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Conserved domains on  [gi|148727345|ref|NP_941970|]
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keratin-associated protein 12-3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
10-53 2.41e-04

Keratin, high sulfur B2 protein;


:

Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.44  E-value: 2.41e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 148727345  10 CQPTCCIHSPCQASCYVPVSCQSSVCMPVSCTRIVCVAPSCQPS 53
Cdd:pfam13885  2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 2-96 3.61e-04

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 37.08  E-value: 3.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727345    2 CHTSCSPACQPTCCIHSPCQASCYVPVSCQSSVCMPVSCTRIVCVAPSCQPSVCVPVSCRPIIYVtPSCQSSGCCQPPCT 81
Cdd:pfam01500  55 CRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCV-VSCTPPTCCQLHHA 133

                          90
                  ....*....|....*
gi 148727345   82 TALCRPISCSTPSCC 96
Cdd:pfam01500 134 QASCCRPSYCGQSCC 148
 
Name Accession Description Interval E-value
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
10-53 2.41e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.44  E-value: 2.41e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 148727345  10 CQPTCCIHSPCQASCYVPVSCQSSVCMPVSCTRIVCVAPSCQPS 53
Cdd:pfam13885  2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 2-96 3.61e-04

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 37.08  E-value: 3.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727345    2 CHTSCSPACQPTCCIHSPCQASCYVPVSCQSSVCMPVSCTRIVCVAPSCQPSVCVPVSCRPIIYVtPSCQSSGCCQPPCT 81
Cdd:pfam01500  55 CRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCV-VSCTPPTCCQLHHA 133

                          90
                  ....*....|....*
gi 148727345   82 TALCRPISCSTPSCC 96
Cdd:pfam01500 134 QASCCRPSYCGQSCC 148
 
Name Accession Description Interval E-value
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
10-53 2.41e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 35.44  E-value: 2.41e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 148727345  10 CQPTCCIHSPCQASCYVPVSCQSSVCMPVSCTRIVCVAPSCQPS 53
Cdd:pfam13885  2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 2-96 3.61e-04

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 37.08  E-value: 3.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727345    2 CHTSCSPACQPTCCIHSPCQASCYVPVSCQSSVCMPVSCTRIVCVAPSCQPSVCVPVSCRPIIYVtPSCQSSGCCQPPCT 81
Cdd:pfam01500  55 CRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCV-VSCTPPTCCQLHHA 133

                          90
                  ....*....|....*
gi 148727345   82 TALCRPISCSTPSCC 96
Cdd:pfam01500 134 QASCCRPSYCGQSCC 148
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 10-95 9.07e-04

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 36.33  E-value: 9.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727345   10 CQPTCCIHSPCQASCYVP-VSCQSSVCMPVSCTRIVCVAPSCQPSVCVPVSCRPIIYVTP-----SCQSSGCCQPPCTTA 83
Cdd:pfam05287  76 SSTSYCVPSPCQRSCYSPrTSCVCSPCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSgfrplGCLSKGFQSLGYGSS 155

                          90
                  ....*....|..
gi 148727345   84 LCRPISCSTPSC 95
Cdd:pfam05287 156 FCRPSYVSSRSY 167
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-96 2.85e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 34.77  E-value: 2.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148727345    7 SPACQPTCCIHSPCQASCYVPVSCQSSVCMPVSCTRIVCVAPSCQPSVCVPVSCRPIIYVTPSCQSSGCCQPPCTTALCR 86
Cdd:pfam01500  65 TSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCG 144

                          90
                  ....*....|
gi 148727345   87 PISCSTPSCC 96
Cdd:pfam01500 145 QSCCRPACCC 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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