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Conserved domains on  [gi|168480115|ref|NP_941008|]
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DDB1- and CUL4-associated factor 13 isoform 1 [Mus musculus]

Protein Classification

WD repeat DCAF13/WDSOF1 family protein( domain architecture ID 10078020)

WD repeat DCAF13/WDSOF1 family protein may play a role in ribosomal RNA processing

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sof1 pfam04158
Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA ...
 354-440 4.44e-49

Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA processing machinery.


:

Pssm-ID: 427753  Cd Length: 87  Bit Score: 161.89  E-value: 4.44e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115  354 ANASEKLGVLTSREKAANDYNQKLKEKFQYHPHVKRIARHRHLPKSIYSQIQEQRVMKEARRRKEMNRRKHSKPGSVPIV 433
Cdd:pfam04158   1 ANASEKLGVLSPRERAALEYNEALKEKYKHMPEIRRIARHRHVPKAIYKAQKIKREMLEARKRKEENRRKHSKPGSVPRK 80


                  ....*..
gi 168480115  434 SERKKHV 440
Cdd:pfam04158  81 PERKKHV 87
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-353 1.08e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.01  E-value: 1.08e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115  59 LASLDGHRDGVNCLAKHPKSlASVLSGACDGEVKIWNLTKRKCIRTIQAHEGFVRGmCTRFC-GTSFFTVGDDKTVKQWK 137
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD-VAASAdGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 138 MDGPgygeeeEPLYTVLG--KTVYTgIDHHWKDPVFATCGQQVDIWDEQRTSPVCSMNWGF--DSISSVKFNPVETFLLG 213
Cdd:cd00200   80 LETG------ECVRTLTGhtSYVSS-VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhtDWVNSVAFSPDGTFVAS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 214 SCaSDRNIVLYDMRQATPLKKviLEMRT---NTICWNPMEAfNFTAANEDYNLYTFDMRALDTpVMVHMDHVSAVLDVDY 290
Cdd:cd00200  153 SS-QDGTIKLWDLRTGKCVAT--LTGHTgevNSVAFSPDGE-KLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAF 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 168480115 291 SPTGKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVMCVKWTSDSKYIMCGSDEMNIRLWK 353
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLsgHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
Sof1 pfam04158
Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA ...
 354-440 4.44e-49

Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA processing machinery.


Pssm-ID: 427753  Cd Length: 87  Bit Score: 161.89  E-value: 4.44e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115  354 ANASEKLGVLTSREKAANDYNQKLKEKFQYHPHVKRIARHRHLPKSIYSQIQEQRVMKEARRRKEMNRRKHSKPGSVPIV 433
Cdd:pfam04158   1 ANASEKLGVLSPRERAALEYNEALKEKYKHMPEIRRIARHRHVPKAIYKAQKIKREMLEARKRKEENRRKHSKPGSVPRK 80


                  ....*..
gi 168480115  434 SERKKHV 440
Cdd:pfam04158  81 PERKKHV 87
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-353 1.08e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.01  E-value: 1.08e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115  59 LASLDGHRDGVNCLAKHPKSlASVLSGACDGEVKIWNLTKRKCIRTIQAHEGFVRGmCTRFC-GTSFFTVGDDKTVKQWK 137
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD-VAASAdGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 138 MDGPgygeeeEPLYTVLG--KTVYTgIDHHWKDPVFATCGQQVDIWDEQRTSPVCSMNWGF--DSISSVKFNPVETFLLG 213
Cdd:cd00200   80 LETG------ECVRTLTGhtSYVSS-VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhtDWVNSVAFSPDGTFVAS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 214 SCaSDRNIVLYDMRQATPLKKviLEMRT---NTICWNPMEAfNFTAANEDYNLYTFDMRALDTpVMVHMDHVSAVLDVDY 290
Cdd:cd00200  153 SS-QDGTIKLWDLRTGKCVAT--LTGHTgevNSVAFSPDGE-KLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAF 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 168480115 291 SPTGKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVMCVKWTSDSKYIMCGSDEMNIRLWK 353
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLsgHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
42-355 1.88e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 1.88e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115  42 VRALNATKLERVFAKPFLASLDGHRDGVNCLAKHP--KSLASvlsGACDGEVKIWNLTKRKCIRTIQAHEGFVRGMctRF 119
Cdd:COG2319   96 ASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPdgKTLAS---GSADGTVRLWDLATGKLLRTLTGHSGAVTSV--AF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 120 C--GTSFFTVGDDKTVKQWKMDGpgygeeeeplytvlGKTVYTGIDHhwKDPVF-----------ATCG--QQVDIWDEQ 184
Cdd:COG2319  171 SpdGKLLASGSDDGTVRLWDLAT--------------GKLLRTLTGH--TGAVRsvafspdgkllASGSadGTVRLWDLA 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 185 RTSPVCSMNWGFDSISSVKFNPVETFLLgSCASDRNIVLYDMRQATPLKkvILEMRT---NTICWNPMEAFnFTAANEDY 261
Cdd:COG2319  235 TGKLLRTLTGHSGSVRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLR--TLTGHSggvNSVAFSPDGKL-LASGSDDG 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 262 NLYTFDMrALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVMCVKWTSDSKY 339
Cdd:COG2319  311 TVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLtgHTGA---VTSVAFSPDGRT 386

                        330
                 ....*....|....*.
gi 168480115 340 IMCGSDEMNIRLWKAN 355
Cdd:COG2319  387 LASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 273-309 1.94e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.94e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 168480115   273 TPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIF 309
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
58-95 7.41e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 7.41e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 168480115   58 FLASLDGHRDGVNCLAKHPKSlASVLSGACDGEVKIWN 95
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 59-134 8.83e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 38.34  E-value: 8.83e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 168480115  59 LASLDGHRDGVNCLAKHPKSLASVLSGACDGEVKIWNLTKRKCIRTIQAHEGFVRGMCTRFCGTSFFTVGDDKTVK 134
Cdd:PTZ00421 118 IVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLN 193
 
Name Accession Description Interval E-value
Sof1 pfam04158
Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA ...
 354-440 4.44e-49

Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA processing machinery.


Pssm-ID: 427753  Cd Length: 87  Bit Score: 161.89  E-value: 4.44e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115  354 ANASEKLGVLTSREKAANDYNQKLKEKFQYHPHVKRIARHRHLPKSIYSQIQEQRVMKEARRRKEMNRRKHSKPGSVPIV 433
Cdd:pfam04158   1 ANASEKLGVLSPRERAALEYNEALKEKYKHMPEIRRIARHRHVPKAIYKAQKIKREMLEARKRKEENRRKHSKPGSVPRK 80


                  ....*..
gi 168480115  434 SERKKHV 440
Cdd:pfam04158  81 PERKKHV 87
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-353 1.08e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.01  E-value: 1.08e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115  59 LASLDGHRDGVNCLAKHPKSlASVLSGACDGEVKIWNLTKRKCIRTIQAHEGFVRGmCTRFC-GTSFFTVGDDKTVKQWK 137
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD-VAASAdGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 138 MDGPgygeeeEPLYTVLG--KTVYTgIDHHWKDPVFATCGQQVDIWDEQRTSPVCSMNWGF--DSISSVKFNPVETFLLG 213
Cdd:cd00200   80 LETG------ECVRTLTGhtSYVSS-VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhtDWVNSVAFSPDGTFVAS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 214 SCaSDRNIVLYDMRQATPLKKviLEMRT---NTICWNPMEAfNFTAANEDYNLYTFDMRALDTpVMVHMDHVSAVLDVDY 290
Cdd:cd00200  153 SS-QDGTIKLWDLRTGKCVAT--LTGHTgevNSVAFSPDGE-KLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGVNSVAF 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 168480115 291 SPTGKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVMCVKWTSDSKYIMCGSDEMNIRLWK 353
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLsgHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
42-355 1.88e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 1.88e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115  42 VRALNATKLERVFAKPFLASLDGHRDGVNCLAKHP--KSLASvlsGACDGEVKIWNLTKRKCIRTIQAHEGFVRGMctRF 119
Cdd:COG2319   96 ASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPdgKTLAS---GSADGTVRLWDLATGKLLRTLTGHSGAVTSV--AF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 120 C--GTSFFTVGDDKTVKQWKMDGpgygeeeeplytvlGKTVYTGIDHhwKDPVF-----------ATCG--QQVDIWDEQ 184
Cdd:COG2319  171 SpdGKLLASGSDDGTVRLWDLAT--------------GKLLRTLTGH--TGAVRsvafspdgkllASGSadGTVRLWDLA 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 185 RTSPVCSMNWGFDSISSVKFNPVETFLLgSCASDRNIVLYDMRQATPLKkvILEMRT---NTICWNPMEAFnFTAANEDY 261
Cdd:COG2319  235 TGKLLRTLTGHSGSVRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLR--TLTGHSggvNSVAFSPDGKL-LASGSDDG 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 262 NLYTFDMrALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVMCVKWTSDSKY 339
Cdd:COG2319  311 TVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLtgHTGA---VTSVAFSPDGRT 386

                        330
                 ....*....|....*.
gi 168480115 340 IMCGSDEMNIRLWKAN 355
Cdd:COG2319  387 LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 101-364 1.82e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.41  E-value: 1.82e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 101 CIRTIQAHEGFVRGMCTRFCGTSFFTVGDDKTVKQWKMdgpgygEEEEPLYTVLGKT--VYTGIDHHWkDPVFATCG--Q 176
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL------ETGELLRTLKGHTgpVRDVAASAD-GTYLASGSsdK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 177 QVDIWDEQRTSPVCSMNWGFDSISSVKFNPVETFLLgSCASDRNIVLYDMRQATpLKKVIL--EMRTNTICWNPMEAFNF 254
Cdd:cd00200   74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILS-SSSRDKTIKVWDVETGK-CLTTLRghTDWVNSVAFSPDGTFVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 255 TAANEDYnLYTFDMRALdTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVMCVK 332
Cdd:cd00200  152 SSSQDGT-IKLWDLRTG-KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrgHENG---VNSVA 226

                        250       260       270
                 ....*....|....*....|....*....|..
gi 168480115 333 WTSDSKYIMCGSDEMNIRLWKANASEKLGVLT 364
Cdd:cd00200  227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
WD40 COG2319
WD40 repeat [General function prediction only];
43-364 5.16e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 5.16e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115  43 RALNATKLERVFAKPFLASLDGHRDGVNCLAKHPkSLASVLSGACDGEVKIWNLTKRKCIRTIQAHEGFVRGMCTRFCGT 122
Cdd:COG2319   55 AGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGK 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 123 SFFTVGDDKTVKQWKMDGpgyGEEEEPL-------YTVL----GKTVYTGIDhhwkdpvfatcGQQVDIWDEQRTSPVCS 191
Cdd:COG2319  134 TLASGSADGTVRLWDLAT---GKLLRTLtghsgavTSVAfspdGKLLASGSD-----------DGTVRLWDLATGKLLRT 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 192 MNWGFDSISSVKFNPVETFLLgSCASDRNIVLYDMRQATPLKkvILEMRTNTIcwnpmEAFNFT-------AANEDYNLY 264
Cdd:COG2319  200 LTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLR--TLTGHSGSV-----RSVAFSpdgrllaSGSADGTVR 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 265 TFDmraLDTPVMVHM--DHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVMCVKWTSDSKYI 340
Cdd:COG2319  272 LWD---LATGELLRTltGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtgHTGA---VRSVAFSPDGKTL 345

                        330       340
                 ....*....|....*....|....
gi 168480115 341 MCGSDEMNIRLWKANASEKLGVLT 364
Cdd:COG2319  346 ASGSDDGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
42-364 4.04e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 4.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115  42 VRALNATKLERVFAKPFLASLDGHRDGVNCLAKHPKSLASVLSGAcDGEVKIWNLTKRKCIRTIQAHEGFVRGMCTRFCG 121
Cdd:COG2319   12 ASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAG-DLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 122 TSFFTVGDDKTVKQWKMDGPG----YGEEEEPLYTVL----GKTVYTGIDHHwkdpvfatcgqQVDIWDEQRTSPVCSMN 193
Cdd:COG2319   91 RLLASASADGTVRLWDLATGLllrtLTGHTGAVRSVAfspdGKTLASGSADG-----------TVRLWDLATGKLLRTLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 194 WGFDSISSVKFNPVETFLLgSCASDRNIVLYDMRQATPLKkvILEMRTNTIcwnpmEAFNFT-------AANEDYNLYTF 266
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLA-SGSDDGTVRLWDLATGKLLR--TLTGHTGAV-----RSVAFSpdgkllaSGSADGTVRLW 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 267 DMRAlDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVMCVKWTSDSKYIMCGS 344
Cdd:COG2319  232 DLAT-GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLtgHSGG---VNSVAFSPDGKLLASGS 307

                        330       340
                 ....*....|....*....|
gi 168480115 345 DEMNIRLWKANASEKLGVLT 364
Cdd:COG2319  308 DDGTVRLWDLATGKLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
59-140 6.82e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 6.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115  59 LASLDGHRDGVNCLAKHP--KSLASvlsGACDGEVKIWNLTKRKCIRTIQAHEGFVRGMCTRFCGTSFFTVGDDKTVKQW 136
Cdd:COG2319  323 LRTLTGHTGAVRSVAFSPdgKTLAS---GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399


                 ....
gi 168480115 137 KMDG 140
Cdd:COG2319  400 DLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 281-372 2.40e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.20  E-value: 2.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 281 HVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVMCVKWTSDSKYIMCGSDEMNIRLWKANASE 358
Cdd:cd00200   50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLtgHTSY---VSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126

                         90
                 ....*....|....
gi 168480115 359 KLGVLTSREKAAND 372
Cdd:cd00200  127 CLTTLRGHTDWVNS 140
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 273-309 1.94e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.94e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 168480115   273 TPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIF 309
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
199-376 5.88e-05

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 45.41  E-value: 5.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 199 ISSVKFNPVETFLLGSCASDRNIVLYDMRQatplkkvilemrtNTICWNPMEAFNFTAANEDYNLYTfdmraldtpvmvh 278
Cdd:COG5170  224 ITSAEFHPEMCNVFMYSSSKGEIKLNDLRQ-------------SALCDNSKKLFELTIDGVDVDFFE------------- 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168480115 279 mDHVSAVLDVDYSPTGKEFVSASFD--------------KSIRIFPVDKSRSREVYHTKRMQHVMCVKWTSDSKYIMCGS 344
Cdd:COG5170  278 -EIVSSISDFKFSDNGRYILSRDYLtvkiwdvnmaknpiKTIPMHCDLMDELNDVYENDAIFDKFEISFSGDDKHVLSGS 356

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 168480115 345 DEMNIRLWKANAS---EKLGVLTSREKAANDYNQK 376
Cdd:COG5170  357 YSNNFGIYPTDSSgfkDVGHVVNLADGSAEDFKVK 391
WD40 pfam00400
WD domain, G-beta repeat;
58-95 7.41e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 7.41e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 168480115   58 FLASLDGHRDGVNCLAKHPKSlASVLSGACDGEVKIWN 95
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-137 3.13e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.13e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 168480115    98 KRKCIRTIQAHEGFVRGMCTRFCGTSFFTVGDDKTVKQWK 137
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 59-95 3.32e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.32e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 168480115    59 LASLDGHRDGVNCLAKHPKSLaSVLSGACDGEVKIWN 95
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-136 3.44e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.44e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 168480115   99 RKCIRTIQAHEGFVRGMCTRFCGTSFFTVGDDKTVKQW 136
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
273-309 4.14e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.14e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 168480115  273 TPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIF 309
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 59-134 8.83e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 38.34  E-value: 8.83e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 168480115  59 LASLDGHRDGVNCLAKHPKSLASVLSGACDGEVKIWNLTKRKCIRTIQAHEGFVRGMCTRFCGTSFFTVGDDKTVK 134
Cdd:PTZ00421 118 IVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLN 193
WD40 pfam00400
WD domain, G-beta repeat;
321-352 9.40e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 9.40e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 168480115  321 HTKRmqhVMCVKWTSDSKYIMCGSDEMNIRLW 352
Cdd:pfam00400  10 HTGS---VTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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