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Conserved domains on  [gi|35903113|ref|NP_919400|]
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glutamate decarboxylase 1b [Danio rerio]

Protein Classification

PLP-dependent decarboxylase( domain architecture ID 10447228)

PLP-dependent decarboxylase such as DOPA decarboxylase, glutamate decarboxylase, and histidine decarboxylase

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
137-511 9.06e-171

Pyridoxal-dependent decarboxylase conserved domain;


:

Pssm-ID: 395219  Cd Length: 373  Bit Score: 489.24  E-value: 9.06e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   137 PHQLlegMEGFNLELSDQPESLEQILVDCRDTLKYGVRTGH-PRFFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVF 215
Cdd:pfam00282   1 PGYL---KPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPAC 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   216 VLMEQLTLKKMREIIGWPNG----DGDALFSPGGAISNMYSVMVARYKYFPEVKTKGMSAAP-----RLVLFTSEHSHYS 286
Cdd:pfam00282  78 TELENVVMNWLGEMLGLPAEflgqEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGKPADSsgilaKLVAYTSDQAHSS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   287 IKKAGAVLGFGkenVILLKTDERGRVIPADLEAKVIDAKQKGYVPLFVNATAGTTVYGAFDPINDIADICEKYNLWLHVD 366
Cdd:pfam00282 158 IEKAALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVD 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   367 GAWGGGLLMSRKHRHKLSGIERANSVTWNPHKMMGVPLQCSAILVREKGILQGCNSMCAGYLFQPDKqydvTYDTGDKAI 446
Cdd:pfam00282 235 AAYGGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGHTDS----AYDTGHKQI 310
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 35903113   447 QCGRHVDIFKFWLMWKAKGTIGFEQHIDRCLELSEYLYNKIKNREGYEMVFEgqPQHTNVCFWYI 511
Cdd:pfam00282 311 PLSRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAE--VGLGLVCFRLK 373
 
Name Accession Description Interval E-value
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
137-511 9.06e-171

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 489.24  E-value: 9.06e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   137 PHQLlegMEGFNLELSDQPESLEQILVDCRDTLKYGVRTGH-PRFFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVF 215
Cdd:pfam00282   1 PGYL---KPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPAC 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   216 VLMEQLTLKKMREIIGWPNG----DGDALFSPGGAISNMYSVMVARYKYFPEVKTKGMSAAP-----RLVLFTSEHSHYS 286
Cdd:pfam00282  78 TELENVVMNWLGEMLGLPAEflgqEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGKPADSsgilaKLVAYTSDQAHSS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   287 IKKAGAVLGFGkenVILLKTDERGRVIPADLEAKVIDAKQKGYVPLFVNATAGTTVYGAFDPINDIADICEKYNLWLHVD 366
Cdd:pfam00282 158 IEKAALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVD 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   367 GAWGGGLLMSRKHRHKLSGIERANSVTWNPHKMMGVPLQCSAILVREKGILQGCNSMCAGYLFQPDKqydvTYDTGDKAI 446
Cdd:pfam00282 235 AAYGGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGHTDS----AYDTGHKQI 310
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 35903113   447 QCGRHVDIFKFWLMWKAKGTIGFEQHIDRCLELSEYLYNKIKNREGYEMVFEgqPQHTNVCFWYI 511
Cdd:pfam00282 311 PLSRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAE--VGLGLVCFRLK 373
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
180-583 1.31e-154

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 447.04  E-value: 1.31e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 180 FFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQLTLKKMREIIGWPNGDGDALFSPGGAISNMYSVMVARYK 259
Cdd:cd06450   1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLPSEDADGVFTSGGSESNLLALLAARDR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 260 YFPEVKTKGMSAAPRLVLFTSEHSHYSIKKAGAVLGfgkENVILLKTDERGRVIPADLEAKVIDAKQKGYVPLFVNATAG 339
Cdd:cd06450  81 ARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLD---VKVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATAG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 340 TTVYGAFDPINDIADICEKYNLWLHVDGAWGGGLLMSRKHRHKLSGIERANSVTWNPHKMMGVPLQCSAILVRekgilqg 419
Cdd:cd06450 158 TTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------- 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 420 cnsmcagylfqpdkqydvtydtgdkaiqcgrhvdIFKFWLMWKAKGTIGFEQHIDRCLELSEYLYNKIKNREGYEMVfeG 499
Cdd:cd06450 231 ----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELL--G 274
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 500 QPQHTNVCFWYIPPSlrgmpngderreKLHRVAPKIKAMMMECGTTMVGYQPQGDKvNFFRMVVSNHAVTKSDIDFLIDE 579
Cdd:cd06450 275 EPNLSLVCFRLKPSV------------KLDELNYDLSDRLNERGGWHVPATTLGGP-NVLRFVVTNPLTTRDDADALLED 341

                ....
gi 35903113 580 IERL 583
Cdd:cd06450 342 IERA 345
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
145-586 9.76e-134

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 398.05  E-value: 9.76e-134
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 145 EGFNLELSDQPESLEQILVDCRDT-LKYGVRTGHPRFFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQLTL 223
Cdd:COG0076  34 AALDEPLPEEGLPPEEALAELEDLvLPGSVDWNHPRFLAFVTGGTTPAALAADLLASALNQNMGDWDTSPAATELEREVV 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 224 KKMREIIGWPNGdGDALFSPGGAISNMYSVMVARYKYFPE-VKTKGMSAAPRLVLFTSEHSHYSIKKAGAVLGFGKENVI 302
Cdd:COG0076 114 RWLADLLGLPEG-AGGVFTSGGTEANLLALLAARDRALARrVRAEGLPGAPRPRIVVSEEAHSSVDKAARLLGLGRDALR 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 303 LLKTDERGRVIPADLEAKVIDAKQKGYVPLFVNATAGTTVYGAFDPINDIADICEKYNLWLHVDGAWGGGLLMSRKHRHK 382
Cdd:COG0076 193 KVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALPSPELRHL 272
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 383 LSGIERANSVTWNPHKMMGVPLQCSAILVREKGILQGCNSMCAGYLFQPDkqyDVTYDTGDKAIQCGRHVDIFKFWLMWK 462
Cdd:COG0076 273 LDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLREAFSFHASYLGPAD---DGVPNLGDYTLELSRRFRALKLWATLR 349
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 463 AKGTIGFEQHIDRCLELSEYLYNKIKNREGYEMVfeGQPQHTNVCFWYIPPslrGMPNGDERREKLHRvapkikaMMMEC 542
Cdd:COG0076 350 ALGREGYRELIERCIDLARYLAEGIAALPGFELL--APPELNIVCFRYKPA---GLDEEDALNYALRD-------RLRAR 417
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 35903113 543 GTTMVGYQPQGDKVNfFRMVVSNHAVTKSDIDFLIDEIERLGQD 586
Cdd:COG0076 418 GRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAAE 460
PLN02590 PLN02590
probable tyrosine decarboxylase
153-555 4.83e-39

probable tyrosine decarboxylase


Pssm-ID: 178200 [Multi-domain]  Cd Length: 539  Bit Score: 150.63  E-value: 4.83e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  153 DQPESLEQILVDCRDTLKYGVRTGH-PRFFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQLTLKKMREIIG 231
Cdd:PLN02590 105 ERPESLKELLDDVSKKIMPGITHWQsPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQ 184
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  232 WPN-----GDGDALFSPGGAISNMYSVMVARYKYFPEVktkGMSAAPRLVLFTSEHSHYSIKKAGAVLGFGKENVILLKT 306
Cdd:PLN02590 185 LPDhflstGNGGGVIQGTGCEAVLVVVLAARDRILKKV---GKTLLPQLVVYGSDQTHSSFRKACLIGGIHEENIRLLKT 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  307 DERGR--VIPADLEAKVIDAKQKGYVPLFVNATAGTTVYGAFDPINDIADICEKYNLWLHVDGAWGGGLLMSRKHRHKLS 384
Cdd:PLN02590 262 DSSTNygMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFID 341
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  385 GIERANSVTWNPHKMMGVPLQCSAILVREKGILQGCNSMCAGYLFQPDKQYDVTYDTGDKAIQCGRHVDIFKFWLMWKAK 464
Cdd:PLN02590 342 GIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSKKDTVVNYKDWQISLSRRFRSLKLWMVLRLY 421
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  465 GTIGFEQHIDRCLELSEYLYNKIKNREGYEMVfeGQPQHTNVCFWYIPpslrgmPNGDErrEKLHRVAPKIKAMMMECGT 544
Cdd:PLN02590 422 GSENLRNFIRDHVNLAKHFEDYVAQDPSFEVV--TTRYFSLVCFRLAP------VDGDE--DQCNERNRELLAAVNSTGK 491
                        410
                 ....*....|.
gi 35903113  545 TMVGYQPQGDK 555
Cdd:PLN02590 492 IFISHTALSGK 502
 
Name Accession Description Interval E-value
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
137-511 9.06e-171

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 489.24  E-value: 9.06e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   137 PHQLlegMEGFNLELSDQPESLEQILVDCRDTLKYGVRTGH-PRFFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVF 215
Cdd:pfam00282   1 PGYL---KPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPAC 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   216 VLMEQLTLKKMREIIGWPNG----DGDALFSPGGAISNMYSVMVARYKYFPEVKTKGMSAAP-----RLVLFTSEHSHYS 286
Cdd:pfam00282  78 TELENVVMNWLGEMLGLPAEflgqEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGKPADSsgilaKLVAYTSDQAHSS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   287 IKKAGAVLGFGkenVILLKTDERGRVIPADLEAKVIDAKQKGYVPLFVNATAGTTVYGAFDPINDIADICEKYNLWLHVD 366
Cdd:pfam00282 158 IEKAALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVD 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   367 GAWGGGLLMSRKHRHKLSGIERANSVTWNPHKMMGVPLQCSAILVREKGILQGCNSMCAGYLFQPDKqydvTYDTGDKAI 446
Cdd:pfam00282 235 AAYGGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGHTDS----AYDTGHKQI 310
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 35903113   447 QCGRHVDIFKFWLMWKAKGTIGFEQHIDRCLELSEYLYNKIKNREGYEMVFEgqPQHTNVCFWYI 511
Cdd:pfam00282 311 PLSRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAE--VGLGLVCFRLK 373
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
180-583 1.31e-154

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 447.04  E-value: 1.31e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 180 FFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQLTLKKMREIIGWPNGDGDALFSPGGAISNMYSVMVARYK 259
Cdd:cd06450   1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLPSEDADGVFTSGGSESNLLALLAARDR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 260 YFPEVKTKGMSAAPRLVLFTSEHSHYSIKKAGAVLGfgkENVILLKTDERGRVIPADLEAKVIDAKQKGYVPLFVNATAG 339
Cdd:cd06450  81 ARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLD---VKVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATAG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 340 TTVYGAFDPINDIADICEKYNLWLHVDGAWGGGLLMSRKHRHKLSGIERANSVTWNPHKMMGVPLQCSAILVRekgilqg 419
Cdd:cd06450 158 TTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------- 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 420 cnsmcagylfqpdkqydvtydtgdkaiqcgrhvdIFKFWLMWKAKGTIGFEQHIDRCLELSEYLYNKIKNREGYEMVfeG 499
Cdd:cd06450 231 ----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELL--G 274
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 500 QPQHTNVCFWYIPPSlrgmpngderreKLHRVAPKIKAMMMECGTTMVGYQPQGDKvNFFRMVVSNHAVTKSDIDFLIDE 579
Cdd:cd06450 275 EPNLSLVCFRLKPSV------------KLDELNYDLSDRLNERGGWHVPATTLGGP-NVLRFVVTNPLTTRDDADALLED 341

                ....
gi 35903113 580 IERL 583
Cdd:cd06450 342 IERA 345
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
145-586 9.76e-134

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 398.05  E-value: 9.76e-134
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 145 EGFNLELSDQPESLEQILVDCRDT-LKYGVRTGHPRFFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQLTL 223
Cdd:COG0076  34 AALDEPLPEEGLPPEEALAELEDLvLPGSVDWNHPRFLAFVTGGTTPAALAADLLASALNQNMGDWDTSPAATELEREVV 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 224 KKMREIIGWPNGdGDALFSPGGAISNMYSVMVARYKYFPE-VKTKGMSAAPRLVLFTSEHSHYSIKKAGAVLGFGKENVI 302
Cdd:COG0076 114 RWLADLLGLPEG-AGGVFTSGGTEANLLALLAARDRALARrVRAEGLPGAPRPRIVVSEEAHSSVDKAARLLGLGRDALR 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 303 LLKTDERGRVIPADLEAKVIDAKQKGYVPLFVNATAGTTVYGAFDPINDIADICEKYNLWLHVDGAWGGGLLMSRKHRHK 382
Cdd:COG0076 193 KVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALPSPELRHL 272
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 383 LSGIERANSVTWNPHKMMGVPLQCSAILVREKGILQGCNSMCAGYLFQPDkqyDVTYDTGDKAIQCGRHVDIFKFWLMWK 462
Cdd:COG0076 273 LDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLREAFSFHASYLGPAD---DGVPNLGDYTLELSRRFRALKLWATLR 349
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 463 AKGTIGFEQHIDRCLELSEYLYNKIKNREGYEMVfeGQPQHTNVCFWYIPPslrGMPNGDERREKLHRvapkikaMMMEC 542
Cdd:COG0076 350 ALGREGYRELIERCIDLARYLAEGIAALPGFELL--APPELNIVCFRYKPA---GLDEEDALNYALRD-------RLRAR 417
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 35903113 543 GTTMVGYQPQGDKVNfFRMVVSNHAVTKSDIDFLIDEIERLGQD 586
Cdd:COG0076 418 GRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAAE 460
PLN02590 PLN02590
probable tyrosine decarboxylase
153-555 4.83e-39

probable tyrosine decarboxylase


Pssm-ID: 178200 [Multi-domain]  Cd Length: 539  Bit Score: 150.63  E-value: 4.83e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  153 DQPESLEQILVDCRDTLKYGVRTGH-PRFFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQLTLKKMREIIG 231
Cdd:PLN02590 105 ERPESLKELLDDVSKKIMPGITHWQsPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQ 184
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  232 WPN-----GDGDALFSPGGAISNMYSVMVARYKYFPEVktkGMSAAPRLVLFTSEHSHYSIKKAGAVLGFGKENVILLKT 306
Cdd:PLN02590 185 LPDhflstGNGGGVIQGTGCEAVLVVVLAARDRILKKV---GKTLLPQLVVYGSDQTHSSFRKACLIGGIHEENIRLLKT 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  307 DERGR--VIPADLEAKVIDAKQKGYVPLFVNATAGTTVYGAFDPINDIADICEKYNLWLHVDGAWGGGLLMSRKHRHKLS 384
Cdd:PLN02590 262 DSSTNygMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFID 341
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  385 GIERANSVTWNPHKMMGVPLQCSAILVREKGILQGCNSMCAGYLFQPDKQYDVTYDTGDKAIQCGRHVDIFKFWLMWKAK 464
Cdd:PLN02590 342 GIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSKKDTVVNYKDWQISLSRRFRSLKLWMVLRLY 421
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  465 GTIGFEQHIDRCLELSEYLYNKIKNREGYEMVfeGQPQHTNVCFWYIPpslrgmPNGDErrEKLHRVAPKIKAMMMECGT 544
Cdd:PLN02590 422 GSENLRNFIRDHVNLAKHFEDYVAQDPSFEVV--TTRYFSLVCFRLAP------VDGDE--DQCNERNRELLAAVNSTGK 491
                        410
                 ....*....|.
gi 35903113  545 TMVGYQPQGDK 555
Cdd:PLN02590 492 IFISHTALSGK 502
PLN02880 PLN02880
tyrosine decarboxylase
153-514 8.92e-36

tyrosine decarboxylase


Pssm-ID: 215475 [Multi-domain]  Cd Length: 490  Bit Score: 140.43  E-value: 8.92e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  153 DQPESLEQILVDCRDTLKYGVRTGH-PRFFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQLTLKKMREIIG 231
Cdd:PLN02880  57 NQPETLDQVLDDVQAKILPGVTHWQsPNYFAYYPSNSSVAGFLGEMLSAGLNIVGFSWITSPAATELEMIVLDWLAKLLN 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  232 WPN-----GDGDALFSPGGAISNMYSVMVARYKYfpeVKTKGMSAAPRLVLFTSEHSHYSIKKAGAVLGFGKENVILLKT 306
Cdd:PLN02880 137 LPEqflstGNGGGVIQGTASEAVLVVLLAARDRV---LRKVGKNALEKLVVYASDQTHSALQKACQIAGIHPENCRLLKT 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  307 DERGR--VIPADLEAKVIDAKQKGYVPLFVNATAGTTVYGAFDPINDIADICEKYNLWLHVDGAWGGGLLMSRKHRHKLS 384
Cdd:PLN02880 214 DSSTNyaLAPELLSEAISTDLSSGLIPFFLCATVGTTSSTAVDPLLELGKIAKSNGMWFHVDAAYAGSACICPEYRHYID 293
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  385 GIERANSVTWNPHKMMGVPLQCSAILVREKGILQGCNSMCAGYLFQPDKQYDVTYDTGDKAIQCGRHVDIFKFWLMWKAK 464
Cdd:PLN02880 294 GVEEADSFNMNAHKWFLTNFDCSLLWVKDRNALIQSLSTNPEFLKNKASQANSVVDYKDWQIPLGRRFRSLKLWMVLRLY 373
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 35903113  465 GTIGFEQHIDRCLELSEYLYNKIKNREGYEMVfeGQPQHTNVCFWYIPPS 514
Cdd:PLN02880 374 GVENLQSYIRNHIKLAKEFEQLVAQDSRFEVV--TPRIFSLVCFRLVPPK 421
PRK02769 PRK02769
histidine decarboxylase; Provisional
244-491 2.70e-23

histidine decarboxylase; Provisional


Pssm-ID: 235068 [Multi-domain]  Cd Length: 380  Bit Score: 102.04  E-value: 2.70e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  244 GGAISNMYSVMVARyKYFPEVktkgmsaaprlVLFTSEHSHYSIKKAGAVLGFgKENVIllKTDERGRVIPADLEAKVID 323
Cdd:PRK02769  92 GGTEGNLYGCYLAR-ELFPDG-----------TLYYSKDTHYSVSKIARLLRI-KSRVI--TSLPNGEIDYDDLISKIKE 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  324 AKQKGYVplfVNATAGTTVYGAFDPINDIADICEKYNL---WLHVDGAWGGGLLMSRKHRHKLSGIERANSVTWNPHKMM 400
Cdd:PRK02769 157 NKNQPPI---IFANIGTTMTGAIDNIKEIQEILKKIGIddyYIHADAALSGMILPFVNNPPPFSFADGIDSIAISGHKFI 233
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  401 GVPLQCSAILVREKGIlqgcnsmcagylfqpDKQY-DVTY-DTGDKAIQCGR--HVDIfkfwLMWKA---KGTIGFEQHI 473
Cdd:PRK02769 234 GSPMPCGIVLAKKKYV---------------ERISvDVDYiGSRDQTISGSRngHTAL----LLWAAirsLGSKGLRQRV 294
                        250
                 ....*....|....*...
gi 35903113  474 DRCLELSEYLYNKIKNRE 491
Cdd:PRK02769 295 QHCLDMAQYAVDRLQANG 312
PLN03032 PLN03032
serine decarboxylase; Provisional
245-488 9.99e-15

serine decarboxylase; Provisional


Pssm-ID: 166673 [Multi-domain]  Cd Length: 374  Bit Score: 76.02  E-value: 9.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  245 GAISNMYSVMVARYKYfpevktkgmsaaPRLVLFTSEHSHYSIKKAGAVLGFGKENVillKTDERGRVIPADLEAKVIDA 324
Cdd:PLN03032  94 GTEGNLHGILVGREVF------------PDGILYASRESHYSVFKAARMYRMEAVKV---PTLPSGEIDYDDLERALAKN 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  325 KQKgyvPLFVNATAGTTVYGAFDPINDIADICEKYN-----LWLHVDGAWGGGLLMSRKHRHKLSGIERANSVTWNPHKM 399
Cdd:PLN03032 159 RDK---PAILNVNIGTTVKGAVDDLDRILRILKELGytedrFYIHCDGALFGLMMPFVSRAPEVTFRKPIGSVSVSGHKF 235
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  400 MGVPLQCSAILVREKGIlqgcNSMcagylfqpdkQYDVTY-DTGDKAIQCGR--HVDIFkFWLMWKAKGTIGFEQHIDRC 476
Cdd:PLN03032 236 LGCPMPCGVALTRKKHV----KAL----------SQNVEYlNSRDATIMGSRngHAPLY-LWYTLRRKGYRGIKRDVQHC 300
                        250
                 ....*....|..
gi 35903113  477 LELSEYLYNKIK 488
Cdd:PLN03032 301 MRNAHYLKDRLT 312
PLN02263 PLN02263
serine decarboxylase
245-489 1.01e-13

serine decarboxylase


Pssm-ID: 177904 [Multi-domain]  Cd Length: 470  Bit Score: 73.70  E-value: 1.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  245 GAISNMYSVMVARyKYFPEVktkgmsaaprlVLFTSEHSHYSIKKAGAVLGFGKENVillKTDERGRVIPADLEAKVIDA 324
Cdd:PLN02263 161 GTEGNLHGILVGR-EVFPDG-----------ILYASRESHYSVFKAARMYRMECVKV---DTLVSGEIDCADFKAKLLAN 225
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  325 KQKgyvPLFVNATAGTTVYGAFDPINDIADICEKY-----NLWLHVDGAWGGGLLMSRKHRHKLSGIERANSVTWNPHKM 399
Cdd:PLN02263 226 KDK---PAIINVNIGTTVKGAVDDLDLVIKTLEECgfsqdRFYIHCDGALFGLMMPFVKRAPKVTFKKPIGSVSVSGHKF 302
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113  400 MGVPLQCSAILVREKGIlqgcNSMCAgylfqpdkqyDVTY-DTGDKAIQCGR--HVDIFkFWLMWKAKGTIGFEQHIDRC 476
Cdd:PLN02263 303 VGCPMPCGVQITRMEHI----NVLSS----------NVEYlASRDATIMGSRngHAPIF-LWYTLNRKGYRGFQKEVQKC 367
                        250
                 ....*....|...
gi 35903113  477 LELSEYLYNKIKN 489
Cdd:PLN02263 368 LRNAHYLKDRLRE 380
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
233-412 4.12e-09

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 55.85  E-value: 4.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 233 PNGDGDALFSPGGAISNMYSVMVARykyfpevktkgmsaAPRLVLFTSEHSHYSIKKAGAVLGFGKENVILLKTDERGRV 312
Cdd:cd01494  14 QPGNDKAVFVPSGTGANEAALLALL--------------GPGDEVIVDANGHGSRYWVAAELAGAKPVPVPVDDAGYGGL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 313 IPADLEakviDAKQKGYVPLFVnATAGTTVYGAFDPINDIADICEKYNLWLHVDGAWGGGLLMSRKHrhkLSGIERANSV 392
Cdd:cd01494  80 DVAILE----ELKAKPNVALIV-ITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPAPGV---LIPEGGADVV 151
                       170       180
                ....*....|....*....|
gi 35903113 393 TWNPHKMMGVPlQCSAILVR 412
Cdd:cd01494 152 TFSLHKNLGGE-GGGVVIVK 170
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
217-508 2.27e-05

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 46.86  E-value: 2.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   217 LMEQlTLKKMREIIGWPNGDgDALFSPGGAISNMysvMVArYKYFPEVKTKGmsaapRLVLFTSEHsHYSIKKAGAVLGF 296
Cdd:pfam00266  44 AYEE-AREKVAEFINAPSND-EIIFTSGTTEAIN---LVA-LSLGRSLKPGD-----EIVITEMEH-HANLVPWQELAKR 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   297 GKENVILLKTDERGRVIPADLEaKVIDAKQKgyvplFVNATAGTTVYGAFDPINDIADICEKYNLWLHVDGAWGgglLMS 376
Cdd:pfam00266 112 TGARVRVLPLDEDGLLDLDELE-KLITPKTK-----LVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAAQA---IGH 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   377 RKHRHKLSGIERANSVTwnpHKMMGvPLQCSAILVREKGI-----LQGCNSMcagyLFQPDKQYDVTYDTGDK------- 444
Cdd:pfam00266 183 RPIDVQKLGVDFLAFSG---HKLYG-PTGIGVLYGRRDLLekmppLLGGGGM----IETVSLQESTFADAPWKfeagtpn 254
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 35903113   445 ---AIQCGRHVDifkfWLMwkakgTIGFEQHIDRCLELSEYLYNKIKNREGYEmVFEGQPQHTNVCF 508
Cdd:pfam00266 255 iagIIGLGAALE----YLS-----EIGLEAIEKHEHELAQYLYERLLSLPGIR-LYGPERRASIISF 311
GLY1 COG2008
Threonine aldolase [Amino acid transport and metabolism];
225-369 4.62e-04

Threonine aldolase [Amino acid transport and metabolism];


Pssm-ID: 441611 [Multi-domain]  Cd Length: 333  Bit Score: 42.75  E-value: 4.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 225 KMREIIGwpngDGDALFSPGGAISNM--YSVMVARYkyfPEVktkgmsaaprlvlFTSEHSHYSIKKAGA--VLGFGKen 300
Cdd:COG2008  43 RVAELFG----KEAALFVPSGTMANQlaLRAHTRPG---DEV-------------ICHETAHIYVDEGGApeALSGVK-- 100
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 35903113 301 VILLkTDERGRVIPADLEAkVIDAKQKGYVPLFV----NATAGTTVYgAFDPINDIADICEKYNLWLHVDGAW 369
Cdd:COG2008 101 LLPV-PGEDGKLTPEDLEA-AIRPGDVHFPQPGLvsleNTTEGGTVY-PLEELRAIAAVAREHGLPLHLDGAR 170
TA_like cd06502
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP) ...
235-368 8.21e-04

Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.


Pssm-ID: 99748 [Multi-domain]  Cd Length: 338  Bit Score: 41.93  E-value: 8.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 235 GDGDALFSPGGAISNMYSVMVarykyfpevktkgmSAAPRLVLFTSEHSHYSIKKAGAVLGFGKENVILLKTdERGRVIP 314
Cdd:cd06502  46 GKEAALFVPSGTAANQLALAA--------------HTQPGGSVICHETAHIYTDEAGAPEFLSGVKLLPVPG-ENGKLTP 110
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 35903113 315 ADLEAKVIDAKQKGYVPLFV----NATAGTTVYgAFDPINDIADICEKYNLWLHVDGA 368
Cdd:cd06502 111 EDLEAAIRPRDDIHFPPPSLvsleNTTEGGTVY-PLDELKAISALAKENGLPLHLDGA 167
Orn_deC_like cd00615
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
341-413 1.21e-03

Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.


Pssm-ID: 99739 [Multi-domain]  Cd Length: 294  Bit Score: 41.08  E-value: 1.21e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 35903113 341 TVYGAFDPINDIADICEKYNLWLHVDGAWGGGLLMS---RKHRHKLSGIERANSVtwnpHKMMGVPLQCSAILVRE 413
Cdd:cd00615 164 TYYGICYNLRKIVEEAHHRGLPVLVDEAHGAHFRFHpilPSSAAMAGADIVVQST----HKTLPALTQGSMIHVKG 235
CsdA COG0520
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
266-368 3.30e-03

Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];


Pssm-ID: 440286 [Multi-domain]  Cd Length: 396  Bit Score: 40.12  E-value: 3.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113 266 TKGMSAA--------PRL----VLFTSEHSHYS--------IKKAGAVlgfgkenVILLKTDERGRVIPADLEAKvIDAK 325
Cdd:COG0520  83 TRGTTEAinlvayglGRLkpgdEILITEMEHHSnivpwqelAERTGAE-------VRVIPLDEDGELDLEALEAL-LTPR 154
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 35903113 326 QKgyvplFVNATAGTTVYGAFDPINDIADICEKYNLWLHVDGA 368
Cdd:COG0520 155 TK-----LVAVTHVSNVTGTVNPVKEIAALAHAHGALVLVDGA 192
Beta_elim_lyase pfam01212
Beta-eliminating lyase;
280-368 3.36e-03

Beta-eliminating lyase;


Pssm-ID: 426128 [Multi-domain]  Cd Length: 288  Bit Score: 39.89  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35903113   280 SEHSHYSIKKAGAVLGFGKENVILLKTDERGRVIPADLEAKVIDAKQKGY--VPLFV----NATAGTTVYgAFDPINDIA 353
Cdd:pfam01212  77 GEPAHIHFDETGGHAELGGVQPRPLDGDEAGNMDLEDLEAAIREVGADIFppTGLISlentHNSAGGQVV-SLENLREIA 155
                          90
                  ....*....|....*
gi 35903113   354 DICEKYNLWLHVDGA 368
Cdd:pfam01212 156 ALAREHGIPVHLDGA 170
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
314-374 6.45e-03

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 39.08  E-value: 6.45e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 35903113 314 PADLEAKVIDAKQKgYVPLFVnATAGttVY---GAFDPINDIADICEKYNLWLHVDGAWGGGLL 374
Cdd:cd06454 117 MEDLEKLLREARRP-YGKKLI-VTEG--VYsmdGDIAPLPELVDLAKKYGAILFVDEAHSVGVY 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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