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Conserved domains on  [gi|30684280|ref|NP_850944|]
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CASC3/Barentsz eIF4AIII binding protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Btz super family cl09653
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 78-167 4.24e-18

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


The actual alignment was detected with superfamily member smart01044:

Pssm-ID: 447763 [Multi-domain]  Cd Length: 106  Bit Score: 79.80  E-value: 4.24e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684280     78 SGGGIDNDKSGVV--KEAGDMNGEEENEKEKL-QAAVPTGGAFYMHDDRFQEMSAGGNRRMRGGRRQWGSGEERKWGHDK 154
Cdd:smart01044   1 RGSGDGDEKSAPVanKETGKMRRRLEDDEYKKnPAYVPKRGAFFMHDDRFAEPEANGNRPKGRGRRRLWQTDEGRWTHDR 80

                           90
                   ....*....|...
gi 30684280    155 FEEMNTGEKHSDR 167
Cdd:smart01044  81 FEEDEQAPKSRPE 93
 
Name Accession Description Interval E-value
Btz smart01044
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 78-167 4.24e-18

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 214991 [Multi-domain]  Cd Length: 106  Bit Score: 79.80  E-value: 4.24e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684280     78 SGGGIDNDKSGVV--KEAGDMNGEEENEKEKL-QAAVPTGGAFYMHDDRFQEMSAGGNRRMRGGRRQWGSGEERKWGHDK 154
Cdd:smart01044   1 RGSGDGDEKSAPVanKETGKMRRRLEDDEYKKnPAYVPKRGAFFMHDDRFAEPEANGNRPKGRGRRRLWQTDEGRWTHDR 80

                           90
                   ....*....|...
gi 30684280    155 FEEMNTGEKHSDR 167
Cdd:smart01044  81 FEEDEQAPKSRPE 93
Btz pfam09405
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 109-167 3.67e-13

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 430588 [Multi-domain]  Cd Length: 121  Bit Score: 66.39  E-value: 3.67e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30684280   109 AAVPTGGAFYMHDDRFQEMSAGGNRRMR-----GGRRQWGSGEERKWGHDKFEEMNTGEKHSDR 167
Cdd:pfam09405  42 AFVPTRGAFFLHDDRFAEPAANGFGKSKgrpygRRRRLWDDASEGKWTHDLFEEVAGEQAPKSK 105
 
Name Accession Description Interval E-value
Btz smart01044
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 78-167 4.24e-18

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 214991 [Multi-domain]  Cd Length: 106  Bit Score: 79.80  E-value: 4.24e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684280     78 SGGGIDNDKSGVV--KEAGDMNGEEENEKEKL-QAAVPTGGAFYMHDDRFQEMSAGGNRRMRGGRRQWGSGEERKWGHDK 154
Cdd:smart01044   1 RGSGDGDEKSAPVanKETGKMRRRLEDDEYKKnPAYVPKRGAFFMHDDRFAEPEANGNRPKGRGRRRLWQTDEGRWTHDR 80

                           90
                   ....*....|...
gi 30684280    155 FEEMNTGEKHSDR 167
Cdd:smart01044  81 FEEDEQAPKSRPE 93
Btz pfam09405
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 109-167 3.67e-13

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 430588 [Multi-domain]  Cd Length: 121  Bit Score: 66.39  E-value: 3.67e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30684280   109 AAVPTGGAFYMHDDRFQEMSAGGNRRMR-----GGRRQWGSGEERKWGHDKFEEMNTGEKHSDR 167
Cdd:pfam09405  42 AFVPTRGAFFLHDDRFAEPAANGFGKSKgrpygRRRRLWDDASEGKWTHDLFEEVAGEQAPKSK 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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