NCBI Conserved Domain Search

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 253.20 E-value: 8.49e-78

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  494 FYDAQVEFVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKLDGVILRPEPDDLCCVKWKENGYYRATVTRLDSKSVDV 573
Cdd:cd20422     1 FYDAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAFYSQASKLDGVVLKPQPGQLCCAKWKEDRYYRAIVTAVKGKMVEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 238624160  574 FLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLADIWPLGKTWSQEATSFFKK 628
Cdd:cd20422    81 FLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFKR 135

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 248.49 E-value: 3.85e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  239 DYFYPQLQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRAPVGTddedsgsatweEREESPDKPGSPCAS 318
Cdd:cd20421     1 DYFYPQLQVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYYEGRVGS-----------GYETRPEKLGSPCAA 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238624160  319 CGLDGQWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYG 379
Cdd:cd20421    70 RGSDGRWYRAVLQQVFSANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 225.07 E-value: 7.14e-68

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1524 IKAYATVIDGPEYFWCQFAdSEKLQYLETEVQSAGKQLSDRRSCTQCPQIGDPCIVRYREDGHYYRALITNICDgELASV 1603
Cdd:cd20426     1 IEAYATAVDSPEYFWCQFA-TEKIQCLAVKVQEAGEQVADRGNFIPSIYVGDPCIVKYSEDNHWYRALVTKIND-NLVSV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 238624160 1604 RLVDFGNAEDCVdAKELWSIPSELLLVPMQAFPCCLAGFSVSGGVCPQEGNDYFYDIVTEDVL 1666
Cdd:cd20426    79 RFVDYGNEEDVV-REQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYFYEIVTEDLL 140

first Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410491 Cd Length: 132 Bit Score: 224.23 E-value: 1.31e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160    6 GLPTPGASLALRVSFVDVHPEVIPVQLWGLVGQRREEYVRLSREIQEAAATRG-PWALGGASASPGELCLVQVGLMWHRC 84
Cdd:cd20420     1 GLPAPGAVLSLRVSRVDVRPGVPLVRLWGLLRERKGEYQRLTREIQAAVKMRGcGAGDGGAEPSVGDLCLVEVGGLWHRC 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 238624160   85 RVVSRQAQDSRVFLLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAGLVP 136
Cdd:cd20420    81 RVVSRQGDDYRVFLLDEGRTVVARAKSLARGRKDFFSLPPEVLGCVLANLVP 132

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 210.05 E-value: 8.58e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  980 YYYSTHDLKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLSYNIMQLSKALLNLKAStLAPGTLCLARYTDGNWYRGII 1059
Cdd:cd20424     1 YYYSMHDIKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKLELS-VNPGTLCLAKYSDQHWYRGII 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 238624160 1060 IE-KEPSKVFFVDFGNTYIAV-DHLLPIPRDAHDVLLLPMQALKCSL 1104
Cdd:cd20424    80 ITnKNSTEVFFVDYGNTEKVEkEDMLPIPSDAYELLLLPMQAIKCSL 126

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 178.03 E-value: 1.07e-51

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1312 KTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVMEQQPNGLLSV 1391
Cdd:cd20425     1 KTEVYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSV 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 238624160 1392 QFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSL 1426
Cdd:cd20425    81 QFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 139.53 E-value: 5.63e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  489 LKMNTFYDAQVEFVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKLDGVILRPEPDDLCCVKW-KENGYYRATVTRLD 567
Cdd:cd20438     1 MEVDAAYVAFVEYVLNPSNFWIRTDEYNNEFQALMKNIADIYNLCGNDEELLKKPEPGLLCCARYsKDRHYYRAVITEVL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238624160  568 SKSVDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLADIWPLGKTWSQEATSFFKK 628
Cdd:cd20438    81 DLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTKNANDFFKK 141

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 137.20 E-value: 3.06e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  982 YSTHDLKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLSYNIMQLSKaLLNLKASTLAPGTLCLARY-TDGNWYRGIII 1060
Cdd:cd20440     1 YSSFNIKVGSEEEVYITHVYSPAKFYCQLDRNTEILEALMEKIAEISK-LFNSQILDNCKTRLCLAKYfEDGQWYRALAH 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 238624160 1061 EKEPS---KVFFVDFGNTYIAV-DHLLPIPRDAHDVLLLPMQALKCSL 1104
Cdd:cd20440    80 PVESSshlSVYFVDYGNKQIVEkNEVLPIPDTAVDLLLTPMQAIKCCL 127

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 114.76 E-value: 1.53e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  1522 KLIKAYATVIDGPEYFWCQF-ADSEKLQYLETEVQSAGKQLSdrRSCTQcPQIGDPCIVRYREDGHYYRALITNICDGEL 1600
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPkSDSKKLEKLTEELQEYYASKP--PESLP-PAVGDGCVAAFSEDGKWYRAKITESLDDGL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 238624160  1601 ASVRLVDFGNAEdCVDAKELWSIPSELLLVPMQAFPCCLAG 1641
Cdd:pfam00567   78 VEVLFIDYGNTE-TVPLSDLRPLPPELESLPPQAIKCQLAG 117

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 114.51 E-value: 2.08e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  771 LEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEpSPYEGDTRVCLAKRTASGRWSRALISGAHSLEH 850
Cdd:cd20439     6 FKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYYLIHN-DPYKHGQIACVAKYSKDGKWYRAAVLKQVSAKE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 238624160  851 VRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNL 891
Cdd:cd20439    85 VDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 107.44 E-value: 4.60e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  1312 KTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQyHTGPQWQSGDVICAVFPEDNLWYRALVMEQQPNGLLSV 1391
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKP-PESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 238624160  1392 QFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWG 1428
Cdd:pfam00567   81 LFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 98.32 E-value: 2.95e-24

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 238624160  824 TRVCLAKRTASGRWSRALISGAHS-LEHVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNLIQPMG 896
Cdd:cd20423     6 NPVCLAKYSEDGKWCRALIDNVYEpVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 95.11 E-value: 9.00e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160   775 STVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEPSPYE---GDTRVCLAKRtaSGRWSRALISGAHSLEHV 851
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPpavGDGCVAAFSE--DGKWYRAKITESLDDGLV 78

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 238624160   852 RVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYN 890
Cdd:pfam00567   79 EVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 93.96 E-value: 2.40e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160   995 VYVTHADDPWTFYCQLARNTNVLEQLSYNiMQLSKALLNLKASTLAPGTLCLARYT-DGNWYRGIIIEKEPS---KVFFV 1070
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEE-LQEYYASKPPESLPPAVGDGCVAAFSeDGKWYRAKITESLDDglvEVLFI 83

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 238624160  1071 DFGNT-YIAVDHLLPIPRDAhdvLLLPMQALKCSLSD 1106
Cdd:pfam00567   84 DYGNTeTVPLSDLRPLPPEL---ESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 90.49 E-value: 4.59e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160   494 FYDAQVEFVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKldgVILRPEPDDLCCVKWKENG-YYRATVT-RLDSKSV 571
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPP---ESLPPAVGDGCVAAFSEDGkWYRAKITeSLDDGLV 78

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 238624160   572 DVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLAD 610
Cdd:pfam00567   79 EVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 90.17 E-value: 1.35e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160   16 LRVSFVDVHPEVIPVQLWGLVGQRRE-EYVRLSREIQEAAATRGPWALGgasaspgELCLVQ--VGLMWHRCRVVSRQAQ 92
Cdd:cd20436     2 LKITHRVCHPKEVLVKFQGQYNSICElDYHILQNEIQNATKSKSSWGVG-------EFCLVEdtTSGEWYRGRVLEKIDE 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238624160   93 DSRVFLLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAGLVPAGgggtgggepQQWSPRAVDFLSNLQGKEVHG 168
Cdd:cd20436    75 KYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIG---------EKWSSTAVNYFSSLIGSQVKG 141

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 89.44 E-value: 1.37e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  771 LEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEPSPYEGD-TRVCLAKRTASGRWSRALISGAHSLE 849
Cdd:cd20440     6 IKVGSEEEVYITHVYSPAKFYCQLDRNTEILEALMEKIAEISKLFNSQILDNCkTRLCLAKYFEDGQWYRALAHPVESSS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 238624160  850 HVRVVFVDYGDRDVVSTKDILSVSDVFFQV---RAQAFRCSL 888
Cdd:cd20440    86 HLSVYFVDYGNKQIVEKNEVLPIPDTAVDLlltPMQAIKCCL 127

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 83.62 E-value: 1.20e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  248 GVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYrapvgtddeDSGSatwEEREESPDKPGSPCASCGLDGQWYR 327
Cdd:cd20437     2 GTTEKVKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHY---------ESVS---KELNPSCENFGLLCAAKGKDGQWHR 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 238624160  328 ALLlETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCAL 377
Cdd:cd20437    70 GFL-QQLLPPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 80.19 E-value: 2.52e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1525 KAYATVIDGPEYFWCQFA-DSEKLQYLETEVQSAGKQLSDRRSCTQCPQIgdpCIVRYREDGHYYRALITNICDGELASV 1603
Cdd:cd20440    13 EVYITHVYSPAKFYCQLDrNTEILEALMEKIAEISKLFNSQILDNCKTRL---CLAKYFEDGQWYRALAHPVESSSHLSV 89

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 238624160 1604 RLVDFGNAEdCVDAKELWSIP---SELLLVPMQAFPCCL 1639
Cdd:cd20440    90 YFVDYGNKQ-IVEKNEVLPIPdtaVDLLLTPMQAIKCCL 127

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 79.01 E-value: 3.51e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1324 SDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVH 1403
Cdd:cd20441     3 SRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNTAVVD 82

                          90       100
                  ....*....|....*....|....*.
gi 238624160 1404 TNRTGRLGPVDAVLPALCLHCSLWGL 1429
Cdd:cd20441    83 KSNIYTLQEKFLSLPRLSIPCSLSGV 108

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 75.87 E-value: 8.91e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  499 VEFvKSPSEFWIRLRKHKN--TFSKLTKRMCSFYSSASKLDGVIlrPEPDDLCCVKWKENG-YYRATVTRLDS--KSVDV 573
Cdd:cd20408     4 TEF-KNPGEFYIQIYTLEVleSLVKLTSQLKKTYASVNNHKEYI--PEVGEVCVAKYSEDQnWYRALVQTVDVqqKKAGV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 238624160  574 FLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLADIWPLGKTWSQEA 622
Cdd:cd20408    81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEEC 129

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 73.99 E-value: 3.18e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  773 VGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSE---PSPYEGDTRVCLAKRTaSGRWSRALISGAHSLE 849
Cdd:cd20437     1 VGTTEKVKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHYESVSkelNPSCENFGLLCAAKGK-DGQWHRGFLQQLLPPS 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 238624160  850 HVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSL 888
Cdd:cd20437    80 QVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 69.05 E-value: 5.92e-14

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238624160  310 DKPGSPC-ASCGLDGQWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGL 380
Cdd:cd20423     3 SLPNPVClAKYSEDGKWCRALIDNVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNL 74

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 69.37 E-value: 1.10e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  989 IGSEELVYVTHADDPWTFYCQLARNTNVLEQLSYNIM--------QLSKALLNLkastlapGTLCLARYTDGNWYRGIII 1060
Cdd:cd20437     1 VGTTEKVKITAAVSPSKFYCQLLSWEPELSKLTTQMTlhyesvskELNPSCENF-------GLLCAAKGKDGQWHRGFLQ 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 238624160 1061 EKEPS---KVFFVDFGNT-YIAVDHLLPIPRdahDVLLLPMQALKCSLSD 1106
Cdd:cd20437    74 QLLPPsqvKVWFIDYGNSeAVSSHSVLKLPP---DFFSLPLMSFPCSLSC 120

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 69.06 E-value: 1.52e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1531 IDGPEYFWCQF-ADSEKLQYLETEVQSAGKQLSDRrscTQCPQIGdpCIVRYREDGHYYRALITNICDGELASVRLVDFG 1609
Cdd:cd20439    19 VNSPGDFWCQLqTKSSELKSLMKQIQSYYLIHNDP---YKHGQIA--CVAKYSKDGKWYRAAVLKQVSAKEVDVIFVDYG 93

                          90       100       110
                  ....*....|....*....|....*....|...
gi 238624160 1610 NAEDcVDAKELWSIPSELLLVPMQAFPCCLAGF 1642
Cdd:cd20439    94 NQER-VLISDLRAIKPQFLLLEGQAFRCSLNNF 125

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 67.90 E-value: 4.83e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  489 LKMNTFYDAQVEFVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKLDgvilrpEPDDLCCV-KWKENG-YYRATV-TR 565
Cdd:cd20439     6 FKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYYLIHNDPY------KHGQIACVaKYSKDGkWYRAAVlKQ 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 238624160  566 LDSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLADI 611
Cdd:cd20439    80 VSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 66.99 E-value: 6.44e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160   250 TEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRAPvgtddedsgsatweEREESPDKPGSPCA---SCglDGQWY 326
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASK--------------PPESLPPAVGDGCVaafSE--DGKWY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 238624160   327 RALLLETfRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYG 379
Cdd:pfam00567   66 RAKITES-LDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 66.62 E-value: 1.30e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  995 VYVTHADDPWTFYCQLArNTNVLEQLsyniMQLSKALLNLKASTL-------APGTLCLARYT-DGNWYRGII----IEK 1062
Cdd:cd20408     1 GTVTEFKNPGEFYIQIY-TLEVLESL----VKLTSQLKKTYASVNnhkeyipEVGEVCVAKYSeDQNWYRALVqtvdVQQ 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 238624160 1063 EPSKVFFVDFGN-TYIAVDHLLPIPRdahDVLLLPMQALKCSLSDIP 1108
Cdd:cd20408    76 KKAGVFYIDYGNeETVPLNRIQPLKK---DIELFPPCAIKCCLANVK 119

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 66.37 E-value: 1.43e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  770 ELEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEP--SPYEGDTrVCLAKRTaSGRWSRALISgaHS 847
Cdd:cd20424     7 DIKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKleLSVNPGT-LCLAKYS-DQHWYRGIII--TN 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 238624160  848 LEHVRVVFVDYGDRDVVSTKDILSVS----DVFFqVRAQAFRCSL 888
Cdd:cd20424    83 KNSTEVFFVDYGNTEKVEKEDMLPIPsdayELLL-LPMQAIKCSL 126

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 64.80 E-value: 4.00e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1326 FYIQLIEDE--AEINNLSERLNdVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVME------QQPNGLLSVQFIDYG 1397
Cdd:cd20443     4 FYVQVVSDQrlSSIQQQLEGLS-LKDKANPPGGFNPKKGELVLAQFSADNSWNRAMVVNaprqgtQSPKDEYEVFYIDYG 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 238624160 1398 NMSVVHTNRTGRLGPVDAVLPALCLHCSLWGLSVP 1432
Cdd:cd20443    83 NQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKVP 117

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 64.75 E-value: 4.70e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  498 QVEFVK-----SPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKlDGVILRPEPDDLCCVKWKENGYYRATVTRLDSKS-V 571
Cdd:cd20437     3 TTEKVKitaavSPSKFYCQLLSWEPELSKLTTQMTLHYESVSK-ELNPSCENFGLLCAAKGKDGQWHRGFLQQLLPPSqV 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 238624160  572 DVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLAD 610
Cdd:cd20437    82 KVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLSC 120

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 64.78 E-value: 6.12e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1307 IAPGFKTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFpEDNLWYRALVMEQQPN 1386
Cdd:cd20440     6 IKVGSEEEVYITHVYSPAKFYCQLDRNTEILEALMEKIAEISKLFNSQILDNCKTRLCLAKYF-EDGQWYRALAHPVESS 84

                          90
                  ....*....|....*....
gi 238624160 1387 GLLSVQFIDYGNMSVVHTN 1405
Cdd:cd20440    85 SHLSVYFVDYGNKQIVEKN 103

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 63.61 E-value: 8.40e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1534 PEYFWCQFADSEKLQYLETEVQSAGKQLSDRRSCTQCpQIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNAEd 1613
Cdd:cd20441     2 PSRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKL-KVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNTA- 79

                          90       100
                  ....*....|....*....|....*...
gi 238624160 1614 CVDAKELWSIPSELLLVPMQAFPCCLAG 1641
Cdd:cd20441    80 VVDKSNIYTLQEKFLSLPRLSIPCSLSG 107

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 63.62 E-value: 1.02e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1543 DSEKLQYLETEVQSAGKQLSDRRSCTqcPQIGDPCIVRYREDGHYYRALITNICDGElASVRLVDFGNAEdCVDAKELWS 1622
Cdd:cd20411    22 NVEKLKALMTELAEYCSKQSVPQQFR--PRIGDACCARFTGDKNWYRAVVLETSDSE-VKVLYADYGNTE-TLPLSRILP 97

                          90
                  ....*....|....*....
gi 238624160 1623 IPSELLLVPMQAFPCCLAG 1641
Cdd:cd20411    98 ITKSHLELPFQIIRCSLAG 116

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 63.60 E-value: 1.68e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  770 ELEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEPSPYEGDTRV----ClAKRTASGRWSRALISGA 845
Cdd:cd20421     6 QLQVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYYEGRVGSGYETRPEKlgspC-AARGSDGRWYRAVLQQV 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 238624160  846 HSLEH-VRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLY 889
Cdd:cd20421    85 FSANRvVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALF 129

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 61.20 E-value: 1.81e-11

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 238624160 1571 PQIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNAEDcVDAKELWSIPSELL 1628
Cdd:cd20410     3 PIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEE-VTLDKLRKITSTFL 59

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 60.22 E-value: 2.71e-11

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 238624160 1573 IGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNaEDCVDAKELWSI 1623
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGN-TETVPLSDLRPL 50

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 63.21 E-value: 3.56e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  504 SPSEFWIRLRKHKNTFSKLT-KRMCSFYSSASKLDGVIlrpEPDDLCCVKWKENG-YYRATVTRLDSKSVDVFLVDRGNS 581
Cdd:cd20436    10 HPKEVLVKFQGQYNSICELDyHILQNEIQNATKSKSSW---GVGEFCLVEDTTSGeWYRGRVLEKIDEKYEVFLIDRGEV 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 238624160  582 ENVDWCDVRMLLPQFRQLPILALKCTLADIWPLGKTWSQEATSFFKKTV 630
Cdd:cd20436    87 LNVHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTAVNYFSSLI 135

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 59.03 E-value: 1.48e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 238624160 1576 PCIVRYREDGHYYRALITNICDG-ELASVRLVDFGNAEdCVDAKELWSIPSELLLVPMQAFPCCL 1639
Cdd:cd20423     8 VCLAKYSEDGKWCRALIDNVYEPvEMVEVTYVDYGNKE-LVSLKNLRSISEEFLKLKAQAFRCSL 71

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 57.91 E-value: 1.75e-10

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 238624160 1362 GDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVHTNR 1406
Cdd:cd20379     2 GDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSD 46

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 60.98 E-value: 1.93e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  777 VEVKVSHIENPGSFWCQLmrNAQGFRTLMCDIEDYCKSSE------PSPYEGDTrvCLAKRTASGRWSRALISGAHSlEH 850
Cdd:cd20426     1 IEAYATAVDSPEYFWCQF--ATEKIQCLAVKVQEAGEQVAdrgnfiPSIYVGDP--CIVKYSEDNHWYRALVTKIND-NL 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  851 VRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNLIQPMGenpfVWDEKAVQAF 910
Cdd:cd20426    76 VSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEG----LWSDEANDYF 131

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 59.74 E-value: 2.71e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1310 GFKTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVMEQQPNGLL 1389
Cdd:cd20437     2 GTTEKVKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHYESVSKELNPSCENFGLLCAAKGKDGQWHRGFLQQLLPPSQV 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 238624160 1390 SVQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSL 1426
Cdd:cd20437    82 KVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 58.94 E-value: 3.76e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  500 EFVkSPSEFWIRLRKHKNTfskltKRMCSFYSSASKLDGVIL--RPEPDDLCCVKWK---ENGYYRATVTRLDSKSVDVF 574
Cdd:cd20431     2 EVV-EVGHFWGYRIDENSS-----EILQQLTAEINQRQLVPLttKPVPNLLCLAPFTdadMKKYYRAKILYVSGSSAEVF 75

                          90       100
                  ....*....|....*....|....*.
gi 238624160  575 LVDRGNSENVDWCDVRMLLPQFRQLP 600
Cdd:cd20431    76 FVDYGNTSQVPSSLLREIPETLLTLP 101

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 57.28 E-value: 4.00e-10

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 238624160   1569 QCPQIGDPCIVRYrEDGHYYRALITNICDGELASVRLVDFGNaEDCVDAKELWSIPSEL 1627
Cdd:smart00333    1 PTFKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGN-EEVVPPSDLRQLPEEL 57

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 59.41 E-value: 6.27e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1316 YVSHINDLSDFYIQLIEDEAEINNLSERLNDV--RTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVMEQqpNGL-LSVQ 1392
Cdd:cd20438    10 FVEYVLNPSNFWIRTDEYNNEFQALMKNIADIynLCGNDEELLKKPEPGLLCCARYSKDRHYYRAVITEV--LDLkVSVY 87

                          90       100       110
                  ....*....|....*....|....*....|....
gi 238624160 1393 FIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSL 1426
Cdd:cd20438    88 FLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSL 121

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 59.02 E-value: 8.37e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1526 AYATVIDGPEYFWCQFADseklqyLETEVQSAGKQLSDRRSCT-------QCPQIGDPCIVRYREDGHYYRALITNICDG 1598
Cdd:cd20438     9 AFVEYVLNPSNFWIRTDE------YNNEFQALMKNIADIYNLCgndeellKKPEPGLLCCARYSKDRHYYRAVITEVLDL 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238624160 1599 ELaSVRLVDFGNAE--DCVDAKELWSIPSELllvPMQAFPCCLAGFSVSGGVCPQEGNDYF 1657
Cdd:cd20438    83 KV-SVYFLDFGNTDtvPFYDVKTLLPEFSEL---PALAMCCSLAHVFPVEEVWTKNANDFF 139

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 55.98 E-value: 8.98e-10

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 238624160  545 PDDLCCVKWKENG-YYRATVTRLDS-KSVDVFLVDRGNSENVDWCDVRML 592
Cdd:cd20379     1 VGDLCAAKYEEDGkWYRARVLEVLSnDKVEVFFVDYGNTETVPLSDLRPL 50

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 58.68 E-value: 9.00e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1571 PQIGDPCIVRYREDGhYYRALITNIcDGELASVRLVDFGNAE--DCVDAKELwsiPSELLLVPMQAFPCCLAGFSVSGGV 1648
Cdd:cd20422    50 PQPGQLCCAKWKEDR-YYRAIVTAV-KGKMVEVFLVDRGNTEmvDWYDVKKL---LPQFRELPALALKCCLADICPLGER 124


                  ....*....
gi 238624160 1649 CPQEGNDYF 1657
Cdd:cd20422   125 WSPEAISAF 133

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 56.13 E-value: 1.00e-09

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 238624160   1037 STLAPGTLCLARYTDGNWYRGIIIEKEPSK---VFFVDFGNT-YIAVDHLLPIPRD 1088
Cdd:smart00333    1 PTFKVGDKVAARWEDGEWYRARIVKVDGEQlyeVFFIDYGNEeVVPPSDLRQLPEE 56

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 58.28 E-value: 1.21e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1527 YATVIDGPEYFWCQFA-DSEKLQYLetevQSAGKQLSDRRSCTQCPQI-GDPCIVRYrEDGHYYRALItnICDGELASVR 1604
Cdd:cd20424    17 YITYVNDPWTFYCQLArNAGVLDQL----ASAISRLSSEIRKLELSVNpGTLCLAKY-SDQHWYRGII--ITNKNSTEVF 89

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 238624160 1605 LVDFGNAEdCVDAKELWSIPS---ELLLVPMQAFPCCL 1639
Cdd:cd20424    90 FVDYGNTE-KVEKEDMLPIPSdayELLLLPMQAIKCSL 126

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 57.85 E-value: 1.31e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1526 AYATVIDGPEYFWCQFADSEKLQYLETEVQSAGKQLSDRRSCtQCPQIGDPCIVRYREDGHYYRALITNICDGELASVRL 1605
Cdd:cd20425     4 VYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVEC-ESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQF 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 238624160 1606 VDFGNAEDcVDAKELWSIPSELLLVPMQAFPCCL 1639
Cdd:cd20425    83 IDYGNTSV-VQPSKIHRLPKELLSIPALSIHCFL 115

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 58.28 E-value: 1.69e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  996 YVTHADDPWTFYCQLArnTNVLEQLSYNIMQLSK--ALLNLKASTLAPGTLCLARYT-DGNWYRGII--IEKEPSKVFFV 1070
Cdd:cd20426     4 YATAVDSPEYFWCQFA--TEKIQCLAVKVQEAGEqvADRGNFIPSIYVGDPCIVKYSeDNHWYRALVtkINDNLVSVRFV 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 238624160 1071 DFGNTY-IAVDHLLPIPRdahDVLLLPMQALKCSLS 1105
Cdd:cd20426    82 DYGNEEdVVREQVRALPS---ELLKIPVQAFPCCLS 114

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 55.43 E-value: 2.02e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 238624160 1362 GDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVV 1402
Cdd:cd20410     6 GEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEV 46

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 57.43 E-value: 2.08e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  980 YYYSthDLKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLSYNIMQL--SKALLNLKASTLAPGTLCLARYTDGNWYRG 1057
Cdd:cd20421     2 YFYP--QLQVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYyeGRVGSGYETRPEKLGSPCAARGSDGRWYRA 79

                          90       100
                  ....*....|....*....|.
gi 238624160 1058 IIIEKEPSK----VFFVDFGN 1074
Cdd:cd20421    80 VLQQVFSANrvveVLHVDYGR 100

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 54.83 E-value: 2.30e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 238624160 1041 PGTLCLARYT-DGNWYRGIIIEKEPS---KVFFVDFGNT-YIAVDHLLPI 1085
Cdd:cd20379     1 VGDLCAAKYEeDGKWYRARVLEVLSNdkvEVFFVDYGNTeTVPLSDLRPL 50

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 57.12 E-value: 2.40e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  982 YSTHDLKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLsyniMQLSKALLNLKASTLAPG-TLCLARYT-DGNWYRGII 1059
Cdd:cd20439     1 YKEYLFKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSL----MKQIQSYYLIHNDPYKHGqIACVAKYSkDGKWYRAAV 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 238624160 1060 IEKEPSK---VFFVDFGNT-YIAVDHLLPI-PRdahdVLLLPMQALKCSLSDI 1107
Cdd:cd20439    77 LKQVSAKevdVIFVDYGNQeRVLISDLRAIkPQ----FLLLEGQAFRCSLNNF 125

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 56.67 E-value: 2.68e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1002 DPWTFYCQLARNTNVLEQLSYNIMQLSKALLNLKASTLAPGTLCLARYT-DGNWYRGIIIEKEPSKVF---FVDFGNTYI 1077
Cdd:cd20441     1 SPSRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDeDLALYRAVITAVLPGKSFkveFIDYGNTAV 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 238624160 1078 aVD----HLLPiprdaHDVLLLPMQALKCSLSDI 1107
Cdd:cd20441    81 -VDksniYTLQ-----EKFLSLPRLSIPCSLSGV 108

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 57.51 E-value: 2.71e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  502 VKSPSEFWIRLRKHKntFSKLTKRMCSFYSSASKLDGVILRPEPDDLCCVKWKENG-YYRATVTRLDSKSVDVFLVDRGN 580
Cdd:cd20426     8 VDSPEYFWCQFATEK--IQCLAVKVQEAGEQVADRGNFIPSIYVGDPCIVKYSEDNhWYRALVTKINDNLVSVRFVDYGN 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 238624160  581 SENVDWCDVRMLLPQFRQLPILALKCTLADIWPLGKTWSQEATSFF 626
Cdd:cd20426    86 EEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYF 131

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 56.29 E-value: 2.80e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  522 LTKRMCSFYSSASKLDGVILRPEPDDLCCVKWKENGYYRATVTRL-DSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQLP 600
Cdd:cd20415     4 LTKKIQEFYKEGDDGGLEILCPVQGQACVALFEDGAWYRARIIGLpGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLP 83

                          90
                  ....*....|...
gi 238624160  601 ILALKCTLADIWP 613
Cdd:cd20415    84 EKARECRLAFIEP 96

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 56.61 E-value: 4.69e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  781 VSHIENPGSFWCQLM--RNAQGFRTLMCDIED-YCKSSEPSPYEGDT-RVCLAKRTASGRWSRALI-SGAHSLEHVRVVF 855
Cdd:cd20408     3 VTEFKNPGEFYIQIYtlEVLESLVKLTSQLKKtYASVNNHKEYIPEVgEVCVAKYSEDQNWYRALVqTVDVQQKKAGVFY 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 238624160  856 VDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNLIQPMG 896
Cdd:cd20408    83 IDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSG 123

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 54.20 E-value: 4.71e-09

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 238624160   1357 PQWQSGDVICAVFpEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVHTNRTGRLGP 1412
Cdd:smart00333    1 PTFKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPE 55

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 56.61 E-value: 4.73e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1529 TVID--GPEYFWCQFADSEKLQYLeTEVQSagkQLSDRRSCTQC-----PQIGDPCIVRYREDGHYYRALITNI-CDGEL 1600
Cdd:cd20408     2 TVTEfkNPGEFYIQIYTLEVLESL-VKLTS---QLKKTYASVNNhkeyiPEVGEVCVAKYSEDQNWYRALVQTVdVQQKK 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 238624160 1601 ASVRLVDFGNAEDcVDAKELWSIPSELLLVPMQAFPCCLAG 1641
Cdd:cd20408    78 AGVFYIDYGNEET-VPLNRIQPLKKDIELFPPCAIKCCLAN 117

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 55.13 E-value: 7.41e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  521 KLTKRMCSFYSSASKLDgVILRPEPDDLCCVKWKENGYYRATVTRLDSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQLP 600
Cdd:cd20427     2 QMEDEMKEFYSKSSTAM-CLRSPSVGQLVAVKAEEDAWLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLP 80

                          90
                  ....*....|....
gi 238624160  601 ILALKCTLADIWPL 614
Cdd:cd20427    81 FQATKCKLAGLEPF 94

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 55.72 E-value: 1.10e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  504 SPSEFWIRLRKHKN-----------TFSKLTKRMCSFYSSAS--KLDGvilRPEPDDLCCVKWKENGYYRATVTRLDSKS 570
Cdd:cd20435     1 DATHYSARILEHRSsdgevtksmssTYLKLSMKLNMYYSDPSnrILHG---KVKVGDLCAVEDENNLYHRVKVLEITEKD 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 238624160  571 -------VDVFLVDRGNSENVDWCDVRMLLPQFRQLP 600
Cdd:cd20435    78 dktkpreVLVKFIDEGRVETVVVSQLLELPEELKSLP 114

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 55.51 E-value: 1.15e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  499 VEFVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKLDGVILRPEPDDLCCVKWKENGYYRATVTRL--DSKSVDVFLV 576
Cdd:cd20421    17 VTEVTDPHRIFCQLRSLSQELKRLSESMHQYYEGRVGSGYETRPEKLGSPCAARGSDGRWYRAVLQQVfsANRVVEVLHV 96

                          90       100       110
                  ....*....|....*....|....*....|..
gi 238624160  577 DRGNSENVDWCDVRMLLPQFRQLPILALKCTL 608
Cdd:cd20421    97 DYGRKEVVSVSNLRYLAPEYFRMPVVTYPCAL 128

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 55.15 E-value: 1.18e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  779 VKVSHIENPGSFWC---QLMRNAQGFRTLMCDIEDYC-KSSEPSPYE---GDtrVCLAKRTASGRWSRALISGAhSLEHV 851
Cdd:cd20411     1 ALVLEVISPDLFYAlpkTGQVNVEKLKALMTELAEYCsKQSVPQQFRpriGD--ACCARFTGDKNWYRAVVLET-SDSEV 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 238624160  852 RVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSL 888
Cdd:cd20411    78 KVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSL 114

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 55.45 E-value: 1.23e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1315 VYVSHINDLSDFYIQLIEDEA--EINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVME-QQPNGLLSV 1391
Cdd:cd20408     1 GTVTEFKNPGEFYIQIYTLEVleSLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTvDVQQKKAGV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 238624160 1392 QFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWGLSVPVC 1434
Cdd:cd20408    81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSG 123

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 55.19 E-value: 1.27e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1302 FPQKTIAPGFKTSVYVSHINDLSDFYIQLIEDEAEINNLSErlnDVRTRPQYHTGPqWQSGDVIC-AVFPEDNLWYRALV 1380
Cdd:cd20439     1 YKEYLFKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMK---QIQSYYLIHNDP-YKHGQIACvAKYSKDGKWYRAAV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 238624160 1381 MEQQPNGLLSVQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWGL 1429
Cdd:cd20439    77 LKQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 55.21 E-value: 1.48e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1315 VYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTG----PQwqSGDVICAVFpEDNLWYRALVMEQQPNGLlS 1390
Cdd:cd20422     4 AQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAFYSQASKLDGvvlkPQ--PGQLCCAKW-KEDRYYRAIVTAVKGKMV-E 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 238624160 1391 VQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSL---WGLSVPVCKEMVSYF 1441
Cdd:cd20422    80 VFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLadiCPLGERWSPEAISAF 133

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 52.66 E-value: 1.75e-08

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 238624160    547 DLCCVKWKENGYYRATVTRLDS-KSVDVFLVDRGNSENVDWCDVRmLLPQFR 597
Cdd:smart00333    7 DKVAARWEDGEWYRARIVKVDGeQLYEVFFIDYGNEEVVPPSDLR-QLPEEL 57

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 53.59 E-value: 2.19e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1042 GTLCLARYTDGNWYRGIII---EKEPSKVFFVDFGNT-YIAVDHLLPIPRDAhdvLLLPMQALKCSLSDI 1107
Cdd:cd20415    28 GQACVALFEDGAWYRARIIglpGHREVEVKYVDFGNTaTVTIKHVRKIKDDF---LSLPEKARECRLAFI 94

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 53.99 E-value: 2.51e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 238624160 1041 PGTLCLARYT-DGNWYRGIIIEKEPS--KVFFVDFGNTYI-AVDHLLPIpRDAHdvLLLPMQALKCSLS 1105
Cdd:cd20411    50 IGDACCARFTgDKNWYRAVVLETSDSevKVLYADYGNTETlPLSRILPI-TKSH--LELPFQIIRCSLA 115

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 54.00 E-value: 2.86e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  994 LVYVTHADDPWTFYCQLARNTNVLEQLS--YNIMQLSKALLNLKAstLAPGTLCLARYT-DGNWYRGIIIEKEPSK---V 1067
Cdd:cd20425     3 EVYVSHVNSPSDFYVQLAQDEDELSMISekLNASKANDEEVECES--LQLGDLICAEYPeDGLWYRAVVKEKIPNNlvsV 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 238624160 1068 FFVDFGNT-YIAVDHLLPIPRDAhdvLLLPMQALKCSL 1104
Cdd:cd20425    81 QFIDYGNTsVVQPSKIHRLPKEL---LSIPALSIHCFL 115

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 51.36 E-value: 3.39e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 238624160  312 PGSPCASC-GLDGQWYRALLLETFRPQRCaQVLHVDYGRKELVSCSSLRYL 361
Cdd:cd20379     1 VGDLCAAKyEEDGKWYRARVLEVLSNDKV-EVFFVDYGNTETVPLSDLRPL 50

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 54.00 E-value: 3.80e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  499 VEFVKSPSEFWIRLRKHKNTFSKLTKRMCSFyssaSKL-DGVILRPEPDDLCCVKWKENG-YYRATVTRLDSKS-VDVFL 575
Cdd:cd20440    16 ITHVYSPAKFYCQLDRNTEILEALMEKIAEI----SKLfNSQILDNCKTRLCLAKYFEDGqWYRALAHPVESSShLSVYF 91

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 238624160  576 VDRGNSENVDWCDVRMLLPQFRQL---PILALKCTL 608
Cdd:cd20440    92 VDYGNKQIVEKNEVLPIPDTAVDLlltPMQAIKCCL 127

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 53.53 E-value: 5.51e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  253 VVVTQVCHPHRIHCQLRSLS--QEIHRLSESMAQVYRAPVGtddedsgsatweEREESPDKpGSPC-ASCGLDGQWYRAL 329
Cdd:cd20408     1 GTVTEFKNPGEFYIQIYTLEvlESLVKLTSQLKKTYASVNN------------HKEYIPEV-GEVCvAKYSEDQNWYRAL 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 238624160  330 LLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDCGRGWS 388
Cdd:cd20408    68 VQTVDVQQKKAGVFYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWS 126

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 52.82 E-value: 6.26e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  504 SPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKLDGVILRPepDDLCCVKWKENG-YYRATVTR-LDSKSVDVFLVDRGNS 581
Cdd:cd20441     1 SPSRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKLKV--GDLVAAEYDEDLaLYRAVITAvLPGKSFKVEFIDYGNT 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 238624160  582 ENVDWCDVRMLLPQFRQLPILALKCTLADI 611
Cdd:cd20441    79 AVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 51.69 E-value: 6.61e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 238624160 1339 NLSERLNDVRTRPQYHTGPqwqsGDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVHTNRTGRLGP 1412
Cdd:cd20409    10 SLSAYCKVAPASSDFSPAV----GEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPP 79

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 52.89 E-value: 7.63e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1307 IAPGFKTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQwQSGDVICAVFpEDNLWYRALVMEQQPN 1386
Cdd:cd20424     8 IKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKLELSV-NPGTLCLAKY-SDQHWYRGIIITNKNS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 238624160 1387 glLSVQFIDYGNMSVVHTNRTGRLgPVDA----VLPALCLHCSL 1426
Cdd:cd20424    86 --TEVFFVDYGNTEKVEKEDMLPI-PSDAyellLLPMQAIKCSL 126

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 52.88 E-value: 8.13e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  245 LQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYrapvgtddedsgsatweEREESPDKPG-SPC-ASCGLD 322
Cdd:cd20439     6 FKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYY-----------------LIHNDPYKHGqIACvAKYSKD 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 238624160  323 GQWYRALLLeTFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGL 380
Cdd:cd20439    69 GKWYRAAVL-KQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 52.45 E-value: 8.27e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 238624160  316 CASCGLDGQWYRALLLETfrPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYG 379
Cdd:cd20411    55 CARFTGDKNWYRAVVLET--SDSEVKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 52.51 E-value: 1.31e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  995 VYVTHADDPWTFYCQLARNTNVLEQLSYNIMQLSKALLNLKASTLAP--GTLCLARYTDGNWYRGII--IEKEPSKVFFV 1070
Cdd:cd20422     4 AQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAFYSQASKLDGVVLKPqpGQLCCAKWKEDRYYRAIVtaVKGKMVEVFLV 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 238624160 1071 DFGNT----YIAVDHLLPIPRDahdvllLPMQALKCSLSDI 1107
Cdd:cd20422    84 DRGNTemvdWYDVKKLLPQFRE------LPALALKCCLADI 118

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 49.44 E-value: 2.00e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 238624160  826 VCLAKRTASGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDI 869
Cdd:cd20379     4 LCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDL 47

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 52.09 E-value: 2.35e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  781 VSHIENPGSFWCQLMRNAQGFRTLMCDIEDY---CKSSE---PSPYEGDtrVCLAKRTASGRWSRALISGAHSLeHVRVV 854
Cdd:cd20438    11 VEYVLNPSNFWIRTDEYNNEFQALMKNIADIynlCGNDEellKKPEPGL--LCCARYSKDRHYYRAVITEVLDL-KVSVY 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 238624160  855 FVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNlIQPMGEnpfVWDEKAVQAF 910
Cdd:cd20438    88 FLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAH-VFPVEE---VWTKNANDFF 139

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 49.99 E-value: 2.69e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 238624160 1362 GDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVHTNRTGRLGP 1412
Cdd:cd20433    31 GDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPP 81

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 50.91 E-value: 3.15e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  499 VEFVKSPSEFWIRL--RKHKNTFSKLTKRMCSFYSSASKLDGVILrPE----PDDLCCVKWKEN-GYYRATVTR-LDSKS 570
Cdd:cd20419     2 VEYIESPSQFYVRFysKDTSEMLEDMMIEMRRCYSNEHVSERYVM-PEafiqPGQVCCVRIPEDvWWYRVIIHQvLNKQE 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 238624160  571 VDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTL 608
Cdd:cd20419    81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 49.74 E-value: 4.28e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1547 LQYLETEVQSAGKQLSDRRSCTQCPQIGDPCIVRYrEDGHYYRALITNICDGELASVRLVDFGNaEDCVDAKELWSIPSE 1626
Cdd:cd20415     1 FLILTKKIQEFYKEGDDGGLEILCPVQGQACVALF-EDGAWYRARIIGLPGHREVEVKYVDFGN-TATVTIKHVRKIKDD 78

                          90
                  ....*....|....
gi 238624160 1627 LLLVPMQAFPCCLA 1640
Cdd:cd20415    79 FLSLPEKARECRLA 92

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 49.60 E-value: 4.64e-07

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 238624160 1360 QSGDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYG 1397
Cdd:cd20412    30 QVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYG 67

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 48.49 E-value: 4.82e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 238624160 1041 PGTLCLARYT-DGNWYRGIIIEKEPS---KVFFVDFGNTY-IAVDHLLPIPRD 1088
Cdd:cd20410     5 VGEPCCAFFSgDGNWYRAMVKEILPGgavKVHFVDYGNVEeVTLDKLRKITST 57

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 50.14 E-value: 6.40e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  497 AQVEFVKSPSEFWIRLRKHKNTFSKLTKRMCSF--YSSASKlDGVILRPEPDDLCCVKWK-ENGYYRATVTRLDSKSVDV 573
Cdd:cd20411     1 ALVLEVISPDLFYALPKTGQVNVEKLKALMTELaeYCSKQS-VPQQFRPRIGDACCARFTgDKNWYRAVVLETSDSEVKV 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 238624160  574 FLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLA 609
Cdd:cd20411    80 LYADYGNTETLPLSRILPITKSHLELPFQIIRCSLA 115

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 50.20 E-value: 7.43e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  778 EVKVSHIENPGSFWCQLMRNAQGFRTLMCDIED-YCKSS-------EPSPyeGDtrVCLAKrTASGRWSRALISGAHSlE 849
Cdd:cd20422     3 DAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAfYSQASkldgvvlKPQP--GQ--LCCAK-WKEDRYYRAIVTAVKG-K 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238624160  850 HVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNlIQPMGENpfvWDEKAVQAF 910
Cdd:cd20422    77 MVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLAD-ICPLGER---WSPEAISAF 133

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 50.15 E-value: 8.22e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  245 LQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRAPVGTDDEdsgsatweereesPDKPGSPCASCGLDGQ 324
Cdd:cd20440     6 IKVGSEEEVYITHVYSPAKFYCQLDRNTEILEALMEKIAEISKLFNSQILD-------------NCKTRLCLAKYFEDGQ 72

                          90       100
                  ....*....|....*....|....*....
gi 238624160  325 WYRALLLETFRPQRcAQVLHVDYGRKELV 353
Cdd:cd20440    73 WYRALAHPVESSSH-LSVYFVDYGNKQIV 100

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 50.55 E-value: 8.43e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  987 LKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLS------YNIMQLSKALLNlkasTLAPGTLCLARYT-DGNWYRGII 1059
Cdd:cd20438     1 MEVDAAYVAFVEYVLNPSNFWIRTDEYNNEFQALMkniadiYNLCGNDEELLK----KPEPGLLCCARYSkDRHYYRAVI 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 238624160 1060 IEKEPSK--VFFVDFGNTYIA----VDHLLPiprdahDVLLLPMQALKCSLSdipHHIP-EEV 1115
Cdd:cd20438    77 TEVLDLKvsVYFLDFGNTDTVpfydVKTLLP------EFSELPALAMCCSLA---HVFPvEEV 130

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 47.60 E-value: 8.82e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 238624160 1037 STLAPGTLCLARYTDGNWYRGIIIEKEPSKVFFVDF--GNTYIAV--DHLLPI 1085
Cdd:cd20384     3 SSLKEGSRCLAKYDDGLWYPATVTDIDEDGKYTVKFdsYGEVAVVelDDILPL 55

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 50.14 E-value: 1.10e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  779 VKVSHIENPGSFWCQL-MRNAQGFRTLMCDIEDYCKSSEPS-------PYEGdtRVCLAKrtASGRWSRALISGAHSLEH 850
Cdd:cd20428     4 VRVTNVCSDGTLYCQVpSKGLSKLNEILDKIEYYFHSRQMTseyfvslPFCG--KICLAR--YKGKWARVEITNVHSSRA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238624160  851 VRVVFVDYGDRDVVSTKDILSVSDVFFQ----VRAQAFRCSLYNLIQPMGenpfVWDEKAVQ 908
Cdd:cd20428    80 LDVHFLDTGTVASVKVSELREIPPPFLRelisIPPQALKCCLADLPLNIG----MWTPDAVL 137

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 48.25 E-value: 1.24e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 238624160 1041 PGTLCLARYT-DGNWYRGIIIE----KEPSKVFFVDFGNTYI-AVDHLLPIprdAHDVLLLPMQALKCSLSDI 1107
Cdd:cd20423     5 PNPVCLAKYSeDGKWCRALIDNvyepVEMVEVTYVDYGNKELvSLKNLRSI---SEEFLKLKAQAFRCSLYNL 74

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 49.75 E-value: 1.30e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  995 VYVTHADDPWTFYCQ-----LARNTNVLEQLSY--NIMQLSKALLnlkASTLAPGTLCLARYTdGNWYRGIIIEKEPSK- 1066
Cdd:cd20428     4 VRVTNVCSDGTLYCQvpskgLSKLNEILDKIEYyfHSRQMTSEYF---VSLPFCGKICLARYK-GKWARVEITNVHSSRa 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 238624160 1067 --VFFVDFGN-TYIAVDHLLPIP-RDAHDVLLLPMQALKCSLSDIPHHI---PEEVTAW 1118
Cdd:cd20428    80 ldVHFLDTGTvASVKVSELREIPpPFLRELISIPPQALKCCLADLPLNIgmwTPDAVLW 138

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 49.04 E-value: 1.60e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  496 DAQVEFVKSPSEFWIRLRKHKNTFSKLTkrmcsfySSASKLDGVILRPE----PDDLCCVKWKENGYYRATVTRLDSKsV 571
Cdd:cd20424    15 EVYITYVNDPWTFYCQLARNAGVLDQLA-------SAISRLSSEIRKLElsvnPGTLCLAKYSDQHWYRGIIITNKNS-T 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 238624160  572 DVFLVDRGNSENVDWCDvrmLLP------QFRQLPILALKCTL 608
Cdd:cd20424    87 EVFFVDYGNTEKVEKED---MLPipsdayELLLLPMQAIKCSL 126

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 48.17 E-value: 1.96e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238624160 1573 IGDPCIVRYReDGHYYRALITNICDGELAS--VRLVDFGnAEDCVDAKELWSIPSELLLVPMQAFPCCLAGF 1642
Cdd:cd20418     6 PEMPCLAEYS-DGKWYRAKLLSILEFNPVKilVRHVDYG-STAALPTSRLRQIPAELMQYPCQAIKVKLAGF 75

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 47.40 E-value: 3.48e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1041 PGTLCLARYTDGNWYRGIII---EKEPSKVF--FVDFGNT-YIAVDHLLPIPRdahDVLLLPMQALKCSL 1104
Cdd:cd20418     6 PEMPCLAEYSDGKWYRAKLLsilEFNPVKILvrHVDYGSTaALPTSRLRQIPA---ELMQYPCQAIKVKL 72

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 47.82 E-value: 5.70e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1532 DGPEYfwCQFAdSEKLQYLETEVQSAGKQLSDRRSCTQC----PQIGDPCIVRYRedGHYYRALITNICDGELASVRLVD 1607
Cdd:cd20428    12 DGTLY--CQVP-SKGLSKLNEILDKIEYYFHSRQMTSEYfvslPFCGKICLARYK--GKWARVEITNVHSSRALDVHFLD 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 238624160 1608 FGNAEDcVDAKELWSIPS----ELLLVPMQAFPCCLAGFSVSGGVCPQE 1652
Cdd:cd20428    87 TGTVAS-VKVSELREIPPpflrELISIPPQALKCCLADLPLNIGMWTPD 134

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 46.14 E-value: 6.70e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 238624160 1042 GTLCLARYT-DGNWYRGIIIEKEPSK---VFFVDFGNT-YIAVDHLLPIP 1086
Cdd:cd20433    31 GDLCAAKFVeDGEWYRAKVEKVEGDKkvhVLYIDYGNReVLPSTRLAALP 80

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 46.52 E-value: 6.85e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  521 KLTKRMCSFYSSASKLDGViLRPEPDDLCCVKWK-ENGYYRATVTR-LDSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQ 598
Cdd:cd20412     8 KLVQEMTQYYESEENRHTL-LTVQVGDIVAAPFRhDGSWYRARVLGfLENGNLDLYFVDYGDSGYVPLEDLRALRSDFLS 86


                  ....*...
gi 238624160  599 LPILALKC 606
Cdd:cd20412    87 LPFQAIEC 94

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 46.23 E-value: 9.24e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238624160 1013 NTNVLEQLSYNIMQLSkaLLNLKAStLAPGTLCLARYTDGN---WYRGIIIEKEPS--KVFFVDFGNTYIAVDHLL 1083
Cdd:cd20431    18 SSEILQQLTAEINQRQ--LVPLTTK-PVPNLLCLAPFTDADmkkYYRAKILYVSGSsaEVFFVDYGNTSQVPSSLL 90

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 47.41 E-value: 9.24e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1519 PKAKLIKayatvidgpeyFWCQFADSEKLQY--LETEVQSAGKQLSdrrsctqCPQIGDPCIVRYREDGHYYRALITNIC 1596
Cdd:cd20436    11 PKEVLVK-----------FQGQYNSICELDYhiLQNEIQNATKSKS-------SWGVGEFCLVEDTTSGEWYRGRVLEKI 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238624160 1597 DgELASVRLVDFGNAEDcVDAKELWSIPSELLLVPMQAFPCCLAGFSVSGGVCPQEGNDYF 1657
Cdd:cd20436    73 D-EKYEVFLIDRGEVLN-VHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTAVNYF 131

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 46.68 E-value: 1.02e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  497 AQVEFVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKLDGVILrpEPDDLCCVKWKENG-YYRATVT-RLDSKSVDVF 574
Cdd:cd20425     4 VYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESL--QLGDLICAEYPEDGlWYRAVVKeKIPNNLVSVQ 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 238624160  575 LVDRGNSENVDWCDVRMLLPQFRQLPILALKCTL 608
Cdd:cd20425    82 FIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 47.03 E-value: 1.56e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  826 VCLAKRTASGRWSRALISgAHSLEHVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNlIQPMGEnpfVWDEK 905
Cdd:cd20436    52 FCLVEDTTSGEWYRGRVL-EKIDEKYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFAN-ILPIGE---KWSST 126

                          90
                  ....*....|.
gi 238624160  906 AVQAFSGFIDS 916
Cdd:cd20436   127 AVNYFSSLIGS 137

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 44.22 E-value: 1.66e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 238624160 1572 QIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNAEDC 1614
Cdd:cd20399     2 KVGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVT 44

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 46.35 E-value: 1.68e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  311 KPGSPCASCGLDGQWYRALLLETfrPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDCGRGWSRS 390
Cdd:cd20422    51 QPGQLCCAKWKEDRYYRAIVTAV--KGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPE 128


                  ....*.
gi 238624160  391 QVGDLK 396
Cdd:cd20422   129 AISAFK 134

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 46.72 E-value: 1.75e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1316 YVSHINDLSDFYIQLIEDEaeINNLSERLNDVRTRPQyHTG---PQWQSGDVICAVFPEDNLWYRALVMEQQPNgLLSVQ 1392
Cdd:cd20426     4 YATAVDSPEYFWCQFATEK--IQCLAVKVQEAGEQVA-DRGnfiPSIYVGDPCIVKYSEDNHWYRALVTKINDN-LVSVR 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 238624160 1393 FIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWG--LSVPVCK-EMVSYF 1441
Cdd:cd20426    80 FVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGfnLSEGLWSdEANDYF 131

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 44.19 E-value: 1.77e-05

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 238624160    817 PSPYEGDtrVCLAKRTaSGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDI 869
Cdd:smart00333    1 PTFKVGD--KVAARWE-DGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDL 50

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 45.96 E-value: 1.98e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  240 YFYPQ--LQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVyrapvgtddedsgsATWEEREESPDKPGSPCA 317
Cdd:cd20424     1 YYYSMhdIKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRL--------------SSEIRKLELSVNPGTLCL 66

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 238624160  318 SCGLDGQWYRALLLETFRPQrcaQVLHVDYGRKELV 353
Cdd:cd20424    67 AKYSDQHWYRGIIITNKNST---EVFFVDYGNTEKV 99

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 45.87 E-value: 1.99e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1533 GPEYFWCQFADSEK-LQYLETEVQSAGKQLSDRRSCTqCPQIGDPCIVRyREDGHYYRALITNICDGELASVRLVDFGNA 1611
Cdd:cd20437    14 SPSKFYCQLLSWEPeLSKLTTQMTLHYESVSKELNPS-CENFGLLCAAK-GKDGQWHRGFLQQLLPPSQVKVWFIDYGNS 91

                          90       100
                  ....*....|....*....|....*....
gi 238624160 1612 EdCVDAKELWSIPSELLLVPMQAFPCCLA 1640
Cdd:cd20437    92 E-AVSSHSVLKLPPDFFSLPLMSFPCSLS 119

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 43.87 E-value: 2.07e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 238624160 1574 GDPCIVRYREDGHYYRALITNIC-DGELASVRLVDFGNAED 1613
Cdd:cd20413     4 GDECLAKYWEDNKFYRAEVTAVHpSGKTAVVKFMEYGNYEE 44

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 44.60 E-value: 2.27e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 238624160  321 LDGQWYRALLlETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYF 366
Cdd:cd20433    40 EDGEWYRAKV-EKVEGDKKVHVLYIDYGNREVLPSTRLAALPPAFS 84

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 44.59 E-value: 2.82e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1552 TEVQSAGKQLSDRRSctqcPQIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNAEDcVDAKELWSIPSELLLVP 1631
Cdd:cd20412    14 TQYYESEENRHTLLT----VQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGY-VPLEDLRALRSDFLSLP 88


                  ....*.
gi 238624160 1632 MQAFPC 1637
Cdd:cd20412    89 FQAIEC 94

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 43.01 E-value: 3.08e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 238624160 1574 GDPCIVRYREDGHYYRALITNI-CDGELASVRLVDFGNAEDcVDAKELWSI 1623
Cdd:cd21182     1 GDKCLAPYSDDGKYYEATIEEItEESDTATVVFDGYGNSEE-VPLSDLKPL 50

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 44.71 E-value: 3.16e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 238624160  312 PGSPCASCGLDGQWYRALLL--ETFRPQRCAqVLHVDYGRKELVSCSSLRYLLPEYFRmpvvtYPCAL 377
Cdd:cd20418     6 PEMPCLAEYSDGKWYRAKLLsiLEFNPVKIL-VRHVDYGSTAALPTSRLRQIPAELMQ-----YPCQA 67

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 45.11 E-value: 3.90e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1529 TVIDGPEYFWCQF-ADSEKLQYLETEVQSAGKQLSDRRSCTQCPQIGDPCIVRyREDGHYYRALITN-ICDGELASVRLV 1606
Cdd:cd20421    18 TEVTDPHRIFCQLrSLSQELKRLSESMHQYYEGRVGSGYETRPEKLGSPCAAR-GSDGRWYRAVLQQvFSANRVVEVLHV 96

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 238624160 1607 DFGNAEdCVDAKELWSIPSELLLVPMQAFPCCLAG 1641
Cdd:cd20421    97 DYGRKE-VVSVSNLRYLAPEYFRMPVVTYPCALFG 130

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 43.83 E-value: 4.17e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 238624160 1571 PQIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNAEDcVDAKELWSIPSEL 1627
Cdd:cd20433    28 PRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREV-LPSTRLAALPPAF 83

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 44.21 E-value: 4.20e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 238624160 1050 TDGNWYRGIIIEKEPSK---VFFVDFG-NTYIAVDHLLPIprdAHDVLLLPMQALKCS 1103
Cdd:cd20412    41 HDGSWYRARVLGFLENGnldLYFVDYGdSGYVPLEDLRAL---RSDFLSLPFQAIECS 95

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 44.76 E-value: 4.33e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1006 FYCQLARNTNVLeqlsyNIM-QLSKalLNLKASTLAP-------GTLCLARYT-DGNWYRGIIIE---------KEPSKV 1067
Cdd:cd20443     4 FYVQVVSDQRLS-----SIQqQLEG--LSLKDKANPPggfnpkkGELVLAQFSaDNSWNRAMVVNaprqgtqspKDEYEV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 238624160 1068 FFVDFGNT-YIAVDHLLPIPrdaHDVLLLPMQALKCSLSDI 1107
Cdd:cd20443    77 FYIDYGNQeTVPLSALRPLD---PSVSSAPGLAQLCSLAHI 114

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 43.83 E-value: 4.47e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238624160  803 TLMCDIEDYCKSSEPS-----PYEGDtrVCLAKRTASGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDI 869
Cdd:cd20433     7 KLMEKLRFEIASNPPLpgsytPRKGD--LCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRL 76

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 43.60 E-value: 4.55e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  804 LMCDIEDYCK----SSEPSPYEGDtrVCLAKRTASGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDI 869
Cdd:cd20409     7 LQESLSAYCKvapaSSDFSPAVGE--VCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRL 74

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 43.43 E-value: 4.82e-05

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 238624160 1367 AVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVV 1402
Cdd:cd20430    27 GKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETV 62

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 44.36 E-value: 6.00e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1316 YVSHINDLSDFYIQLIEDEAeinnlSERLNDVRTRPQ-YHTGPQ-----------WQSGDVICAVFPEDNLWYRALVMEQ 1383
Cdd:cd20419     1 FVEYIESPSQFYVRFYSKDT-----SEMLEDMMIEMRrCYSNEHvseryvmpeafIQPGQVCCVRIPEDVWWYRVIIHQV 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 238624160 1384 QPNGLLSVQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSL 1426
Cdd:cd20419    76 LNKQEVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 43.96 E-value: 6.07e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  801 FRTLMCDIED-YCKSSEPS-----PYEGdtRVCLAKRTaSGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDILSVSD 874
Cdd:cd20415     1 FLILTKKIQEfYKEGDDGGleilcPVQG--QACVALFE-DGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKD 77

                          90
                  ....*....|....
gi 238624160  875 VFFQVRAQAFRCSL 888
Cdd:cd20415    78 DFLSLPEKARECRL 91

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 43.24 E-value: 6.15e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238624160 1365 IC-AVFPEDNLWYRALVME-QQPNGLLSVQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWGLSVPV 1433
Cdd:cd20423     8 VClAKYSEDGKWCRALIDNvYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPS 78

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 44.80 E-value: 7.32e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  314 SPCASCG--------LDGQWYRALLLETfrpqrCAQVL---HVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGlWD 382
Cdd:cd20426    44 IPSIYVGdpcivkysEDNHWYRALVTKI-----NDNLVsvrFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSG-FN 117

                          90
                  ....*....|....*...
gi 238624160  383 CGRG-WSRSQVGDLKALI 399
Cdd:cd20426   118 LSEGlWSDEANDYFYEIV 135

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 43.59 E-value: 1.07e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1340 LSERLNDVRTRPQYHTGPqwqsGDVICAVFPEDNLWYRALVMEQQPNGlLSVQFIDYGNMSVVHTNRTGRLGPVDAVLPA 1419
Cdd:cd20411    33 LAEYCSKQSVPQQFRPRI----GDACCARFTGDKNWYRAVVLETSDSE-VKVLYADYGNTETLPLSRILPITKSHLELPF 107


                  ....*....
gi 238624160 1420 LCLHCSLWG 1428
Cdd:cd20411   108 QIIRCSLAG 116

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 44.64 E-value: 1.17e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 238624160  549 CCVKWKENG-YYRATVTRL--DSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLadIWP 613
Cdd:cd20442    56 CLAKSKKNLkWYRAVVEHLypETEKMLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLCRW--NWP 121

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 43.78 E-value: 1.23e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1559 KQLSDRRSCTQcPQIGDPCIVRYREDGhYYRALITNI--CDGE----LASVRLVDFGNAEDcVDAKELWSIPSELLLVPM 1632
Cdd:cd20435    39 SDPSNRILHGK-VKVGDLCAVEDENNL-YHRVKVLEIteKDDKtkprEVLVKFIDEGRVET-VVVSQLLELPEELKSLPP 115

                          90
                  ....*....|.
gi 238624160 1633 QA---FPCCLA 1640
Cdd:cd20435   116 QAvevFLCNVK 126

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 41.56 E-value: 1.45e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 238624160  542 RPEPDDLCCVKWKENG-YYRATVTR-LDSKSVDVFLVDRGNSENVDWCDVRMLLPQF 596
Cdd:cd20410     2 KPIVGEPCCAFFSGDGnWYRAMVKEiLPGGAVKVHFVDYGNVEEVTLDKLRKITSTF 58

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 43.21 E-value: 1.57e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  777 VEVKVSHIENPGSFWCQLMR------------NAQGFRTLMCDiedyckssEPSPYEGDTrVClAKRTASGRWSRALISG 844
Cdd:cd20425     2 TEVYVSHVNSPSDFYVQLAQdedelsmiseklNASKANDEEVE--------CESLQLGDL-IC-AEYPEDGLWYRAVVKE 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 238624160  845 AHSLEHVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSL 888
Cdd:cd20425    72 KIPNNLVSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 41.17 E-value: 1.67e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 238624160  311 KPGSPCasCGL---DGQWYRALLLETFRPQrCAQVLHVDYGRKELVSCSSLRYLLPEY 365
Cdd:cd20410     4 IVGEPC--CAFfsgDGNWYRAMVKEILPGG-AVKVHFVDYGNVEEVTLDKLRKITSTF 58

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 41.14 E-value: 2.00e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 238624160 1571 PQIGDPCIVRYreDGHYYRALITNICDGELA-SVRLVDFGNAEdCVDAKELWSIPSEL 1627
Cdd:cd20444     1 PTPGQMVIAKF--DGNHYRAIVLRVLNPDLKiLVRFVDFGNVE-VMKLENLYECPEYL 55

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 41.29 E-value: 2.84e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 238624160 1570 CPQIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNAEDcVDAKELWSIPSELL 1628
Cdd:cd20409    25 SPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEE-VALSRLRPIPPSLL 82

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 41.31 E-value: 2.89e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238624160  545 PDDLCCVKWKENG-YYRATVTRLDS--KSVDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLADIWP 613
Cdd:cd20423     5 PNPVCLAKYSEDGkWCRALIDNVYEpvEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQ 76

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 42.44 E-value: 3.42e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1527 YATVIDGPEYFWCQFA---DSEKLQYLETEVQS--AGKQLSDR-RSCTQCPQIGDPCIVRYREDGHYYRALITNICDGEL 1600
Cdd:cd20419     1 FVEYIESPSQFYVRFYskdTSEMLEDMMIEMRRcySNEHVSERyVMPEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQE 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 238624160 1601 ASVRLVDFGNAEdCVDAKELWSIPSELLLVPMQAFPCCL 1639
Cdd:cd20419    81 VEVFYPDFGDIG-TVQKSRLRFLKCCYSKLPAQAIPASL 118

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 43.10 E-value: 3.47e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  769 GELEVGSTVEVkvshIENpGSFWCQLMRNAQGFRTLMCDIEDYCKSSEPSPYEGDTR--VCLAKRTASGRWSRALISGAH 846
Cdd:cd20442     1 GQIEKGTLLSV----SKN-GTFYVRLLRNSEQLTDLESLIAKEAKKCKFVPVEDIKEglECLAKSKKNLKWYRAVVEHLY 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 238624160  847 SL-EHVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRC 886
Cdd:cd20442    76 PEtEKMLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 41.96 E-value: 4.34e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238624160    69 PGELCLVQVGLMWHRCRV-VSRQAQDSRVFLLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAG 133
Cdd:pfam00567   52 DGCVAAFSEDGKWYRAKItESLDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 40.02 E-value: 4.49e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 238624160 1359 WQSGDVICAVFPEDNLWYRALVMEQQPNGLLS-VQFIDYGN 1398
Cdd:cd20413     1 WKPGDECLAKYWEDNKFYRAEVTAVHPSGKTAvVKFMEYGN 41

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 42.72 E-value: 4.97e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1005 TFYCQLARNTNVLEQLSYNIMQLSKALLNLKASTLAPGTLCLARYTDGN-WYRGIIIEKEPSK----VFFVDFGNTyiAV 1079
Cdd:cd20442    16 TFYVRLLRNSEQLTDLESLIAKEAKKCKFVPVEDIKEGLECLAKSKKNLkWYRAVVEHLYPETekmlVFFVDHGIT--EV 93

                          90       100       110
                  ....*....|....*....|....*....|..
gi 238624160 1080 DHLLPIPRDAHDVLLLPMQALKCSLSDIPHHI 1111
Cdd:cd20442    94 VSMGNIKQLSNDLLQIPRQAVLCRWNWPESSK 125

first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the first/N-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410505 Cd Length: 164 Bit Score: 42.80 E-value: 5.02e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  502 VKSPSEFWIRLRK-------HKNTFSKLTKRMCSFYSSaSKLDGVILRP---EPDDLCCVKWKE-NGYYRATVTRL---- 566
Cdd:cd20434     6 IEDPGCFWGRILKgsgdlvvNPEEYENLQDEMNQFYHK-GYKDVEEIKPstlEEGQVCVVFCEElKCWCRAVVESLmssa 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 238624160  567 DSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLADIWPL---------------GKTWSQEATSFFKKTV 630
Cdd:cd20434    85 DDYLAECFLVDYAKYIPVKSKDIRVALEAFMKLPYRAKKFRLYGIKPVtlhvdlcedkakivpARKWDSAAIQYFQNLL 163

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 39.56 E-value: 5.92e-04

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 238624160    311 KPGSPCASCGLDGQWYRALLLETFRPQRCaQVLHVDYGRKELVSCSSLRyLLPE 364
Cdd:smart00333    4 KVGDKVAARWEDGEWYRARIVKVDGEQLY-EVFFIDYGNEEVVPPSDLR-QLPE 55

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 40.87 E-value: 1.32e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1314 SVYVSHINDLSDFYIQLIEDEAEINNLSERLNDV---RTRPQYHTGPQwQSGDViCAVFPEDNLWYRALVMEQ-QPNGLL 1389
Cdd:cd20421    14 TVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYyegRVGSGYETRPE-KLGSP-CAARGSDGRWYRAVLQQVfSANRVV 91

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 238624160 1390 SVQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWG 1428
Cdd:cd20421    92 EVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 39.36 E-value: 1.35e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238624160 1018 EQLSYNIMQLSKALLNLKASTL---APGTLCLARYTDGN-WYRGIIIEKEPSK---VFFVDFGNT-YIAVDHLLPIP 1086
Cdd:cd20409     2 RQLAELQESLSAYCKVAPASSDfspAVGEVCCAQFTEDNqWYRASVLAYSSEDsvlVGYIDFGNSeEVALSRLRPIP 78

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 38.44 E-value: 1.44e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 238624160 1359 WQSGDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVHTN 1405
Cdd:cd20399     1 WKVGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLS 47

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 39.11 E-value: 1.67e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238624160  540 ILRPEPDDLCCVKWKENGYYRATVTRL--DSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTLADIWP 613
Cdd:cd20407     1 LPEPIEVGVICAAPVMNAWYRAQVVGVfeETDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the first/N-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410505 Cd Length: 164 Bit Score: 41.25 E-value: 1.81e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  779 VKVSHIENPGSFWC-------QLMRNAQGFRTLMCDIED----YCKSSE---PSPYEgDTRVCLAKRTASGRWSRALI-S 843
Cdd:cd20434     1 IQVLKIEDPGCFWGrilkgsgDLVVNPEEYENLQDEMNQfyhkGYKDVEeikPSTLE-EGQVCVVFCEELKCWCRAVVeS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 238624160  844 GAHSLEHVRV--VFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNlIQPM 895
Cdd:cd20434    80 LMSSADDYLAecFLVDYAKYIPVKSKDIRVALEAFMKLPYRAKKFRLYG-IKPV 132

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 40.51 E-value: 1.91e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 238624160  552 KWkengyYRATVTRL-DSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQ----LPILALKCTLADIWPLGKTWSQEA 622
Cdd:cd20428    65 KW-----ARVEITNVhSSRALDVHFLDTGTVASVKVSELREIPPPFLRelisIPPQALKCCLADLPLNIGMWTPDA 135

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 37.88 E-value: 2.32e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 238624160   69 PGELCLVQVGL--MWHRCRVVSRQAQDS-RVFLLDEGRTIT 106
Cdd:cd20379     1 VGDLCAAKYEEdgKWYRARVLEVLSNDKvEVFFVDYGNTET 41

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 38.82 E-value: 3.49e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  803 TLMCDIEDYCKSSEPSPyeGDTRVCLAKRTAS-----GRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDILSVSDVFF 877
Cdd:cd20412     8 KLVQEMTQYYESEENRH--TLLTVQVGDIVAApfrhdGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSDFL 85

                          90
                  ....*....|
gi 238624160  878 QVRAQAFRCS 887
Cdd:cd20412    86 SLPFQAIECS 95

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 39.35 E-value: 4.02e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160  781 VSHIENPGSFWCQLMRN--AQGFRTLMCDIEDyCKSSE--------PSPYEGDTRVCLAKRTASGRWSRALISGAHSLEH 850
Cdd:cd20419     2 VEYIESPSQFYVRFYSKdtSEMLEDMMIEMRR-CYSNEhvseryvmPEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQE 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 238624160  851 VRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSL 888
Cdd:cd20419    81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 38.05 E-value: 4.20e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 238624160  547 DLCCVKWKENG-YYRATVTRLDS-KSVDVFLVDRGNSENVDWCDVRMLLPQF 596
Cdd:cd20433    32 DLCAAKFVEDGeWYRAKVEKVEGdKKVHVLYIDYGNREVLPSTRLAALPPAF 83

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 38.21 E-value: 4.41e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 238624160  311 KPGSPCasCGL---DGQWYRALLLeTFRPQRCAQVLHVDYGRKELVSCSSLRYLLPE 364
Cdd:cd20409    27 AVGEVC--CAQfteDNQWYRASVL-AYSSEDSVLVGYIDFGNSEEVALSRLRPIPPS 80

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 39.38 E-value: 4.71e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238624160  316 CASCGLDGQWYRALLLETFRPQrcAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCAL 377
Cdd:cd20438    62 CARYSKDRHYYRAVITEVLDLK--VSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSL 121

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 39.33 E-value: 5.66e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160 1003 PWTFYCQLARNTNVLEQLSYNIMQLSKALLNLKASTLAPGTLCLARYT-DGNWYRGIIIEKEPSK--VFFVDFGNTYIAv 1079
Cdd:cd20436    11 PKEVLVKFQGQYNSICELDYHILQNEIQNATKSKSSWGVGEFCLVEDTtSGEWYRGRVLEKIDEKyeVFLIDRGEVLNV- 89

                          90       100
                  ....*....|....*....|....*...
gi 238624160 1080 dHLLPIPRDAHDVLLLPMQALKCSLSDI 1107
Cdd:cd20436    90 -HATNMASASGELFQLPPKAVCGIFANI 116

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 37.57 E-value: 5.82e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238624160 1041 PGTLCLArYTDGNWYRGIIIE--KEPSKVF--FVDFGNTY-IAVDHLLPIpRdaHDVLLLPMQALKCSLSDI 1107
Cdd:cd20407     7 VGVICAA-PVMNAWYRAQVVGvfEETDEVEikYLDYGGYErVPVDDLRQI-R--SDFMTLPFQATECYLANI 74

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 36.94 E-value: 6.45e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 238624160  825 RVCLAKRTASGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDILSVSDVF 876
Cdd:cd20410     7 EPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTF 58

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 38.58 E-value: 7.59e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 238624160  316 CASCGLDGQWYRALLLETFRPQRcAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCAL 377
Cdd:cd20419    58 CVRIPEDVWWYRVIIHQVLNKQE-VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 37.19 E-value: 7.66e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238624160   69 PGELCLVQVGLMWHRCRVVSRQAQDSRVF--LLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAGLVP 136
Cdd:cd20407     7 VGVICAAPVMNAWYRAQVVGVFEETDEVEikYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76