NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|34303979|ref|NP_899131|]
View 

serum paraoxonase/arylesterase 2 [Mus musculus]

Protein Classification

strictosidine synthase family protein( domain architecture ID 13665270)

strictosidine synthase family protein with similarity to strictosidine synthase that catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 167-252 1.93e-45

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


:

Pssm-ID: 334656  Cd Length: 86  Bit Score: 150.31  E-value: 1.93e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34303979   167 NDIIAVGPTHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPEEVKLVAEGFDSANGINISPDKKYVYVADILAHEIHV 246
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 34303979   247 LEKQPN 252
Cdd:pfam01731  81 MKKHAN 86
YncE super family cl34599
DNA-binding beta-propeller fold protein YncE [General function prediction only];
220-287 1.41e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


The actual alignment was detected with superfamily member COG3391:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.68  E-value: 1.41e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 34303979 220 DSANGINISPDKKYVYVADILAHEIHVLEKQpnMNLTQLKVLQ---LGTLVDNLSIDPSSGDIWVGCHPNG 287
Cdd:COG3391 152 AGPHGIAVDPDGKRLYVANSGSNTVSVIVSV--IDTATGKVVAtipVGGGPVGVAVSPDGRRLYVANRGSN 220
 
Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 167-252 1.93e-45

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 150.31  E-value: 1.93e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34303979   167 NDIIAVGPTHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPEEVKLVAEGFDSANGINISPDKKYVYVADILAHEIHV 246
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 34303979   247 LEKQPN 252
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 184-296 1.48e-11

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 63.76  E-value: 1.48e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34303979 184 YFSDPFlKYLETylnlhwANVVYYSPE-EVKLVAEGFDSANGINISPDKKYVYVADILAHEIHVLEKQPNMNLTQLKVL- 261
Cdd:COG3386 107 YFTDMG-EYLPT------GALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADGTLGNRRVFa 179

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 34303979 262 ---QLGTLVDNLSIDpSSGDIWVgCHPNGQRLFVYHPN 296
Cdd:COG3386 180 dlpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFDPD 215
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 204-250 1.36e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 39.88  E-value: 1.36e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 34303979 204 VVYYSPEEVKL----VAEGFDSANGINISPDKKYVYVADILAHEIHVLEKQ 250
Cdd:cd14962  80 VFVFDRDGKFLraigAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLD 130
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
220-287 1.41e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.68  E-value: 1.41e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 34303979 220 DSANGINISPDKKYVYVADILAHEIHVLEKQpnMNLTQLKVLQ---LGTLVDNLSIDPSSGDIWVGCHPNG 287
Cdd:COG3391 152 AGPHGIAVDPDGKRLYVANSGSNTVSVIVSV--IDTATGKVVAtipVGGGPVGVAVSPDGRRLYVANRGSN 220
 
Name Accession Description Interval E-value
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 167-252 1.93e-45

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 150.31  E-value: 1.93e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34303979   167 NDIIAVGPTHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPEEVKLVAEGFDSANGINISPDKKYVYVADILAHEIHV 246
Cdd:pfam01731   1 NDIVAVGPDSFYATNDHYFGDPFLQNLEMYLGLIWTGVVYYSPSEVKVVASGFSFANGINYSPDKKYIYVASSLRHSIHV 80


                  ....*.
gi 34303979   247 LEKQPN 252
Cdd:pfam01731  81 MKKHAN 86
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 184-296 1.48e-11

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 63.76  E-value: 1.48e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34303979 184 YFSDPFlKYLETylnlhwANVVYYSPE-EVKLVAEGFDSANGINISPDKKYVYVADILAHEIHVLEKQPNMNLTQLKVL- 261
Cdd:COG3386 107 YFTDMG-EYLPT------GALYRVDPDgSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLDADGTLGNRRVFa 179

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 34303979 262 ---QLGTLVDNLSIDpSSGDIWVgCHPNGQRLFVYHPN 296
Cdd:COG3386 180 dlpDGPGGPDGLAVD-ADGNLWV-ALWGGGGVVRFDPD 215
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 198-296 1.72e-05

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 45.72  E-value: 1.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34303979   198 NLHWANVVYYSPE-EVKLVAEGFDSANGINISPDKKYVYVADILAHEIHVLEKQP-NMNLTQLKVL----QLGTLVDNLS 271
Cdd:pfam08450 111 GGDPGALYRLDPDgKLTRVLDGLTISNGLAWSPDGRTLYFADSPARKIWAYDYDLdGGLISNRRVFadfkPGLGRPDGMA 190

                          90       100
                  ....*....|....*....|....*
gi 34303979   272 IDpSSGDIWVgCHPNGQRLFVYHPN 296
Cdd:pfam08450 191 VD-AEGNVWV-ARWGGGKVVRFDPD 213
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 204-250 1.36e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 39.88  E-value: 1.36e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 34303979 204 VVYYSPEEVKL----VAEGFDSANGINISPDKKYVYVADILAHEIHVLEKQ 250
Cdd:cd14962  80 VFVFDRDGKFLraigAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLD 130
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
220-287 1.41e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.68  E-value: 1.41e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 34303979 220 DSANGINISPDKKYVYVADILAHEIHVLEKQpnMNLTQLKVLQ---LGTLVDNLSIDPSSGDIWVGCHPNG 287
Cdd:COG3391 152 AGPHGIAVDPDGKRLYVANSGSNTVSVIVSV--IDTATGKVVAtipVGGGPVGVAVSPDGRRLYVANRGSN 220
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
224-288 4.12e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.14  E-value: 4.12e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 34303979 224 GINISPDKKYVYVADILAHEIHVLEKQpnmNLTQLKVLQLGTLVDNLSIDPSSGDIWVGCHPNGQ 288
Cdd:COG3391 114 GLAVDPDGGRLYVADSGNGRVSVIDTA---TGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNT 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH