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Conserved domains on  [gi|30696707|ref|NP_851199|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
247-421 2.30e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 2.30e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 247 ASNNDCGVRDFDMERYKLVQLFR-YLWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNG 325
Cdd:COG2319 137 SGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 326 VTFATGNQDKTCRIWDTRKlSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGIS 405
Cdd:COG2319 217 KLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA 295

                       170
                ....*....|....*.
gi 30696707 406 FSPDTESLFIGVWDRT 421
Cdd:COG2319 296 FSPDGKLLASGSDDGT 311
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
247-421 2.30e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 2.30e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 247 ASNNDCGVRDFDMERYKLVQLFR-YLWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNG 325
Cdd:COG2319 137 SGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 326 VTFATGNQDKTCRIWDTRKlSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGIS 405
Cdd:COG2319 217 KLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA 295

                       170
                ....*....|....*.
gi 30696707 406 FSPDTESLFIGVWDRT 421
Cdd:COG2319 296 FSPDGKLLASGSDDGT 311
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 273-421 1.08e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.10  E-value: 1.08e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 273 PVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWDTRKlSESVAVL 352
Cdd:cd00200  53 PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTL 131

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30696707 353 KGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGISFSPDTESLFIGVWDRT 421
Cdd:cd00200 132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 302-341 2.09e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.09e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30696707    302 NGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWD 341
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
303-341 2.28e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30696707   303 GQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWD 341
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
247-421 2.30e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 2.30e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 247 ASNNDCGVRDFDMERYKLVQLFR-YLWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNG 325
Cdd:COG2319 137 SGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 326 VTFATGNQDKTCRIWDTRKlSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGIS 405
Cdd:COG2319 217 KLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA 295

                       170
                ....*....|....*.
gi 30696707 406 FSPDTESLFIGVWDRT 421
Cdd:COG2319 296 FSPDGKLLASGSDDGT 311
WD40 COG2319
WD40 repeat [General function prediction only];
251-421 8.64e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 8.64e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 251 DCGVRDFDMERYKLVQLFR-YLWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNGVTFA 329
Cdd:COG2319 183 DGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 330 TGNQDKTCRIWDTRKlSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGISFSPD 409
Cdd:COG2319 263 SGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341

                       170
                ....*....|..
gi 30696707 410 TESLFIGVWDRT 421
Cdd:COG2319 342 GKTLASGSDDGT 353
WD40 COG2319
WD40 repeat [General function prediction only];
247-421 5.32e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.15  E-value: 5.32e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 247 ASNNDCGVRDFDMERYKLVQLFR-YLWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNG 325
Cdd:COG2319 221 SGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG 300

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 326 VTFATGNQDKTCRIWDTrKLSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGIS 405
Cdd:COG2319 301 KLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVA 379

                       170
                ....*....|....*.
gi 30696707 406 FSPDTESLFIGVWDRT 421
Cdd:COG2319 380 FSPDGRTLASGSADGT 395
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 273-421 1.08e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.10  E-value: 1.08e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 273 PVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWDTRKlSESVAVL 352
Cdd:cd00200  53 PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTL 131

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30696707 353 KGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGISFSPDTESLFIGVWDRT 421
Cdd:cd00200 132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200
WD40 COG2319
WD40 repeat [General function prediction only];
272-421 2.61e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 2.61e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 272 WPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWDTRKlSESVAV 351
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRT 157

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30696707 352 LKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGykkeQEIDFF----GEISGISFSPDTESLFIGVWDRT 421
Cdd:COG2319 158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG----KLLRTLtghtGAVRSVAFSPDGKLLASGSADGT 227
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 247-421 5.04e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 5.04e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 247 ASNNDCGVRDFDMERYKLVQLFRY-LWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNG 325
Cdd:cd00200 110 SSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 326 VTFATGNQDKTCRIWDTRKlSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQeidFFG---EIS 402
Cdd:cd00200 190 EKLLSSSSDGTIKLWDLST-GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---LSGhtnSVT 265

                       170
                ....*....|....*....
gi 30696707 403 GISFSPDTESLFIGVWDRT 421
Cdd:cd00200 266 SLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
247-387 2.09e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 2.09e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 247 ASNNDCGVRDFDMERYKLVQLFR-YLWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNG 325
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 342

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30696707 326 VTFATGNQDKTCRIWDTRKLSEsVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKS 387
Cdd:COG2319 343 KTLASGSDDGTVRLWDLATGEL-LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 247-384 7.69e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 7.69e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 247 ASNNDCGVRDFDMERYKLVQLFR-YLWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNG 325
Cdd:cd00200 152 SSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 30696707 326 VTFATGNQDKTCRIWDTRKLSEsVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYD 384
Cdd:cd00200 232 YLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 273-421 3.36e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 3.36e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 273 PVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWDTRKlSESVAVL 352
Cdd:cd00200  11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET-GECVRTL 89

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30696707 353 KGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGISFSPDTESLFIGVWDRT 421
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158
WD40 COG2319
WD40 repeat [General function prediction only];
271-421 1.15e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 1.15e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 271 LWPVNHSSLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWDTRKlSESVA 350
Cdd:COG2319  36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLR 114

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30696707 351 VLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGyKKEQEI-DFFGEISGISFSPDTESLFIGVWDRT 421
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-KLLRTLtGHSGAVTSVAFSPDGKLLASGSDDGT 185
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 306-421 4.93e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 4.93e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 306 IGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWDTrKLSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDT 385
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 30696707 386 KSGYKKEQEIDFFGEISGISFSPDTESLFIGVWDRT 421
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116
WD40 COG2319
WD40 repeat [General function prediction only];
278-421 2.79e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 2.79e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 278 SLSPDGKLVAVVGDDPDGLLVDTSNGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWDTRKLSEsVAVLKGNLG 357
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGAL-LATLLGHTA 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30696707 358 AVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGISFSPDTESLFIGVWDRT 421
Cdd:COG2319  80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 302-341 2.09e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.09e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30696707    302 NGQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWD 341
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
281-415 1.38e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.23  E-value: 1.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707 281 PDGKLVAVVGDDPDGLLV-DTSNGQTIGTLKgHLDYSFASAWHPNGVT-FATGNQDKTCRIWD--TRKLSESVAVLKGnl 356
Cdd:COG3391  77 ADGRRLYVANSGSGRVSViDLATGKVVATIP-VGGGPRGLAVDPDGGRlYVADSGNGRVSVIDtaTGKVVATIPVGAG-- 153

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30696707 357 gaVRSIRFTSDGR--YVAMAEPAD---FVHIYDTKSGyKKEQEIDFFGEISGISFSPDTESLFI 415
Cdd:COG3391 154 --PHGIAVDPDGKrlYVANSGSNTvsvIVSVIDTATG-KVVATIPVGGGPVGVAVSPDGRRLYV 214
WD40 pfam00400
WD domain, G-beta repeat;
303-341 2.28e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30696707   303 GQTIGTLKGHLDYSFASAWHPNGVTFATGNQDKTCRIWD 341
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 274-409 1.17e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 44.64  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30696707  274 VNHSSLSPDGKLVAVV--GDdpdGLLVDTSNGQTIG-TLKGHLDYSFAsAWHPNG-----VTFATGNQDktcrIW--DTR 343
Cdd:COG4946  304 LTSFALSPDGKRVAFEarGE---VFTVPAEKGPTRNlTNTPGVRERLP-AWSPDGksiayFSDASGEYE----LYiaPAD 375

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30696707  344 KLSESVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGykKEQEID---FFGEISGISFSPD 409
Cdd:COG4946  376 GSGEPKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASG--KVRKVDtdgYGDGISDLAWSPD 442
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 348-421 7.87e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.17  E-value: 7.87e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30696707 348 SVAVLKGNLGAVRSIRFTSDGRYVAMAEPADFVHIYDTKSGYKKEQEIDFFGEISGISFSPDTESLFIGVWDRT 421
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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