NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|37537716|ref|NP_892116|]
View 

eukaryotic translation initiation factor 5 [Homo sapiens]

Protein Classification

eukaryotic translation initiation factor 5( domain architecture ID 10486941)

eukaryotic translation initiation factor 5 (eIF5) plays a critical role in the translation initiation process by promoting the dissociation of eIF2-GDP from the ribosome, which is necessary for the transition from initiation to the elongation phase of protein synthesis

Gene Ontology:  GO:0005525|GO:0003743|GO:0003723|GO:0071074|GO:0005092|GO:0045296|GO:0005096
PubMed:  21686265

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 233-385 7.42e-63

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


:

Pssm-ID: 211399  Cd Length: 157  Bit Score: 199.76  E-value: 7.42e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716 233 ERTIEERVNILFDFVKKKKEEGViDSSDKEIVAEAERLDV-KAMGPLVLTEVLFNEKIREQIKKYRRHFLRFCHNnKKAQ 311
Cdd:cd11561   1 EEEEDERVDELGEFLKKNKDESG-LSELKEILKEAERLDVvKDKAVLVLAEVLFDENIVKEIKKRKALLLKLVTD-EKAQ 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 37537716 312 RYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEA 385
Cdd:cd11561  79 KALLGGIERFCGKHSPELLKKVPLILKALYDNDILEEEVILKWYEKVSKKYVSKEKSKKVRKAAEPFVEWLEEA 152
eIF-5_eIF-2B pfam01873
Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of ...
 9-128 3.07e-54

Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homolog. The region contains a putative zinc binding C4 finger.


:

Pssm-ID: 426485  Cd Length: 115  Bit Score: 176.16  E-value: 3.07e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716     9 VSDQFYRYKMPRLIAKVEGKGngiKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDvKNDRYIVNGSHEANKLQDM 88
Cdd:pfam01873   2 VTDSFYRYKMPPPQVKREGKG---KTVIVNFSEIAKALNRDPEHVLKYLLKELGTQGSID-ENGRLIINGKFSAKQIEDL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 37537716    89 LDGFIKKFVLCPECENPETDLHVNPKKQTIgnSCKACGYR 128
Cdd:pfam01873  78 LDKYIEEYVLCPECGSPDTELIKENRLLFL--KCEACGAR 115
 
Name Accession Description Interval E-value
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 233-385 7.42e-63

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 199.76  E-value: 7.42e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716 233 ERTIEERVNILFDFVKKKKEEGViDSSDKEIVAEAERLDV-KAMGPLVLTEVLFNEKIREQIKKYRRHFLRFCHNnKKAQ 311
Cdd:cd11561   1 EEEEDERVDELGEFLKKNKDESG-LSELKEILKEAERLDVvKDKAVLVLAEVLFDENIVKEIKKRKALLLKLVTD-EKAQ 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 37537716 312 RYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEA 385
Cdd:cd11561  79 KALLGGIERFCGKHSPELLKKVPLILKALYDNDILEEEVILKWYEKVSKKYVSKEKSKKVRKAAEPFVEWLEEA 152
eIF-5_eIF-2B pfam01873
Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of ...
 9-128 3.07e-54

Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homolog. The region contains a putative zinc binding C4 finger.


Pssm-ID: 426485  Cd Length: 115  Bit Score: 176.16  E-value: 3.07e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716     9 VSDQFYRYKMPRLIAKVEGKGngiKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDvKNDRYIVNGSHEANKLQDM 88
Cdd:pfam01873   2 VTDSFYRYKMPPPQVKREGKG---KTVIVNFSEIAKALNRDPEHVLKYLLKELGTQGSID-ENGRLIINGKFSAKQIEDL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 37537716    89 LDGFIKKFVLCPECENPETDLHVNPKKQTIgnSCKACGYR 128
Cdd:pfam01873  78 LDKYIEEYVLCPECGSPDTELIKENRLLFL--KCEACGAR 115
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
13-128 1.65e-49

domain present in translation initiation factor eIF2B and eIF5;


Pssm-ID: 214764  Cd Length: 110  Bit Score: 163.57  E-value: 1.65e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716     13 FYRYKMPRLIAKVEGKGngiKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNdRYIVNGSHEANKLQDMLDGF 92
Cdd:smart00653   1 FYRFKMPPPQVLREGKG---KTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGKG-RLIVNGRFTPKKLQDLLRRY 76

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 37537716     93 IKKFVLCPECENPETDLHVNpkKQTIGNSCKACGYR 128
Cdd:smart00653  77 IKEYVLCPECGSPDTELIKE--NRLFFLKCEACGAR 110
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
299-385 8.63e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 99.67  E-value: 8.63e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716    299 HFLRFCHNNKKAQRYLLHGLECVVAMHQaQLISKIPHILKEMYDADLLEEEVIISWSEKAskkyVSKELAKEIRVKAEPF 378
Cdd:smart00515   2 PLLKFLAKDEEEQLELLYAIEEFCVELE-KLGKLLPKILKSLYDADILEEEAILKWYEKA----VSAEGKKKVRKNAKPF 76


                   ....*..
gi 37537716    379 IKWLKEA 385
Cdd:smart00515  77 VTWLQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 311-385 6.37e-20

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 83.35  E-value: 6.37e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 37537716   311 QRYLLHGLECVVAmHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKkyvSKELAKEIRVKAEPFIKWLKEA 385
Cdd:pfam02020   1 QVDLLLALQEFCA-KLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSS---AEKGMKKVRKQAKPFVEWLEEA 71
GCD7 COG1601
Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ...
 15-126 7.07e-19

Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 441209  Cd Length: 133  Bit Score: 82.17  E-value: 7.07e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716  15 RYKMPRLIAKVEGKgngiKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDvkNDRYIVNGSHEANKLQDMLDGFIK 94
Cdd:COG1601  24 RFEVPEPEVRIEGN----RTIIRNFSDIADALNRDPEHLLKYLLKELGTAGSIE--GGRAILQGKFSPEDINALIDRYVK 97

                        90       100       110
                ....*....|....*....|....*....|..
gi 37537716  95 KFVLCPECENPETDLhVNPKKQTIgNSCKACG 126
Cdd:COG1601  98 EYVICPECGSPDTRL-VKEGRVLM-LKCEACG 127
PRK03988 PRK03988
translation initiation factor IF-2 subunit beta; Validated
 15-126 2.05e-15

translation initiation factor IF-2 subunit beta; Validated


Pssm-ID: 235189  Cd Length: 138  Bit Score: 72.64  E-value: 2.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716   15 RYKMPRLIAKVEGKgngiKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTqfDVKNDRYIVNGSHEANKLQDMLDGFIK 94
Cdd:PRK03988  27 RFEVPKPDVRIEGN----RTIIRNFKEIADRLNRDPKHVAKFLLKELGTAG--NIEGGRLILQGKFSPRVINEKIDRYVK 100

                         90       100       110
                 ....*....|....*....|....*....|..
gi 37537716   95 KFVLCPECENPETDLhVNPKKQTIgNSCKACG 126
Cdd:PRK03988 101 EYVICPECGSPDTKL-IKEGRIWV-LKCEACG 130
 
Name Accession Description Interval E-value
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 233-385 7.42e-63

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 199.76  E-value: 7.42e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716 233 ERTIEERVNILFDFVKKKKEEGViDSSDKEIVAEAERLDV-KAMGPLVLTEVLFNEKIREQIKKYRRHFLRFCHNnKKAQ 311
Cdd:cd11561   1 EEEEDERVDELGEFLKKNKDESG-LSELKEILKEAERLDVvKDKAVLVLAEVLFDENIVKEIKKRKALLLKLVTD-EKAQ 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 37537716 312 RYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEA 385
Cdd:cd11561  79 KALLGGIERFCGKHSPELLKKVPLILKALYDNDILEEEVILKWYEKVSKKYVSKEKSKKVRKAAEPFVEWLEEA 152
eIF-5_eIF-2B pfam01873
Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of ...
 9-128 3.07e-54

Domain found in IF2B/IF5; This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homolog. The region contains a putative zinc binding C4 finger.


Pssm-ID: 426485  Cd Length: 115  Bit Score: 176.16  E-value: 3.07e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716     9 VSDQFYRYKMPRLIAKVEGKGngiKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDvKNDRYIVNGSHEANKLQDM 88
Cdd:pfam01873   2 VTDSFYRYKMPPPQVKREGKG---KTVIVNFSEIAKALNRDPEHVLKYLLKELGTQGSID-ENGRLIINGKFSAKQIEDL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 37537716    89 LDGFIKKFVLCPECENPETDLHVNPKKQTIgnSCKACGYR 128
Cdd:pfam01873  78 LDKYIEEYVLCPECGSPDTELIKENRLLFL--KCEACGAR 115
eIF2B_5 smart00653
domain present in translation initiation factor eIF2B and eIF5;
13-128 1.65e-49

domain present in translation initiation factor eIF2B and eIF5;


Pssm-ID: 214764  Cd Length: 110  Bit Score: 163.57  E-value: 1.65e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716     13 FYRYKMPRLIAKVEGKGngiKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNdRYIVNGSHEANKLQDMLDGF 92
Cdd:smart00653   1 FYRFKMPPPQVLREGKG---KTVIVNFADIAKALNRPPDHVLKFLLAELGTQGSIDGKG-RLIVNGRFTPKKLQDLLRRY 76

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 37537716     93 IKKFVLCPECENPETDLHVNpkKQTIGNSCKACGYR 128
Cdd:smart00653  77 IKEYVLCPECGSPDTELIKE--NRLFFLKCEACGAR 110
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
299-385 8.63e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 99.67  E-value: 8.63e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716    299 HFLRFCHNNKKAQRYLLHGLECVVAMHQaQLISKIPHILKEMYDADLLEEEVIISWSEKAskkyVSKELAKEIRVKAEPF 378
Cdd:smart00515   2 PLLKFLAKDEEEQLELLYAIEEFCVELE-KLGKLLPKILKSLYDADILEEEAILKWYEKA----VSAEGKKKVRKNAKPF 76


                   ....*..
gi 37537716    379 IKWLKEA 385
Cdd:smart00515  77 VTWLQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 311-385 6.37e-20

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 83.35  E-value: 6.37e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 37537716   311 QRYLLHGLECVVAmHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKkyvSKELAKEIRVKAEPFIKWLKEA 385
Cdd:pfam02020   1 QVDLLLALQEFCA-KLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSS---AEKGMKKVRKQAKPFVEWLEEA 71
GCD7 COG1601
Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ...
 15-126 7.07e-19

Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain [Translation, ribosomal structure and biogenesis]; Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 441209  Cd Length: 133  Bit Score: 82.17  E-value: 7.07e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716  15 RYKMPRLIAKVEGKgngiKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDvkNDRYIVNGSHEANKLQDMLDGFIK 94
Cdd:COG1601  24 RFEVPEPEVRIEGN----RTIIRNFSDIADALNRDPEHLLKYLLKELGTAGSIE--GGRAILQGKFSPEDINALIDRYVK 97

                        90       100       110
                ....*....|....*....|....*....|..
gi 37537716  95 KFVLCPECENPETDLhVNPKKQTIgNSCKACG 126
Cdd:COG1601  98 EYVICPECGSPDTRL-VKEGRVLM-LKCEACG 127
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 238-354 7.13e-18

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 79.83  E-value: 7.13e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716 238 ERVNILFDFVKKKKEEGVidSSDKEIVAEAERLDVK-----AMGPLVLTEVLFN-------------EKIREQIKKYRRH 299
Cdd:cd11473   1 EKNKKLRDSLLKELEEDK--SSDVESVKAAKSKLDLdpislEEVVKVLLTAVVNavesadsisltqkEQLVLVLKKYGPV 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 37537716 300 FLRFCHNNKKAQRYLLHGLECVVAMHQ-AQLISKIPHILKEMYDADLLEEEVIISW 354
Cdd:cd11473  79 LRELLKLIKKDQLYLLLKIEKLCLQLKlSELISLLEKILDLLYDADVLSEEAILSW 134
PRK03988 PRK03988
translation initiation factor IF-2 subunit beta; Validated
 15-126 2.05e-15

translation initiation factor IF-2 subunit beta; Validated


Pssm-ID: 235189  Cd Length: 138  Bit Score: 72.64  E-value: 2.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716   15 RYKMPRLIAKVEGKgngiKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTqfDVKNDRYIVNGSHEANKLQDMLDGFIK 94
Cdd:PRK03988  27 RFEVPKPDVRIEGN----RTIIRNFKEIADRLNRDPKHVAKFLLKELGTAG--NIEGGRLILQGKFSPRVINEKIDRYVK 100

                         90       100       110
                 ....*....|....*....|....*....|..
gi 37537716   95 KFVLCPECENPETDLhVNPKKQTIgNSCKACG 126
Cdd:PRK03988 101 EYVICPECGSPDTKL-IKEGRIWV-LKCEACG 130
W2_eIF2B_epsilon cd11558
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ...
 287-385 1.10e-12

C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211396  Cd Length: 169  Bit Score: 65.74  E-value: 1.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716 287 EKIREQIKKYRRhFLRFCHNNKKAQRYLLHGLEcVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWseKASKKYVSKE 366
Cdd:cd11558  70 EALKKLLSKWGP-LLENYVKSQDDQVELLLALE-EFCLESEEGGPLFAKLLHALYDLDILEEEAILEW--WEEPDAGADE 145

                        90
                ....*....|....*....
gi 37537716 367 LAKEIRVKAEPFIKWLKEA 385
Cdd:cd11558 146 EMKKVRELVKKFIEWLEEA 164
PRK12336 PRK12336
translation initiation factor IF-2 subunit beta; Provisional
 15-126 5.04e-12

translation initiation factor IF-2 subunit beta; Provisional


Pssm-ID: 183451 [Multi-domain]  Cd Length: 201  Bit Score: 64.58  E-value: 5.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37537716   15 RYKMPRLIAKVEGKgngiKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDvkNDRYIVNGSHEANKLQDMLDGFIK 94
Cdd:PRK12336  23 RFSIPEPKIFIEGK----TTILTNFGEIADALNRDPDHLMKFLQRELGTAGKIE--GGRAVFNGKFTEEDIQAAIDAYVD 96

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 37537716   95 KFVLCPECENPETDLhvnpkkQTIGNS----CKACG 126
Cdd:PRK12336  97 EYVICSECGLPDTRL------VKEDRVlmlrCDACG 126
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 334-385 1.27e-05

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 45.67  E-value: 1.27e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 37537716 334 PHILKEMYDADLLEEEVIISWSEKASKkyvSKelAKEIRVKA-EPFIKWLKEA 385
Cdd:cd11560 144 QKIVKLLYKADVLSEDAILKWYKKGHS---PK--GKQVFLKQmEPFVEWLQEA 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH