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Conserved domains on  [gi|264681528|ref|NP_848795|]
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protein unc-45 homolog B isoform 1 [Mus musculus]

Protein Classification

UNC45-central domain-containing protein( domain architecture ID 10569479)

UNC45-central domain-containing protein similar to Homo sapiens SWI5-dependent HO expression protein 4 (SHE4) required for mother cell-specific ho expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UNC45-central pfam11701
Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C. ...
 344-489 1.09e-34

Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats pfam00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organized myofibrils. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known.


:

Pssm-ID: 432011  Cd Length: 151  Bit Score: 129.58  E-value: 1.09e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  344 CLPLTDNTRMLASILINKLyddlrCDPERDHFRKICEEYITSKFDPQDMDKNVNAIQTVSGILQGPFDLGNQLLGMKGVM 423
Cdd:pfam11701  11 DLRLPESVRSLALLILSKL-----LEAAKEEFEEKFSEFITSLLADGTNDDLIIAFSALAALFPVPPDVASALFLSEGFL 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 264681528  424 EMMVALCGS-EREADQLVAVEALIHASTKLSRATFIITNGVTLLKQIYKTTKNEkIKIRTLVGLCKL 489
Cdd:pfam11701  86 ESLLPLVESkKSRKVELAALELLSAACIDKACREAISKNYVDWLEELLKSSDDE-IKALAAVVLAKL 151
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
5-136 5.08e-12

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 66.48  E-value: 5.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528   5 EAAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRC 84
Cdd:COG4785   72 LAQLYYERGVAYDSLGDYDLAIADFDQALELDPD---LAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRG 148

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 264681528  85 QALEHLGKLDQAFKDVQRCATLEP-------------RNQNFQETLRRLNTSIQEQLRVQFSTDS 136
Cdd:COG4785  149 IALYYLGRYELAIADLEKALELDPndperalwlylaeRKLDPEKALALLLEDWATAYLLQGDTEE 213
 
Name Accession Description Interval E-value
UNC45-central pfam11701
Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C. ...
 344-489 1.09e-34

Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats pfam00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organized myofibrils. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known.


Pssm-ID: 432011  Cd Length: 151  Bit Score: 129.58  E-value: 1.09e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  344 CLPLTDNTRMLASILINKLyddlrCDPERDHFRKICEEYITSKFDPQDMDKNVNAIQTVSGILQGPFDLGNQLLGMKGVM 423
Cdd:pfam11701  11 DLRLPESVRSLALLILSKL-----LEAAKEEFEEKFSEFITSLLADGTNDDLIIAFSALAALFPVPPDVASALFLSEGFL 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 264681528  424 EMMVALCGS-EREADQLVAVEALIHASTKLSRATFIITNGVTLLKQIYKTTKNEkIKIRTLVGLCKL 489
Cdd:pfam11701  86 ESLLPLVESkKSRKVELAALELLSAACIDKACREAISKNYVDWLEELLKSSDDE-IKALAAVVLAKL 151
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
5-136 5.08e-12

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 66.48  E-value: 5.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528   5 EAAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRC 84
Cdd:COG4785   72 LAQLYYERGVAYDSLGDYDLAIADFDQALELDPD---LAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRG 148

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 264681528  85 QALEHLGKLDQAFKDVQRCATLEP-------------RNQNFQETLRRLNTSIQEQLRVQFSTDS 136
Cdd:COG4785  149 IALYYLGRYELAIADLEKALELDPndperalwlylaeRKLDPEKALALLLEDWATAYLLQGDTEE 213
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 3-120 7.91e-12

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 69.24  E-value: 7.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528    3 EAEAAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDkallATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYR 82
Cdd:TIGR00990 124 KKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPD----PVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNR 199

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 264681528   83 RCQALEHLGKLDQAFKDVQ-RCATLEPRNQNFQETLRRL 120
Cdd:TIGR00990 200 RANAYDGLGKYADALLDLTaSCIIDGFRNEQSAQAVERL 238
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 6-127 1.15e-08

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 57.87  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528   6 AAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDKAllaTLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRCQ 85
Cdd:PLN03088   2 AKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNA---ELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGT 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 264681528  86 ALEHLGKLDQAFKDVQRCATLEPRNQNFQETLRRLNTSIQEQ 127
Cdd:PLN03088  79 ACMKLEEYQTAKAALEKGASLAPGDSRFTKLIKECDEKIAEE 120
 
Name Accession Description Interval E-value
UNC45-central pfam11701
Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C. ...
 344-489 1.09e-34

Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats pfam00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organized myofibrils. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known.


Pssm-ID: 432011  Cd Length: 151  Bit Score: 129.58  E-value: 1.09e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  344 CLPLTDNTRMLASILINKLyddlrCDPERDHFRKICEEYITSKFDPQDMDKNVNAIQTVSGILQGPFDLGNQLLGMKGVM 423
Cdd:pfam11701  11 DLRLPESVRSLALLILSKL-----LEAAKEEFEEKFSEFITSLLADGTNDDLIIAFSALAALFPVPPDVASALFLSEGFL 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 264681528  424 EMMVALCGS-EREADQLVAVEALIHASTKLSRATFIITNGVTLLKQIYKTTKNEkIKIRTLVGLCKL 489
Cdd:pfam11701  86 ESLLPLVESkKSRKVELAALELLSAACIDKACREAISKNYVDWLEELLKSSDDE-IKALAAVVLAKL 151
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
5-136 5.08e-12

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 66.48  E-value: 5.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528   5 EAAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRC 84
Cdd:COG4785   72 LAQLYYERGVAYDSLGDYDLAIADFDQALELDPD---LAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRG 148

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 264681528  85 QALEHLGKLDQAFKDVQRCATLEP-------------RNQNFQETLRRLNTSIQEQLRVQFSTDS 136
Cdd:COG4785  149 IALYYLGRYELAIADLEKALELDPndperalwlylaeRKLDPEKALALLLEDWATAYLLQGDTEE 213
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 3-120 7.91e-12

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 69.24  E-value: 7.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528    3 EAEAAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDkallATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYR 82
Cdd:TIGR00990 124 KKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPD----PVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNR 199

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 264681528   83 RCQALEHLGKLDQAFKDVQ-RCATLEPRNQNFQETLRRL 120
Cdd:TIGR00990 200 RANAYDGLGKYADALLDLTaSCIIDGFRNEQSAQAVERL 238
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 2-110 1.26e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 61.93  E-value: 1.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528   2 AEAEAAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALY 81
Cdd:COG3914   74 LLLLAALLELAALLLQALGRYEEALALYRRALALNPD---NAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYL 150

                         90       100
                 ....*....|....*....|....*....
gi 264681528  82 RRCQALEHLGKLDQAFKDVQRCATLEPRN 110
Cdd:COG3914  151 NLGEALRRLGRLEEAIAALRRALELDPDN 179
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
13-110 2.01e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.25  E-value: 2.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  13 GNRHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRCQALEHLGK 92
Cdd:COG0457   15 GLAYRRLGRYEEAIEDYEKALELDPD---DAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGR 91

                         90
                 ....*....|....*...
gi 264681528  93 LDQAFKDVQRCATLEPRN 110
Cdd:COG0457   92 YEEALEDYDKALELDPDD 109
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
13-199 2.81e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.86  E-value: 2.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  13 GNRHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRCQALEHLGK 92
Cdd:COG0457   49 GLAYLRLGRYEEALADYEQALELDPD---DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGR 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  93 LDQAFKDVQRCATLEPrnqNFQETLRRLNTSIQEQLRVQFSTDSRVQTMFEILLNENSEADKREKAANNLIVLGREEAGA 172
Cdd:COG0457  126 YDEAIEAYERALELDP---DDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLA 202

                        170       180
                 ....*....|....*....|....*..
gi 264681528 173 ERIFQSNGVALLLQLMNTQRPELLLAA 199
Cdd:COG0457  203 LEQALRKKLAILTLAALAELLLLALAL 229
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 6-127 1.15e-08

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 57.87  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528   6 AAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDKAllaTLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRCQ 85
Cdd:PLN03088   2 AKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNA---ELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGT 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 264681528  86 ALEHLGKLDQAFKDVQRCATLEPRNQNFQETLRRLNTSIQEQ 127
Cdd:PLN03088  79 ACMKLEEYQTAKAALEKGASLAPGDSRFTKLIKECDEKIAEE 120
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 13-158 2.00e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.08  E-value: 2.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  13 GNRHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRCQALEHLGK 92
Cdd:COG3914  119 GNLLLALGRLEEALAALRRALALNPD---FAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGR 195

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 264681528  93 LDQAFKDVQRCATLEPRN----QNFQETLRRLN-----TSIQEQLRVQFSTDSRVQTMFEILLNENSEADKREKA 158
Cdd:COG3914  196 LEEAIAAYRRALELDPDNadahSNLLFALRQACdwevyDRFEELLAALARGPSELSPFALLYLPDDDPAELLALA 270
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
13-177 3.87e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.40  E-value: 3.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  13 GNRHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRCQALEHLGK 92
Cdd:COG0457   83 GLALQALGRYEEALEDYDKALELDPD---DAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGR 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  93 LDQAFKDVQRCATLEPRNQNFQETLRRLNTSIQEQLRVQFSTDSRVQTMFEILLNENSEADKREKAANNLIVLGREEAGA 172
Cdd:COG0457  160 YEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALA 239


                 ....*
gi 264681528 173 ERIFQ 177
Cdd:COG0457  240 LYQYR 244
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 13-121 7.34e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 51.93  E-value: 7.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  13 GNRHFQLQDYKAATKSYSQALKLTKDKAllaTLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRCQALEHLGK 92
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEKALRLDPDNA---DALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGD 100

                         90       100
                 ....*....|....*....|....*....
gi 264681528  93 LDQAFKDVQRCATLEPRNQNFQETLRRLN 121
Cdd:COG4235  101 YAEAIAAWQKLLALLPADAPARLLEASIA 129
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 3-120 4.30e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.19  E-value: 4.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528   3 EAEAAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDKAllaTLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYR 82
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNP---EAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLN 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 264681528  83 RCQALEHLGKLDQAFKDVQRCATLEPRNQNFQETLRRL 120
Cdd:COG4783   78 LGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARA 115
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
16-109 9.87e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.86  E-value: 9.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  16 HFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKMESYAQAAsDASRAIDINSADIKALYRRCQALEHLGKLDQ 95
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPD---NADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDE 77

                         90
                 ....*....|....
gi 264681528  96 AFKDVQRCATLEPR 109
Cdd:COG3063   78 ALAYLERALELDPS 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 2-108 1.45e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.19  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528   2 AEAEAAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDKAllaTLYRNRAACGLKMESYAQAASDASRAIDINSADIKALY 81
Cdd:COG5010   50 LAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNP---ELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYS 126

                         90       100
                 ....*....|....*....|....*..
gi 264681528  82 RRCQALEHLGKLDQAFKDVQRCATLEP 108
Cdd:COG5010  127 NLAALLLSLGQDDEAKAALQRALGTSP 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
21-112 4.04e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.06  E-value: 4.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  21 DYKAATKSYSQALKLTKDKALLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRCQALEHLGKLDQAFKDV 100
Cdd:COG4785   51 AALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDF 130

                         90
                 ....*....|..
gi 264681528 101 QRCATLEPRNQN 112
Cdd:COG4785  131 DRALELDPDYAY 142
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 13-110 4.16e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.26  E-value: 4.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  13 GNRHFQLQDYKAATKSYSQALKLTKDKA----LLATLYrnraacgLKMESYAQAASDASRAIDINSADIKALYRRCQALE 88
Cdd:COG2956  151 AELYLEQGDYDEAIEALEKALKLDPDCArallLLAELY-------LEQGDYEEAIAALERALEQDPDYLPALPRLAELYE 223

                         90       100
                 ....*....|....*....|..
gi 264681528  89 HLGKLDQAFKDVQRCATLEPRN 110
Cdd:COG2956  224 KLGDPEEALELLRKALELDPSD 245
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
42-110 5.66e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.77  E-value: 5.66e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 264681528  42 LATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRN 110
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD 75
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 17-110 6.73e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.64  E-value: 6.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  17 FQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRCQALEHLGKLDQA 96
Cdd:COG4783   49 LQLGDLDEAIVLLHEALELDPD---EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEA 125

                         90
                 ....*....|....
gi 264681528  97 FKDVQRCATLEPRN 110
Cdd:COG4783  126 IAALEKALELDPDD 139
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 16-121 9.19e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.97  E-value: 9.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  16 HFQLQDYKAATKSYSQALKLTKDKALLATLYRNRAACGLKMESYAQAASDASRAIDINSADIK---ALYRRCQALEHLGK 92
Cdd:COG1729    3 LLKAGDYDEAIAAFKAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLELGD 82

                         90       100
                 ....*....|....*....|....*....
gi 264681528  93 LDQAFKDVQRCATLEPRNQNFQETLRRLN 121
Cdd:COG1729   83 YDKARATLEELIKKYPDSEAAKEARARLA 111
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 1-110 2.84e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 41.51  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528    1 MAEAEAAQLKEEGNRHFQLQDYKAATKSYSQALKLtkDKALLATlYRNRAACGLKMESYAQAASDASRAIDINSADIKAL 80
Cdd:TIGR00990 326 LGEKEAIALNLRGTFKCLKGKHLEALADLSKSIEL--DPRVTQS-YIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIY 402

                          90       100       110
                  ....*....|....*....|....*....|
gi 264681528   81 YRRCQALEHLGKLDQAFKDVQRCATLEPRN 110
Cdd:TIGR00990 403 YHRAQLHFIKGEFAQAGKDYQKSIDLDPDF 432
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1-120 5.45e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.40  E-value: 5.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528   1 MAEAEAAQLKEEGNRHFQLQDYKAATKSYSQALKLTKDKALLATLYRNRAACGLKMESYAQAASDASRAIDINSADIKAL 80
Cdd:COG5010   12 LYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELY 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 264681528  81 YRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQETLRRL 120
Cdd:COG5010   92 YNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAAL 131
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 13-120 6.83e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.33  E-value: 6.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 264681528  13 GNRHFQLQDYKAATKSYSQALKLTKDKALLatlYRNRAACGLKMESYAQAASDASRAIDINSADIKALYRRCQALEHLGK 92
Cdd:COG2956  117 AEIYEQEGDWEKAIEVLERLLKLGPENAHA---YCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGD 193

                         90       100
                 ....*....|....*....|....*...
gi 264681528  93 LDQAFKDVQRCATLEPRNQNFQETLRRL 120
Cdd:COG2956  194 YEEAIAALERALEQDPDYLPALPRLAEL 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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