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Conserved domains on  [gi|30425563|ref|NP_848665|]
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reticulon-4 receptor-like 2 precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18784505)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-261 3.05e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.78  E-value: 3.05e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  47 QANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLrslepdt 126
Cdd:COG4886  37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEEL------- 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 127 fQGLERLQSLHLYRCQLSSLPGNIFRgLVSLQYLYLQENSLLHLQDDLfADLANLSHLFLHGNRLRLLTEHvFRGLGSLD 206
Cdd:COG4886 110 -SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEE-LGNLTNLK 185

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 30425563 207 RLLLHGNRLQGVHrAAFRGLSRLTILYLFNNSLASLPgEALADLPSLEFLRLNAN 261
Cdd:COG4886 186 ELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNN 238
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
261-311 1.85e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 1.85e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 30425563    261 NPWACDCRARPLWAWFQRARVSSS--DVTCATPPERQGRdLRALREADFQaCP 311
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP-LLELLHSEFK-CP 51
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 289-369 1.55e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   289 ATPPERQGRDLRAlREADFQACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADPStlyrdlPAEDSRGRQGGDAPTED 368
Cdd:PHA03247  256 APPPVVGEGADRA-PETARGATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPA------PPDPPPPAPAGDAEEED 328


                  .
gi 30425563   369 D 369
Cdd:PHA03247  329 D 329
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-261 3.05e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.78  E-value: 3.05e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  47 QANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLrslepdt 126
Cdd:COG4886  37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEEL------- 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 127 fQGLERLQSLHLYRCQLSSLPGNIFRgLVSLQYLYLQENSLLHLQDDLfADLANLSHLFLHGNRLRLLTEHvFRGLGSLD 206
Cdd:COG4886 110 -SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEE-LGNLTNLK 185

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 30425563 207 RLLLHGNRLQGVHrAAFRGLSRLTILYLFNNSLASLPgEALADLPSLEFLRLNAN 261
Cdd:COG4886 186 ELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
156-215 2.16e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 2.16e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   156 SLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRL 215
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 44-220 9.14e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 9.14e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  44 VSCQANNFSSVP-LSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPgtFRHLQALEELDLGDNRhLRSL 122
Cdd:cd21340   7 LYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR-ISVV 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 123 EpdtfqGLERLQSL-HLY--------RCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDdlFADLANLSHLFLHGNRLRL 193
Cdd:cd21340  84 E-----GLENLTNLeELHienqrlppGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISD 156

                       170       180
                ....*....|....*....|....*....
gi 30425563 194 LTE--HVFRGLGSLDRLLLHGNRLQGVHR 220
Cdd:cd21340 157 LEEllDLLSSWPSLRELDLTGNPVCKKPK 185
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-261 3.78e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.25  E-value: 3.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   49 NNFS-SVPLSLPPSTQRLFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPD 125
Cdd:PLN00113 128 NNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGsfSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRE 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  126 tfqgLERLQSLHLYRCQLSSLPGNI---FRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGL 202
Cdd:PLN00113 208 ----LGQMKSLKWIYLGYNNLSGEIpyeIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSL 283

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 30425563  203 GSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Cdd:PLN00113 284 QKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN 342
LRRCT smart00082
Leucine rich repeat C-terminal domain;
261-311 1.85e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 1.85e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 30425563    261 NPWACDCRARPLWAWFQRARVSSS--DVTCATPPERQGRdLRALREADFQaCP 311
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP-LLELLHSEFK-CP 51
PHA03247 PHA03247
large tegument protein UL36; Provisional
 289-369 1.55e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   289 ATPPERQGRDLRAlREADFQACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADPStlyrdlPAEDSRGRQGGDAPTED 368
Cdd:PHA03247  256 APPPVVGEGADRA-PETARGATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPA------PPDPPPPAPAGDAEEED 328


                  .
gi 30425563   369 D 369
Cdd:PHA03247  329 D 329
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 234-299 6.68e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 38.91  E-value: 6.68e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30425563    234 LFNNSLASLPGEALADLPSLEFLRLNANPWACDCR-AR-PLWAWFQRARVSSSDVT-CATPPERQGRDL 299
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGlARlPRWAEEKGVKVRQPEAAlCAGPGALAGQPL 70
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-261 3.05e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.78  E-value: 3.05e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  47 QANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLrslepdt 126
Cdd:COG4886  37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEEL------- 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 127 fQGLERLQSLHLYRCQLSSLPGNIFRgLVSLQYLYLQENSLLHLQDDLfADLANLSHLFLHGNRLRLLTEHvFRGLGSLD 206
Cdd:COG4886 110 -SNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEE-LGNLTNLK 185

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 30425563 207 RLLLHGNRLQGVHrAAFRGLSRLTILYLFNNSLASLPgEALADLPSLEFLRLNAN 261
Cdd:COG4886 186 ELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-261 3.26e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.78  E-value: 3.26e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  43 TVSCQANNFSSVPLSLPPST--QRLFLQNNLIRTLrPGTFGS--NLLTLWLFSNNLSTIyPGTFRHLQALEELDLGDNRh 118
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNltNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ- 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 119 LRSLePDTFQGLERLQSLHLYRCQLSSLPGNIfRGLVSLQYLYLQENSLLHLQDdlFADLANLSHLFLHGNRLRLLTEhv 198
Cdd:COG4886 194 ITDL-PEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP-- 267

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30425563 199 FRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Cdd:COG4886 268 LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-261 8.24e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 8.24e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  43 TVSCQANNFSSVPLSLPPST--QRLFLQNNLIRTLrPGTFG--SNLLTLWLFSNNLSTIyPGTFRHLQALEELDLGDNRh 118
Cdd:COG4886 163 SLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDL-PEPLGnlTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ- 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 119 LRSLEpdTFQGLERLQSLHLYRCQLSSLPGNIfrGLVSLQYLYLQENSLLHLqddlfadlaNLSHLFLHGNRLRLLTEHV 198
Cdd:COG4886 240 LTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDL---------KLKELELLLGLNSLLLLLL 306

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30425563 199 FRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Cdd:COG4886 307 LLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369
LRR_8 pfam13855
Leucine rich repeat;
156-215 2.16e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 2.16e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   156 SLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRL 215
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 44-220 9.14e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 9.14e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  44 VSCQANNFSSVP-LSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPgtFRHLQALEELDLGDNRhLRSL 122
Cdd:cd21340   7 LYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR-ISVV 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 123 EpdtfqGLERLQSL-HLY--------RCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDdlFADLANLSHLFLHGNRLRL 193
Cdd:cd21340  84 E-----GLENLTNLeELHienqrlppGEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISD 156

                       170       180
                ....*....|....*....|....*....
gi 30425563 194 LTE--HVFRGLGSLDRLLLHGNRLQGVHR 220
Cdd:cd21340 157 LEEllDLLSSWPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
204-262 2.97e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 2.97e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 30425563   204 SLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANP 262
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-261 3.78e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.25  E-value: 3.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   49 NNFS-SVPLSLPPSTQRLFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPD 125
Cdd:PLN00113 128 NNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGsfSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRE 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  126 tfqgLERLQSLHLYRCQLSSLPGNI---FRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGL 202
Cdd:PLN00113 208 ----LGQMKSLKWIYLGYNNLSGEIpyeIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSL 283

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 30425563  203 GSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Cdd:PLN00113 284 QKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN 342
LRR_8 pfam13855
Leucine rich repeat;
132-191 8.55e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 8.55e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   132 RLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRL 191
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
180-239 3.60e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 3.60e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   180 NLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSL 239
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
108-167 3.82e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 3.82e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   108 LEELDLGDNRhLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSL 167
Cdd:pfam13855   3 LRSLDLSNNR-LTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 65-262 1.28e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.87  E-value: 1.28e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  65 LFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIyPGtFRHLQALEELDLGDNRhLRSLEPdtFQGLERLQSLHLYRCQLS 144
Cdd:cd21340   7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI-EN-LEFLTNLTHLYLQNNQ-IEKIEN--LENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 145 SLPGniFRGLVSLQYLYLQENSL-----LHLQDDLFADLAN-LSHLFLHGNRLRLLTEhvfrglgsldrlllhgnrlqgv 218
Cdd:cd21340  82 VVEG--LENLTNLEELHIENQRLppgekLTFDPRSLAALSNsLRVLNISGNNIDSLEP---------------------- 137

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 30425563 219 hraaFRGLSRLTILYLFNNSLASLP--GEALADLPSLEFLRLNANP 262
Cdd:cd21340 138 ----LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
60-117 1.61e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.61e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563    60 PSTQRLFLQNNLIRTLRPGTFG--SNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNR 117
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 54-261 1.79e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 1.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   54 VPLSLP--PSTQRLFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNrHLRSLEPDTFQG 129
Cdd:PLN00113 180 IPNSLTnlTSLEFLTLASNQLVGQIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN-NLTGPIPSSLGN 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  130 LERLQSLHLYRCQLS-SLPGNIFrGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLrllTEHVFRGLGSLDRL 208
Cdd:PLN00113 259 LKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNF---TGKIPVALTSLPRL 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  209 ---LLHGNRLQG-------------VHRAAFRGLS-----------RLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Cdd:PLN00113 335 qvlQLWSNKFSGeipknlgkhnnltVLDLSTNNLTgeipeglcssgNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-261 1.87e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   43 TVSCQANNFS-SVP---LSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRh 118
Cdd:PLN00113  97 TINLSNNQLSgPIPddiFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNV- 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  119 LRSLEPDTFQGLERLQSLHLYRCQLSslpGNIFRGL---VSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLT 195
Cdd:PLN00113 176 LVGKIPNSLTNLTSLEFLTLASNQLV---GQIPRELgqmKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPI 252

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30425563  196 EHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Cdd:PLN00113 253 PSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
43-261 3.28e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.39  E-value: 3.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   43 TVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLrPGTFGSNLLTLWLFSNNLSTIypgtfrhlqaleeldlgdnrhlrsl 122
Cdd:PRK15370 224 TLYANSNQLTSIPATLPDTIQEMELSINRITEL-PERLPSALQSLDLFHNKISCL------------------------- 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  123 ePDTFQglERLQSLHLYRCQLSSLPGNIFRGLVslqYLYLQENSLLHLQDDLfadLANLSHLFLHGNRLRLLTEHVFRGL 202
Cdd:PRK15370 278 -PENLP--EELRYLSVYDNSIRTLPAHLPSGIT---HLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASLPPEL 348

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  203 GSLDrllLHGNRLQGVHRAAfrgLSRLTILYLFNNSLASLPgealADLP-SLEFLRLNAN 261
Cdd:PRK15370 349 QVLD---VSKNQITVLPETL---PPTITTLDVSRNALTNLP----ENLPaALQIMQASRN 398
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 130-258 4.27e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 4.27e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 130 LERLQSLHLYRCQLSSLPGniFRGLVSLQYLYLQENSLLHLQDdlFADLANLSHLFLHGNRLRlltehvfrglgsldrll 209
Cdd:cd21340   1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIE----------------- 59

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 30425563 210 lhgnRLQGvhraaFRGLSRLTILYLFNNSLASLpgEALADLPSLEFLRL 258
Cdd:cd21340  60 ----KIEN-----LENLVNLKKLYLGGNRISVV--EGLENLTNLEELHI 97
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
43-174 8.70e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 8.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   43 TVSCQANNFSSVPLSLPPSTQRLFLQNNLIrTLRPGTFGSNLLTLWLFSNNLSTIyPGTFRhlQALEELDLGDNRhlRSL 122
Cdd:PRK15370 287 YLSVYDNSIRTLPAHLPSGITHLNVQSNSL-TALPETLPPGLKTLEAGENALTSL-PASLP--PELQVLDVSKNQ--ITV 360

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 30425563  123 EPDTFQglERLQSLHLYRCQLSSLPGNIfrgLVSLQYLYLQENSLLHLQDDL 174
Cdd:PRK15370 361 LPETLP--PTITTLDVSRNALTNLPENL---PAALQIMQASRNNLVRLPESL 407
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
41-262 1.28e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.46  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   41 PP---TVSCQANNFSSVPLsLPPSTQRLFLQNNLIRTLRpgTFGSNLLTLWLFSNNLST---IYPGtfrhlqaLEELDLG 114
Cdd:PRK15387 241 PPelrTLEVSGNQLTSLPV-LPPGLLELSIFSNPLTHLP--ALPSGLCKLWIFGNQLTSlpvLPPG-------LQELSVS 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  115 DNRhLRSLEPDTfqglERLQSLHLYRCQLSSLPgNIFRGLVSLQYLYLQENSLLHLQDDLF-------------ADLANL 181
Cdd:PRK15387 311 DNQ-LASLPALP----SELCKLWAYNNQLTSLP-TLPSGLQELSVSDNQLASLPTLPSELYklwaynnrltslpALPSGL 384

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  182 SHLFLHGNRLRLLTEHVfrglGSLDRLLLHGNRLQGVHRAAfrglSRLTILYLFNNSLASLPgEALADLPSLEFLRLNAN 261
Cdd:PRK15387 385 KELIVSGNRLTSLPVLP----SELKELMVSGNRLTSLPMLP----SGLLSLSVYRNQLTRLP-ESLIHLSSETTVNLEGN 455


                 .
gi 30425563  262 P 262
Cdd:PRK15387 456 P 456
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-261 1.36e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   49 NNFSSVPLSlppstqrlflQNNLIRTLRPGTFGS-NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNrhlrSLEPDTF 127
Cdd:PLN00113 356 NNLTVLDLS----------TNNLTGEIPEGLCSSgNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN----SFSGELP 421

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  128 QGLERLQSLHLYRCQLSSLPGNIFRG---LVSLQYLYLQENSLLHLQDDLFADlANLSHLFLHGNRLRLLTEHVFRGLGS 204
Cdd:PLN00113 422 SEFTKLPLVYFLDISNNNLQGRINSRkwdMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSE 500

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 30425563  205 LDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNAN 261
Cdd:PLN00113 501 LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN 557
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 178-261 1.17e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 178 LANLSHLFLHGNRLRLLTE-HVFRglgSLDRLLLHGNRLQGVhrAAFRGLSRLTILYLFNNSLASLPGeaLADLPSLEFL 256
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNlSLCK---NLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKL 73


                ....*
gi 30425563 257 RLNAN 261
Cdd:cd21340  74 YLGGN 78
LRRCT smart00082
Leucine rich repeat C-terminal domain;
261-311 1.85e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 1.85e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 30425563    261 NPWACDCRARPLWAWFQRARVSSS--DVTCATPPERQGRdLRALREADFQaCP 311
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP-LLELLHSEFK-CP 51
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
154-262 5.11e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 5.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 154 LVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRlqgvhraAFRGLSRLTILY 233
Cdd:COG4886  47 LLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLD 119

                        90       100
                ....*....|....*....|....*....
gi 30425563 234 LFNNSLASLPgEALADLPSLEFLRLNANP 262
Cdd:COG4886 120 LSGNQLTDLP-EELANLTNLKELDLSNNQ 147
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 103-261 7.18e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 7.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 103 RHLQALEELDLGDNRHLRSLEpdtfqglerlqslhlyrcQLSSLPGNiFRGLVSLQYLYLQENSLLHLQDDLFADL---A 179
Cdd:cd00116  48 RPQPSLKELCLSLNETGRIPR------------------GLQSLLQG-LTKGCGLQELDLSDNALGPDGCGVLESLlrsS 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 180 NLSHLFLHGNRL-RLLTEHVFRGLGS----LDRLLLHGNRL--QGVHRAA--FRGLSRLTILYLFNNSL----ASLPGEA 246
Cdd:cd00116 109 SLQELKLNNNGLgDRGLRLLAKGLKDlppaLEKLVLGRNRLegASCEALAkaLRANRDLKELNLANNGIgdagIRALAEG 188

                       170
                ....*....|....*
gi 30425563 247 LADLPSLEFLRLNAN 261
Cdd:cd00116 189 LKANCNLEVLDLNNN 203
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 83-124 1.15e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 30425563    83 NLLTLWLFSNNLSTIYPgtFRHLQALEELDLGDNRHLRSLEP 124
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKITDLSD 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 289-369 1.55e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563   289 ATPPERQGRDLRAlREADFQACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADPStlyrdlPAEDSRGRQGGDAPTED 368
Cdd:PHA03247  256 APPPVVGEGADRA-PETARGATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPA------PPDPPPPAPAGDAEEED 328


                  .
gi 30425563   369 D 369
Cdd:PHA03247  329 D 329
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 228-262 2.78e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 2.78e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 30425563   228 RLTILYLFNNSLASLPGeaLADLPSLEFLRLNANP 262
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNN 34
PLN03150 PLN03150
hypothetical protein; Provisional
 115-215 3.52e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.80  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  115 DNRHLRSLEPDTFQGLERLQSLHLYRcqlSSLPGNI---FRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRL 191
Cdd:PLN03150 426 DNQGLRGFIPNDISKLRHLQSINLSG---NSIRGNIppsLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502

                         90       100
                 ....*....|....*....|....
gi 30425563  192 RlltehvFRGLGSLDRLLLHGNRL 215
Cdd:PLN03150 503 S------GRVPAALGGRLLHRASF 520
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-196 4.60e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.15  E-value: 4.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  43 TVSCQANNFSSVP-LSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRS 121
Cdd:COG4886 232 TLDLSNNQLTDLPeLGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30425563 122 LEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTE 196
Cdd:COG4886 312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLL 386
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 59-261 5.26e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.49  E-value: 5.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  59 PPSTQRLFLQ-NNLIRTLR----PGTF---GSNLLTLWLFSNNLSTIYPGTF---RHLQALEELDLGDNRHLRSLEPDTF 127
Cdd:cd00116  50 QPSLKELCLSlNETGRIPRglqsLLQGltkGCGLQELDLSDNALGPDGCGVLeslLRSSSLQELKLNNNGLGDRGLRLLA 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 128 QGL----ERLQSLHLYRCQLSSLP----GNIFRGLVSLQYLYLQENSLL-----HLQDDLfADLANLSHLFLHGNRLR-- 192
Cdd:cd00116 130 KGLkdlpPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGdagirALAEGL-KANCNLEVLDLNNNGLTde 208

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 193 --LLTEHVFRGLGSLDRLLLHGNRL-----QGVHRAAFRGLSRLTILYLFNNSLASLPG----EALADLPSLEFLRLNAN 261
Cdd:cd00116 209 gaSALAETLASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAkdlaEVLAEKESLLELDLRGN 288
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 234-299 6.68e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 38.91  E-value: 6.68e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30425563    234 LFNNSLASLPGEALADLPSLEFLRLNANPWACDCR-AR-PLWAWFQRARVSSSDVT-CATPPERQGRDL 299
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGlARlPRWAEEKGVKVRQPEAAlCAGPGALAGQPL 70
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 132-168 8.31e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 8.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 30425563   132 RLQSLHLYRCQLSSLPGniFRGLVSLQYLYLQENSLL 168
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKI 36
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 56-200 8.48e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.11  E-value: 8.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563  56 LSLPPSTQRLFLQNN-----LIRTLRPG-TFGSNLLTLWLFSNNL----STIYPGTFRHLQALEELDLGDN----RHLRS 121
Cdd:cd00116 161 LRANRDLKELNLANNgigdaGIRALAEGlKANCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNnltdAGAAA 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30425563 122 LEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGL----VSLQYLYLQENSLLHLQDDLFADLanlshlfLHGNRLRLLTEH 197
Cdd:cd00116 241 LASALLSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGEEGAQLLAES-------LLEPGNELESLW 313


                ...
gi 30425563 198 VFR 200
Cdd:cd00116 314 VKD 316
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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