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Conserved domains on  [gi|30698715|ref|NP_849872|]
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beta carbonic anhydrase 4 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00416 PLN00416
carbonate dehydratase
 1-258 0e+00

carbonate dehydratase


:

Pssm-ID: 177809  Cd Length: 258  Bit Score: 558.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715    1 MATESYEAAIKGLNDLLSTKADLGNVAAAKIKALTAELKELDSSNSDAIERIKTGFTQFKTEKYLKNSTLFNHLAKTQTP 80
Cdd:PLN00416   1 MATESYEAAIKGLNDLLSTKADLGNVAAAKIKALTAELKELDSSNSDAIERIKTGFTQFKTEKYLKNSTLFNHLAKTQTP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715   81 KFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQKRHSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGLMSIE 160
Cdd:PLN00416  81 KFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQKRHSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGLMSIE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715  161 DDAAPTQSDFIENWVKIGASARNKIKEEHKDLSYDDQCNKCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGHYNFVKG 240
Cdd:PLN00416 161 DDAAPTQSDFIENWVKIGASARNKIKEEHKDLSYDDQCNKCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGHYNFVKG 240

                        250
                 ....*....|....*...
gi 30698715  241 TFDLWELDFKTTPAFAFS 258
Cdd:PLN00416 241 TFDLWELDFKTTPAFAFS 258
 
Name Accession Description Interval E-value
PLN00416 PLN00416
carbonate dehydratase
 1-258 0e+00

carbonate dehydratase


Pssm-ID: 177809  Cd Length: 258  Bit Score: 558.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715    1 MATESYEAAIKGLNDLLSTKADLGNVAAAKIKALTAELKELDSSNSDAIERIKTGFTQFKTEKYLKNSTLFNHLAKTQTP 80
Cdd:PLN00416   1 MATESYEAAIKGLNDLLSTKADLGNVAAAKIKALTAELKELDSSNSDAIERIKTGFTQFKTEKYLKNSTLFNHLAKTQTP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715   81 KFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQKRHSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGLMSIE 160
Cdd:PLN00416  81 KFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQKRHSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGLMSIE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715  161 DDAAPTQSDFIENWVKIGASARNKIKEEHKDLSYDDQCNKCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGHYNFVKG 240
Cdd:PLN00416 161 DDAAPTQSDFIENWVKIGASARNKIKEEHKDLSYDDQCNKCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGHYNFVKG 240

                        250
                 ....*....|....*...
gi 30698715  241 TFDLWELDFKTTPAFAFS 258
Cdd:PLN00416 241 TFDLWELDFKTTPAFAFS 258
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 55-245 2.22e-96

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 280.20  E-value: 2.22e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715  55 GFTQFKTEKYLKNSTLFNHLAKTQTPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQ-KRHSGVGAAVEYA 133
Cdd:cd00884   1 GFRRFRKEYFPEERELFEKLAKGQSPKALFIACSDSRVVPALITQTQPGELFVVRNVGNLVPPYEPdGGFHGTSAAIEYA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715 134 VVHLKVENILVIGHSCCGGIKGLMSIEDDaaPTQSDFIENWVKIGASARNKIKEEHKDLSYDDQCNKCEKEAVNVSLGNL 213
Cdd:cd00884  81 VAVLKVEHIVVCGHSDCGGIRALLSPEDL--LDKLPFIGKWLRIAEPAKEVVLAELSHADFDDQLRALEKENVLLSLENL 158

                       170       180       190
                ....*....|....*....|....*....|..
gi 30698715 214 LSYPFVRAEVVKNTLAIRGGHYNFVKGTFDLW 245
Cdd:cd00884 159 LTYPFVRERLEAGTLSLHGWYYDIETGELYAY 190
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
47-251 3.91e-66

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 204.24  E-value: 3.91e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715  47 DAIERIKTGFTQFKTEKYLKNSTLFNHLAKTQTPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQkrhsGV 126
Cdd:COG0288   2 EALKRLLEGNRRFVAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFDQGPGDLFVVRNAGNVVPPYDP----GV 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715 127 GAAVEYAVVHLKVENILVIGHSCCGGIKGLMsieDDAAPTQSDFIENWVKIGASARNKIKEEHKDLSYDDQCNKCEKEAV 206
Cdd:COG0288  78 LASIEYAVEVLGVKLIVVLGHSGCGAVKAAL---DGLELEELGLIGNWLRHIRPAVERVRAELPAADGEERLDRLVELNV 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 30698715 207 NVSLGNLLSYPFVRAEVVKNTLAIRGGHYNFVKGtfDLWELDFKT 251
Cdd:COG0288 155 REQVENLRTSPIVREAVAAGKLKVHGWVYDLATG--RVEFLDPEG 197
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 83-241 1.15e-59

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 185.79  E-value: 1.15e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715    83 LVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDqkrhSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGLMSIEDD 162
Cdd:pfam00484   2 LIIGCSDSRVPPELIFDTGPGDLFVVRNAGNLVPPYD----LNVLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDAAGP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715   163 AAPtqSDFIENWVKIGASARNKIKEEHKDL-SYDDQCNKCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGHYNFVKGT 241
Cdd:pfam00484  78 AEL--PGFIDNWLRHIRPAVERVAEELESLdDPEERDDALEELNVREQVENLRTFPIVREAVAKGKLKIHGWVYDLETGE 155
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 75-245 5.89e-56

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 176.54  E-value: 5.89e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715     75 AKTQTPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDqkrhSGVGAAVEYAVVHLKVENILVIGHSCCGGIK 154
Cdd:smart00947   1 AKGQHPKALIIGCSDSRVPPELIFGLGPGDLFVIRNAGNIVPPYD----DGVLASLEYAVEVLGVKEIVVCGHTDCGAVK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715    155 GLMSIEDdaaptqsDFIENWVKIGASARNKIKEEHKDLsyddqcNKCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGH 234
Cdd:smart00947  77 AALDDEP-------GLIDNWLERIRPARERALEELGDV------DALEELNVRDQVENLRTSPAIREAVAKGKLKVHGWV 143

                          170
                   ....*....|.
gi 30698715    235 YNFVKGTFDLW 245
Cdd:smart00947 144 YDIETGKLEVL 154
 
Name Accession Description Interval E-value
PLN00416 PLN00416
carbonate dehydratase
 1-258 0e+00

carbonate dehydratase


Pssm-ID: 177809  Cd Length: 258  Bit Score: 558.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715    1 MATESYEAAIKGLNDLLSTKADLGNVAAAKIKALTAELKELDSSNSDAIERIKTGFTQFKTEKYLKNSTLFNHLAKTQTP 80
Cdd:PLN00416   1 MATESYEAAIKGLNDLLSTKADLGNVAAAKIKALTAELKELDSSNSDAIERIKTGFTQFKTEKYLKNSTLFNHLAKTQTP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715   81 KFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQKRHSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGLMSIE 160
Cdd:PLN00416  81 KFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQKRHSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGLMSIE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715  161 DDAAPTQSDFIENWVKIGASARNKIKEEHKDLSYDDQCNKCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGHYNFVKG 240
Cdd:PLN00416 161 DDAAPTQSDFIENWVKIGASARNKIKEEHKDLSYDDQCNKCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGHYNFVKG 240

                        250
                 ....*....|....*...
gi 30698715  241 TFDLWELDFKTTPAFAFS 258
Cdd:PLN00416 241 TFDLWELDFKTTPAFAFS 258
PLN03014 PLN03014
carbonic anhydrase
 1-249 7.01e-112

carbonic anhydrase


Pssm-ID: 178588 [Multi-domain]  Cd Length: 347  Bit Score: 325.54  E-value: 7.01e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715    1 MATESYEAAIKGLNDLLSTKADLGNVAAAKIKALTAELKELDSSNS---DAIERIKTGFTQFKTEKYLKNSTLFNHLAKT 77
Cdd:PLN03014  78 MGTEAYDEAIEALKKLLIEKEELKTVAAAKVEQITAALQTGTSSDKkafDPVETIKQGFIKFKKEKYETNPALYGELAKG 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715   78 QTPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQKRHSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGLM 157
Cdd:PLN03014 158 QSPKYMVFACSDSRVCPSHVLDFQPGDAFVVRNIANMVPPFDKVKYGGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLM 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715  158 SIEDDAApTQSDFIENWVKIGASARNKIKEEHKDLSYDDQCNKCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGHYNF 237
Cdd:PLN03014 238 SFPLDGN-NSTDFIEDWVKICLPAKSKVISELGDSAFEDQCGRCEREAVNVSLANLLTYPFVREGLVKGTLALKGGYYDF 316

                        250
                 ....*....|..
gi 30698715  238 VKGTFDLWELDF 249
Cdd:PLN03014 317 VKGAFELWGLEF 328
PLN03019 PLN03019
carbonic anhydrase
 1-253 1.52e-101

carbonic anhydrase


Pssm-ID: 166660  Cd Length: 330  Bit Score: 298.98  E-value: 1.52e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715    1 MATESYEAAIKGLNDLLSTKADLGNVAAAKIKALTAELKELDSSNS---DAIERIKTGFTQFKTEKYLKNSTLFNHLAKT 77
Cdd:PLN03019  73 MGNESYEDAIEALKKLLIEKDDLKDVAAAKVKKITAELQAASSSDSksfDPVERIKEGFVTFKKEKYETNPALYGELAKG 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715   78 QTPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQKRHSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGLM 157
Cdd:PLN03019 153 QSPKYMVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPFDKVKYAGVGAAIEYAVLHLKVENIVVIGHSACGGIKGLM 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715  158 SIEDDAApTQSDFIENWVKIGASARNKIKEEHKDLSYDDQCNKCEKeAVNVSLGNLLSYPFVRAEVVKNTLAIRGGHYNF 237
Cdd:PLN03019 233 SFPLDGN-NSTDFIEDWVKICLPAKSKVLAESESSAFEDQCGRCER-AVNVSLANLLTYPFVREGVVKGTLALKGGYYDF 310

                        250
                 ....*....|....*.
gi 30698715  238 VKGTFDLWELDFKTTP 253
Cdd:PLN03019 311 VNGSFELWELQFGISP 326
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 55-245 2.22e-96

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 280.20  E-value: 2.22e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715  55 GFTQFKTEKYLKNSTLFNHLAKTQTPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQ-KRHSGVGAAVEYA 133
Cdd:cd00884   1 GFRRFRKEYFPEERELFEKLAKGQSPKALFIACSDSRVVPALITQTQPGELFVVRNVGNLVPPYEPdGGFHGTSAAIEYA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715 134 VVHLKVENILVIGHSCCGGIKGLMSIEDDaaPTQSDFIENWVKIGASARNKIKEEHKDLSYDDQCNKCEKEAVNVSLGNL 213
Cdd:cd00884  81 VAVLKVEHIVVCGHSDCGGIRALLSPEDL--LDKLPFIGKWLRIAEPAKEVVLAELSHADFDDQLRALEKENVLLSLENL 158

                       170       180       190
                ....*....|....*....|....*....|..
gi 30698715 214 LSYPFVRAEVVKNTLAIRGGHYNFVKGTFDLW 245
Cdd:cd00884 159 LTYPFVRERLEAGTLSLHGWYYDIETGELYAY 190
PLN03006 PLN03006
carbonate dehydratase
 22-252 1.85e-67

carbonate dehydratase


Pssm-ID: 178583  Cd Length: 301  Bit Score: 211.14  E-value: 1.85e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715   22 DLGNVAAAKIKALTAELKEL---DSSNSDAIERIKTGFTQFKTEKYLKNSTLFNHLAKTQTPKFLVFACSDSRVCPSHIL 98
Cdd:PLN03006  52 NLQVMASGKTPGLTQEANGVaidRQNNTDVFDDMKQRFLAFKKLKYMDDFEHYKNLADAQAPKFLVIACADSRVCPSAVL 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715   99 NFQPGEAFVVRNIANMVPPFDQKRhSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGLMSIEDDAapTQSDFIENWVKIG 178
Cdd:PLN03006 132 GFQPGDAFTVRNIANLVPPYESGP-TETKAALEFSVNTLNVENILVIGHSRCGGIQALMKMEDEG--DSRSFIHNWVVVG 208

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30698715  179 ASARNKIKEEHKDLSYDDQCNKCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGHYNFVKGTFDLWELDFKTT 252
Cdd:PLN03006 209 KKAKESTKAVASNLHFDHQCQHCEKASINHSLERLLGYPWIEEKVRQGSLSLHGGYYNFVDCTFEKWTVDYAAS 282
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
47-251 3.91e-66

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 204.24  E-value: 3.91e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715  47 DAIERIKTGFTQFKTEKYLKNSTLFNHLAKTQTPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQkrhsGV 126
Cdd:COG0288   2 EALKRLLEGNRRFVAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFDQGPGDLFVVRNAGNVVPPYDP----GV 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715 127 GAAVEYAVVHLKVENILVIGHSCCGGIKGLMsieDDAAPTQSDFIENWVKIGASARNKIKEEHKDLSYDDQCNKCEKEAV 206
Cdd:COG0288  78 LASIEYAVEVLGVKLIVVLGHSGCGAVKAAL---DGLELEELGLIGNWLRHIRPAVERVRAELPAADGEERLDRLVELNV 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 30698715 207 NVSLGNLLSYPFVRAEVVKNTLAIRGGHYNFVKGtfDLWELDFKT 251
Cdd:COG0288 155 REQVENLRTSPIVREAVAAGKLKVHGWVYDLATG--RVEFLDPEG 197
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 83-241 1.15e-59

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 185.79  E-value: 1.15e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715    83 LVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDqkrhSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGLMSIEDD 162
Cdd:pfam00484   2 LIIGCSDSRVPPELIFDTGPGDLFVVRNAGNLVPPYD----LNVLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDAAGP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715   163 AAPtqSDFIENWVKIGASARNKIKEEHKDL-SYDDQCNKCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGHYNFVKGT 241
Cdd:pfam00484  78 AEL--PGFIDNWLRHIRPAVERVAEELESLdDPEERDDALEELNVREQVENLRTFPIVREAVAKGKLKIHGWVYDLETGE 155
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 75-245 5.89e-56

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 176.54  E-value: 5.89e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715     75 AKTQTPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDqkrhSGVGAAVEYAVVHLKVENILVIGHSCCGGIK 154
Cdd:smart00947   1 AKGQHPKALIIGCSDSRVPPELIFGLGPGDLFVIRNAGNIVPPYD----DGVLASLEYAVEVLGVKEIVVCGHTDCGAVK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715    155 GLMSIEDdaaptqsDFIENWVKIGASARNKIKEEHKDLsyddqcNKCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGH 234
Cdd:smart00947  77 AALDDEP-------GLIDNWLERIRPARERALEELGDV------DALEELNVRDQVENLRTSPAIREAVAKGKLKVHGWV 143

                          170
                   ....*....|.
gi 30698715    235 YNFVKGTFDLW 245
Cdd:smart00947 144 YDIETGKLEVL 154
PLN02154 PLN02154
carbonic anhydrase
 39-247 7.28e-55

carbonic anhydrase


Pssm-ID: 215111  Cd Length: 290  Bit Score: 178.40  E-value: 7.28e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715   39 KELDSSnSDAIERIKTGFTQFKTEKYLKNSTLFNHLAKTQTPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPF 118
Cdd:PLN02154  67 RETETS-YDFLDEMRHRFLKFKRQKYLPEIEKFKALAIAQSPKVMVIGCADSRVCPSYVLGFQPGEAFTIRNVANLVTPV 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715  119 dQKRHSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGLMSIEDDAApTQSDFIENWVKIGASARNKIKEEHKDLSYDDQC 198
Cdd:PLN02154 146 -QNGPTETNSALEFAVTTLQVENIIVMGHSNCGGIAALMSHQNHQG-QHSSLVERWVMNGKAAKLRTQLASSHLSFDEQC 223

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 30698715  199 NKCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGHYNFVKGTFDLWEL 247
Cdd:PLN02154 224 RNCEKESIKDSVMNLITYSWIRDRVKRGEVKIHGCYYNLSDCSLEKWRL 272
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 78-245 5.94e-44

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 144.57  E-value: 5.94e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715  78 QTPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDqkrhSGVGAAVEYAVVHLKVENILVIGHSCCGGIKGlm 157
Cdd:cd00382   1 QKPKALIIGCSDSRVPPELIFGLGPGDLFVVRNAGNLVPPYD----LDVLASLEYAVEVLGVKHIIVCGHTDCGAVKA-- 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715 158 sieddaaptqsdfienwvkigasarnkikeehkdlsyddqcnkCEKEAVNVSLGNLLSYPFVRAEVVKNTLAIRGGHYNF 237
Cdd:cd00382  75 -------------------------------------------LVEENVREQVENLRSHPLIQEAVAPGELKVHGWVYDI 111


                ....*...
gi 30698715 238 VKGTFDLW 245
Cdd:cd00382 112 ETGKLEVL 119
beta_CA_cladeA cd00883
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 62-221 2.70e-35

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238448  Cd Length: 182  Bit Score: 124.21  E-value: 2.70e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715  62 EKYLKNSTLFNHLAKTQTPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDqkrhSGVGAAVEYAVVHLKVEN 141
Cdd:cd00883   7 EKKAKDPDFFPRLAKGQTPEYLWIGCSDSRVPENTILGLLPGEVFVHRNIANLVSPTD----LNCLSVLQYAVDVLKVKH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715 142 ILVIGHSCCGGIKGLMSieddaaPTQSDFIENWV-KIGASARNKIKEEHKDLSYDDQCNK-CE---KEAVNvslgNLLSY 216
Cdd:cd00883  83 IIVCGHYGCGGVKAALT------GKRLGLLDNWLrPIRDVYRLHAAELDALEDEEERVDRlVElnvVEQVK----NLCKT 152


                ....*
gi 30698715 217 PFVRA 221
Cdd:cd00883 153 PIVQD 157
beta_CA_cladeC cd03378
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 48-155 2.08e-19

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239473 [Multi-domain]  Cd Length: 154  Bit Score: 82.19  E-value: 2.08e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715  48 AIERIKTG---FTQFKTEKYLKNSTLFNHLAKTQTPKFLVFACSDSRVCPSHILNFQPGEAFVVR---NIANmvppfdqk 121
Cdd:cd03378   4 ALERLKEGnkrFVSGKPLHPDQDLARRRELAKGQKPFAVILSCSDSRVPPEIIFDQGLGDLFVVRvagNIVD-------- 75

                        90       100       110
                ....*....|....*....|....*....|....
gi 30698715 122 rhSGVGAAVEYAVVHLKVENILVIGHSCCGGIKG 155
Cdd:cd03378  76 --DDVLGSLEYAVEVLGVPLVVVLGHESCGAVAA 107
PRK10437 PRK10437
carbonic anhydrase; Provisional
 71-175 5.37e-18

carbonic anhydrase; Provisional


Pssm-ID: 182460  Cd Length: 220  Bit Score: 79.98  E-value: 5.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715   71 FNHLAKTQTPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPFDQKRHSgvgaAVEYAVVHLKVENILVIGHSCC 150
Cdd:PRK10437  26 FEKLAQAQKPRFLWIGCSDSRVPAERLTGLEPGELFVHRNVANLVIHTDLNCLS----VVQYAVDVLEVEHIIICGHYGC 101

                         90       100
                 ....*....|....*....|....*
gi 30698715  151 GGIKGlmSIEDdaapTQSDFIENWV 175
Cdd:PRK10437 102 GGVQA--AVEN----PELGLINNWL 120
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 79-176 1.41e-07

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 49.56  E-value: 1.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715  79 TPKFLVFACSDSRVCPSHILNFQPGEAFVVRNIANMVppfdqkRHSGVGAAVeYAVVHLKVENILVIGHSCCG------- 151
Cdd:cd03379   2 ARKLAIVTCMDARLDPEKALGLKLGDAKVIRNAGGRV------TDDAIRSLV-VSVYLLGTREIIVIHHTDCGmltftde 74

                        90       100
                ....*....|....*....|....*
gi 30698715 152 GIKGLMSIEDDAAPTQSDFIENWVK 176
Cdd:cd03379  75 ELKEKMKERGIAEAYGGIDKEFWFL 99
PRK15219 PRK15219
carbonic anhydrase; Provisional
 21-155 4.23e-06

carbonic anhydrase; Provisional


Pssm-ID: 237927 [Multi-domain]  Cd Length: 245  Bit Score: 46.75  E-value: 4.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698715   21 ADLGNVAAAKIKALTAElkELDSSNSDA-IERIKTGFTQFKTEKYLKNSTLFNHL--AKTQTPKFLVFACSDSRVCPSHI 97
Cdd:PRK15219  30 AGLGVPQISYAASLTKE--ERDKMTPDQiIESLKQGNKRFRSGKPAQHDYLAQKRasAAGQYPAAVILSCIDSRAPAEII 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30698715   98 LNFQPGEAF---VVRNIANmvppfdqkrhSGVGAAVEYAVVHLKVENILVIGHSCCGGIKG 155
Cdd:PRK15219 108 LDTGIGETFnsrVAGNISN----------DDLLGSMEFACAVAGAKVVLVMGHTACGAVKG 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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