NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|33149306|ref|NP_872625|]
View 

uroplakin-3b isoform b precursor [Homo sapiens]

Protein Classification

UP_IIIb domain-containing protein( domain architecture ID 10177858)

UP_IIIb domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
UP_IIIb cd09969
Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is ...
 29-202 6.99e-91

Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


:

Pssm-ID: 197378  Cd Length: 184  Bit Score: 266.95  E-value: 6.99e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33149306  29 ELVPYTPQITAWDLEGKVTATTFSLEQPRCVFDGLaSASDTVWLVVAFSNASRGFQNPETLADIPASPQLLTDGHYMTLP 108
Cdd:cd09969   1 EKISYVPQLTPAPLEGRITSSTFVLEQPRCVFSSS-SDGDDIWLVVALSNATQNFNAPVKSSDIPTASSFSTKGYYLTLR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33149306 109 LSPDQLPCGDPmagSGGAPVLRVGHDHGCHQQpFCNAPLPGPGPYRVKFLLMDTRGsPRAETKWSDPITLHQGKTPGSID 188
Cdd:cd09969  80 ASRALYPCGNP---SMGLPVLRVGADTGCTDN-NCNGPLPGPGPYRVKFLVMNNRG-PVAETNWSDPITLRTGKSPQTID 154

                       170
                ....*....|....
gi 33149306 189 TWPGRRSGSMIVIT 202
Cdd:cd09969 155 TWPGRRSGGMIVIT 168
 
Name Accession Description Interval E-value
UP_IIIb cd09969
Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is ...
 29-202 6.99e-91

Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197378  Cd Length: 184  Bit Score: 266.95  E-value: 6.99e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33149306  29 ELVPYTPQITAWDLEGKVTATTFSLEQPRCVFDGLaSASDTVWLVVAFSNASRGFQNPETLADIPASPQLLTDGHYMTLP 108
Cdd:cd09969   1 EKISYVPQLTPAPLEGRITSSTFVLEQPRCVFSSS-SDGDDIWLVVALSNATQNFNAPVKSSDIPTASSFSTKGYYLTLR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33149306 109 LSPDQLPCGDPmagSGGAPVLRVGHDHGCHQQpFCNAPLPGPGPYRVKFLLMDTRGsPRAETKWSDPITLHQGKTPGSID 188
Cdd:cd09969  80 ASRALYPCGNP---SMGLPVLRVGADTGCTDN-NCNGPLPGPGPYRVKFLVMNNRG-PVAETNWSDPITLRTGKSPQTID 154

                       170
                ....*....|....
gi 33149306 189 TWPGRRSGSMIVIT 202
Cdd:cd09969 155 TWPGRRSGGMIVIT 168
 
Name Accession Description Interval E-value
UP_IIIb cd09969
Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is ...
 29-202 6.99e-91

Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197378  Cd Length: 184  Bit Score: 266.95  E-value: 6.99e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33149306  29 ELVPYTPQITAWDLEGKVTATTFSLEQPRCVFDGLaSASDTVWLVVAFSNASRGFQNPETLADIPASPQLLTDGHYMTLP 108
Cdd:cd09969   1 EKISYVPQLTPAPLEGRITSSTFVLEQPRCVFSSS-SDGDDIWLVVALSNATQNFNAPVKSSDIPTASSFSTKGYYLTLR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33149306 109 LSPDQLPCGDPmagSGGAPVLRVGHDHGCHQQpFCNAPLPGPGPYRVKFLLMDTRGsPRAETKWSDPITLHQGKTPGSID 188
Cdd:cd09969  80 ASRALYPCGNP---SMGLPVLRVGADTGCTDN-NCNGPLPGPGPYRVKFLVMNNRG-PVAETNWSDPITLRTGKSPQTID 154

                       170
                ....*....|....
gi 33149306 189 TWPGRRSGSMIVIT 202
Cdd:cd09969 155 TWPGRRSGGMIVIT 168
UP_III cd09968
Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a ...
 29-202 1.41e-88

Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197377  Cd Length: 187  Bit Score: 261.16  E-value: 1.41e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33149306  29 ELVPYTPQITAWDLEGKVTATTFSLEQPRCVFDGLASASDTVWLVVAFSNASRGFQNPETLAD-IPASPQLLTDGHYMTL 107
Cdd:cd09968   1 EAVSYVPQLASTFLEGNPTSTTFTLEQPRCVFDSSASDTDDVWLVVAVSNATNNFNAPQNSTDpISTYSQFSGGQYYLTL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33149306 108 PLSPDQLPCGDPmagSGGAPVLRVGHDHGCHQQPFCNAPLPGPGPYRVKFLLMDTRGsPRAETKWSDPITLHQGKTPGSI 187
Cdd:cd09968  81 RASRDLYPCGNP---SLNAYVLRVGADGNCTDNGNCNGPLPGPGPYRVKYLVMNGSG-VVAQTNWSDPIRLNQAKSYQTI 156

                       170
                ....*....|....*
gi 33149306 188 DTWPGRRSGSMIVIT 202
Cdd:cd09968 157 DTWPGRRSGGMIVIT 171
UP_III_II cd09966
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with ...
 31-202 2.54e-72

Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers; six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197375  Cd Length: 181  Bit Score: 219.60  E-value: 2.54e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33149306  31 VPYTPQITAWDLEGKVTATTFSLEQPRCVFDGlaSASDTVWLVVAFSNASRGFQNPETLADIPASPQLLTDGHYMTLPLS 110
Cdd:cd09966   1 LSYVPQLTASTGAGNPTLSTFTLEQPPCMFDS--SSTDDVWLVVALPNATLAFQNVTLSTDISTYLTFTTGNYYKTLRAS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33149306 111 PDQLPCGDPMAgSGGAPVLRVGHDHGCHQQpFCNAPLPGPGPYRVKFLLMDTRGsPRAETKWSDPITLHQGKTPGSidTW 190
Cdd:cd09966  79 FDLPPCRNRRD-IVSAYVLRVGNTTTCLSG-YCNTPLPGPGPYRVKYLVMNGSG-PSAQTEWSTPIRLNQNKIYST--TW 153

                       170
                ....*....|..
gi 33149306 191 PGRRSGSMIVIT 202
Cdd:cd09966 154 PGARSGGMIVIT 165
UP_IIIa cd09970
Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is ...
 47-202 1.10e-19

Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197379  Cd Length: 212  Bit Score: 84.65  E-value: 1.10e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33149306  47 TATTFSLEQPRCVFD--GLASASDTVWLVVAFSNASRGFQNPETLADIPASPQLLTDGHYMTLP---LSPDQLPCGD-PM 120
Cdd:cd09970  20 TLTTITLEKPFCMFDskEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGRTGPykaAAFDLPPCSDlPS 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33149306 121 AGSGG----------APVLRVGHDHGCHQQP----FCNAPLPGPGPYRVKFLLMD-TRGSPRAETKWSDPITLHQGKTPG 185
Cdd:cd09970 100 LDAIGdvskasqilnAYLVRVGANGTCLWDPnfkgLCNPPLSAATEYRFKYVLVNmSTGLVEDQTLWSDPIRTNQLTPYS 179

                       170
                ....*....|....*..
gi 33149306 186 SIDTWPGRRSGSMIVIT 202
Cdd:cd09970 180 TIDTWPGRRSGGMIVIT 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH