdd:smart00429   61 -YHNIPGSVPVRTVGLRNGGVPSSPQPF 87
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1749-1827 1.69e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.20  E-value: 1.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  1749 PYITGVFPNS--VIGSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVVVGSKGLALGNL 1826
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   .
gi 126116589  1827 T 1827
Cdd:pfam01833   81 T 81
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1659-1745 1.74e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 43.46  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGV--KVLMGHFPCKVLSVNY---TAIECETSPAAQQLVD--VDLLIHGV 1731
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVrhGVRVGGVPCNPEPPEYsssEKIVCTTGPAGNPVFNgpVEVTVGHG 80

                          90
                  ....*....|....
gi 126116589 1732 PAQCQGNCTFSYLE 1745
Cdd:cd01180    81 SFRTESSEGFSFVD 94
PetE COG3794
Plastocyanin [Energy production and conversion];
1407-1479 2.57e-04

Plastocyanin [Energy production and conversion];


Pssm-ID: 443008 [Multi-domain]  Cd Length: 76  Bit Score: 42.29  E-value: 2.57e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 126116589 1407 YAWSPPVLNVSVGDTVAWHWQThpflrGIGYRIFSVSSPgsviydGKGFTSGRQKsTSGSFSYQFTSPGIHYY 1479
Cdd:COG3794     1 MAFEPATLTVKPGDTVTWVNTD-----SVPHNVTSDDGP------DGAFDSGLLA-PGETFSVTFDEPGTYDY 61
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 31-118 4.18e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 42.30  E-value: 4.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   31 PKVTEIIPKYGSINGATRLTIRGEGF-SQANQFNYGVdnaELGNSVqlissfqsitCDVEKD-ASHSTQITCYTRAMPED 108
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLgLRKNDVRHGV---RVGGVP----------CNPEPPeYSSSEKIVCTTGPAGNP 67

                          90
                  ....*....|..
gi 126116589  109 SYT--VRVSVDG 118
Cdd:cd01180    68 VFNgpVEVTVGH 79
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 31-124 4.96e-04

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 41.83  E-value: 4.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589   31 PKVTEIIPKYGSINGATRLTIRGE----GFSQAnqfnygvdnAELGNSVQLISSFQsitcdvekdashSTQITCYTRAMP 106
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKhlnaGSSVR---------VTVGGQPCKILSVS------------SSQIVCLTPPSA 59

                          90
                  ....*....|....*....
gi 126116589  107 E-DSYTVRVSVDGVPVTEN 124
Cdd:cd01179    60 SpGEAPVKVLIDGARRLAP 78
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1566-1651 8.62e-04

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 41.29  E-value: 8.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1566 PSISNITPSTGTVN--ELITIIGHGFSNLPWAnKVTI-GSYPCVVEESSEDSITCHIDPQNSMDVGireTVTLTVYNLGT 1642
Cdd:cd00102     1 PVITSISPSSGPVSggTEVTITGSNFGSGSNL-RVTFgGGVPCSVLSVSSTAIVCTTPPYANPGPG---PVEVTVDRGNG 76


                  ....*....
gi 126116589 1643 AINTLSNEF 1651
Cdd:cd00102    77 GITSSPLTF 85
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 146-207 9.78e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 41.15  E-value: 9.78e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126116589  146 PTIRSITPLSGTP--GTLITIqgriftdvYGSNIALSSNGKNVRilrVYIGGMPCELLIPQSDN 207
Cdd:cd01180     1 PVITEFFPLSGPLegGTRLTI--------CGSNLGLRKNDVRHG---VRVGGVPCNPEPPEYSS 53
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1332-1384 1.03e-03

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 40.67  E-value: 1.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 126116589 1332 VTSMFPQRGSLFGGTEITIRG----FGFSTipaenTVLLGSIPCNVTSSSENVIKCI 1384
Cdd:cd01179     3 ITSLSPSYGPQSGGTRLTITGkhlnAGSSV-----RVTVGGQPCKILSVSSSQIVCL 54
Amicyanin cd13921
Amicyanin is a type I blue copper protein that plays an essential role in electron transfer; ...
 1406-1479 1.49e-03

Amicyanin is a type I blue copper protein that plays an essential role in electron transfer; In Paracoccus denitrificans bacteria, amicyanin acts as an intermediary of a three-member redox complex along with methylamine dehydrogenase (MADH) and cytochrome c-551i. The electron is transferred from the active site of MADH via the amicyanin copper ion to the cytochrome heme iron. The electron transfer from MADH to cytochrome c-551i does not involve a ternary complex but occurs via a ping-pong mechanism in which amicyanin uses the same interface for the reactions with MADH and cytochrome c-551i.


Pssm-ID: 259988 [Multi-domain]  Cd Length: 81  Bit Score: 40.39  E-value: 1.49e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 126116589 1406 GYAWSPPVLNVSVGDTVAWhwqthpflrgigyrIFSVSSPGSVIYDGKGFTSGRQKsTSGSFSYQFTSPGIHYY 1479
Cdd:cd13921     8 DFKFNPAEVTVKVGDTVTW--------------TNKDSVPHTVTAEDGAFDSGMLA-TGKSFSYTFTAAGTYDY 66
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1916-1997 2.57e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 39.99  E-value: 2.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1916 PFLRGIIPSRGPP--GTEIEITGSNFGFEILEI--SVMINNIQCNVTMANDSVVQ---CIVGD----HAGGTFPVMMHHK 1984
Cdd:cd01180     1 PVITEFFPLSGPLegGTRLTICGSNLGLRKNDVrhGVRVGGVPCNPEPPEYSSSEkivCTTGPagnpVFNGPVEVTVGHG 80

                          90
                  ....*....|...
gi 126116589 1985 TKGSAmSTVVFEY 1997
Cdd:cd01180    81 SFRTE-SSEGFSF 92
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1916-1997 2.70e-03

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 39.51  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 1916 PFLRGIIPSRGPP--GTEIEITGS--NFGFEIleiSVMINNIQCNVTMANDSVVQCIVGDHA-GGTFPVMMHHktkGSAM 1990
Cdd:cd01179     1 PSITSLSPSYGPQsgGTRLTITGKhlNAGSSV---RVTVGGQPCKILSVSSSQIVCLTPPSAsPGEAPVKVLI---DGAR 74


                  ....*....
gi 126116589 1991 --STVVFEY 1997
Cdd:cd01179    75 rlAPLVFTY 83
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
 2001-2085 2.75e-03

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


Pssm-ID: 238583  Cd Length: 101  Bit Score: 40.16  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589 2001 IQNINPSQGSFGGGQTMTVTGTGFNPQNSII---------LVCGSECAIDRLRSDYTTLLCEIP--SNNGTGAEQACEVS 2069
Cdd:cd01178     4 IEKKSLNSCSVNGGEELFLTGKNFLKDSKVVfqekgqdgeAQWEAEATIDKEKSHQNHLVVEVPpyHNKHVAAPVQVQFY 83

                          90
                  ....*....|....*.
gi 126116589 2070 VVNGKDLSQSMTPFTY 2085
Cdd:cd01178    84 VVNGKRKRSQPQTFTY 99
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1240-1310 3.12e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 39.61  E-value: 3.12e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126116589 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNELTQ-NMAVYVGGKTCQILHWNFTD---IRCLLPKLSPGKHDIYVEV 1310
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDvRHGVRVGGVPCNPEPPEYSSsekIVCTTGPAGNPVFNGPVEV 75
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 272-327 5.49e-03

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 39.32  E-value: 5.49e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  272 VTMIFPSQGSIRGGTTLTISGRFFDQTDFP-VRVLVGG---EPCDILNVTEnsICCKTPP 327
Cdd:cd01181     3 ITRIEPEWSFLSGGTPITVTGTNLNTVQEPrIRVKYGGvekTSCKVRNSTL--MTCPAPS 60
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3294-3387 7.85e-03

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 40.08  E-value: 7.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126116589  3294 GNARISNVEFYHSGQEGFRDSTDPRyaVTFLN-------LGQIQEHGSSY--IRGCAFHHGFSPAIGVFGTDGLDIDDNI 3364
Cdd:pfam13229   32 SNATIENNTITNNGGDGIEISGSSN--NTISNntisnngGGGIALRGSSNnlIENNTISNNGGAGIYLSDSSNNTIENNI 109

                           90       100
                   ....*....|....*....|....*
gi 126116589  3365 IHFTVGEGIRI--WGNANRVRGNLI 3387
Cdd:pfam13229  110 IHNNGGSGIVIedSSNNVTISNNTV 134
IPT smart00429
ig-like, plexins, transcription factors;
1240-1297 8.95e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 38.17  E-value: 8.95e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 126116589   1240 PIITDFSPKVRTILGEVNLTIKGYNFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLP 1297
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPSSSTAIVCKTP 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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