|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
604-912 |
9.35e-76 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 257.15 E-value: 9.35e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 604 TNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKI 683
Cdd:COG2319 109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 684 WNSMTGELVHTYDEHSEQVNCCHFTNSSHhlLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSA 763
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSPDGK--LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 764 DGTLKLWDATSANERKSinvkqfflnLEDPQEDmeviVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEiHTGHHST 842
Cdd:COG2319 267 DGTVRLWDLATGELLRT---------LTGHSGG----VNSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRT-LTGHTGA 332
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 843 IQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 912
Cdd:COG2319 333 VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
607-910 |
3.93e-75 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 251.10 E-value: 3.93e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 607 SRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 686
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 687 MTGELVHTYDEHSEQVNCCHFTNSSHhlLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGT 766
Cdd:cd00200 81 ETGECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 767 LKLWDATSANERKSInvkqfflnledpqEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIhTGHHSTIQY 845
Cdd:cd00200 159 IKLWDLRTGKCVATL-------------TGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTL-RGHENGVNS 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32483359 846 CDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 910
Cdd:cd00200 225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| NB-ARC |
pfam00931 |
NB-ARC domain; |
129-374 |
1.38e-73 |
|
NB-ARC domain;
Pssm-ID: 395745 [Multi-domain] Cd Length: 245 Bit Score: 244.98 E-value: 1.38e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 129 RKKLVNAIQQKLSKlKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPgGVHWVSVGKQDKSGLLMK--LQNLCTRL 206
Cdd:pfam00931 1 REDMVEKVIGKLSE-KDEPGIVGIHGMGGVGKTTLAAQIFNDFDEVEGHFD-SVAWVVVSKTFTISTLQQtiLQNLGLSE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 207 DQDESFSQRlplnieEAKDRLRILMLRKhpRSLLILDDVWDS--W-----VLKAFDSQCQILLTTRDKSVTDSVMGPkYV 279
Cdd:pfam00931 79 DDWDNKEEG------ELARKIRRALLTK--RFLLVLDDVWDEedWdkigiPLPDRENGCRVLLTTRSEEVAGRVGGP-SD 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 280 VPVESSLGKEKGLEILSLFVNMKKAD----LPEQAHSIIKECKGSPLVVSLIGALL--RDFPNRWEYYLKQLQNKQfkri 353
Cdd:pfam00931 150 PHEVELLEPDEAWELFENKVFPKTLGecelLEDVAKEIVEKCRGLPLALKVLGGLLscKKTVEEWKHVYDVLQSEL---- 225
|
250 260
....*....|....*....|.
gi 32483359 354 rKSSSYDYEALDEAMSISVEM 374
Cdd:pfam00931 226 -KSNSYSLNSVRSILQLSYEN 245
|
|
| APAF1_C |
pfam17908 |
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the ... |
453-587 |
1.21e-69 |
|
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the apoptotic Apaf-1 protein.
Pssm-ID: 465560 Cd Length: 135 Bit Score: 229.23 E-value: 1.21e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 453 LQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHI 532
Cdd:pfam17908 1 LQDLHRKLVERYQRHCQPHTLSPDDEDDLYWYNYLGYHLASANMHEELCALLLDLDWIEAKVKLTGPSDLLHDYVKYRHI 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 32483359 533 LDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQE 587
Cdd:pfam17908 81 LDENDCAVLEDFEEFLSVNGHLLERDPFPDIIQLALCQPETSEVYQQAKLLARQR 135
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
805-1234 |
9.82e-65 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 225.56 E-value: 9.82e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 805 SWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSW 884
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 885 VHGVMFSPDGSSFLTSSDDQTIRLWEtkkvcknsavmlkqevdvvfqenevmvlaVDHIRRLQLINGRTGQidylteaqV 964
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWD-----------------------------LATGLLLRTLTGHTGA--------V 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 965 SCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGH 1043
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGH 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1044 QETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHE 1122
Cdd:COG2319 204 TGAVRSVAFSPDGKLLaSGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1123 LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHlcaplseeGAATHGGWVTDLCFSPDGKMLISAG--GYIK 1200
Cdd:COG2319 284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR--------TLTGHTGAVRSVAFSPDGKTLASGSddGTVR 355
|
410 420 430
....*....|....*....|....*....|....
gi 32483359 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1234
Cdd:COG2319 356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
961-1234 |
1.62e-56 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 197.94 E-value: 1.62e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 961 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF- 1039
Cdd:cd00200 9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRt 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1040 LRGHQETVKDFRLLKNSRLLSWS-FDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLL 1118
Cdd:cd00200 89 LTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1119 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPlseegaatHGGWVTDLCFSPDGKMLISAG-- 1196
Cdd:cd00200 169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG--------HENGVNSVAFSPDGYLLASGSed 240
|
250 260 270
....*....|....*....|....*....|....*...
gi 32483359 1197 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1234
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278
|
|
| CARD_APAF1 |
cd08323 |
Caspase activation and recruitment domain similar to that found in Apoptotic ... |
7-92 |
5.34e-52 |
|
Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1; Caspase activation and recruitment domain (CARD) similar to that found in apoptotic protease-activating factor 1 (APAF-1), which is an activator of caspase-9. APAF-1 contains WD-40 repeats, a CARD, and an ATPase domain. Upon stimulation, APAF-1, together with caspase-9, forms the heptameric 'apoptosome', which leads to the processing and activation of caspase-9, starting a caspase cascade which leads to apoptosis. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 260034 Cd Length: 86 Bit Score: 176.93 E-value: 5.34e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 7 NCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAAL 86
Cdd:cd08323 1 SCLLQHRAALERDIKTSYIMDHMISDGVLTLSEEEKVRAQPTQQERAAALIKIILRKDNDAYISFYNALLHEGYKDLAAL 80
|
....*.
gi 32483359 87 LHDGIP 92
Cdd:cd08323 81 LHDGLP 86
|
|
| CARD |
pfam00619 |
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signaling. ... |
6-90 |
7.27e-19 |
|
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (pfam00531) domain-like fold.
Pssm-ID: 459874 [Multi-domain] Cd Length: 85 Bit Score: 82.22 E-value: 7.27e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 6 RNCLLQHREALEKDIKT-SYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLhEGYKDLA 84
Cdd:pfam00619 1 RKLLKKNRVALVERLGTlDGLLDYLLEKNVLTEEEEEKIKANPTRLDKARELLDLVLKKGPKACQIFLEALK-EGDPDLA 79
|
....*.
gi 32483359 85 ALLHDG 90
Cdd:pfam00619 80 SDLEGL 85
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
629-786 |
1.06e-11 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 69.35 E-value: 1.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 629 RIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFST-DDRFIATCSVDKKVKIWNSMTGELVHTYDEHSeQVNCCHF 707
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKA-NICCVQF 625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 708 TNSSHHlLLATGSSDCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSpDDKLLASCSADGTLKLWD----ATSANERK--- 779
Cdd:PLN00181 626 PSESGR-SLAFGSADHKVYYYDLrNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDlsmsISGINETPlhs 703
|
170
....*....|
gi 32483359 780 ---SINVKQF 786
Cdd:PLN00181 704 fmgHTNVKNF 713
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
732-771 |
2.20e-10 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 56.94 E-value: 2.20e-10
10 20 30 40
....*....|....*....|....*....|....*....|
gi 32483359 732 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
733-771 |
9.40e-10 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 55.04 E-value: 9.40e-10
10 20 30
....*....|....*....|....*....|....*....
gi 32483359 733 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1119-1155 |
1.49e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.77 E-value: 1.49e-06
10 20 30
....*....|....*....|....*....|....*..
gi 32483359 1119 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1155
Cdd:smart00320 4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1119-1155 |
1.77e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 45.80 E-value: 1.77e-06
10 20 30
....*....|....*....|....*....|....*..
gi 32483359 1119 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1155
Cdd:pfam00400 3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
28-437 |
2.95e-05 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 48.65 E-value: 2.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 28 HMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGIT 107
Cdd:COG5635 60 ALVSRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALLALLELAALLKAVLLSLSGGSDLVLLLSESDLLLA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 108 SYVRTVLCEGGVPQRPVVFV-TRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSV----LAAEAVRDHSLLEGCFPggv 182
Cdd:COG5635 140 LLILLLDADGLLVSLDDLYVpLNLLERIESLKRLELLEAKKKRLLILGEPGSGKTTllryLALELAERYLDAEDPIP--- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 183 hwvsvgkqdksgLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRilMLRKHPRSLLILDDvWD--------SWVLKAF 254
Cdd:COG5635 217 ------------ILIELRDLAEEASLEDLLAEALEKRGGEPEDALE--RLLRNGRLLLLLDG-LDevpdeadrDEVLNQL 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 255 D------SQCQILLTTRdksvtdsvmgpkyvvPVESSLGKEKGLEILSL----------FVNMKKADLPEQAHSIIKECK 318
Cdd:COG5635 282 RrfleryPKARVIITSR---------------PEGYDSSELEGFEVLELaplsdeqieeFLKKWFEATERKAERLLEALE 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 319 ---------GSPLVVSLIGALLRD---FPNR----WEYYLKQL--QNKQFKRIRKSSSYDYEALDEAMS-ISVEMLREDi 379
Cdd:COG5635 347 enpelrelaRNPLLLTLLALLLRErgeLPDTraelYEQFVELLleRWDEQRGLTIYRELSREELRELLSeLALAMQENG- 425
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32483359 380 kdyytDLSILQKDVKvptKVLCILWDMEtEEVEDILQEFVNKSLLFCDRNG-------KSFRYYL 437
Cdd:COG5635 426 -----RTEFAREELE---EILREYLGRR-KDAEALLDELLLRTGLLVERGEgrysfahRSFQEYL 481
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
1056-1221 |
2.41e-04 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 45.46 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1056 SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISH-DATKFSSTSADKTAKIWSFDLLLPLHELRGH-NGCvrCS 1133
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKaNIC--CV 623
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1134 AFSVDS-TLLATGDDNGEIRIWNVSNGElLHLCAPLSEEGAATHGGWVtdlcfspDGKMLISAG--GYIKWWNV---VTG 1207
Cdd:PLN00181 624 QFPSESgRSLAFGSADHKVYYYDLRNPK-LPLCTMIGHSKTVSYVRFV-------DSSTLVSSStdNTLKLWDLsmsISG 695
|
170
....*....|....*.
gi 32483359 1208 --ESSQTFYTNGTNLK 1221
Cdd:PLN00181 696 inETPLHSFMGHTNVK 711
|
|
| FxSxx_TPR |
NF040586 |
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ... |
119-266 |
2.80e-03 |
|
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.
Pssm-ID: 468560 [Multi-domain] Cd Length: 836 Bit Score: 41.83 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 119 VPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAE-AVR---DHSLlegcfpggVHWVSVgkQDKSG 194
Cdd:NF040586 1 VPPRNPNFTGREELLERLRDQLRSGGAAVVPQALHGLGGVGKTQLALEyAHRfraDYDL--------VWWIPA--DQPEL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 195 LLMKLQNLCTRLdqdesfsqRLPLNIEEAKDRLRIL--MLRK---HPRSLLILDDVWDSWVLKAF---DSQCQILLTTRD 266
Cdd:NF040586 71 VRASLAELARRL--------GLPLGPDDVDEAARAVldALRRgepYRRWLLVFDNADDPEDLRDLlptGGPGHVLITSRN 142
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
604-912 |
9.35e-76 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 257.15 E-value: 9.35e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 604 TNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKI 683
Cdd:COG2319 109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 684 WNSMTGELVHTYDEHSEQVNCCHFTNSSHhlLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSA 763
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAVRSVAFSPDGK--LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 764 DGTLKLWDATSANERKSinvkqfflnLEDPQEDmeviVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEiHTGHHST 842
Cdd:COG2319 267 DGTVRLWDLATGELLRT---------LTGHSGG----VNSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRT-LTGHTGA 332
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 843 IQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 912
Cdd:COG2319 333 VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
607-910 |
3.93e-75 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 251.10 E-value: 3.93e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 607 SRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 686
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 687 MTGELVHTYDEHSEQVNCCHFTNSSHhlLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGT 766
Cdd:cd00200 81 ETGECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 767 LKLWDATSANERKSInvkqfflnledpqEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIhTGHHSTIQY 845
Cdd:cd00200 159 IKLWDLRTGKCVATL-------------TGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTL-RGHENGVNS 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32483359 846 CDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 910
Cdd:cd00200 225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| NB-ARC |
pfam00931 |
NB-ARC domain; |
129-374 |
1.38e-73 |
|
NB-ARC domain;
Pssm-ID: 395745 [Multi-domain] Cd Length: 245 Bit Score: 244.98 E-value: 1.38e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 129 RKKLVNAIQQKLSKlKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPgGVHWVSVGKQDKSGLLMK--LQNLCTRL 206
Cdd:pfam00931 1 REDMVEKVIGKLSE-KDEPGIVGIHGMGGVGKTTLAAQIFNDFDEVEGHFD-SVAWVVVSKTFTISTLQQtiLQNLGLSE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 207 DQDESFSQRlplnieEAKDRLRILMLRKhpRSLLILDDVWDS--W-----VLKAFDSQCQILLTTRDKSVTDSVMGPkYV 279
Cdd:pfam00931 79 DDWDNKEEG------ELARKIRRALLTK--RFLLVLDDVWDEedWdkigiPLPDRENGCRVLLTTRSEEVAGRVGGP-SD 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 280 VPVESSLGKEKGLEILSLFVNMKKAD----LPEQAHSIIKECKGSPLVVSLIGALL--RDFPNRWEYYLKQLQNKQfkri 353
Cdd:pfam00931 150 PHEVELLEPDEAWELFENKVFPKTLGecelLEDVAKEIVEKCRGLPLALKVLGGLLscKKTVEEWKHVYDVLQSEL---- 225
|
250 260
....*....|....*....|.
gi 32483359 354 rKSSSYDYEALDEAMSISVEM 374
Cdd:pfam00931 226 -KSNSYSLNSVRSILQLSYEN 245
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
608-1033 |
1.17e-70 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 242.51 E-value: 1.17e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 608 RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSM 687
Cdd:COG2319 71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 688 TGELVHTYDEHSEQVNCCHFTNSSHhlLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTL 767
Cdd:COG2319 151 TGKLLRTLTGHSGAVTSVAFSPDGK--LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 768 KLWDATSANERKSInvkqfflnledpqedmevivkccswsadgarimvaaknkiflfdihtsgllgeihTGHHSTIQYCD 847
Cdd:COG2319 229 RLWDLATGKLLRTL-------------------------------------------------------TGHSGSVRSVA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 848 FSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWEtkkvcknsavmlkqevd 927
Cdd:COG2319 254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD----------------- 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 928 vvfqenevmvlaVDHIRRLQLINGRTGqidylteaQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVW 1007
Cdd:COG2319 317 ------------LATGKLLRTLTGHTG--------AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376
|
410 420
....*....|....*....|....*.
gi 32483359 1008 HIQFTADEKTLISSSDDAEIQVWNWQ 1033
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
623-1206 |
3.28e-70 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 241.35 E-value: 3.28e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQV 702
Cdd:COG2319 2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 703 NCCHFtnSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSIn 782
Cdd:COG2319 82 LSVAF--SPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 783 vkqfflnledpqedmevivkccswsadgarimvaaknkiflfdihtsgllgeihtghhstiqycdfspqnhlavvalsqy 862
Cdd:COG2319 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 863 cvelwntdsrskvadcRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWEtkkvcknsavmlkqevdvvfqenevmvlaVDH 942
Cdd:COG2319 159 ----------------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD-----------------------------LAT 193
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 943 IRRLQLINGrtgqidylteaqvsccclsphlqyiafgdengaieilelvnnrifqsrfqHKKTVWHIQFTADEKTLISSS 1022
Cdd:COG2319 194 GKLLRTLTG--------------------------------------------------HTGAVRSVAFSPDGKLLASGS 223
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1023 DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKF 1100
Cdd:COG2319 224 ADGTVRLWDLATGKLLRtLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL 303
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1101 SSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHlcaPLSEegaatHGGWV 1180
Cdd:COG2319 304 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR---TLTG-----HTGAV 375
|
570 580
....*....|....*....|....*...
gi 32483359 1181 TDLCFSPDGKMLISAG--GYIKWWNVVT 1206
Cdd:COG2319 376 TSVAFSPDGRTLASGSadGTVRLWDLAT 403
|
|
| APAF1_C |
pfam17908 |
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the ... |
453-587 |
1.21e-69 |
|
APAF-1 helical domain; This domain represents the C-terminal alpha helical domain of the apoptotic Apaf-1 protein.
Pssm-ID: 465560 Cd Length: 135 Bit Score: 229.23 E-value: 1.21e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 453 LQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHI 532
Cdd:pfam17908 1 LQDLHRKLVERYQRHCQPHTLSPDDEDDLYWYNYLGYHLASANMHEELCALLLDLDWIEAKVKLTGPSDLLHDYVKYRHI 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 32483359 533 LDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQE 587
Cdd:pfam17908 81 LDENDCAVLEDFEEFLSVNGHLLERDPFPDIIQLALCQPETSEVYQQAKLLARQR 135
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
805-1234 |
9.82e-65 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 225.56 E-value: 9.82e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 805 SWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSW 884
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 885 VHGVMFSPDGSSFLTSSDDQTIRLWEtkkvcknsavmlkqevdvvfqenevmvlaVDHIRRLQLINGRTGQidylteaqV 964
Cdd:COG2319 81 VLSVAFSPDGRLLASASADGTVRLWD-----------------------------LATGLLLRTLTGHTGA--------V 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 965 SCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGH 1043
Cdd:COG2319 124 RSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGH 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1044 QETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHE 1122
Cdd:COG2319 204 TGAVRSVAFSPDGKLLaSGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1123 LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHlcaplseeGAATHGGWVTDLCFSPDGKMLISAG--GYIK 1200
Cdd:COG2319 284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR--------TLTGHTGAVRSVAFSPDGKTLASGSddGTVR 355
|
410 420 430
....*....|....*....|....*....|....
gi 32483359 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1234
Cdd:COG2319 356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
961-1234 |
1.62e-56 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 197.94 E-value: 1.62e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 961 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF- 1039
Cdd:cd00200 9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRt 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1040 LRGHQETVKDFRLLKNSRLLSWS-FDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLL 1118
Cdd:cd00200 89 LTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1119 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPlseegaatHGGWVTDLCFSPDGKMLISAG-- 1196
Cdd:cd00200 169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG--------HENGVNSVAFSPDGYLLASGSed 240
|
250 260 270
....*....|....*....|....*....|....*...
gi 32483359 1197 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1234
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278
|
|
| CARD_APAF1 |
cd08323 |
Caspase activation and recruitment domain similar to that found in Apoptotic ... |
7-92 |
5.34e-52 |
|
Caspase activation and recruitment domain similar to that found in Apoptotic Protease-Activating Factor 1; Caspase activation and recruitment domain (CARD) similar to that found in apoptotic protease-activating factor 1 (APAF-1), which is an activator of caspase-9. APAF-1 contains WD-40 repeats, a CARD, and an ATPase domain. Upon stimulation, APAF-1, together with caspase-9, forms the heptameric 'apoptosome', which leads to the processing and activation of caspase-9, starting a caspase cascade which leads to apoptosis. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 260034 Cd Length: 86 Bit Score: 176.93 E-value: 5.34e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 7 NCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAAL 86
Cdd:cd08323 1 SCLLQHRAALERDIKTSYIMDHMISDGVLTLSEEEKVRAQPTQQERAAALIKIILRKDNDAYISFYNALLHEGYKDLAAL 80
|
....*.
gi 32483359 87 LHDGIP 92
Cdd:cd08323 81 LHDGLP 86
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
879-1203 |
1.87e-51 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 183.31 E-value: 1.87e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 879 RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKkvcknsavmlkqevdvvfqenevmvlavdhirRLQLINGRTGQIDy 958
Cdd:cd00200 6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE--------------------------------TGELLRTLKGHTG- 52
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 959 lteaQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI 1038
Cdd:cd00200 53 ----PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1039 F-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1116
Cdd:cd00200 129 TtLRGHTDWVNSVAFSPDGTFVaSSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1117 LLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCaplseEGaatHGGWVTDLCFSPDGKMLISAG 1196
Cdd:cd00200 209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL-----SG---HTNSVTSLAWSPDGKRLASGS 280
|
....*....
gi 32483359 1197 --GYIKWWN 1203
Cdd:cd00200 281 adGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
969-1237 |
1.44e-49 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 181.65 E-value: 1.44e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 969 LSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETV 1047
Cdd:COG2319 44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRtLTGHTGAV 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1048 KDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGH 1126
Cdd:COG2319 124 RSVAFSPDgKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1127 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLcaplseegAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1204
Cdd:COG2319 204 TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT--------LTGHSGSVRSVAFSPDGRLLASGSadGTVRLWDL 275
|
250 260 270
....*....|....*....|....*....|...
gi 32483359 1205 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1237
Cdd:COG2319 276 ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
652-1113 |
8.43e-49 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 175.60 E-value: 8.43e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 652 EIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFtnSSHHLLLATGSSDCFLKLWDLN 731
Cdd:cd00200 4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA--SADGTYLASGSSDKTIRLWDLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 732 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSInvkqfflnledpqedmevivkccswsadga 811
Cdd:cd00200 82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL------------------------------ 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 812 rimvaaknkiflfdihtsgllgeihtghhstiqycdfspqnhlavvalsqycvelwntdsrskvadcRGHLSWVHGVMFS 891
Cdd:cd00200 132 -------------------------------------------------------------------RGHTDWVNSVAFS 144
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 892 PDGSSFLTSSDDQTIRLWETKKvcknsavmlkqevdvvfqenevmvlavdhIRRLQLINGrtgqidylteaqvsccclsp 971
Cdd:cd00200 145 PDGTFVASSSQDGTIKLWDLRT-----------------------------GKCVATLTG-------------------- 175
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 972 hlqyiafgdengaieilelvnnrifqsrfqHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDF 1050
Cdd:cd00200 176 ------------------------------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLgTLRGHENGVNSV 225
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 32483359 1051 RLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1113
Cdd:cd00200 226 AFSPDGYLLaSGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
604-774 |
1.66e-46 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 172.79 E-value: 1.66e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 604 TNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKI 683
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 684 WNSMTGELVHTYDEHSEQVNCCHFTNSSHHLllATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSA 763
Cdd:COG2319 315 WDLATGKLLRTLTGHTGAVRSVAFSPDGKTL--ASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
|
170
....*....|.
gi 32483359 764 DGTLKLWDATS 774
Cdd:COG2319 393 DGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1002-1213 |
1.37e-45 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 166.36 E-value: 1.37e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1002 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNS-RLLSWSFDGTVKVWNIITGNKEK 1079
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVAASADGtYLASGSSDKTIRLWDLETGECVR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1080 DFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNG 1159
Cdd:cd00200 88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 32483359 1160 ELLHLCaplseegaATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF 1213
Cdd:cd00200 168 KCVATL--------TGHTGEVNSVAFSPDGEKLLSSSsdGTIKLWDLSTGKCLGTL 215
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
969-1243 |
3.31e-42 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 160.08 E-value: 3.31e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 969 LSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETV 1047
Cdd:COG2319 2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAtLLGHTAAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1048 KDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGH 1126
Cdd:COG2319 82 LSVAFSPDgRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1127 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHlcaPLSEegaatHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1204
Cdd:COG2319 162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR---TLTG-----HTGAVRSVAFSPDGKLLASGSadGTVRLWDL 233
|
250 260 270
....*....|....*....|....*....|....*....
gi 32483359 1205 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1243
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL 272
|
|
| CARD |
pfam00619 |
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signaling. ... |
6-90 |
7.27e-19 |
|
Caspase recruitment domain; Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (pfam00531) domain-like fold.
Pssm-ID: 459874 [Multi-domain] Cd Length: 85 Bit Score: 82.22 E-value: 7.27e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 6 RNCLLQHREALEKDIKT-SYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLhEGYKDLA 84
Cdd:pfam00619 1 RKLLKKNRVALVERLGTlDGLLDYLLEKNVLTEEEEEKIKANPTRLDKARELLDLVLKKGPKACQIFLEALK-EGDPDLA 79
|
....*.
gi 32483359 85 ALLHDG 90
Cdd:pfam00619 80 SDLEGL 85
|
|
| CARD |
cd01671 |
Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase ... |
9-87 |
1.22e-17 |
|
Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase activation and recruitment domains (CARDs) are death domains (DDs) found associated with caspases. Caspases are aspartate-specific cysteine proteases with functions in apoptosis, immune signaling, inflammation, and host-defense mechanisms. In addition to caspases, proteins containing CARDs include adaptor proteins such as RAIDD, CARD9, and RIG-I-like helicases, which can form multiprotein complexes and play important roles in mediating the signals to induce immune and inflammatory responses. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 260018 [Multi-domain] Cd Length: 79 Bit Score: 78.71 E-value: 1.22e-17
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 32483359 9 LLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALL 87
Cdd:cd01671 1 LRKNRVELVEDLDVEDILDHLIQKGVLTEEDKEEILSEKTRQDKARKLLDILPRRGPKAFEVFCEALRETGQPHLAELL 79
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1119-1213 |
3.00e-13 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 71.60 E-value: 3.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1119 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHlcaplSEEGaatHGGWVTDLCFSPDGKMLISAG-- 1196
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-----TLKG---HTGPVRDVAASADGTYLASGSsd 72
|
90
....*....|....*..
gi 32483359 1197 GYIKWWNVVTGESSQTF 1213
Cdd:cd00200 73 KTIRLWDLETGECVRTL 89
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
629-786 |
1.06e-11 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 69.35 E-value: 1.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 629 RIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFST-DDRFIATCSVDKKVKIWNSMTGELVHTYDEHSeQVNCCHF 707
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKA-NICCVQF 625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 708 TNSSHHlLLATGSSDCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSpDDKLLASCSADGTLKLWD----ATSANERK--- 779
Cdd:PLN00181 626 PSESGR-SLAFGSADHKVYYYDLrNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDlsmsISGINETPlhs 703
|
170
....*....|
gi 32483359 780 ---SINVKQF 786
Cdd:PLN00181 704 fmgHTNVKNF 713
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
732-771 |
2.20e-10 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 56.94 E-value: 2.20e-10
10 20 30 40
....*....|....*....|....*....|....*....|
gi 32483359 732 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
733-771 |
9.40e-10 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 55.04 E-value: 9.40e-10
10 20 30
....*....|....*....|....*....|....*....
gi 32483359 733 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
646-685 |
9.61e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 51.93 E-value: 9.61e-09
10 20 30 40
....*....|....*....|....*....|....*....|
gi 32483359 646 TGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWN 685
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
661-868 |
2.67e-08 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 58.56 E-value: 2.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 661 LCCA--FSTDDRFIATCSVDKKVKIW--NSMT--GELVH----TYDEHSEQVNCCHftNSSHHLLLATGSSDCFLKLWDL 730
Cdd:PLN00181 485 LVCAigFDRDGEFFATAGVNKKIKIFecESIIkdGRDIHypvvELASRSKLSGICW--NSYIKSQVASSNFEGVVQVWDV 562
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 731 NQKECRNTMFGHTNSVNHCRFSP-DDKLLASCSADGTLKLWdatSANERKSINVKQFFLNledpqedmeviVKCCSWSAD 809
Cdd:PLN00181 563 ARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLW---SINQGVSIGTIKTKAN-----------ICCVQFPSE 628
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32483359 810 GARIMV--AAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLaVVALSQYCVELWN 868
Cdd:PLN00181 629 SGRSLAfgSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTL-VSSSTDNTLKLWD 688
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
647-685 |
4.45e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 50.04 E-value: 4.45e-08
10 20 30
....*....|....*....|....*....|....*....
gi 32483359 647 GEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWN 685
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
871-910 |
9.32e-07 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.54 E-value: 9.32e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 32483359 871 SRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 910
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
688-729 |
1.28e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.15 E-value: 1.28e-06
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 32483359 688 TGELVHTYDEHSEQVNCCHFtnSSHHLLLATGSSDCFLKLWD 729
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAF--SPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1119-1155 |
1.49e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.77 E-value: 1.49e-06
10 20 30
....*....|....*....|....*....|....*..
gi 32483359 1119 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1155
Cdd:smart00320 4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1119-1155 |
1.77e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 45.80 E-value: 1.77e-06
10 20 30
....*....|....*....|....*....|....*..
gi 32483359 1119 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1155
Cdd:pfam00400 3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1176-1248 |
8.49e-06 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 49.26 E-value: 8.49e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 32483359 1176 HGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTV--DNLGILYILQTLE 1248
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSgdGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGssDKTIRLWDLETGE 84
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
872-910 |
8.94e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.87 E-value: 8.94e-06
10 20 30
....*....|....*....|....*....|....*....
gi 32483359 872 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 910
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
624-819 |
1.54e-05 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 49.31 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 624 SEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDeVLCCAFSTDD-RFIATCSVDKKVKIWNSMTGEL-VHTYDEHSEQ 701
Cdd:PLN00181 585 SADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKT 663
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 702 VNCCHFTNSShhlLLATGSSDCFLKLWDLN------QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWdatsa 775
Cdd:PLN00181 664 VSYVRFVDSS---TLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVY----- 735
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 32483359 776 NERKSINVKQFFLNLEDPQEDMEV-----IVKCCSWSADGARIMVAAKN 819
Cdd:PLN00181 736 HKAFPMPVLSYKFKTIDPVSGLEVddasqFISSVCWRGQSSTLVAANST 784
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
689-729 |
1.66e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.10 E-value: 1.66e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 32483359 689 GELVHTYDEHSEQVNCCHFtnSSHHLLLATGSSDCFLKLWD 729
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVWD 39
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
28-437 |
2.95e-05 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 48.65 E-value: 2.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 28 HMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGIT 107
Cdd:COG5635 60 ALVSRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALLALLELAALLKAVLLSLSGGSDLVLLLSESDLLLA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 108 SYVRTVLCEGGVPQRPVVFV-TRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSV----LAAEAVRDHSLLEGCFPggv 182
Cdd:COG5635 140 LLILLLDADGLLVSLDDLYVpLNLLERIESLKRLELLEAKKKRLLILGEPGSGKTTllryLALELAERYLDAEDPIP--- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 183 hwvsvgkqdksgLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRilMLRKHPRSLLILDDvWD--------SWVLKAF 254
Cdd:COG5635 217 ------------ILIELRDLAEEASLEDLLAEALEKRGGEPEDALE--RLLRNGRLLLLLDG-LDevpdeadrDEVLNQL 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 255 D------SQCQILLTTRdksvtdsvmgpkyvvPVESSLGKEKGLEILSL----------FVNMKKADLPEQAHSIIKECK 318
Cdd:COG5635 282 RrfleryPKARVIITSR---------------PEGYDSSELEGFEVLELaplsdeqieeFLKKWFEATERKAERLLEALE 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 319 ---------GSPLVVSLIGALLRD---FPNR----WEYYLKQL--QNKQFKRIRKSSSYDYEALDEAMS-ISVEMLREDi 379
Cdd:COG5635 347 enpelrelaRNPLLLTLLALLLRErgeLPDTraelYEQFVELLleRWDEQRGLTIYRELSREELRELLSeLALAMQENG- 425
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 32483359 380 kdyytDLSILQKDVKvptKVLCILWDMEtEEVEDILQEFVNKSLLFCDRNG-------KSFRYYL 437
Cdd:COG5635 426 -----RTEFAREELE---EILREYLGRR-KDAEALLDELLLRTGLLVERGEgrysfahRSFQEYL 481
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
1110-1165 |
4.15e-05 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 43.42 E-value: 4.15e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 32483359 1110 KIWSFDLllplhelRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLC 1165
Cdd:pfam12894 28 RVWTLSP-------DKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF 76
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1176-1203 |
1.51e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 40.37 E-value: 1.51e-04
10 20 30
....*....|....*....|....*....|
gi 32483359 1176 HGGWVTDLCFSPDGKMLISAG--GYIKWWN 1203
Cdd:smart00320 11 HTGPVTSVAFSPDGKYLASGSddGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
610-643 |
2.06e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 39.99 E-value: 2.06e-04
10 20 30
....*....|....*....|....*....|....
gi 32483359 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFK 643
Cdd:smart00320 7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| COG3903 |
COG3903 |
Predicted ATPase [General function prediction only]; |
150-185 |
2.19e-04 |
|
Predicted ATPase [General function prediction only];
Pssm-ID: 443109 [Multi-domain] Cd Length: 933 Bit Score: 45.78 E-value: 2.19e-04
10 20 30
....*....|....*....|....*....|....*.
gi 32483359 150 VTIHGMAGCGKSVLAAEAVRDhslLEGCFPGGVHWV 185
Cdd:COG3903 179 VTLTGPGGVGKTRLALEVAHR---LADRFPDGVWFV 211
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
1056-1221 |
2.41e-04 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 45.46 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1056 SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISH-DATKFSSTSADKTAKIWSFDLLLPLHELRGH-NGCvrCS 1133
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKaNIC--CV 623
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1134 AFSVDS-TLLATGDDNGEIRIWNVSNGElLHLCAPLSEEGAATHGGWVtdlcfspDGKMLISAG--GYIKWWNV---VTG 1207
Cdd:PLN00181 624 QFPSESgRSLAFGSADHKVYYYDLRNPK-LPLCTMIGHSKTVSYVRFV-------DSSTLVSSStdNTLKLWDLsmsISG 695
|
170
....*....|....*.
gi 32483359 1208 --ESSQTFYTNGTNLK 1221
Cdd:PLN00181 696 inETPLHSFMGHTNVK 711
|
|
| CARD_BIRC2_BIRC3 |
cd08329 |
Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, ... |
11-75 |
3.90e-04 |
|
Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2); Caspase activation and recruitment domain (CARD) similar to those found in Baculoviral IAP repeat (BIR)-containing protein 2 (BIRC2) or cellular Inhibitor of Apoptosis Protein 1 (c-IAP1), and BIRC3 (or c-IAP2). IAPs are anti-apoptotic proteins that contain at least one BIR domain. Most IAPs also contain a C-terminal RING domain. In addition, both BIRC2 and BIRC3 contain a CARD. BIRC2 and BIRC3, through their binding with TRAF (TNF receptor-associated factor) 2, are recruited to TNFR-1/2 signaling complexes, where they regulate caspase-8 activity. They also play important roles in pro-survival NF-kB signaling pathways. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 260038 Cd Length: 94 Bit Score: 40.89 E-value: 3.90e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 32483359 11 QHREALEKDIKTSY-IMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNAL 75
Cdd:cd08329 13 KNRMALFQHLTCVLpILDHLLSANVITEQEYDVIKQKTQTPLQARELIDTILVKGNAAAEVFRNCL 78
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1074-1113 |
6.09e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.45 E-value: 6.09e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 32483359 1074 TGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1113
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| CARD_CASP2 |
cd08332 |
Caspase activation and recruitment domain of Caspase-2; Caspase activation and recruitment ... |
1-87 |
1.80e-03 |
|
Caspase activation and recruitment domain of Caspase-2; Caspase activation and recruitment domain (CARD) similar to that found in caspase-2. Caspases are aspartate-specific cysteine proteases with functions in apoptosis and immune signaling. Caspase-2 (also known as ICH1, NEDD2, or CASP2) is one of the most evolutionarily conserved caspases, and plays a role in apoptosis, DNA damage response, cell cycle regulation, and tumor suppression. It is localized in the nucleus and exhibits properties of both an initiator and an effector caspase. In general, CARDs are death domains (DDs) found associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 260040 Cd Length: 87 Bit Score: 38.56 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGY 80
Cdd:cd08332 1 MQKRHREALKKNRVKLAKELVLDELLIHLLQKDILTDSMVESIMAKPTSFSQNVALLNLLPKRGPRAFSAFCEALRETSQ 80
|
....*..
gi 32483359 81 KDLAALL 87
Cdd:cd08332 81 EHLADLL 87
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1075-1113 |
2.29e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.94 E-value: 2.29e-03
10 20 30
....*....|....*....|....*....|....*....
gi 32483359 1075 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1113
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
610-642 |
2.65e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.55 E-value: 2.65e-03
10 20 30
....*....|....*....|....*....|...
gi 32483359 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVF 642
Cdd:pfam00400 6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| FxSxx_TPR |
NF040586 |
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ... |
119-266 |
2.80e-03 |
|
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.
Pssm-ID: 468560 [Multi-domain] Cd Length: 836 Bit Score: 41.83 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 119 VPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAE-AVR---DHSLlegcfpggVHWVSVgkQDKSG 194
Cdd:NF040586 1 VPPRNPNFTGREELLERLRDQLRSGGAAVVPQALHGLGGVGKTQLALEyAHRfraDYDL--------VWWIPA--DQPEL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 195 LLMKLQNLCTRLdqdesfsqRLPLNIEEAKDRLRIL--MLRK---HPRSLLILDDVWDSWVLKAF---DSQCQILLTTRD 266
Cdd:NF040586 71 VRASLAELARRL--------GLPLGPDDVDEAARAVldALRRgepYRRWLLVFDNADDPEDLRDLlptGGPGHVLITSRN 142
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1176-1203 |
3.17e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.55 E-value: 3.17e-03
10 20 30
....*....|....*....|....*....|
gi 32483359 1176 HGGWVTDLCFSPDGKMLISAG--GYIKWWN 1203
Cdd:pfam00400 10 HTGSVTSLAFSPDGKLLASGSddGTVKVWD 39
|
|
| eIF2A |
pfam08662 |
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ... |
796-901 |
3.24e-03 |
|
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.
Pssm-ID: 462552 [Multi-domain] Cd Length: 194 Bit Score: 40.33 E-value: 3.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 796 DMEVIVKCCSWSADGARIMVA---AKNKIFLFDiHTSGLLGEIHTGHHSTIQycdFSPQNHLAVVA----LSQYcVELWN 868
Cdd:pfam08662 57 DKEGPIHDVAWSPNGKEFAVIygyMPAKVSFFD-LKGNVIHSFGEQPRNTIF---WSPFGRLVLLAgfgnLAGD-IEFWD 131
|
90 100 110
....*....|....*....|....*....|...
gi 32483359 869 TDSRSKVADCRGhlSWVHGVMFSPDGSSFLTSS 901
Cdd:pfam08662 132 VVNKKKIATAEA--SNATLCEWSPDGRYFLTAT 162
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
1014-1111 |
3.95e-03 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 41.42 E-value: 3.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 1014 DEKTLISSSDDAEIQVWNWQ--------LDKCIFLRGHQETVK--DFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVC 1083
Cdd:PTZ00421 87 DPQKLFTASEDGTIMGWGIPeegltqniSDPIVHLQGHTKKVGivSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKC 166
|
90 100
....*....|....*....|....*...
gi 32483359 1084 HQGTVLSCDISHDATKFSSTSADKTAKI 1111
Cdd:PTZ00421 167 HSDQITSLEWNLDGSLLCTTSKDKKLNI 194
|
|
| ANAPC4_WD40 |
pfam12894 |
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ... |
659-708 |
5.76e-03 |
|
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
Pssm-ID: 403945 [Multi-domain] Cd Length: 91 Bit Score: 37.26 E-value: 5.76e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 32483359 659 EVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT 708
Cdd:pfam12894 40 EVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
|
|
| CARD_CASP9 |
cd08326 |
Caspase activation and recruitment domain of Caspase-9; Caspase activation and recruitment ... |
6-87 |
7.13e-03 |
|
Caspase activation and recruitment domain of Caspase-9; Caspase activation and recruitment domain (CARD) similar to that found in caspase-9 (CASP9, MCH6, APAF3), which interacts with the CARD of apoptotic protease-activating factor 1 (APAF-1). Caspases are aspartate-specific cysteine proteases with functions in apoptosis and immune signaling. Initiator caspases are the first to be activated following death- or inflammation-inducing signals. Caspase-9 is the initiator caspase associated with the intrinsic or mitochondrial pathway of apoptosis, induced by many pro-apoptotic signals. Together with APAF-1, it forms the heptameric 'apoptosome' in response to the release of cytochrome c from mitochondria. Activated caspase-9 cleaves and activates downstream effector caspases, like caspase-3, caspase-6, and caspase-7, resulting in apoptosis. In general, CARDs are death domains (DDs) associated with caspases. They are known to be important in the signaling pathways for apoptosis, inflammation and host-defense mechanisms. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.
Pssm-ID: 176740 Cd Length: 84 Bit Score: 37.02 E-value: 7.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483359 6 RNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAA 85
Cdd:cd08326 2 RQILRRHRARLVEELQPKYLWDHLLSRGVFTPDMIEEIQAAGSRRDQARQLLIDLETRGKQAFPAFLSALRETGQTDLAE 81
|
..
gi 32483359 86 LL 87
Cdd:cd08326 82 LL 83
|
|
| |
