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Conserved domains on  [gi|166197692|ref|NP_899087|]
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protein TESPA1 isoform a [Mus musculus]

Protein Classification

KRAP_IP3R_bind domain-containing protein( domain architecture ID 10631611)

KRAP_IP3R_bind domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAP_IP3R_bind super family cl20655
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 130-289 1.90e-59

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


The actual alignment was detected with superfamily member pfam14722:

Pssm-ID: 464280  Cd Length: 145  Bit Score: 191.39  E-value: 1.90e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197692  130 LDLGSSLASSSMTGGTNKtssSISEILDQVQEDAEDILFSLGFGHENHKDTSRIPARFFSNPSQAKGINFQLFLKSQVQR 209
Cdd:pfam14722   1 LSRGTSFNSSHSTASTPQ---SISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197692  210 MEMEDPClmLASRFKQVQTLAVTADAFFCLYSYVSKTPVQkftpsnmfwnfdptdvpsIRILAPEPEPYSP--------R 281
Cdd:pfam14722  78 MDIENPN--LASRFRQLEVLDHVANAFSSLYSDVSITPVQ------------------AEEKSVGSEPQSPsvsetkehR 137


                  ....*...
gi 166197692  282 ERLRRAIS 289
Cdd:pfam14722 138 RRMGKLLS 145
 
Name Accession Description Interval E-value
KRAP_IP3R_bind pfam14722
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 130-289 1.90e-59

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


Pssm-ID: 464280  Cd Length: 145  Bit Score: 191.39  E-value: 1.90e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197692  130 LDLGSSLASSSMTGGTNKtssSISEILDQVQEDAEDILFSLGFGHENHKDTSRIPARFFSNPSQAKGINFQLFLKSQVQR 209
Cdd:pfam14722   1 LSRGTSFNSSHSTASTPQ---SISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197692  210 MEMEDPClmLASRFKQVQTLAVTADAFFCLYSYVSKTPVQkftpsnmfwnfdptdvpsIRILAPEPEPYSP--------R 281
Cdd:pfam14722  78 MDIENPN--LASRFRQLEVLDHVANAFSSLYSDVSITPVQ------------------AEEKSVGSEPQSPsvsetkehR 137


                  ....*...
gi 166197692  282 ERLRRAIS 289
Cdd:pfam14722 138 RRMGKLLS 145
 
Name Accession Description Interval E-value
KRAP_IP3R_bind pfam14722
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 130-289 1.90e-59

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


Pssm-ID: 464280  Cd Length: 145  Bit Score: 191.39  E-value: 1.90e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197692  130 LDLGSSLASSSMTGGTNKtssSISEILDQVQEDAEDILFSLGFGHENHKDTSRIPARFFSNPSQAKGINFQLFLKSQVQR 209
Cdd:pfam14722   1 LSRGTSFNSSHSTASTPQ---SISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166197692  210 MEMEDPClmLASRFKQVQTLAVTADAFFCLYSYVSKTPVQkftpsnmfwnfdptdvpsIRILAPEPEPYSP--------R 281
Cdd:pfam14722  78 MDIENPN--LASRFRQLEVLDHVANAFSSLYSDVSITPVQ------------------AEEKSVGSEPQSPsvsetkehR 137


                  ....*...
gi 166197692  282 ERLRRAIS 289
Cdd:pfam14722 138 RRMGKLLS 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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