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Conserved domains on  [gi|39979630|ref|NP_951014|]
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TATA box-binding protein-like 2 isoform 1 [Mus musculus]

Protein Classification

TBP family protein( domain architecture ID 10139969)

TBP family protein similar to TATA-box-binding protein (TBP), a general transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TBP_eukaryotes cd04516
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are ...
 173-347 9.34e-122

eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


:

Pssm-ID: 239952  Cd Length: 174  Bit Score: 347.67  E-value: 9.34e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 173 VPQLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVV 252
Cdd:cd04516   1 VPKIQNIVATVNLGCKLDLKKIALRARNAEYNPKRFAAVIMRIREPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARII 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 253 QKLGFPVRFFNFKIQNMVGSCDVKFPIRLEILALTHRQFsSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSE 332
Cdd:cd04516  81 QKLGFPAKFTDFKIQNIVGSCDVKFPIRLEGLAHAHKQF-SSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKSREE 159

                       170
                ....*....|....*
gi 39979630 333 IYEAFENMYPILESF 347
Cdd:cd04516 160 IYQAFENIYPILLQF 174
 
Name Accession Description Interval E-value
TBP_eukaryotes cd04516
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are ...
 173-347 9.34e-122

eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239952  Cd Length: 174  Bit Score: 347.67  E-value: 9.34e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 173 VPQLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVV 252
Cdd:cd04516   1 VPKIQNIVATVNLGCKLDLKKIALRARNAEYNPKRFAAVIMRIREPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARII 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 253 QKLGFPVRFFNFKIQNMVGSCDVKFPIRLEILALTHRQFsSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSE 332
Cdd:cd04516  81 QKLGFPAKFTDFKIQNIVGSCDVKFPIRLEGLAHAHKQF-SSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKSREE 159

                       170
                ....*....|....*
gi 39979630 333 IYEAFENMYPILESF 347
Cdd:cd04516 160 IYQAFENIYPILLQF 174
PLN00062 PLN00062
TATA-box-binding protein; Provisional
 173-350 2.55e-120

TATA-box-binding protein; Provisional


Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 344.37  E-value: 2.55e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630  173 VPQLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVV 252
Cdd:PLN00062   1 VPTLQNIVSTVNLDCKLDLKKIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSKLAARKYARII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630  253 QKLGFPVRFFNFKIQNMVGSCDVKFPIRLEILALTHRQFsSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSE 332
Cdd:PLN00062  81 QKLGFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYAHGAF-SSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITGAKVREE 159

                        170
                 ....*....|....*...
gi 39979630  333 IYEAFENMYPILESFKKV 350
Cdd:PLN00062 160 IYTAFENIYPVLTEFRKR 177
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
177-347 6.60e-60

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 190.41  E-value: 6.60e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 177 QNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVVQKLG 256
Cdd:COG2101   7 ENIVASGSLGQELDLEKLAEDLPNAEYNPEQFPGLVYRLKEPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKLRKLG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 257 FPV-RFFNFKIQNMVGSCDVKFPIRLEILALTHRQFSSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSEIYE 335
Cdd:COG2101  87 IEIpDEPEITVQNIVASADLGREINLNALAIGLGLENIEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAKDEEEAER 166

                       170
                ....*....|..
gi 39979630 336 AFENMYPILESF 347
Cdd:COG2101 167 AVDKLRERLEEL 178
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
174-255 3.38e-40

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 136.41  E-value: 3.38e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630   174 PQLQNVVSTANLACKLDLRKIALNAK-NTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVV 252
Cdd:pfam00352   2 IKIQNVVASADLGFPIDLEKLALKLLeNVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPIL 81


                  ...
gi 39979630   253 QKL 255
Cdd:pfam00352  82 QKL 84
 
Name Accession Description Interval E-value
TBP_eukaryotes cd04516
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are ...
 173-347 9.34e-122

eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239952  Cd Length: 174  Bit Score: 347.67  E-value: 9.34e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 173 VPQLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVV 252
Cdd:cd04516   1 VPKIQNIVATVNLGCKLDLKKIALRARNAEYNPKRFAAVIMRIREPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARII 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 253 QKLGFPVRFFNFKIQNMVGSCDVKFPIRLEILALTHRQFsSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSE 332
Cdd:cd04516  81 QKLGFPAKFTDFKIQNIVGSCDVKFPIRLEGLAHAHKQF-SSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKSREE 159

                       170
                ....*....|....*
gi 39979630 333 IYEAFENMYPILESF 347
Cdd:cd04516 160 IYQAFENIYPILLQF 174
PLN00062 PLN00062
TATA-box-binding protein; Provisional
 173-350 2.55e-120

TATA-box-binding protein; Provisional


Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 344.37  E-value: 2.55e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630  173 VPQLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVV 252
Cdd:PLN00062   1 VPTLQNIVSTVNLDCKLDLKKIALQARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSKLAARKYARII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630  253 QKLGFPVRFFNFKIQNMVGSCDVKFPIRLEILALTHRQFsSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSE 332
Cdd:PLN00062  81 QKLGFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYAHGAF-SSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITGAKVREE 159

                        170
                 ....*....|....*...
gi 39979630  333 IYEAFENMYPILESFKKV 350
Cdd:PLN00062 160 IYTAFENIYPVLTEFRKR 177
TBP_TLF cd00652
TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription ...
 173-345 1.98e-110

TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA. New members of the TBP family, called TBP-like proteins (TBLP, TLF, TLP) or TBP-related factors (TRF1, TRF2,TRP), are similar to the core domain of TBPs, with identical or chemically similar amino acids at many equivalent positions, suggesting similar structure. However, TLFs contain distinct, conserved amino acids at several positions that distinguish them from TBP.


Pssm-ID: 238352 [Multi-domain]  Cd Length: 174  Bit Score: 319.11  E-value: 1.98e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 173 VPQLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVV 252
Cdd:cd00652   1 SPKIQNIVATVNLGCELDLRKIALAARNAEYNPKRFPGVIMRLREPKTTALIFSSGKMVITGAKSEEDAKLAARKYARIL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 253 QKLGFPV-RFFNFKIQNMVGSCDVKFPIRLEILALTHRQFsSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERS 331
Cdd:cd00652  81 QKLGFPVeKFPEFKVQNIVASCDLGFPIRLEELALKHPEN-ASYEPELFPGLIYRMDEPKVVLLIFVSGKIVITGAKSRE 159

                       170
                ....*....|....
gi 39979630 332 EIYEAFENMYPILE 345
Cdd:cd00652 160 DIYEAVEKIYPILK 173
TLF cd04517
TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and ...
 172-345 2.52e-65

TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the basal transcription machinery. Yet, in contrast to TBPs, TLFs seem not to interact with the TATA-box and even have a negative effect on the transcription of TATA-containing promoters. Recent results indicate that TLFs are involved in the transcription via TATA-less promoters.


Pssm-ID: 239953  Cd Length: 174  Bit Score: 204.49  E-value: 2.52e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 172 IVPQLQNVVSTANLACKLDLRKIALNAKNTEYNPkRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARV 251
Cdd:cd04517   1 LDILIVNVVCQFSLRCHIDLRKLALAGRNVEYNP-RYPKVTMRLREPRATASVWSSGKITITGATSEEEAKQAARRAARL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 252 VQKLGFPV-RFFNFKIQNMVGSCDVKFPIRLEILALTHRQfSSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKER 330
Cdd:cd04517  80 LQKLGFKVvRFSNFRVVNVLATCSMPFPIRLDELAAKNRS-SASYEPELHPGVVYRITGPRATLSIFSTGSVTVTGARSM 158

                       170
                ....*....|....*
gi 39979630 331 SEIYEAFENMYPILE 345
Cdd:cd04517 159 EDVREAVEKIYPIVF 173
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
177-347 6.60e-60

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 190.41  E-value: 6.60e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 177 QNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVVQKLG 256
Cdd:COG2101   7 ENIVASGSLGQELDLEKLAEDLPNAEYNPEQFPGLVYRLKEPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKLRKLG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 257 FPV-RFFNFKIQNMVGSCDVKFPIRLEILALTHRQFSSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSEIYE 335
Cdd:COG2101  87 IEIpDEPEITVQNIVASADLGREINLNALAIGLGLENIEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAKDEEEAER 166

                       170
                ....*....|..
gi 39979630 336 AFENMYPILESF 347
Cdd:COG2101 167 AVDKLRERLEEL 178
PRK00394 PRK00394
transcription factor; Reviewed
 175-347 1.01e-56

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 182.36  E-value: 1.01e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630  175 QLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVVQK 254
Cdd:PRK00394   2 KIENIVASTDLGQELDLEKVAEDLPNAEYNPEQFPGLVYRLEDPKIAALIFRSGKVVCTGAKSVEDLHEAVKIIIKKLKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630  255 LGFPVRF-FNFKIQNMVGSCDVKFPIRLEILALTHRQFSSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSEI 333
Cdd:PRK00394  82 LGIKVIDePEIKVQNIVASADLGVELNLNAIAIGLGLENIEYEPEQFPGLVYRLDDPKVVVLLFGSGKLVITGAKSEEDA 161

                        170
                 ....*....|....
gi 39979630  334 YEAFENMYPILESF 347
Cdd:PRK00394 162 EKAVEKILEKLEEL 175
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
 174-338 1.77e-51

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 168.58  E-value: 1.77e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 174 PQLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVVQ 253
Cdd:cd04518   2 LKIENIVASVDLGQELDLEKVAAELPNAEYNPDQFPGLVYRLEDPKIAALIFRSGKMVCTGAKSVEDLHRAVKEIIKKLK 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 254 KLGFPVRF-FNFKIQNMVGSCDVKFPIRLEILALTHRqfSSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSE 332
Cdd:cd04518  82 DYGIKVIEkPEIKVQNIVASADLGREVNLDAIAIGLP--NAEYEPEQFPGLVYRLDEPKVVLLLFSSGKMVITGAKSEED 159


                ....*.
gi 39979630 333 IYEAFE 338
Cdd:cd04518 160 AKRAVE 165
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
174-255 3.38e-40

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 136.41  E-value: 3.38e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630   174 PQLQNVVSTANLACKLDLRKIALNAK-NTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVV 252
Cdd:pfam00352   2 IKIQNVVASADLGFPIDLEKLALKLLeNVEYEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPIL 81


                  ...
gi 39979630   253 QKL 255
Cdd:pfam00352  82 QKL 84
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
263-347 1.01e-39

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 135.26  E-value: 1.01e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630   263 NFKIQNMVGSCDVKFPIRLEILALTHRQFSSsYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSEIYEAFENMYP 342
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKLLENVE-YEPERFPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAP 79


                  ....*
gi 39979630   343 ILESF 347
Cdd:pfam00352  80 ILQKL 84
PRK00394 PRK00394
transcription factor; Reviewed
 175-256 2.10e-24

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 98.00  E-value: 2.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630  175 QLQNVVSTANLACKLDLRKIA--LNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVV 252
Cdd:PRK00394  93 KVQNIVASADLGVELNLNAIAigLGLENIEYEPEQFPGLVYRLDDPKVVVLLFGSGKLVITGAKSEEDAEKAVEKILEKL 172


                 ....
gi 39979630  253 QKLG 256
Cdd:PRK00394 173 EELG 176
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
174-257 1.39e-23

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 95.65  E-value: 1.39e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 174 PQLQNVVSTANLACKLDLRKIA--LNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARV 251
Cdd:COG2101  95 ITVQNIVASADLGREINLNALAigLGLENIEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITGAKDEEEAERAVDKLRER 174


                ....*.
gi 39979630 252 VQKLGF 257
Cdd:COG2101 175 LEELGL 180
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
 174-255 4.33e-23

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 94.24  E-value: 4.33e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 174 PQLQNVVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEEESRLAARKYARVVQ 253
Cdd:cd04518  93 IKVQNIVASADLGREVNLDAIAIGLPNAEYEPEQFPGLVYRLDEPKVVLLLFSSGKMVITGAKSEEDAKRAVEKLLSRLK 172


                ..
gi 39979630 254 KL 255
Cdd:cd04518 173 EL 174
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
265-349 7.77e-17

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 77.16  E-value: 7.77e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 265 KIQNMVGSCDVKFPIRLEILAlthRQFS-SSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSEIYEAFENmypI 343
Cdd:COG2101   5 EIENIVASGSLGQELDLEKLA---EDLPnAEYNPEQFPGLVYRLKEPKTAALIFRSGKMVCTGAKSEEDLIEAVEK---V 78


                ....*.
gi 39979630 344 LESFKK 349
Cdd:COG2101  79 IEKLRK 84
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
 265-344 3.50e-14

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 69.58  E-value: 3.50e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39979630 265 KIQNMVGSCDVKFPIRLEILALthRQFSSSYEPELFPGLIYKMVKPQVVLLIFASGKVVLTGAKERSEIYEAFENMYPIL 344
Cdd:cd04518   3 KIENIVASVDLGQELDLEKVAA--ELPNAEYNPDQFPGLVYRLEDPKIAALIFRSGKMVCTGAKSVEDLHRAVKEIIKKL 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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