NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|613410249|ref|NP_941960|]
View 

keratin-associated protein 10-4 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 202-376 8.20e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 60.19  E-value: 8.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249  202 SSCTPSCCQQSSCQPACCTSSSCQQACCVPVCCKTVCCKPVCSedsssccqqsscqpACCTSSPCQQACCVPVCCKPVCC 281
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQ--------------PCCQTSCCQPTCCQTSSCQTGCG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249  282 KPVCSVPICSGASSlcCQQSSCQPACCTSSQSQQGCCVPVCCKPVSCVPVCSGAsssccqqsscqpaccttSCCRPSSSV 361
Cdd:pfam01500  84 GIGYGQEGSSGAVS--SRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQA-----------------SCCRPSYCG 144

                         170
                  ....*....|....*
gi 613410249  362 SLLCRPVCRPACCVP 376
Cdd:pfam01500 145 QSCCRPACCCQCSEP 159
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 32-165 1.82e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 56.34  E-value: 1.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249   32 CPESCCEPPCCAPSCCAPAPCLSLVCTPVSRVSSpCCPVTCEPSpCQSGCtssCTPSCCQQSSCQLACCASSPCQQACCV 111
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSS-CCRPTCQPC-CQTSC---CQPTCCQTSSCQTGCGGIGYGQEGSSG 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 613410249  112 PVCCKTVCCKPVCCVPVCCGDSSCCQQSSCQSACCT----SSPCQQACCVPICCKPVC 165
Cdd:pfam01500  95 AVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLhhaqASCCRPSYCGQSCCRPAC 152
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 202-376 8.20e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 60.19  E-value: 8.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249  202 SSCTPSCCQQSSCQPACCTSSSCQQACCVPVCCKTVCCKPVCSedsssccqqsscqpACCTSSPCQQACCVPVCCKPVCC 281
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQ--------------PCCQTSCCQPTCCQTSSCQTGCG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249  282 KPVCSVPICSGASSlcCQQSSCQPACCTSSQSQQGCCVPVCCKPVSCVPVCSGAsssccqqsscqpaccttSCCRPSSSV 361
Cdd:pfam01500  84 GIGYGQEGSSGAVS--SRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQA-----------------SCCRPSYCG 144

                         170
                  ....*....|....*
gi 613410249  362 SLLCRPVCRPACCVP 376
Cdd:pfam01500 145 QSCCRPACCCQCSEP 159
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 32-165 1.82e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 56.34  E-value: 1.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249   32 CPESCCEPPCCAPSCCAPAPCLSLVCTPVSRVSSpCCPVTCEPSpCQSGCtssCTPSCCQQSSCQLACCASSPCQQACCV 111
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSS-CCRPTCQPC-CQTSC---CQPTCCQTSSCQTGCGGIGYGQEGSSG 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 613410249  112 PVCCKTVCCKPVCCVPVCCGDSSCCQQSSCQSACCT----SSPCQQACCVPICCKPVC 165
Cdd:pfam01500  95 AVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLhhaqASCCRPSYCGQSCCRPAC 152
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 202-376 8.20e-11

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 60.19  E-value: 8.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249  202 SSCTPSCCQQSSCQPACCTSSSCQQACCVPVCCKTVCCKPVCSedsssccqqsscqpACCTSSPCQQACCVPVCCKPVCC 281
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQ--------------PCCQTSCCQPTCCQTSSCQTGCG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249  282 KPVCSVPICSGASSlcCQQSSCQPACCTSSQSQQGCCVPVCCKPVSCVPVCSGAsssccqqsscqpaccttSCCRPSSSV 361
Cdd:pfam01500  84 GIGYGQEGSSGAVS--SRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQA-----------------SCCRPSYCG 144

                         170
                  ....*....|....*
gi 613410249  362 SLLCRPVCRPACCVP 376
Cdd:pfam01500 145 QSCCRPACCCQCSEP 159
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 32-165 1.82e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 56.34  E-value: 1.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249   32 CPESCCEPPCCAPSCCAPAPCLSLVCTPVSRVSSpCCPVTCEPSpCQSGCtssCTPSCCQQSSCQLACCASSPCQQACCV 111
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSS-CCRPTCQPC-CQTSC---CQPTCCQTSSCQTGCGGIGYGQEGSSG 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 613410249  112 PVCCKTVCCKPVCCVPVCCGDSSCCQQSSCQSACCT----SSPCQQACCVPICCKPVC 165
Cdd:pfam01500  95 AVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLhhaqASCCRPSYCGQSCCRPAC 152
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 258-399 3.09e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 55.57  E-value: 3.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249  258 PACCTSSPCQQACCVPVCCKPVCCKPVCSVPICSgaSSLCCQQSSCQPACCTSSQSQqgCCVPVCCKPVSCVPVCSGASS 337
Cdd:pfam01500  12 PTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCC--QPTTFQSSCCRPTCQPCCQTS--CCQPTCCQTSSCQTGCGGIGY 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 613410249  338 SCCQQSSCQPacCTTSCCRPSSSVSLLCRPVCRPACCVPvPSCCAPTSScQPSCCRPASCVS 399
Cdd:pfam01500  88 GQEGSSGAVS--SRTRWCRPDCRVEGTCLPPCCVVSCTP-PTCCQLHHA-QASCCRPSYCGQ 145
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 207-387 3.50e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 55.57  E-value: 3.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249  207 SCCQQSSCQ-PACCTSSSCQQACCVPVCCKTVCCKPVCSEdsssccqqsscqPACCTSSPCQQACCVPVC---CKPVCCK 282
Cdd:pfam01500   2 ACCGTSFCGfPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQ------------TSCCQPTTFQSSCCRPTCqpcCQTSCCQ 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249  283 PVCSVPICSGASslCCQQSSCQPACCTSSQSQQGCCVPVCCKPVSCVPVCsgasssccqqssCQPACCTTSCCRPSSSVS 362
Cdd:pfam01500  70 PTCCQTSSCQTG--CGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPC------------CVVSCTPPTCCQLHHAQA 135

                         170       180
                  ....*....|....*....|....*.
gi 613410249  363 LLCRPV-CRPACCVPVPSCCAPTSSC 387
Cdd:pfam01500 136 SCCRPSyCGQSCCRPACCCQCSEPTC 161
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 45-243 7.60e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 54.41  E-value: 7.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249   45 SCCAPAPCLSLVCTPVSRVSSPCCPVTCEPSPCqsgctssCTPSCCQQSSCQLACCASSPCQQACcvPVCCKTVCCKPVC 124
Cdd:pfam01500   2 ACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSC-------CRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTC 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249  125 CVPVCCGDSSCCQQSSCQSACCTSSP----CQQACCVPICCKPVCSgisssccqqsscvscvsspccqavcepspcqsgC 200
Cdd:pfam01500  73 CQTSSCQTGCGGIGYGQEGSSGAVSSrtrwCRPDCRVEGTCLPPCC---------------------------------V 119

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 613410249  201 ISSCTPSCCQQSSCQPACCTSSSCQQACCVPVCCkTVCCKPVC 243
Cdd:pfam01500 120 VSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACC-CQCSEPTC 161
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
89-130 5.11e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.92  E-value: 5.11e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 613410249   89 CCQQSSCQLACCASSPCQQACCVPVCCKTVCCKPVCCVPVCC 130
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
84-128 8.93e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.15  E-value: 8.93e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 613410249   84 SCTPSCCQQSSCQLACCASSPCQQACCVPVCCKTVCCKPVCCVPV 128
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
202-242 9.47e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.15  E-value: 9.47e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 613410249  202 SSCTPSCCQQSSCQPACCTSSSCQQACCVPVCCKTVCCKPV 242
Cdd:pfam13885   5 SCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
203-243 2.24e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.99  E-value: 2.24e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 613410249  203 SCTPSCCQQSSCQPACCTSSSCQQACCVPVCCKTVCCKPVC 243
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 129-308 4.21e-07

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 49.40  E-value: 4.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249  129 CCGDSSCCQQSSCQSACCTSSPCQQACCVPICCKPVCSgissscCQQSSCVSCVSSPCCQAVCEPSpCQSGCissCTPSC 208
Cdd:pfam01500   3 CCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCC------QTSCCQPTTFQSSCCRPTCQPC-CQTSC---CQPTC 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249  209 CQQSSCQPACCTSSSCQQACCVPVCCKTVCCKPVcsedsssccqqsscqpaCCTSSPCQQACCVPVCCKPVCCKPVCSVP 288
Cdd:pfam01500  73 CQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPD-----------------CRVEGTCLPPCCVVSCTPPTCCQLHHAQA 135

                         170       180
                  ....*....|....*....|
gi 613410249  289 ICSGASslCCQQSSCQPACC 308
Cdd:pfam01500 136 SCCRPS--YCGQSCCRPACC 153
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
82-123 5.06e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 45.84  E-value: 5.06e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 613410249   82 TSSCTPSCCQQSSCQLACCASSPCQQACCVPVCCKTVCCKPV 123
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
233-289 5.81e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 40.06  E-value: 5.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 613410249  233 CCKTVCCKPVCSEdsssccqqsscqPACCTSSPCQQACCVPVCCKPVCCKPVCSVPI 289
Cdd:pfam13885   1 CCQPSCCQPSCCQ------------PSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 2-131 7.74e-05

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 43.27  E-value: 7.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249    2 SVCSSDLSYSSRVCLPGSCDScsDSWQVDDCPESCCEPPCCAPSCCAPAPCLSLVCTPVS--------RVSSPCCPVTCE 73
Cdd:pfam05287  28 SSCPSNLSYSTDLCSPSSCQL--GSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCVPSPcqrscyspRTSCVCSPCQTT 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 613410249   74 PSPCQSGCTSSCTPSCCQQSSCQLACCASSPCQQACCVPVCCKTVCCKPVCCVPVCCG 131
Cdd:pfam05287 106 SAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGYGSSFCRPSYVS 163
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
258-290 1.54e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.90  E-value: 1.54e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 613410249  258 PACCTSSPCQQACCVPVCCKPVCCKPVCSVPIC 290
Cdd:pfam13885   9 PSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
294-332 1.70e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.90  E-value: 1.70e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 613410249  294 SSLCCQQSSCQPACCTSSQSQQGCCVPVCCKPVSCVPVC 332
Cdd:pfam13885   3 QPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 191-322 5.80e-04

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 40.57  E-value: 5.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249  191 CEPSPCQSGC--ISSCTPSCCQQSSCQPACCTSSSCQQACCVPVCCKTVCCKPVCSEDSSSCCQQSSCQPACCTSSpCQQ 268
Cdd:pfam05287  41 CSPSSCQLGSslRDNCQETCGEPTSCQTSSCEPCTSSTSYCVPSPCQRSCYSPRTSCVCSPCQTTSAGSLGFGSSS-CQS 119

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 613410249  269 ACCVPVCCKPVCCKPVCSVPI---CSGASSLCCQQSSCQPACCTSSQSQQGCCVPVC 322
Cdd:pfam05287 120 LGYGSNSCQPLGCGSSGFRPLgclSKGFQSLGYGSSFCRPSYVSSRSYQPSCFRPSC 176
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
99-164 1.11e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 36.59  E-value: 1.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 613410249   99 CCASSPCQQACCVPVCCKTVCCKPVCCVPVCcgdssccqqsscqsacctsspCQQACCVPICCKPV 164
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSC---------------------CRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
32-75 4.51e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 34.67  E-value: 4.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 613410249   32 CPESCCEPPCCAPSCCAPAPCLSLVCTPVSRVSSPCCPVTCEPS 75
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 52-233 5.53e-03

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 37.49  E-value: 5.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249   52 CLSLVCTPVSRVSSPCCPVTCEPSPCQSGCTssCTPSCCQQSSCQLACCASSPCQQACCVPVCCKTVCCKPVCCVPVCCG 131
Cdd:pfam05287   5 CCSGNFSSRSLRNHLHYPVSSCGSSCPSNLS--YSTDLCSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 613410249  132 DSSCCQQSSCQSACCTSSPCQqaccvPICCKPVCSGISSSCCQQSSCVSCVSSPCCQAVCEPSPCQSgciSSCTPSCCQQ 211
Cdd:pfam05287  83 PSPCQRSCYSPRTSCVCSPCQ-----TTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFRPLGCLS---KGFQSLGYGS 154

                         170       180
                  ....*....|....*....|..
gi 613410249  212 SSCQPACCTSSSCQQACCVPVC 233
Cdd:pfam05287 155 SFCRPSYVSSRSYQPSCFRPSC 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH