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Conserved domains on  [gi|34335251|ref|NP_892118|]
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disks large-associated protein 4 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GKAP super family cl24154
Guanylate-kinase-associated protein (GKAP) protein;
121-453 2.55e-172

Guanylate-kinase-associated protein (GKAP) protein;


The actual alignment was detected with superfamily member pfam03359:

Pssm-ID: 460897  Cd Length: 341  Bit Score: 486.93  E-value: 2.55e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335251   121 PKRKLSSIGIQVDCIQPV--PKEEPSPATKFQSIGVQVEDDWRSSVPSHSMS--SRRDTDSDTQD-ANDSSCKSSERS-L 194
Cdd:pfam03359   1 PKKKRSSIGIQVDCIETVsdSDEESKPLREFQSIGVQVEDDKRRARFKRSNSvtAAVQADLELEGfPGLSLEVPTEDKgL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335251   195 PDCTPHPNSISIDAGPRQ--APKIAQIKRNLSYGDNSDPALEASSLPPPDPWLETSSSSPAEPAQPG-ACRRDGYWFLKL 271
Cdd:pfam03359  81 QFGGSFQRHSSEPASTSQysIQRSVHTQGQWAYREDYDPALDPSSLPPPDPWLEDGPRSLPDSGRASpVCRRDGEWFLKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335251   272 LQAETERLEGWCCQMDKETKENNLSEEVLGKVLSAVGSAQLLMSQKFQQFRGLCEQNLNPDANPRPTAQDLAGFWDLLQL 351
Cdd:pfam03359 161 LQAETERMEGWCQQMEREAEENDLPEEILGKIRSAVGSAQLLMSQKFQQFRGLCEQNLNPNANPRPTSQDLAGFWDLLQL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335251   352 SIEDISMKFDELYHLKANSWQLVeTPEKRKEEKKPPPPVPKKPAKSKPAVSRDKASDASDKQRQEARKRLLAAKRAASVR 431
Cdd:pfam03359 241 SIEDISMKFDELHQLKANNWKLE-DPPEKKENKKLPPPVPKKPSKGRPPLVRERSLDSVDRQRQEARKRLMAAKRAASVR 319
                         330       340
                  ....*....|....*....|..
gi 34335251   432 QNSATESADSIEIYVPEAQTRL 453
Cdd:pfam03359 320 QNSATESADSIEIYIPEAQTRL 341
 
Name Accession Description Interval E-value
GKAP pfam03359
Guanylate-kinase-associated protein (GKAP) protein;
121-453 2.55e-172

Guanylate-kinase-associated protein (GKAP) protein;


Pssm-ID: 460897  Cd Length: 341  Bit Score: 486.93  E-value: 2.55e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335251   121 PKRKLSSIGIQVDCIQPV--PKEEPSPATKFQSIGVQVEDDWRSSVPSHSMS--SRRDTDSDTQD-ANDSSCKSSERS-L 194
Cdd:pfam03359   1 PKKKRSSIGIQVDCIETVsdSDEESKPLREFQSIGVQVEDDKRRARFKRSNSvtAAVQADLELEGfPGLSLEVPTEDKgL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335251   195 PDCTPHPNSISIDAGPRQ--APKIAQIKRNLSYGDNSDPALEASSLPPPDPWLETSSSSPAEPAQPG-ACRRDGYWFLKL 271
Cdd:pfam03359  81 QFGGSFQRHSSEPASTSQysIQRSVHTQGQWAYREDYDPALDPSSLPPPDPWLEDGPRSLPDSGRASpVCRRDGEWFLKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335251   272 LQAETERLEGWCCQMDKETKENNLSEEVLGKVLSAVGSAQLLMSQKFQQFRGLCEQNLNPDANPRPTAQDLAGFWDLLQL 351
Cdd:pfam03359 161 LQAETERMEGWCQQMEREAEENDLPEEILGKIRSAVGSAQLLMSQKFQQFRGLCEQNLNPNANPRPTSQDLAGFWDLLQL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335251   352 SIEDISMKFDELYHLKANSWQLVeTPEKRKEEKKPPPPVPKKPAKSKPAVSRDKASDASDKQRQEARKRLLAAKRAASVR 431
Cdd:pfam03359 241 SIEDISMKFDELHQLKANNWKLE-DPPEKKENKKLPPPVPKKPSKGRPPLVRERSLDSVDRQRQEARKRLMAAKRAASVR 319
                         330       340
                  ....*....|....*....|..
gi 34335251   432 QNSATESADSIEIYVPEAQTRL 453
Cdd:pfam03359 320 QNSATESADSIEIYIPEAQTRL 341
 
Name Accession Description Interval E-value
GKAP pfam03359
Guanylate-kinase-associated protein (GKAP) protein;
121-453 2.55e-172

Guanylate-kinase-associated protein (GKAP) protein;


Pssm-ID: 460897  Cd Length: 341  Bit Score: 486.93  E-value: 2.55e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335251   121 PKRKLSSIGIQVDCIQPV--PKEEPSPATKFQSIGVQVEDDWRSSVPSHSMS--SRRDTDSDTQD-ANDSSCKSSERS-L 194
Cdd:pfam03359   1 PKKKRSSIGIQVDCIETVsdSDEESKPLREFQSIGVQVEDDKRRARFKRSNSvtAAVQADLELEGfPGLSLEVPTEDKgL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335251   195 PDCTPHPNSISIDAGPRQ--APKIAQIKRNLSYGDNSDPALEASSLPPPDPWLETSSSSPAEPAQPG-ACRRDGYWFLKL 271
Cdd:pfam03359  81 QFGGSFQRHSSEPASTSQysIQRSVHTQGQWAYREDYDPALDPSSLPPPDPWLEDGPRSLPDSGRASpVCRRDGEWFLKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335251   272 LQAETERLEGWCCQMDKETKENNLSEEVLGKVLSAVGSAQLLMSQKFQQFRGLCEQNLNPDANPRPTAQDLAGFWDLLQL 351
Cdd:pfam03359 161 LQAETERMEGWCQQMEREAEENDLPEEILGKIRSAVGSAQLLMSQKFQQFRGLCEQNLNPNANPRPTSQDLAGFWDLLQL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34335251   352 SIEDISMKFDELYHLKANSWQLVeTPEKRKEEKKPPPPVPKKPAKSKPAVSRDKASDASDKQRQEARKRLLAAKRAASVR 431
Cdd:pfam03359 241 SIEDISMKFDELHQLKANNWKLE-DPPEKKENKKLPPPVPKKPSKGRPPLVRERSLDSVDRQRQEARKRLMAAKRAASVR 319
                         330       340
                  ....*....|....*....|..
gi 34335251   432 QNSATESADSIEIYVPEAQTRL 453
Cdd:pfam03359 320 QNSATESADSIEIYIPEAQTRL 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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