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Conserved domains on  [gi|30678731|ref|NP_849277|]
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F-box family protein [Arabidopsis thaliana]

Protein Classification

F-box protein( domain architecture ID 10584247)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515
SCOP:  4001927

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
13-49 8.78e-06

F-box-like; This is an F-box-like family.


:

Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 42.47  E-value: 8.78e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 30678731    13 LSILSCLDdPSDIVRASAVSRSWRQFVVKYSLSKNLC 49
Cdd:pfam12937  10 LQIFSYLD-PKDLLRLALVCRRWRELASDDSLWRRLC 45
 
Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
13-49 8.78e-06

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 42.47  E-value: 8.78e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 30678731    13 LSILSCLDdPSDIVRASAVSRSWRQFVVKYSLSKNLC 49
Cdd:pfam12937  10 LQIFSYLD-PKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
5-39 9.48e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 36.27  E-value: 9.48e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 30678731   5 NNLDTDTSLSILSCLDdPSDIVRASAVSRSWRQFV 39
Cdd:cd09917   1 SDLPDEILLKILSYLD-PRDLLRLSLVCKRWRELA 34
FBOX smart00256
A Receptor for Ubiquitination Targets;
7-39 2.95e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.11  E-value: 2.95e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 30678731      7 LDTDTSLSILSCLDdPSDIVRASAVSRSWRQFV 39
Cdd:smart00256   1 LPDEILEEILSKLD-PKDLLRLRKVSRKWRSLI 32
 
Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
13-49 8.78e-06

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 42.47  E-value: 8.78e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 30678731    13 LSILSCLDdPSDIVRASAVSRSWRQFVVKYSLSKNLC 49
Cdd:pfam12937  10 LQIFSYLD-PKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
5-39 9.48e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 36.27  E-value: 9.48e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 30678731   5 NNLDTDTSLSILSCLDdPSDIVRASAVSRSWRQFV 39
Cdd:cd09917   1 SDLPDEILLKILSYLD-PRDLLRLSLVCKRWRELA 34
F-box_EMI cd22086
F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI ...
15-39 2.86e-03

F-box domain found in the early mitotic inhibitor (EMI) family of F-box proteins; The EMI family includes FBX5 (EMI1) and FBX43 (EMI2), which are anaphase-promoting complex/cyclosome (APC/C) inhibitors that bind APC/C-CCD20 (Cell division cycle protein 20) and/or APC/C-CDH1 (CDC20 homologue 1) complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438858  Cd Length: 48  Bit Score: 35.55  E-value: 2.86e-03
                        10        20
                ....*....|....*....|....*
gi 30678731  15 ILSCLDdPSDIVRASAVSRSWRQFV 39
Cdd:cd22086  15 ILSYLS-PEDLCRVSCVSKTWRQIC 38
FBOX smart00256
A Receptor for Ubiquitination Targets;
7-39 2.95e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 35.11  E-value: 2.95e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 30678731      7 LDTDTSLSILSCLDdPSDIVRASAVSRSWRQFV 39
Cdd:smart00256   1 LPDEILEEILSKLD-PKDLLRLRKVSRKWRSLI 32
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
6-39 4.25e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 34.82  E-value: 4.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 30678731     6 NLDTDTSLSILSCLDdPSDIVRASAVSRSWRQFV 39
Cdd:pfam00646   3 DLPDDLLLEILSRLD-PKDLLRLSLVSKRWRSLV 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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