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Conserved domains on  [gi|50233904|ref|NP_956441|]
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probable cytosolic iron-sulfur protein assembly protein ciao1 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-326 1.18e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 211.04  E-value: 1.18e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904  22 VAWNPAGTTLATCGGDRAIRIWGKEGDSWECKCVlsdGHQRTVRKVAWSPCGKYLASASFDATTCIWKKtdEDFECLTVL 101
Cdd:cd00200  15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK---GHTGPVRDVAASADGTYLASGSSDKTIRLWDL--ETGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 102 EGHENEVKCVAWAPSGSLLATCSRDKSVWIWEVdeeDEYECLSVVNSHTQDVKHVVWHPTQELLASASYDNKICIYkeED 181
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW--DL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 182 DDWECRATLEGHESTVWSLTFDPEGRRLASCSDDRTVKIWKESTtgdgssdesWKCICTLSGfHGRTIYDIAWCRlTGAL 261
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST---------GKCLGTLRG-HENGVNSVAFSP-DGYL 233

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50233904 262 ATACGDDG-VRVFSedptADPEQPIFALSahvpkAHNQDVNCVSWNPkEAGLLATCSDNGEFAIWK 326
Cdd:cd00200 234 LASGSEDGtIRVWD----LRTGECVQTLS-----GHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-326 1.18e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 211.04  E-value: 1.18e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904  22 VAWNPAGTTLATCGGDRAIRIWGKEGDSWECKCVlsdGHQRTVRKVAWSPCGKYLASASFDATTCIWKKtdEDFECLTVL 101
Cdd:cd00200  15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK---GHTGPVRDVAASADGTYLASGSSDKTIRLWDL--ETGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 102 EGHENEVKCVAWAPSGSLLATCSRDKSVWIWEVdeeDEYECLSVVNSHTQDVKHVVWHPTQELLASASYDNKICIYkeED 181
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW--DL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 182 DDWECRATLEGHESTVWSLTFDPEGRRLASCSDDRTVKIWKESTtgdgssdesWKCICTLSGfHGRTIYDIAWCRlTGAL 261
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST---------GKCLGTLRG-HENGVNSVAFSP-DGYL 233

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50233904 262 ATACGDDG-VRVFSedptADPEQPIFALSahvpkAHNQDVNCVSWNPkEAGLLATCSDNGEFAIWK 326
Cdd:cd00200 234 LASGSEDGtIRVWD----LRTGECVQTLS-----GHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
6-325 8.54e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 202.06  E-value: 8.54e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904   6 ELQHRVSAHPDSrCWYVAWNPAGTTLATCGGDRAIRIWgkEGDSWECKCVLSdGHQRTVRKVAWSPCGKYLASASFDATT 85
Cdd:COG2319 111 LLLRTLTGHTGA-VRSVAFSPDGKTLASGSADGTVRLW--DLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTV 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904  86 CIWKktDEDFECLTVLEGHENEVKCVAWAPSGSLLATCSRDKSVWIWEVDEEdeyECLSVVNSHTQDVKHVVWHPTQELL 165
Cdd:COG2319 187 RLWD--LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSPDGRLL 261

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 166 ASASYDNKICIYkeEDDDWECRATLEGHESTVWSLTFDPEGRRLASCSDDRTVKIWkesttgdgsSDESWKCICTLSGfH 245
Cdd:COG2319 262 ASGSADGTVRLW--DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW---------DLATGKLLRTLTG-H 329

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 246 GRTIYDIAWCRLTGALATACGDDGVRVFSedpTADPEQPifalsaHVPKAHNQDVNCVSWNPkEAGLLATCSDNGEFAIW 325
Cdd:COG2319 330 TGAVRSVAFSPDGKTLASGSDDGTVRLWD---LATGELL------RTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-222 1.39e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 1.39e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 50233904    183 DWECRATLEGHESTVWSLTFDPEGRRLASCSDDRTVKIWK 222
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
184-221 3.14e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 3.14e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 50233904   184 WECRATLEGHESTVWSLTFDPEGRRLASCSDDRTVKIW 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 22-273 3.89e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.63  E-value: 3.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904   22 VAWNPAGTTLATCGGDRAIRIWgkegdswECKCVLSDGH-----------QRTVRKVAWSPCGK-YLASASFDATTCIWK 89
Cdd:PLN00181 489 IGFDRDGEFFATAGVNKKIKIF-------ECESIIKDGRdihypvvelasRSKLSGICWNSYIKsQVASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904   90 KTDEdfECLTVLEGHENEVKCVAWAPSG-SLLATCSRDKSVWIWEVDEEdeyecLSVVNSHTQDVKHVVWHPTQ--ELLA 166
Cdd:PLN00181 562 VARS--QLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQG-----VSIGTIKTKANICCVQFPSEsgRSLA 634

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904  167 SASYDNKICIYKEEDDDWECrATLEGHESTVWSLTFdPEGRRLASCSDDRTVKIWKESTTGDGSSD---ESWKCICTLSG 243
Cdd:PLN00181 635 FGSADHKVYYYDLRNPKLPL-CTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISGINEtplHSFMGHTNVKN 712

                        250       260       270
                 ....*....|....*....|....*....|
gi 50233904  244 FHGRTIYDiawcrltGALATACGDDGVRVF 273
Cdd:PLN00181 713 FVGLSVSD-------GYIATGSETNEVFVY 735
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-326 1.18e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 211.04  E-value: 1.18e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904  22 VAWNPAGTTLATCGGDRAIRIWGKEGDSWECKCVlsdGHQRTVRKVAWSPCGKYLASASFDATTCIWKKtdEDFECLTVL 101
Cdd:cd00200  15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK---GHTGPVRDVAASADGTYLASGSSDKTIRLWDL--ETGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 102 EGHENEVKCVAWAPSGSLLATCSRDKSVWIWEVdeeDEYECLSVVNSHTQDVKHVVWHPTQELLASASYDNKICIYkeED 181
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW--DL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 182 DDWECRATLEGHESTVWSLTFDPEGRRLASCSDDRTVKIWKESTtgdgssdesWKCICTLSGfHGRTIYDIAWCRlTGAL 261
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST---------GKCLGTLRG-HENGVNSVAFSP-DGYL 233

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50233904 262 ATACGDDG-VRVFSedptADPEQPIFALSahvpkAHNQDVNCVSWNPkEAGLLATCSDNGEFAIWK 326
Cdd:cd00200 234 LASGSEDGtIRVWD----LRTGECVQTLS-----GHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
6-325 8.54e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 202.06  E-value: 8.54e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904   6 ELQHRVSAHPDSrCWYVAWNPAGTTLATCGGDRAIRIWgkEGDSWECKCVLSdGHQRTVRKVAWSPCGKYLASASFDATT 85
Cdd:COG2319 111 LLLRTLTGHTGA-VRSVAFSPDGKTLASGSADGTVRLW--DLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTV 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904  86 CIWKktDEDFECLTVLEGHENEVKCVAWAPSGSLLATCSRDKSVWIWEVDEEdeyECLSVVNSHTQDVKHVVWHPTQELL 165
Cdd:COG2319 187 RLWD--LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSPDGRLL 261

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 166 ASASYDNKICIYkeEDDDWECRATLEGHESTVWSLTFDPEGRRLASCSDDRTVKIWkesttgdgsSDESWKCICTLSGfH 245
Cdd:COG2319 262 ASGSADGTVRLW--DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW---------DLATGKLLRTLTG-H 329

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 246 GRTIYDIAWCRLTGALATACGDDGVRVFSedpTADPEQPifalsaHVPKAHNQDVNCVSWNPkEAGLLATCSDNGEFAIW 325
Cdd:COG2319 330 TGAVRSVAFSPDGKTLASGSDDGTVRLWD---LATGELL------RTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
4-325 2.32e-48

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.01  E-value: 2.32e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904   4 ALELQHRVSAHPDSRCWYVAWNPAGTTLATCGGDRAIRIWGKEGDSWEckcVLSDGHQRTVRKVAWSPCGKYLASASFDA 83
Cdd:COG2319  24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL---ATLLGHTAAVLSVAFSPDGRLLASASADG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904  84 TTCIWKKTDEdfECLTVLEGHENEVKCVAWAPSGSLLATCSRDKSVWIWEVDEEdeyECLSVVNSHTQDVKHVVWHPTQE 163
Cdd:COG2319 101 TVRLWDLATG--LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG---KLLRTLTGHSGAVTSVAFSPDGK 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 164 LLASASYDNKICIYkeEDDDWECRATLEGHESTVWSLTFDPEGRRLASCSDDRTVKIWkESTTGdgssdeswKCICTLSG 243
Cdd:COG2319 176 LLASGSDDGTVRLW--DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW-DLATG--------KLLRTLTG 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 244 fHGRTIYDIAWCRLTGALATACGDDGVRVFSedptADPEQPIfalsaHVPKAHNQDVNCVSWNPkEAGLLATCSDNGEFA 323
Cdd:COG2319 245 -HSGSVRSVAFSPDGRLLASGSADGTVRLWD----LATGELL-----RTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVR 313


                ..
gi 50233904 324 IW 325
Cdd:COG2319 314 LW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 97-319 1.62e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.54  E-value: 1.62e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904  97 CLTVLEGHENEVKCVAWAPSGSLLATCSRDKSVWIWEVDEEDEYECLSVvnsHTQDVKHVVWHPTQELLASASYDNKICI 176
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 177 YKEEDDdwECRATLEGHESTVWSLTFDPEGRRLASCSDDRTVKIWKESTTgdgssdeswKCICTLSGfHGRTIYDIAWCR 256
Cdd:cd00200  78 WDLETG--ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG---------KCLTTLRG-HTDWVNSVAFSP 145

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50233904 257 LTGALATACGDDGVRVFSedptADPEQPIfalsaHVPKAHNQDVNCVSWNPKEAGLLATCSDN 319
Cdd:cd00200 146 DGTFVASSSQDGTIKLWD----LRTGKCV-----ATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199
WD40 COG2319
WD40 repeat [General function prediction only];
10-135 5.87e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.53  E-value: 5.87e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904  10 RVSAHPDSRCWYVAWNPAGTTLATCGGDRAIRIWgkEGDSWECKCVLSdGHQRTVRKVAWSPCGKYLASASFDATTCIWK 89
Cdd:COG2319 282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 50233904  90 KtdEDFECLTVLEGHENEVKCVAWAPSGSLLATCSRDKSVWIWEVD 135
Cdd:COG2319 359 L--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-325 1.97e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.37  E-value: 1.97e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 186 CRATLEGHESTVWSLTFDPEGRRLASCSDDRTVKIWKeSTTGDgssdeswkCICTLSGfHGRTIYDIAWCRLTGALATAC 265
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGE--------LLRTLKG-HTGPVRDVAASADGTYLASGS 70

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904 266 GDDGVRVFsedptaDPEQPIfalSAHVPKAHNQDVNCVSWNPKEaGLLATCSDNGEFAIW 325
Cdd:cd00200  71 SDKTIRLW------DLETGE---CVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVW 120
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-222 1.39e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 1.39e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 50233904    183 DWECRATLEGHESTVWSLTFDPEGRRLASCSDDRTVKIWK 222
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
184-221 3.14e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 3.14e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 50233904   184 WECRATLEGHESTVWSLTFDPEGRRLASCSDDRTVKIW 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 94-133 4.19e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 4.19e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 50233904     94 DFECLTVLEGHENEVKCVAWAPSGSLLATCSRDKSVWIWE 133
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-133 3.66e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 3.66e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 50233904    95 FECLTVLEGHENEVKCVAWAPSGSLLATCSRDKSVWIWE 133
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 22-273 3.89e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.63  E-value: 3.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904   22 VAWNPAGTTLATCGGDRAIRIWgkegdswECKCVLSDGH-----------QRTVRKVAWSPCGK-YLASASFDATTCIWK 89
Cdd:PLN00181 489 IGFDRDGEFFATAGVNKKIKIF-------ECESIIKDGRdihypvvelasRSKLSGICWNSYIKsQVASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904   90 KTDEdfECLTVLEGHENEVKCVAWAPSG-SLLATCSRDKSVWIWEVDEEdeyecLSVVNSHTQDVKHVVWHPTQ--ELLA 166
Cdd:PLN00181 562 VARS--QLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQG-----VSIGTIKTKANICCVQFPSEsgRSLA 634

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904  167 SASYDNKICIYKEEDDDWECrATLEGHESTVWSLTFdPEGRRLASCSDDRTVKIWKESTTGDGSSD---ESWKCICTLSG 243
Cdd:PLN00181 635 FGSADHKVYYYDLRNPKLPL-CTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISGINEtplHSFMGHTNVKN 712

                        250       260       270
                 ....*....|....*....|....*....|
gi 50233904  244 FHGRTIYDiawcrltGALATACGDDGVRVF 273
Cdd:PLN00181 713 FVGLSVSD-------GYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-89 2.47e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.47e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 50233904     49 SWECKCVLSdGHQRTVRKVAWSPCGKYLASASFDATTCIWK 89
Cdd:smart00320   1 SGELLKTLK-GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 141-178 2.70e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.70e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 50233904    141 ECLSVVNSHTQDVKHVVWHPTQELLASASYDNKICIYK 178
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 101-182 4.17e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 4.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904  101 LEGHENEVKCVAWAPSGS-LLATCSRDKSVWIWEVDEEDE-----YECLSVVNSHTQDVKHVVWHPTQE-LLASASYDNK 173
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIPHNDEsvkeiKDPQCILKGHKKKISIIDWNPMNYyIMCSSGFDSF 149


                 ....*....
gi 50233904  174 ICIYKEEDD 182
Cdd:PTZ00420 150 VNIWDIENE 158
PTZ00420 PTZ00420
coronin; Provisional
 190-316 9.55e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.17  E-value: 9.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904  190 LEGHESTVWSLTFDP-EGRRLASCSDDRTVKIWkESTTGDGSSDESWKCICTLSGfHGRTIYDIAWCRLTGALATACG-D 267
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVW-EIPHNDESVKEIKDPQCILKG-HKKKISIIDWNPMNYYIMCSSGfD 147

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 50233904  268 DGVRVFsedptaDPEQPIFALSAHVPKahnqDVNCVSWNPKEAGLLATC 316
Cdd:PTZ00420 148 SFVNIW------DIENEKRAFQINMPK----KLSSLKWNIKGNLLSGTC 186
PTZ00420 PTZ00420
coronin; Provisional
 1-123 1.87e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.01  E-value: 1.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904    1 MKGALELQHRVSAHP-------DSRCWYVAWNPA-GTTLATCGGDRAIRIWGKEGDSWECK------CVLsDGHQRTVRK 66
Cdd:PTZ00420  52 LIGAIRLENQMRKPPviklkghTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDESVKeikdpqCIL-KGHKKKISI 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 50233904   67 VAWSPCGKY-LASASFDATTCIWKKTDED--FECLTvleghENEVKCVAWAPSGSLLA-TC 123
Cdd:PTZ00420 131 IDWNPMNYYiMCSSGFDSFVNIWDIENEKraFQINM-----PKKLSSLKWNIKGNLLSgTC 186
WD40 pfam00400
WD domain, G-beta repeat;
50-88 2.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 50233904    50 WECKCVLSdGHQRTVRKVAWSPCGKYLASASFDATTCIW 88
Cdd:pfam00400   1 GKLLKTLE-GHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
141-177 3.93e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 3.93e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 50233904   141 ECLSVVNSHTQDVKHVVWHPTQELLASASYDNKICIY 177
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 104-134 1.03e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.44  E-value: 1.03e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 50233904   104 HENEVKCVAWAPSGSLLATCSRDKSVWIWEV 134
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVWEV 153
PTZ00421 PTZ00421
coronin; Provisional
 22-165 1.37e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.26  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904   22 VAWNPAGTT-LATCGGDRAIRIWGKEGDSWECKC----VLSDGHQRTVRKVAWSPCGK-YLASASFDATTCIWKKtdEDF 95
Cdd:PTZ00421  81 VAFNPFDPQkLFTASEDGTIMGWGIPEEGLTQNIsdpiVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDV--ERG 158

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904   96 ECLTVLEGHENEVKCVAWAPSGSLLATCSRDKSVWIweVDEEDEYECLSVVNSHTQDVKHVVWHPTQELL 165
Cdd:PTZ00421 159 KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI--IDPRDGTIVSSVEAHASAKSQRCLWAKRKDLI 226
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 22-135 3.18e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 38.02  E-value: 3.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904    22 VAWNPAGTTLATCGG--DRAIRIWGKEGDSwecKCVLSDGHQRTVRkvaWSPCGKYLASASF---DATTCIWKKtdEDFE 96
Cdd:pfam08662  65 VAWSPNGKEFAVIYGymPAKVSFFDLKGNV---IHSFGEQPRNTIF---WSPFGRLVLLAGFgnlAGDIEFWDV--VNKK 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 50233904    97 CLTVLEgHENEVKCvAWAPSGSLLATCSR------DKSVWIWEVD 135
Cdd:pfam08662 137 KIATAE-ASNATLC-EWSPDGRYFLTATTaprlrvDNGFKIWHYN 179
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 6-43 5.37e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 5.37e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 50233904      6 ELQHRVSAHpDSRCWYVAWNPAGTTLATCGGDRAIRIW 43
Cdd:smart00320   3 ELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 76-221 7.98e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 37.95  E-value: 7.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50233904   76 LASASFDATTCIWKKTDEDFEC-----LTVLEGHENEVKCVAWAPSG-SLLATCSRDKSVWIWEVDEEDEYEclsVVNSH 149
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEEGLTQnisdpIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVE---VIKCH 167

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 50233904  150 TQDVKHVVWHPTQELLASASYDNKICIYKEEDDDWECraTLEGHEST-----VWSLTFDPEGRRLASCSDDRTVKIW 221
Cdd:PTZ00421 168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS--SVEAHASAksqrcLWAKRKDLIITLGCSKSQQRQIMLW 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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