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Conserved domains on  [gi|41872557|ref|NP_957716|]
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neuropilin-2 isoform 6 precursor [Homo sapiens]

Protein Classification

CUB domain-containing protein( domain architecture ID 11504381)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
280-426 3.18e-56

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 185.25  E-value: 3.18e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557 280 PLGMESGRiANEQISASSTYSDGrWTPQQSRLHGDdNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRetQNGYYVK 359
Cdd:cd00057   2 PLGMESGL-ADDQITASSSYSSG-WEASRARLNSD-NAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGG--GSSEWVT 76
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41872557 360 SYKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFG 426
Cdd:cd00057  77 SYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
28-141 1.15e-41

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 145.63  E-value: 1.15e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557  28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPePNQKIVLNFNpHFEIEKH-DCKYDFIEIRDGDSESADLLGKHCG 106
Cdd:cd00041   1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAP-PGYRIRLTFE-DFDLESSpNCSYDYLEIYDGPSTSSPLLGRFCG 78
                        90       100       110
                ....*....|....*....|....*....|....*
gi 41872557 107 NIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEI 141
Cdd:cd00041  79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
149-265 4.22e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 130.61  E-value: 4.22e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557 149 CSKNFTSP-NGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPlqvgegDCKYDWLDIWDGIPHVGPLIG 227
Cdd:cd00041   1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSP------NCSYDYLEIYDGPSTSSPLLG 74
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 41872557 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Cdd:cd00041  75 RFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
FA58C super family cl25480
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
438-545 1.63e-21

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


The actual alignment was detected with superfamily member cd00057:

Pssm-ID: 330301 [Multi-domain]  Cd Length: 143  Bit Score: 90.87  E-value: 1.63e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557 438 LGMLSGLiADSQISASSTQEYLWSPSAARLvSSRSGWFPRIPQAqpgEEWLQVDLGTPKTVKGVIIQGARGGDSItavea 517
Cdd:cd00057   3 LGMESGL-ADDQITASSSYSSGWEASRARL-NSDNAWTPAVNDP---PQWLQVDLGKTRRVTGIQTQGRKGGGSS----- 72
                        90       100
                ....*....|....*....|....*...
gi 41872557 518 rAFVRKFKVSYSLNGKDWEYIQDPRTQQ 545
Cdd:cd00057  73 -EWVTSYKVQYSLDGETWTTYKDKGEEK 99
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
280-426 3.18e-56

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 185.25  E-value: 3.18e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557 280 PLGMESGRiANEQISASSTYSDGrWTPQQSRLHGDdNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRetQNGYYVK 359
Cdd:cd00057   2 PLGMESGL-ADDQITASSSYSSG-WEASRARLNSD-NAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGG--GSSEWVT 76
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41872557 360 SYKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFG 426
Cdd:cd00057  77 SYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
28-141 1.15e-41

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 145.63  E-value: 1.15e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557  28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPePNQKIVLNFNpHFEIEKH-DCKYDFIEIRDGDSESADLLGKHCG 106
Cdd:cd00041   1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAP-PGYRIRLTFE-DFDLESSpNCSYDYLEIYDGPSTSSPLLGRFCG 78
                        90       100       110
                ....*....|....*....|....*....|....*
gi 41872557 107 NIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEI 141
Cdd:cd00041  79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
277-427 4.24e-41

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 144.96  E-value: 4.24e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557    277 CNVPLGMESgriaNEQISASSTYsdgrWTPQQSRLHGD-DNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNG 355
Cdd:smart00231   2 CNEPLGLES----DSQITASSSY----WAAKIARLNGGsDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVT 73
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41872557    356 YYvksykLEVSTNGEDWMVYRHGkNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGC 427
Cdd:smart00231  74 YK-----LEYSDDGVNWTTYKDG-NSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
CUB pfam00431
CUB domain;
28-139 1.10e-37

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 134.73  E-value: 1.10e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557    28 CGGRLNSKDaGYITSPGYPQDYPSHQNCEWIVYAPePNQKIVLNFnPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCG 106
Cdd:pfam00431   1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAP-PGFRVKLTF-QDFELEDHDeCGYDYVEIRDGPSASSPLLGRFCG 77
                          90       100       110
                  ....*....|....*....|....*....|...
gi 41872557   107 NIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139
Cdd:pfam00431  78 SGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
38-139 5.75e-37

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 132.51  E-value: 5.75e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557     38 GYITSPGYPQDYPSHQNCEWIVYAPePNQKIVLNFNpHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISS 116
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAP-PGYRIELQFT-DFDLESSDnCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISS 78
                           90       100
                   ....*....|....*....|....
gi 41872557    117 -GSMLYIKFTSDYARQGAGFSLRY 139
Cdd:smart00042  79 sSNSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
149-265 4.22e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 130.61  E-value: 4.22e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557 149 CSKNFTSP-NGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPlqvgegDCKYDWLDIWDGIPHVGPLIG 227
Cdd:cd00041   1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSP------NCSYDYLEIYDGPSTSSPLLG 74
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 41872557 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Cdd:cd00041  75 RFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
158-264 2.06e-32

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 119.80  E-value: 2.06e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557    158 GTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPlqvgegDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSE 237
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSD------NCEYDYVEIYDGPSASSPLLGRFCGSEAPPP 74
                           90       100
                   ....*....|....*....|....*...
gi 41872557    238 LRSSTG-ILSLTFHTDMAVAKDGFSARY 264
Cdd:smart00042  75 VISSSSnSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
149-264 5.32e-31

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 116.24  E-value: 5.32e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557   149 CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPlqvgegDCKYDWLDIWDGIPHVGPLIGK 228
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHD------ECGYDYVEIRDGPSASSPLLGR 74
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 41872557   229 YCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Cdd:pfam00431  75 FCGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
292-424 4.67e-29

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 111.39  E-value: 4.67e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557   292 QISASSTYSDGrwTPQQSRLHGDDN-GWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRetqNGYYVKSYKLEVSTNGE 370
Cdd:pfam00754   1 QITASSSYSGE--GPAAAALDGDPNtAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDG---SNGYVTSYKIEYSLDGE 75
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 41872557   371 DWMVYRHGKnhkvFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSG--IALRLEL 424
Cdd:pfam00754  76 NWTTVKDEK----IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGngIALRAEL 127
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
438-545 1.63e-21

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 90.87  E-value: 1.63e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557 438 LGMLSGLiADSQISASSTQEYLWSPSAARLvSSRSGWFPRIPQAqpgEEWLQVDLGTPKTVKGVIIQGARGGDSItavea 517
Cdd:cd00057   3 LGMESGL-ADDQITASSSYSSGWEASRARL-NSDNAWTPAVNDP---PQWLQVDLGKTRRVTGIQTQGRKGGGSS----- 72
                        90       100
                ....*....|....*....|....*...
gi 41872557 518 rAFVRKFKVSYSLNGKDWEYIQDPRTQQ 545
Cdd:cd00057  73 -EWVTSYKVQYSLDGETWTTYKDKGEEK 99
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
449-544 7.78e-17

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 77.10  E-value: 7.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557   449 QISASSTQEYLWSPSAARLVSSRSGWfprIPQAQPGEEWLQVDLGTPKTVKGVIIQGARGGdsitaveARAFVRKFKVSY 528
Cdd:pfam00754   1 QITASSSYSGEGPAAAALDGDPNTAW---SAWSGDDPQWIQVDLGKPKKITGVVTQGRQDG-------SNGYVTSYKIEY 70
                          90
                  ....*....|....*.
gi 41872557   529 SLNGKDWEYIQDPRTQ 544
Cdd:pfam00754  71 SLDGENWTTVKDEKIP 86
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
433-540 6.29e-09

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 54.82  E-value: 6.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557    433 PCSNMLGMLSgliaDSQISASSTQeylWSPSAARL-VSSRSGWfprIPQAQPGEEWLQVDLGTPKTVKGVIIQGARGGDS 511
Cdd:smart00231   1 PCNEPLGLES----DSQITASSSY---WAAKIARLnGGSDGGW---CPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGD 70
                           90       100
                   ....*....|....*....|....*....
gi 41872557    512 ITavearafvrKFKVSYSLNGKDWEYIQD 540
Cdd:smart00231  71 WV---------TYKLEYSDDGVNWTTYKD 90
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
280-426 3.18e-56

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 185.25  E-value: 3.18e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557 280 PLGMESGRiANEQISASSTYSDGrWTPQQSRLHGDdNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRetQNGYYVK 359
Cdd:cd00057   2 PLGMESGL-ADDQITASSSYSSG-WEASRARLNSD-NAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRKGG--GSSEWVT 76
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41872557 360 SYKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFG 426
Cdd:cd00057  77 SYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVTNDFPPPIVARYIRILPTTWNGNISLRLELYG 143
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
28-141 1.15e-41

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 145.63  E-value: 1.15e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557  28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPePNQKIVLNFNpHFEIEKH-DCKYDFIEIRDGDSESADLLGKHCG 106
Cdd:cd00041   1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAP-PGYRIRLTFE-DFDLESSpNCSYDYLEIYDGPSTSSPLLGRFCG 78
                        90       100       110
                ....*....|....*....|....*....|....*
gi 41872557 107 NIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEI 141
Cdd:cd00041  79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
277-427 4.24e-41

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 144.96  E-value: 4.24e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557    277 CNVPLGMESgriaNEQISASSTYsdgrWTPQQSRLHGD-DNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNG 355
Cdd:smart00231   2 CNEPLGLES----DSQITASSSY----WAAKIARLNGGsDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVT 73
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41872557    356 YYvksykLEVSTNGEDWMVYRHGkNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGC 427
Cdd:smart00231  74 YK-----LEYSDDGVNWTTYKDG-NSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWNGNIILRVELLGC 139
CUB pfam00431
CUB domain;
28-139 1.10e-37

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 134.73  E-value: 1.10e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557    28 CGGRLNSKDaGYITSPGYPQDYPSHQNCEWIVYAPePNQKIVLNFnPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCG 106
Cdd:pfam00431   1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAP-PGFRVKLTF-QDFELEDHDeCGYDYVEIRDGPSASSPLLGRFCG 77
                          90       100       110
                  ....*....|....*....|....*....|...
gi 41872557   107 NIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139
Cdd:pfam00431  78 SGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
38-139 5.75e-37

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 132.51  E-value: 5.75e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557     38 GYITSPGYPQDYPSHQNCEWIVYAPePNQKIVLNFNpHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISS 116
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAP-PGYRIELQFT-DFDLESSDnCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISS 78
                           90       100
                   ....*....|....*....|....
gi 41872557    117 -GSMLYIKFTSDYARQGAGFSLRY 139
Cdd:smart00042  79 sSNSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
149-265 4.22e-36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 130.61  E-value: 4.22e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557 149 CSKNFTSP-NGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPlqvgegDCKYDWLDIWDGIPHVGPLIG 227
Cdd:cd00041   1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSP------NCSYDYLEIYDGPSTSSPLLG 74
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 41872557 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Cdd:cd00041  75 RFCGSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
158-264 2.06e-32

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 119.80  E-value: 2.06e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557    158 GTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPlqvgegDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSE 237
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSD------NCEYDYVEIYDGPSASSPLLGRFCGSEAPPP 74
                           90       100
                   ....*....|....*....|....*...
gi 41872557    238 LRSSTG-ILSLTFHTDMAVAKDGFSARY 264
Cdd:smart00042  75 VISSSSnSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
149-264 5.32e-31

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 116.24  E-value: 5.32e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557   149 CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPlqvgegDCKYDWLDIWDGIPHVGPLIGK 228
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHD------ECGYDYVEIRDGPSASSPLLGR 74
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 41872557   229 YCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Cdd:pfam00431  75 FCGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
292-424 4.67e-29

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 111.39  E-value: 4.67e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557   292 QISASSTYSDGrwTPQQSRLHGDDN-GWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRetqNGYYVKSYKLEVSTNGE 370
Cdd:pfam00754   1 QITASSSYSGE--GPAAAALDGDPNtAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDG---SNGYVTSYKIEYSLDGE 75
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 41872557   371 DWMVYRHGKnhkvFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSG--IALRLEL 424
Cdd:pfam00754  76 NWTTVKDEK----IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGngIALRAEL 127
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
438-545 1.63e-21

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 90.87  E-value: 1.63e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557 438 LGMLSGLiADSQISASSTQEYLWSPSAARLvSSRSGWFPRIPQAqpgEEWLQVDLGTPKTVKGVIIQGARGGDSItavea 517
Cdd:cd00057   3 LGMESGL-ADDQITASSSYSSGWEASRARL-NSDNAWTPAVNDP---PQWLQVDLGKTRRVTGIQTQGRKGGGSS----- 72
                        90       100
                ....*....|....*....|....*...
gi 41872557 518 rAFVRKFKVSYSLNGKDWEYIQDPRTQQ 545
Cdd:cd00057  73 -EWVTSYKVQYSLDGETWTTYKDKGEEK 99
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
449-544 7.78e-17

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 77.10  E-value: 7.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557   449 QISASSTQEYLWSPSAARLVSSRSGWfprIPQAQPGEEWLQVDLGTPKTVKGVIIQGARGGdsitaveARAFVRKFKVSY 528
Cdd:pfam00754   1 QITASSSYSGEGPAAAALDGDPNTAW---SAWSGDDPQWIQVDLGKPKKITGVVTQGRQDG-------SNGYVTSYKIEY 70
                          90
                  ....*....|....*.
gi 41872557   529 SLNGKDWEYIQDPRTQ 544
Cdd:pfam00754  71 SLDGENWTTVKDEKIP 86
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
433-540 6.29e-09

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 54.82  E-value: 6.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41872557    433 PCSNMLGMLSgliaDSQISASSTQeylWSPSAARL-VSSRSGWfprIPQAQPGEEWLQVDLGTPKTVKGVIIQGARGGDS 511
Cdd:smart00231   1 PCNEPLGLES----DSQITASSSY---WAAKIARLnGGSDGGW---CPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGD 70
                           90       100
                   ....*....|....*....|....*....
gi 41872557    512 ITavearafvrKFKVSYSLNGKDWEYIQD 540
Cdd:smart00231  71 WV---------TYKLEYSDDGVNWTTYKD 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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