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Conserved domains on  [gi|42570631|ref|NP_973389|]
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phosphatidic acid phosphatase 1 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02715 super family cl30830
lipid phosphate phosphatase
 1-302 0e+00

lipid phosphate phosphatase


The actual alignment was detected with superfamily member PLN02715:

Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 628.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631    1 MQEIDLSVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPI 80
Cdd:PLN02715  26 IQEIDLGVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPI 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631   81 IVFVCFYLKRTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGVVCHGKAAEVKEGHK 160
Cdd:PLN02715 106 ILFVCFYLKRRCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGVICHGKAAEVKEGHK 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  161 SFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCY 240
Cdd:PLN02715 186 SFPSGHTSWSFAGLTFLSLYLSGKIKAFNGEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAFCY 265

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42570631  241 RQFYPNPYHEEGWGPYAYFKAAQERGVPVTSSQNGDALRAMSLQMDSTSLENMESGTSTAPR 302
Cdd:PLN02715 266 RQFYPNPYHEEGWGPYAYFKAAQERGVPVASSQNGDALRAMSLQMDSTSLENMESGTSTAPR 327
 
Name Accession Description Interval E-value
PLN02715 PLN02715
lipid phosphate phosphatase
 1-302 0e+00

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 628.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631    1 MQEIDLSVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPI 80
Cdd:PLN02715  26 IQEIDLGVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPI 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631   81 IVFVCFYLKRTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGVVCHGKAAEVKEGHK 160
Cdd:PLN02715 106 ILFVCFYLKRRCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGVICHGKAAEVKEGHK 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  161 SFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCY 240
Cdd:PLN02715 186 SFPSGHTSWSFAGLTFLSLYLSGKIKAFNGEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAFCY 265

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42570631  241 RQFYPNPYHEEGWGPYAYFKAAQERGVPVTSSQNGDALRAMSLQMDSTSLENMESGTSTAPR 302
Cdd:PLN02715 266 RQFYPNPYHEEGWGPYAYFKAAQERGVPVASSQNGDALRAMSLQMDSTSLENMESGTSTAPR 327
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 55-243 6.55e-85

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 253.30  E-value: 6.55e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  55 TDLKYPFKDN-TVPIWSVPVYAVLLPIIVFVCFYLK-RTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRC 132
Cdd:cd03390   1 PSISYPFAESeTVPTWLLVIISVGIPLLVIILISLFfRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 133 FPDGK--ELYDALGGVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLV 210
Cdd:cd03390  81 FPDGGtpSDTLVGIDICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPRGSSWRLLLALLPLLLAILV 160

                       170       180       190
                ....*....|....*....|....*....|...
gi 42570631 211 GISRVDDYWHHWQDVFAGALIGTLVAAFCYRQF 243
Cdd:cd03390 161 AVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 103-244 1.33e-24

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 95.95  E-value: 1.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631   103 LLFAVLITGVITDSIKVATGRPRPNFYWRCFPDgkelydalggvvcHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLS 182
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGL-------------VPAPSTLPGLGYSFPSGHSATAFALALLLALLLR 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42570631   183 GKIKAfnneghvAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQFY 244
Cdd:pfam01569  69 RLRKI-------VRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
104-240 4.36e-18

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 78.16  E-value: 4.36e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631    104 LFAVLITGVITDSIKVATGRPRPNFYWRCFpdgkelydalggVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSG 183
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGD------------ACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPA 68

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 42570631    184 kikafnnegHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCY 240
Cdd:smart00014  69 ---------RAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 26-243 9.83e-15

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 71.22  E-value: 9.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  26 WIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPIIVFVCFYLKRTCVYDLhhsiLGLLF 105
Cdd:COG0671   5 LLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLL----LLAAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 106 AVLITGVITDSIKVATGRPRPNfywrcfpdgkelydalggVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLsgki 185
Cdd:COG0671  81 LLLLLLLLLLLLKYLFGRPRPF------------------VVPDLELLLGTAGGYSFPSGHAAAAFALALVLALLL---- 138

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 42570631 186 kafnneghvAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQF 243
Cdd:COG0671 139 ---------PRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
 
Name Accession Description Interval E-value
PLN02715 PLN02715
lipid phosphate phosphatase
 1-302 0e+00

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 628.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631    1 MQEIDLSVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPI 80
Cdd:PLN02715  26 IQEIDLGVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPI 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631   81 IVFVCFYLKRTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGVVCHGKAAEVKEGHK 160
Cdd:PLN02715 106 ILFVCFYLKRRCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGVICHGKAAEVKEGHK 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  161 SFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCY 240
Cdd:PLN02715 186 SFPSGHTSWSFAGLTFLSLYLSGKIKAFNGEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAFCY 265

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42570631  241 RQFYPNPYHEEGWGPYAYFKAAQERGVPVTSSQNGDALRAMSLQMDSTSLENMESGTSTAPR 302
Cdd:PLN02715 266 RQFYPNPYHEEGWGPYAYFKAAQERGVPVASSQNGDALRAMSLQMDSTSLENMESGTSTAPR 327
PLN02250 PLN02250
lipid phosphate phosphatase
 1-300 7.17e-152

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 427.81  E-value: 7.17e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631    1 MQEIDLSVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPI 80
Cdd:PLN02250   1 MPEIQLGAHTIRSHGVKVARTHMHDWLILLLLVVIEVVLNVIEPFHRFVGKDMLTDLSYPLQDNTIPFWAVPLIAILLPF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631   81 IVFVCFYLKRTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDAL-GGVVCHGKAAEVKEGH 159
Cdd:PLN02250  81 AVILVYYFIRRDVYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGVFHPVtTDVLCTGAKSVIKEGH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  160 KSFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFC 239
Cdd:PLN02250 161 KSFPSGHTSWSFAGLGFLSLYLSGKIRVFDRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASFC 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42570631  240 YRQFYPNPYHEEGWGPYAYFKAAQERGVPVTSSQNGDALRAMSLQMDSTSLENmESGTSTA 300
Cdd:PLN02250 241 YLQFFPPPYDIDGWGPHAYFQMLAESRNGAQSSNGINHLSVQQTELESVYIDS-QHGMETS 300
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 1-266 1.63e-141

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 402.10  E-value: 1.63e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631    1 MQEIDLSVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPI 80
Cdd:PLN02731  20 MREAQLGGHTLRSHGMTVARTHMHDWIILVLLVILECVLLIIHPFYRFVGKDMMTDLSYPLKSNTVPIWSVPVYAMLLPL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631   81 IVFVCFYLKRTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGVVCHGKAAEVKEGHK 160
Cdd:PLN02731 100 VIFIFIYFRRRDVYDLHHAVLGLLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALYDSLGDVICHGDKSVIREGHK 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  161 SFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCY 240
Cdd:PLN02731 180 SFPSGHTSWSFSGLGFLSLYLSGKIQAFDGKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLAISTICY 259

                        250       260
                 ....*....|....*....|....*....
gi 42570631  241 RQFYPNPYHEEGWGPYAYFK---AAQERG 266
Cdd:PLN02731 260 LQFFPPPYHTEGWGPYAYFQvleAARVQG 288
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 55-243 6.55e-85

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 253.30  E-value: 6.55e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  55 TDLKYPFKDN-TVPIWSVPVYAVLLPIIVFVCFYLK-RTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRC 132
Cdd:cd03390   1 PSISYPFAESeTVPTWLLVIISVGIPLLVIILISLFfRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 133 FPDGK--ELYDALGGVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLV 210
Cdd:cd03390  81 FPDGGtpSDTLVGIDICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPRGSSWRLLLALLPLLLAILV 160

                       170       180       190
                ....*....|....*....|....*....|...
gi 42570631 211 GISRVDDYWHHWQDVFAGALIGTLVAAFCYRQF 243
Cdd:cd03390 161 AVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 104-238 3.25e-32

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 116.58  E-value: 3.25e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 104 LFAVLITGVITDSIKVATGRPRPNFYWRCFPDgkelYDALG----------GVVCHGKAAEVKEGHKSFPSGHTSWSFAG 173
Cdd:cd03384  10 LFGLFATQLLTDLGKYVTGRLRPHFLDVCKPN----YTDLTcsldhqyiadCTCCTGDPDLIREARLSFPSGHASLSMYA 85

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42570631 174 LTFLSLYLSGKIKAFNNegHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAF 238
Cdd:cd03384  86 AVFLALYLQARLKLRGS--RLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALF 148
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 96-240 4.71e-28

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 104.85  E-value: 4.71e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  96 LHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYdalggvvchgkaaeVKEGHKSFPSGHTSWSFAGLT 175
Cdd:cd01610   1 RRLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDGDPLL--------------LTEGGYSFPSGHAAFAFALAL 66

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42570631 176 FLSLYLSGKIkafnneghvAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCY 240
Cdd:cd01610  67 FLALLLPRRL---------LRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 103-244 1.33e-24

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 95.95  E-value: 1.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631   103 LLFAVLITGVITDSIKVATGRPRPNFYWRCFPDgkelydalggvvcHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLS 182
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGL-------------VPAPSTLPGLGYSFPSGHSATAFALALLLALLLR 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42570631   183 GKIKAfnneghvAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQFY 244
Cdd:pfam01569  69 RLRKI-------VRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
104-240 4.36e-18

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 78.16  E-value: 4.36e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631    104 LFAVLITGVITDSIKVATGRPRPNFYWRCFpdgkelydalggVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSG 183
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGD------------ACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPA 68

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 42570631    184 kikafnnegHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCY 240
Cdd:smart00014  69 ---------RAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 96-240 1.06e-15

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 71.59  E-value: 1.06e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  96 LHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRcfpdgkelydalggvvchgkaaevkeGHKSFPSGHTSWSFAGLT 175
Cdd:cd03394   1 DREGLLILAEAAALTAAVTEGLKFAVGRARPDGSNN--------------------------GYRSFPSGHTASAFAAAT 54

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42570631 176 FLSlYLSGKIKAfnneGHVAklclvifpLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCY 240
Cdd:cd03394  55 FLQ-YRYGWRWY----GIPA--------YALASLVGASRVVANRHWLSDVLAGAAIGILVGYLVT 106
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 26-243 9.83e-15

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 71.22  E-value: 9.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  26 WIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPIIVFVCFYLKRTCVYDLhhsiLGLLF 105
Cdd:COG0671   5 LLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLL----LLAAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 106 AVLITGVITDSIKVATGRPRPNfywrcfpdgkelydalggVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLsgki 185
Cdd:COG0671  81 LLLLLLLLLLLLKYLFGRPRPF------------------VVPDLELLLGTAGGYSFPSGHAAAAFALALVLALLL---- 138

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 42570631 186 kafnneghvAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQF 243
Cdd:COG0671 139 ---------PRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 72-240 1.04e-12

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 65.32  E-value: 1.04e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  72 PVYAVLLPIIVFVCFYLKRTcvydlHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKelydalggvvchgk 151
Cdd:cd03392  41 PAVLLIIVLLLALLLLLKRR-----RRAALFLLLALLGGGALNTLLKLLVQRPRPPLHLLVPEGGY-------------- 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 152 aaevkeghkSFPSGHTSWSFAGLTFLSLYLSGKIKAFnneghVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALI 231
Cdd:cd03392 102 ---------SFPSGHAMGATVLYGFLAYLLARRLPRR-----RVRILLLILAAILILLVGLSRLYLGVHYPSDVLAGWLL 167


                ....*....
gi 42570631 232 GTLVAAFCY 240
Cdd:cd03392 168 GLAWLALLI 176
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 103-243 1.86e-09

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 56.18  E-value: 1.86e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 103 LLFAVLITGVITDSIKVATGRPRPNFYwrcFPDGkelydALGGVVCHGKAAevkegHKSFPSGHTSWSFAGLTFLSLyls 182
Cdd:cd03389  74 LFATVALSGILVNLLKFIIGRARPKLL---FDDG-----LYGFDPFHADYA-----FTSFPSGHSATAGAAAAALAL--- 137

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42570631 183 gkikafnneghvaklclvIFP------LLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQF 243
Cdd:cd03389 138 ------------------LFPryrwafILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALALYQRF 186
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 55-243 2.20e-09

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 55.73  E-value: 2.20e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  55 TDLKYPFKDNTVPIWSVPVYAVLLPIIVFVCFYLKRTcvydlhHSILGLLFAVLITGVITDSI-----KVATGRPRPnfy 129
Cdd:cd03395  15 GTLVHPLLDDLMPFLTGKKLSVPIFLLLALFILFRKG------PIGLLILLLVLLAVGFADQLasgflKPLVARLRP--- 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 130 wrCFPDgkELYDALGGVVCHGKAaevkeghkSFPSGHTSWSFAGLTFLSLYLSgkikafnneghvaKLCLVIFPLLAACL 209
Cdd:cd03395  86 --CNAL--DGVRLVVLGDQGGSY--------SFASSHAANSFALALFIWLFFR-------------RGLFSPVLLLWALL 140

                       170       180       190
                ....*....|....*....|....*....|....
gi 42570631 210 VGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQF 243
Cdd:cd03395 141 VGYSRVYVGVHYPGDVIAGALIGIISGLLFYLLF 174
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 100-238 4.57e-08

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 51.55  E-value: 4.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 100 ILGLLFAVLITGVItdsiKVATGRPRPnfyWRCFPDgkeLYDALGgvvchgkaaevkEGHKSFPSGHTSWSFAGLTFLSL 179
Cdd:cd03391  53 LLGLLLDIITVAIL----KALVRRRRP---AYNSPD---MLDYVA------------VDKYSFPSGHASRAAFVARFLLN 110

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 42570631 180 YLsgkikafnneghVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAF 238
Cdd:cd03391 111 HL------------VLAVPLRVLLVLWATVVGISRVLLGRHHVLDVLAGAFLGYLEALL 157
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 162-240 2.91e-06

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 46.50  E-value: 2.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 162 FPSGH--TSWSFAGLTFLSLYLSGKikafNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFC 239
Cdd:cd03382  83 MPSSHsqFMGFFAVYLLLFIYLRLG----RLNSLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGILW 158


                .
gi 42570631 240 Y 240
Cdd:cd03382 159 F 159
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 69-241 3.26e-06

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 46.91  E-value: 3.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  69 WSVPVYAVLLPIIVFVCFYLKRtcvydLHHSILGLLFAVLITGVITDSI---KVATGRPRPN------------FYWRCF 133
Cdd:cd03396  40 LLSIALAVLLLALALLFFRRKR-----LRRRRRALLLLILVIGLGLLVVailKSHWGRPRPWdltefggdapytPLFSGP 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 134 PDGKElydalggvvchgkaaevkeGHKSFPSGHTSwsfAGLTFLSLYLSGKIKAFnnegHVAKLCLViFPLLAACLVGIS 213
Cdd:cd03396 115 SNGCG-------------------KGCSFPSGHAS---AGFALLALYFLFRRRRP----RLARLVLA-AGLALGALMGLA 167

                       170       180
                ....*....|....*....|....*...
gi 42570631 214 RVDDYWHHWQDVFAGALIGTLVAAFCYR 241
Cdd:cd03396 168 RMARGAHFLSDVLWSLLLVWLIALLLYR 195
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 161-241 2.84e-04

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 40.32  E-value: 2.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 161 SFPSGHTS--WSFAgltfLSLYLSGKIKAfnneghvaklclVIFPLLAACLVGISRVddyW--HHWQ-DVFAGALIGTLV 235
Cdd:cd03385  78 SFPSDHTTlfFSIA----FSLLLRRRKWA------------GWILLILALLVAWSRI---YlgVHYPlDMLGAALVAVLS 138


                ....*.
gi 42570631 236 AAFCYR 241
Cdd:cd03385 139 ALLVFQ 144
PAP2_like_1 cd03380
PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium ...
 103-237 3.32e-04

PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases.


Pssm-ID: 239475  Cd Length: 209  Bit Score: 40.88  E-value: 3.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 103 LLFAVLITGVITDSIKVATGRPRPNfywrcfpdgkELYDALGGVVChgKAAEVKEGHKSFPSGHTSWSFAGLTFLSLyls 182
Cdd:cd03380  98 LARALTDAGIATWDAKYHYNRPRPF----------VAIRLQWLPIC--TPEEGTPKHPSYPSGHATFGGAAALVLAE--- 162

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42570631 183 gkikafnneghvaklclvIFPLLAACL------VGISRVddywH---HWQ-DVFAGALIGTLVAA 237
Cdd:cd03380 163 ------------------LFPERAAELlaraaeAGNSRV----VagvHWPsDVEAGRILGEAIAA 205
COG3907 COG3907
Membrane-associated enzyme, PAP2 (acid phosphatase) superfamily [General function prediction ...
 75-245 9.33e-04

Membrane-associated enzyme, PAP2 (acid phosphatase) superfamily [General function prediction only];


Pssm-ID: 443113  Cd Length: 236  Bit Score: 39.88  E-value: 9.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631  75 AVLLPIIVFVCFYLKRtcvYDLHHSILGLLFAVLITGVITDSI-KVATGRPRPnfyWRCfpdgkelyDALGGVVCH---- 149
Cdd:COG3907  75 AVLLLLLLLASFKRPR---LRRYRRRLLYLLLSLALGLLVVSLlKSHTGRPCP---WDL--------VEFGGDAPYvplf 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 150 GKAAEVKEGHKSFPSGHTSwsfAGLTFLSLYLsgkikAFNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGA 229
Cdd:COG3907 141 EPGPAGAGPGRCFPAGHAS---AGFALLALYF-----LLRRRRPRLARLGLAAGLALGLLMGLAQMLRGAHFLSHTLWSA 212

                       170
                ....*....|....*.
gi 42570631 230 LIGTLVAAFCYRQFYP 245
Cdd:COG3907 213 WICWLVALLLYWLLLR 228
PAP2_diacylglycerolkinase cd03383
PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like ...
 163-243 1.00e-03

PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be determined.


Pssm-ID: 239478 [Multi-domain]  Cd Length: 109  Bit Score: 38.08  E-value: 1.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 163 PSGHTSWSFAGLTFLSLylsgkikafNNEGHVaklcLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQ 242
Cdd:cd03383  42 PSGHAAIAFSIATAISL---------ITNNPI----ISILSVLLAVMVAHSRVEMKIHTMWEVVVGAILGALITLLIFKI 108


                .
gi 42570631 243 F 243
Cdd:cd03383 109 F 109
PAP2_haloperoxidase cd03398
PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as ...
 158-238 2.98e-03

PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products, such as volatile halogenated hydrocarbons, chiral halogenated terpenes, acetogenins and indoles.


Pssm-ID: 239492  Cd Length: 232  Bit Score: 38.17  E-value: 2.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42570631 158 GHKSFPSGHTSWSFAGLTFLSlYLSGKIKAFNNEGHVAKLCLVIFPLL-------AACLVGISRVddyWH--HWQ-DVFA 227
Cdd:cd03398 143 PHPSYPSGHATFAGAAATVLK-ALFGSDKVPDTVSEPDEGGPSTGVTRvwaelneLADEVAISRV---YAgvHFRsDDAA 218

                        90
                ....*....|.
gi 42570631 228 GALIGTLVAAF 238
Cdd:cd03398 219 GAALGEQIGAA 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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