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Conserved domains on  [gi|41055799|ref|NP_957273|]
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zinc finger protein 143 [Danio rerio]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-364 5.42e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.27  E-value: 5.42e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 191 AHHLKVHERSHTGdKPYICDHLGCGKKFATGYGLKSHVRT--HTGE--KPYRCQELNCLKSFKTSGDLQKHTRTHTGEKP 266
Cdd:COG5048 273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 267 FKCPFEGCGRSFTTSNIRK-----VHIRTHTGERPYYCAEPNCGRAFASATNYKNHMRIHTGEKPYVCTVPGCDKRFTEY 341
Cdd:COG5048 352 AKEKLLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                       170       180
                ....*....|....*....|....
gi 41055799 342 SSLYkHHVVHTPCK-PYNCNHCGK 364
Cdd:COG5048 432 YNLI-PHKKIHTNHaPLLCSILKS 454
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-364 5.42e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.27  E-value: 5.42e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 191 AHHLKVHERSHTGdKPYICDHLGCGKKFATGYGLKSHVRT--HTGE--KPYRCQELNCLKSFKTSGDLQKHTRTHTGEKP 266
Cdd:COG5048 273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 267 FKCPFEGCGRSFTTSNIRK-----VHIRTHTGERPYYCAEPNCGRAFASATNYKNHMRIHTGEKPYVCTVPGCDKRFTEY 341
Cdd:COG5048 352 AKEKLLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                       170       180
                ....*....|....*....|....
gi 41055799 342 SSLYkHHVVHTPCK-PYNCNHCGK 364
Cdd:COG5048 432 YNLI-PHKKIHTNHaPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-280 2.11e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.11e-05
                          10        20
                  ....*....|....*....|....*...
gi 41055799   253 DLQKHTRTHTGEKPFKCPFegCGRSFTT 280
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-364 5.42e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.27  E-value: 5.42e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 191 AHHLKVHERSHTGdKPYICDHLGCGKKFATGYGLKSHVRT--HTGE--KPYRCQELNCLKSFKTSGDLQKHTRTHTGEKP 266
Cdd:COG5048 273 SSPNESDSSSEKG-FSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISP 351

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 267 FKCPFEGCGRSFTTSNIRK-----VHIRTHTGERPYYCAEPNCGRAFASATNYKNHMRIHTGEKPYVCTVPGCDKRFTEY 341
Cdd:COG5048 352 AKEKLLNSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                       170       180
                ....*....|....*....|....
gi 41055799 342 SSLYkHHVVHTPCK-PYNCNHCGK 364
Cdd:COG5048 432 YNLI-PHKKIHTNHaPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-394 1.51e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.72  E-value: 1.51e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 237 YRCQELNCLKSFKTSGDLQKHTRT--HTGE--KPFKCPFEGCGRSFTTSNIRKVHIRTHTGERPYYCAEPNCGRAFASAT 312
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 313 NYKNH-----MRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTPCKPYNCN--HCGKTYKQISTLAMHKRTAHNdTEP 385
Cdd:COG5048 368 NNEPPqslqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTN-HAP 446


                ....*....
gi 41055799 386 IEEEQEGYF 394
Cdd:COG5048 447 LLCSILKSF 455
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
295-370 2.34e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 2.34e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41055799 295 RPYYCaePNCGRAFASATNYKNHMRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTPCKPYNCNHCGKTYKQIS 370
Cdd:COG5048  32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 313-380 1.92e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 53.57  E-value: 1.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 313 NYKNHMRIHTGEKPYVCTVPGCDKRFTEYSSLyKHHVVHTPC--------------------KPYNCNHCGKTYKQISTL 372
Cdd:COG5189 336 DTPSRMLKVKDGKPYKCPVEGCNKKYKNQNGL-KYHMLHGHQnqklhenpspekmnifsakdKPYRCEVCDKRYKNLNGL 414


                ....*...
gi 41055799 373 AMHKRTAH 380
Cdd:COG5189 415 KYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-317 4.48e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.48e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 166 SPRIQHVGE--KAFRCEHEGCGKLYTTAHHLKVHERSHTGDKPYICDHLGCGKKF---ATGYGLKSHV--RTHTGEKPYR 238
Cdd:COG5048 309 LRSVNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFsplLNNEPPQSLQqyKDLKNDKKSE 388

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41055799 239 CQELNCLKSFKTSGDLQKHTRTHTGEKPFKCPFEGCGRSFTTSNIRKVHIRTHTGERPYYCaepNCGRAFASATNYKNH 317
Cdd:COG5048 389 TLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC---SILKSFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 263-352 2.20e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.10  E-value: 2.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 263 GEKPFKCPFEGCGRSFTTSNIRKVH-IRTHTGERPYYCAEPNCGRAFASAtnyknhmrihtgEKPYVCTVpgCDKRFTEY 341
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSAK------------DKPYRCEV--CDKRYKNL 411

                        90
                ....*....|.
gi 41055799 342 SSLyKHHVVHT 352
Cdd:COG5189 412 NGL-KYHRKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 163-232 5.27e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.95  E-value: 5.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 163 DCRSPRIQHVGEKAFRCEHEGCGKLYTTAHHLKVH---------------ERSHTG----DKPYICDHlgCGKKFATGYG 223
Cdd:COG5189 336 DTPSRMLKVKDGKPYKCPVEGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEV--CDKRYKNLNG 413


                ....*....
gi 41055799 224 LKSHvRTHT 232
Cdd:COG5189 414 LKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-280 2.11e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.11e-05
                          10        20
                  ....*....|....*....|....*...
gi 41055799   253 DLQKHTRTHTGEKPFKCPFegCGRSFTT 280
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
224-250 5.97e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.97e-05
                          10        20
                  ....*....|....*....|....*..
gi 41055799   224 LKSHVRTHTGEKPYRCQElnCLKSFKT 250
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-339 6.98e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 6.98e-05
                          10        20
                  ....*....|....*....|....*..
gi 41055799   313 NYKNHMRIHTGEKPYVCTVpgCDKRFT 339
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
250-361 8.77e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 8.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 250 TSGDLQKHTRTHTGE----KPFKCPFegCGRSFTTSNIRKVHIRTHTGERPYYCAEPNCGRAFASATNYKNHMRIHTGEK 325
Cdd:COG5048  13 NSVLSSTPKSTLKSLsnapRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNP 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 41055799 326 PYVCTVPGC----DKRFTEYSSLYKHHVVHTPCKPYNCNH 361
Cdd:COG5048  91 SDLNSKSLPlsnsKASSSSLSSSSSNSNDNNLLSSHSLPP 130
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
204-267 1.06e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 1.06e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41055799 204 DKPYICDhlGCGKKFATGYGLKSHVRTHTGEKPYRCQELNCLKSFKTSGDLQKHTRTHTGEKPF 267
Cdd:COG5048  31 PRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSD 92
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
235-313 1.17e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.17e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41055799 235 KPYRCqeLNCLKSFKTSGDLQKHTRTHTGEKPFKCPFEGCGRSFTTSNIRKVHIRTHTGERPYYCAEPNCGRAFASATN 313
Cdd:COG5048  32 RPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS 108
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
193-390 4.00e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 4.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 193 HLKVHERSHTGDKPYICDHLGCGKKFATGYGLKSHVRTHTGEKPYRCQELNCLKSFKTSGDL------------------ 254
Cdd:COG5048  48 HLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSlsssssnsndnnllsshs 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799 255 ----QKHTRTHTGEKP---FKCPFEGCGRSFT----TSNIRKVHIRTHTGERPYYCAEPNCGRAFASA--TNYKNHMRIH 321
Cdd:COG5048 128 lppsSRDPQLPDLLSIsnlRNNPLPGNNSSSVntpqSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSipSSSENSPLSS 207

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41055799 322 TGEKPYVCTVPGCDKRFTEYSSLYKHHVVH---------TPCKPYNCNHCGKTYKQISTLAMHKRTAHNDTEPIEEEQ 390
Cdd:COG5048 208 SYSIPSSSSDQNLENSSSSLPLTTNSQLSPksllsqspsSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKG 285
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 209-296 8.27e-04

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.94  E-value: 8.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41055799   209 CDHLGCGKKFATGYGLKSHVRTHTGE------KPYRCQELNCLKSFKTSGDLQKHTRTH-TGEKPFKCpfEGCGRSFTT- 280
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHyKPNRYFKC--ENCLLRFRTh 79

                          90
                  ....*....|....*..
gi 41055799   281 -SNIRKVHIRTHTGERP 296
Cdd:pfam15909  80 rSLFKHLHVCAEHAQSP 96
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 1.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....*.
gi 41055799   285 KVHIRTHTGERPYYCaePNCGRAFAS 310
Cdd:pfam13465   3 KRHMRTHTGEKPYKC--PECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
193-220 3.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.83e-03
                          10        20
                  ....*....|....*....|....*...
gi 41055799   193 HLKVHERSHTGDKPYICDHlgCGKKFAT 220
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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