|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
115-536 |
4.18e-102 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 314.50 E-value: 4.18e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 115 QMKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQ-GSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQ 193
Cdd:cd13136 1 LHREILALALPAILSNITVPLLGLVDTAVVGHlGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 194 HQISILLFIGLACGVTMMVL-TRLFGSWALTGVKNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALA 272
Cdd:cd13136 81 ALLVRALLLALAIGLLLILLqSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 273 VASAINGVGDVVLCTFLGYGIAGAAWATMVSQVVAAYMMMDALNKKGY---SAFSFCVPSPSELLTIFGLAAPVFITMMS 349
Cdd:cd13136 161 VGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRllgKSLSRRLPSKAALKRLFKLNRDIFIRTLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 350 KVLFYTLLVYFATSMGTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFmPELLFGInRNLPKARVLLKSLVIIGATLGIVV 429
Cdd:cd13136 241 LLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEAL-VGRALGA-GDRKAARRVARRLLQWGLGLGVLL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 430 GTIGTAVPWLFPGIFTRDKVVTSEMHKVIIPYFLALSITPSTHSLEGTLLAGRDLRYISLSMTGCLAVAGLLLMLLSnGG 509
Cdd:cd13136 319 ALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSLAVFLPLLFLLV-PL 397
|
410 420
....*....|....*....|....*..
gi 240254498 510 FGLRGCWYALVGFQWARFSLSLFRLLS 536
Cdd:cd13136 398 WGNHGLWLALILFMLLRGLTLALRLPR 424
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
116-533 |
3.09e-50 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 178.41 E-value: 3.09e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 116 MKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQ 195
Cdd:COG0534 7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 196 ISILLFIGLACGVTMMVLTRLFGSWALTGVK-NADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVA 274
Cdd:COG0534 87 LGQALLLALLLGLLLTLLGLLFAPPLLRLLGaDPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 275 SAINGVGDVVLCTFLGYGIAGAAWATMVSQVVAA-YMMMDALNKKGYSAFSF--CVPSPSELLTIFGLAAPVFITMMSKV 351
Cdd:COG0534 167 NVLNIVLDPLLIFGGGLGVAGAALATVISQAVSAlLLLYYLFRKRSLLRLRLrdLRPDRKILKRILRIGLPAGLQQLAES 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 352 LFYTLLVYFATSMGTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFMpellfGIN---RNLPKARVLLKSLVIIGATLGIV 428
Cdd:COG0534 247 LGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLV-----GQNlgaGDYDRARRAARLALLLALGIGLL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 429 VGTIGTAVPWLFPGIFTRDKVVTSEMHKVIIPYFLALSITPSTHSLEGTLLAGRDLRYISLSMTGCLAVAGLLLM-LLSN 507
Cdd:COG0534 322 LALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAyLLAF 401
|
410 420
....*....|....*....|....*.
gi 240254498 508 GGFGLRGCWYALVGFQWARFSLSLFR 533
Cdd:COG0534 402 LGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
135-538 |
1.29e-29 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 121.08 E-value: 1.29e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 135 LMSLIDTAVIGQGSSLELAALGPATvicdyLCYTFMF-----LSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVT 209
Cdd:cd13137 19 LVGLVDVFMVGRLGAEAIAAVGLAT-----QVLWLLLvlnmaLGTGTVALVSQSYGAGDYERARRALGQSLLLALLLSLP 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 210 MMVLTRLFGSWALTGV-KNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVL--- 285
Cdd:cd13137 94 LALLGLLFAEPLLRLLgADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVLDYVLifg 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 286 -CTFLGYGIAGAAWATMVSQVVAAYMMMDALNKKGY---SAFSFCVPSPSELLTIFGLAAPVFITMMSKVLFYTLLVYFA 361
Cdd:cd13137 174 lWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLpikISFKGFRLDRKIIKKLLRIGLPAGLEQLLRSLGFLVLLAIV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 362 TSMGTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSfmpelLFGIN---RNLPKARVLLKSLVIIGATLGIVVGTIGTAVPW 438
Cdd:cd13137 254 ASYGTAALAAYQIGLRIESLAFMPGFGFSMAAST-----LVGQNlgaGDPDEARRYGKRALRLGVLFMGLLGLLLFIFAP 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 439 LFPGIFTRDKVVTSEMHKVIIPYFLALSITPSTHSLEGTLLAGRDLRYISLSMTGCLAVAGLLLM--LLSNGGFGLRGCW 516
Cdd:cd13137 329 PLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAylLGFVLGLGLTGIW 408
|
410 420
....*....|....*....|..
gi 240254498 517 YALVGFQWARFSLSLFRLLSRD 538
Cdd:cd13137 409 LAMFVDTIVRAILLLYRFRKGK 430
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
135-518 |
1.25e-26 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 112.55 E-value: 1.25e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 135 LMSLIDTAVIGQ-GSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVL 213
Cdd:cd13138 21 LYNLVDLLIVGQfLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVGTLLVLFLILGIVLTIL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 214 TRLFGSWALTGVK-NADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLCTFLGYG 292
Cdd:cd13138 101 GLLFAPPILRLMNtPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIACVLNIILDLLFIAVFHMG 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 293 IAGAAWATMVSQVVAAYMMMDALNKKGYSA---FSFCVPSPSELLTIFGLAAPVFITMMSKVLFYTLLVYFATSMGTNII 369
Cdd:cd13138 181 VAGAALATVIAQAISVLLALYYLRKKKLPFklsLKDFRFDKEILKEILKIGLPSALQQSLVSISFLIINSIVNSYGVVAS 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 370 AAHQVMLQIYTMSTVWGEPLSQTAQSFMPELLfGiNRNLPKArvllKSLVIIGATLGIVVGTIGTAVPWLFP----GIFT 445
Cdd:cd13138 261 AAYGIANKINSFAFLPPSAIGQAVSTFVAQNI-G-AGKIERA----KKGLRTGIIISLIIGLIIILLVFFFApqllGLFT 334
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 240254498 446 RDKVV---TSEMHKVIIPYFLALSItpsTHSLEGTLLA-GRDLRYISLSMTGCLAVAGLLLMLLSN-GGFGLRGCWYA 518
Cdd:cd13138 335 SDPEVieiGAEYLRIYSIDYILFGI---LFVFNGLFRGlGKTKFPMIISILRLWLVRIPLAYLLSRlTGLGLFGIWLA 409
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
125-452 |
2.99e-24 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 103.86 E-value: 2.99e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 125 PAAGLWLCGPLMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGL 204
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 205 ACGVTMMVLTRLFGSWALT-GVKNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDV 283
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSlMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 284 VL--CTFLGYGIAGAAWATMVSQVVAAYMMMDALNKK---GYSAFSFCVPSPSELLTIFGLAAPVFITMMSKVLFYTLLV 358
Cdd:TIGR00797 161 ILifGKFGFLGIVGAALATVISYWLMFLLLLYYIKKAkkiGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 359 YFATSMGTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFMPELLfGInRNLPKARVLLKSLVIIGATLGIVVGTIGTAVPW 438
Cdd:TIGR00797 241 LLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQAL-GA-GDPKRAKEVARVALKLSLLLGLVLAIILILFRE 318
|
330
....*....|....
gi 240254498 439 LFPGIFTRDKVVTS 452
Cdd:TIGR00797 319 FIARLFTNDPEVLE 332
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
131-535 |
5.90e-22 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 98.55 E-value: 5.90e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 131 LCGPLMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTM 210
Cdd:cd12082 9 LLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAILLGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 211 MVLTRLFGSW-ALTGVKNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLCTFL 289
Cdd:cd12082 89 AALLLFFSPLiLSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLDPLLIFGL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 290 G---YGIAGAAWATMVSQVVAA---YMMMDALNKKGYSAFSFCVPSPSELLTIFGLAAPVFITMMSKVLFYTLLVYFATS 363
Cdd:cd12082 169 GppeLGIAGAALATVISYVIGAlllLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 364 -MGTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFMPELLfgINRNLPKARVLLKSLVIIGATLGIVVGTIGtavpWLFPG 442
Cdd:cd12082 249 fGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNL--GAGNFDRARRITWVALLIGLLIGAVLGLLI----LLFPE 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 443 ----IFTRDKVVTSEMHKVIIPYFLALSITPSTHSLEGTLLAGRDLRYISLSMTGCLAVAGL-LLMLLSNGGFGLRGCWY 517
Cdd:cd12082 323 pilsLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLpLAYVLAYLGLGLYGIWL 402
|
410
....*....|....*...
gi 240254498 518 ALVGFQWARFSLSLFRLL 535
Cdd:cd12082 403 ALVISLILAALVLLLFFR 420
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
135-537 |
5.46e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 95.65 E-value: 5.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 135 LMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVLT 214
Cdd:cd13134 21 LLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGVALLFNLLLGLVFSLLL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 215 RLFGSWALT-GVKNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLCT----FL 289
Cdd:cd13134 101 LFFGAELLRlMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNIVGNYLLIFgwfgLP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 290 GYGIAGAAWATMVSQVVAAYMMMDAL--NKKGYSAFSFCVPSPSELL-TIFGLAAPVFITMMSKVLFYTLLVYFATSMGT 366
Cdd:cd13134 181 KLGVAGVAISTVISRAVGLVLLFILLfrKLKIRFRLKDLRPFPKKLLkKILKIGLPSAGEELSYNLSQTVITAFIARLGT 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 367 NIIAAHQVMLQIYTMSTVWGEPLSQTAQSFMPELLfGiNRNLPKARVLLKSLVIIGATLGIVVGTIgtavPWLF----PG 442
Cdd:cd13134 261 AALAARTYASNISMFVFLFSLAIGQATQIIVGHLV-G-AGDFDEAYKRVLKSLKIGLLVSLAVALL----LALFrepiLG 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 443 IFTRDKVVTSEMHKVIIPYFLALSITPSTHSLEGTLLAGRDLRYISLSMTGCLAVAGLLLMLLS--NGGFGLRGCWYALV 520
Cdd:cd13134 335 LFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYLLgiVLGLGLLGVWIAFA 414
|
410
....*....|....*..
gi 240254498 521 GFQWARFSLSLFRLLSR 537
Cdd:cd13134 415 ADEWVRGIIMLWRWRSG 431
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
117-538 |
5.05e-20 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 92.59 E-value: 5.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 117 KEIVMFTGPAAGLWLCGPLMSLIDTAVIGQGSSLELAALGPATVICdYLCYTFMF-LSVATSNLVATSLARQDKDEVQHQ 195
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLY-FAILMLFFgLSSGVQVFVAQYNGAGRYSRIGRV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 196 ISILLFIGLACGVTMMVLTRLFGSWALTGV-KNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVA 274
Cdd:cd13133 84 LWQGLYFSLLLAPLLALLSALAAPLLFLLLgHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 275 SAINGVGDVVLC----TFLGYGIAGAAWATMVSQVVAA----YMMMDALNKKGYSAFSFCVPSPSELLTIFGLAAPVFIT 346
Cdd:cd13133 164 VVVNIVLDYALIfgklGFPAMGIAGAAIATVIAEAVSLlfflLLLFRRKNRRRFGLRRAWRFDRELLRRILRLGLPSGLQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 347 MMSKVLFYTLLVYFATSMGTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFMPELLfGINRnLPKARVLLKSLVIIGATLG 426
Cdd:cd13133 244 FFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQAL-GAGR-PDLAMRVTRRGLKLALAYM 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 427 IVVGTIGTAVPWLFPGIFTRDKVVTSEMHKVIIP-YFLALSITPS--THSLEGTLLAGRDLRYISLSMTGCLAVAGLLLM 503
Cdd:cd13133 322 LLLGILFLLFPELLLSIFTPGADFALIAELAVPLlRFVAAYILFDalALVFAGALRGAGDTRFVMLAELIVAWLYLLPPA 401
|
410 420 430
....*....|....*....|....*....|....*.
gi 240254498 504 LLSNG-GFGLRGCWYALVGFQWARFSLSLFRLLSRD 538
Cdd:cd13133 402 YLLVVlGAGLAGAWTVETVYVIVLALIFLLRFRSGK 437
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
135-520 |
2.62e-15 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 78.31 E-value: 2.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 135 LMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVLT 214
Cdd:cd13131 21 AMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRAVRQGLWLALLLSLPLMLLL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 215 rLFGSWALT--GVkNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLC----TF 288
Cdd:cd13131 101 -WLAPPILPlmGQ-EPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLALVLNIPLNYVLIfgkfGL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 289 LGYGIAGAAWATMVSQVVAAYMMMDALNK----KGYSAFS-FCVPSPSELLTIFGLAAPVFITMMSKVLFYTLLVYFATS 363
Cdd:cd13131 179 PALGGAGAGLATAIVYWLMFLALAFYIRRhkrfRRYRLFArFWRPDWARLKELLRLGLPIGLTIFFEVSLFAAVALLMGR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 364 MGTNIIAAHQVMLQIytmstvwgeplsqTAQSFMPELLFGI-----------NRNLPKARVllksLVIIGATLGIVVGTI 432
Cdd:cd13131 259 LGTTVLAAHQIALNF-------------ASLLFMVPLGISMaatvrvgfalgAGDPADARR----AGLVGLGLGVGFAAL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 433 GTAVPWLFP----GIFTRDKVV---TSEMHKVIIPYFLALSI-TPSTHSLEGTllagRDLRYISLSMTGCLAVAGLLLML 504
Cdd:cd13131 322 TALLLLLFPeqiaGLYTNDPAVialAASLLVFAALFQLFDGIqVVAAGALRGY----KDTRVPFLLALISYWGIGLPLGY 397
|
410
....*....|....*...
gi 240254498 505 L--SNGGFGLRGCWYALV 520
Cdd:cd13131 398 LlaFTTGLGAFGVWIGLI 415
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
137-519 |
3.52e-15 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 77.55 E-value: 3.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 137 SLIDTAVIGQG-SSLELAALG---PATVICDYLcytFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMV 212
Cdd:cd13143 24 NIVDGIFVGHGvGALALAAVNlvfPIIMLLMAL---GLMIGVGGASLISRRLGAGDREKANRIFSTALLLSLILGLLLTI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 213 LTRLFGSWALTGV-KNADIVPAANKYVQIRGLAWPAVLIGWVAQ-------SASLGMKdswgplkALAVASAINGVGDVV 284
Cdd:cd13143 101 LGLLFLDPLLRLLgASGELLPYAVDYLRIILLGAPFTILSSVLNnllraegKPKLAML-------GMLIGAVLNIILDPL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 285 LCTFLGYGIAGAAWATMVSQVVAAYMMMDALNKKG---YSAFSFCVPSPSELLTIFGLAAPVFITMMSKVLFYTLLVYFA 361
Cdd:cd13143 174 FIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKsllKLSLLRFKLSLKIIKEILALGFPSFLMQLSSSVVTIVLNLTL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 362 TSMGTNI-IAAHQVMLQIYTMSTVWGEPLSQTAQSfmpelLFGIN---RNLPKARVLLKSLVIIGATLGIVVGTIGTAVP 437
Cdd:cd13143 254 LGYGGDIgVAAFGIVTRILTFLFLPLIGLSQGLQP-----IIGYNygaGNYDRVKQALKLALIVALIYGLVLFLILLLFP 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 438 WLFPGIFTRDKVVTSEMHKVIIPYFLALSITPSTHSLEGTLLAGRDLRY---ISLSMTGCLAVAGLLLMllsNGGFGLRG 514
Cdd:cd13143 329 EQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRaalLSLLRQGLFLIPLLLIL---PRLFGLDG 405
|
....*
gi 240254498 515 CWYAL 519
Cdd:cd13143 406 IWLAF 410
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
137-448 |
1.95e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 75.64 E-value: 1.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 137 SLIDTAVIGQGSSLELAALGPATVICdYLCYTFMFLSVA-TSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVLTR 215
Cdd:cd13140 25 NLTDMFWVGRLGSDAVAAVGTAGFFV-WLAYALALLSKIgAQVKVSQSIGAKDEKEARKYARNALQLNLLLGILYGLLLL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 216 LFGSwALTG---VKNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLC----TF 288
Cdd:cd13140 104 LFAK-PLIGffnLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAIGLVLNIILDPLLIfgfgPF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 289 LGYGIAGAAWATMVSQVVAAYMMMDALNKKGYSAFSFCV---PSPSELLTIFGLAAPVFITMMSKVLFYTLLVYFATSMG 365
Cdd:cd13140 183 PALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRIlkrPDRKYIKEILKLGLPVALQSILFALISMILARIIASFG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 366 TNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFmpellFGIN---RNLPKARVLLKSLVIIGATLGIVVGTIGTAVPWLFPG 442
Cdd:cd13140 263 PVAIAAQKVGSQIESISWMTAEGFSTALAAF-----VGQNygaGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFS 337
|
....*.
gi 240254498 443 IFTRDK 448
Cdd:cd13140 338 LFIPDP 343
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
129-467 |
1.69e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 72.61 E-value: 1.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 129 LWLCGPLMS---------LIDTAVIGQGSSLELAALGPATVICdYLCYTFMF-LSVATSNLVATSLARQDKDEVQH---- 194
Cdd:cd13142 14 LKLAWPIIVsnllqvaynLADTFWLGRLGADAVAAPSISWPLI-FLFISLGGgLTVAGTALVAQYTGAGDYDKANKvagq 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 195 QISILLFIGLACGVTMMVLTR-LFGSWALTGvknADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAV 273
Cdd:cd13142 93 TFSFVIILSLILAVLGYILSRpLLLLLIGAP---EEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIMFG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 274 ASAINGVGDVVL----CTFLGYGIAGAAWATMVSQVVAAYMMMDALNKKGYS---AFSFCVPSPSELLTIFGLAAPVFIT 346
Cdd:cd13142 170 SVLLNVILDPLLifgiGPFPGLGVAGAALATVISRGIAAVIGLYLLFKGRVGlkiSLRDLKPDWEWLKKIFRIGLPSSIE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 347 MMSKVLFYTLLVYFATSMGTNIIAAHQVMLQIYTMSTVWGEPLSQtAQSFMpellFGIN---RNLPKA-RVLLKSLVIIG 422
Cdd:cd13142 250 QSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLAR-ATSTM----VGQNlgaGQIDRAeEIVKKAALLIF 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 240254498 423 ATLGIvVGTIGTAVPWLFPGIFTRDKVV---TSEMHKVIIPYFLALSI 467
Cdd:cd13142 325 LILVI-GGVLAFLFAEPIVRVFINDPEVikeGADFLRIVAPSFPFFGL 371
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
105-318 |
1.77e-11 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 66.34 E-value: 1.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 105 DDLATQSIWGQMKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQGssLELAALGPATVICDYLCYTFMF-------LSVATS 177
Cdd:cd13124 212 SPRSKISTKEILKELLSYAIPITLSSLILPLLQLIDSFTVPRR--LQAAGLSESEATALYGILTGRAqplvqlpTVIATA 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 178 nlVATSL--------ARQDKDEVQHQIS----ILLFIGLACGVTMMVLTR-----LFGSwaltgvknadivPAANKYVQI 240
Cdd:cd13124 290 --LSTSLvpaiseayAKGDKKELRRRINqalrLTLLIGLPAAVGLAVLAEpintlLFGD------------SEGGLILQI 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 241 rgLAWPAVLIGWVAQSASL--GMKDSWGPLKALAVASAINGVGDVVLCTFLGygIAGAAWATMVSQVVAAYMMMDALNKK 318
Cdd:cd13124 356 --LAPSILFLSLQQVTAAIlqGLGKVKIPVINLLIGLLVKIVLNYVLIPIFG--IYGAAIATVIGFLVAALLNLRALKKL 431
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
115-467 |
3.00e-10 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 62.59 E-value: 3.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 115 QMKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMF-LSVATSNLVATSLARQDKDEV- 192
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLgLASALDTLCGQAFGAKNYKLVg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 193 ---QHQISILLFIGLACGVTMMV----------------LTRLFGSWALTGVKNADIVPAANKYVQIRGLAWPAVLIGwv 253
Cdd:cd13132 81 vylQRALVILLLCCVPISLLWLNtepillllgqdpeiarLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYIS-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 254 aqsaslgmkdswgplkalAVASAINGVGDVVLCTFLGYGIAGAAWATMVSQ-----VVAAYMMMDALNKKGYSAFSfcVP 328
Cdd:cd13132 159 ------------------LVALLLNILLNYLLVFVLGLGFIGAALATSISYwlivvLLLLYIFFSKGHKATWGGFS--RE 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 329 SPSELLTIFGLAAPVFITMMSKVLFYTLLVYFATSM-GTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFMPELLfGINRn 407
Cdd:cd13132 219 AFRGWGPFLKLAIPSALMLCLEWWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNEL-GAGN- 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 240254498 408 lPK-ARVLLKSLVIIGATLGIVVGTIGTAVPWLFPGIFTRDKVVTSEMHKVIipYFLALSI 467
Cdd:cd13132 297 -PKrAKLAAIVALILSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLL--PILALFQ 354
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
108-371 |
8.46e-10 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 61.33 E-value: 8.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 108 ATQSIWGQMKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQgsSLELAALGPATVICDYLCYTFMFL-------SVATSnlV 180
Cdd:COG5841 224 SKESSKDILKELLRIAIPITLSSLVLPLFQLIDSFTVPR--RLQAAGLSASEATSLYGILSGMAQplvnlptVLATA--L 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 181 ATSL--------ARQDKDEVQHQIS----ILLFIGLACGVTMMVLTR-----LFGSwaltgvknadivPAANKYVQIrgL 243
Cdd:COG5841 300 ATSLvpaiseafAKKDRKLVRRRINqalrLTLLIGLPAAVGLAVLAEpintlLFGN------------PEGGGILAI--L 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 244 AWPAVLIGWVAQSASL--GMKDSWGPLKALAVASAINGVGDVVLCTFLGygIAGAAWATMVSQVVAAYMMMDALNKkgYS 321
Cdd:COG5841 366 APSAIFLSLQQVTTGIlqGLGKQKIPVINLLIGLLVKIILNYLLVPLFG--IYGAALATVIGYLVAAILNLAALKK--YT 441
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 240254498 322 AFSFcvPSPSELLTIFGLAAPVFITMMskVLFYTLLVYFATSMGTNIIAA 371
Cdd:COG5841 442 GFKL--DLRRRLLKPLLASLIMGIVVL--LLYRLLSLFLPESRLGALLAT 487
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
134-306 |
1.96e-09 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 59.75 E-value: 1.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 134 PLMSLIDTAVIGQ-GSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMV 212
Cdd:PRK10367 26 PLLGLVDTAVIGHlDSPVYLGGVAVGATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQALARALVQPLLLALGAGALIAL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 213 LTRLFGSWALTGVKNADIVPA-ANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLCTFLGY 291
Cdd:PRK10367 106 LRTPLIDLALHIVGGSEAVLEqARRFLEIRWLSAPASLANLVLLGWLLGVQYARAPVILLVVGNILNIVLDLWLVMGLHM 185
|
170
....*....|....*
gi 240254498 292 GIAGAAWATMVSQVV 306
Cdd:PRK10367 186 NVQGAALATVIAEYA 200
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
135-518 |
3.70e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 52.62 E-value: 3.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 135 LMSLIDTAVIGQGSSLELAALGPATVIcDYLCYTFMF-LSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVL 213
Cdd:cd13144 26 LYNIVDSIFVARLGENALTAVSLAFPI-QNLMIAVAVgTGVGVNALLSRSLGEKDQKEANKAANNGLLLALLSYLLFLLL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 214 TRLFGSW--ALTGVkNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVL----CT 287
Cdd:cd13144 105 GLFGVKPffRLFTD-DPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAIINIILDPILifglFG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 288 FLGYGIAGAAWATMVSQVVAAYMMMDALNKKGYSAFSFCVPSPSELLT---IFGLAAPVFITMMSKVLFYTLLVYFATSM 364
Cdd:cd13144 184 FPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLFRPSLRIikeIYAVGLPSIIMQAISSVMVFGLNKILAGF 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 365 GTNIIAAHQVMLQIYTMstvwgeplsqtaqSFMPelLFGIN-------------RNLPKARVLLKslviIGATLGIVVGT 431
Cdd:cd13144 264 GPTAVAVFGIYFKLQSF-------------VFMP--VFGLNnglipivaynygaGNKDRIREAIK----YAILIAVVIML 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 432 IGTAVPWLFP----GIFTrdkvVTSEMHKVIIPYFLALSI----TPSTHSLEGTLLA-GRDLRYISLSMTGCLAVAGLLL 502
Cdd:cd13144 325 AGGLLFQLFPdqllGLFN----ASEEMLAIGVPALRIISLsflfAALSIILSGLFQAlGRGVYSLIISVARQLVVLLPLA 400
|
410
....*....|....*.
gi 240254498 503 MLLSNgGFGLRGCWYA 518
Cdd:cd13144 401 WLLAK-MFGLNGVWWS 415
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
113-312 |
7.79e-06 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 48.47 E-value: 7.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 113 WGQMKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQ-GSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDE 191
Cdd:cd12082 215 LELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAfGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDR 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 192 V----QHQISILLFIGLACGVTMMVLTRLfgsWALTGVKNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGP 267
Cdd:cd12082 295 ArritWVALLIGLLIGAVLGLLILLFPEP---ILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKS 371
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 240254498 268 LKALAVASAINGVGDVVLCTFLGYGIAGAAWATMVSQVVAAYMMM 312
Cdd:cd12082 372 LIVSLLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLL 416
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
125-284 |
2.12e-05 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 44.86 E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 125 PAAGLWLCGPLMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGL 204
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 205 ACGVTMMVLTRLFGS-WALTGVKNADIVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDV 283
Cdd:pfam01554 81 LLSLPIALLVLLFSEpILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNY 160
|
.
gi 240254498 284 V 284
Cdd:pfam01554 161 L 161
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
172-312 |
2.96e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 46.77 E-value: 2.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 172 LSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVLTRLFGSWALTGVKNADIVPAANKYVQIRGLAWPAVLIG 251
Cdd:cd13147 64 LGAGASSAISRRIGAKDKEGADNAAVHSILLGLIISIILTIVLLPFLEPILVLMGAGEVLDLAVDYGRIIFLGSIFLIFN 143
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 240254498 252 WVAQSASLGMKDSWGPLKALAVASAINGVGDVVLCTFLGYGIAGAAWATMVSQVVAAYMMM 312
Cdd:cd13147 144 NVAYGILRGEGDTKRAMYAMVAGSILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLL 204
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
107-371 |
1.20e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 44.60 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 107 LATQSIWgqmKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQGSSLELAALG---PATVICDYLCYTfmfLSVATSNLVATS 183
Cdd:cd13149 2 LTEGSIP---RHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISftfPVVLFLNSLTIG---LGIGASAVISRA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 184 LARQDKDEVQHQISILLFIGLACGVTMMVLTRLFGS--WALTGVKNaDIVPAANKYVQIRGLAWPAVLIGWVAQSASLGM 261
Cdd:cd13149 76 IGAGDRNKAKRLATDSLILSLLLSVIVSLLGLFTIPplFSLLGASG-EILPLIVEYMAIWYLGLVFLVLPMVGNAIIRAT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 262 KDSWGPLKALAVASAINGVGDVVLctFLGY------GIAGAAWATMVSQVVAAYMMMDALNKKgYSAFSFCVPSPSELLT 335
Cdd:cd13149 155 GDTKRPSLVMLGAALVNVILDPIL--IFGFgpipgmGIAGAAIATVISRALGLGAALYFLHYH-HRLIDFSEPSLKALFR 231
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 240254498 336 ----IFGLAAPVFITMMSKVLFYTLLVYFATSMGTNIIAA 371
Cdd:cd13149 232 swkdILSIGIPAALSNILTPLSAAFITALVATYGPAAVAA 271
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
131-312 |
3.42e-04 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 43.01 E-value: 3.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 131 LCGPLMSLIDTAVIGQGSSLELAAL-GPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVT 209
Cdd:COG2244 187 LLGLLLTNLDRLLLGALLGPAAVGIySAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLP 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 210 MMVLTRLFGSWALTGVKNADIVPAANkYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVLctFL 289
Cdd:COG2244 267 LALGLALLAPPLLSLLFGPEYAEAAP-VLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLL--IP 343
|
170 180
....*....|....*....|...
gi 240254498 290 GYGIAGAAWATMVSQVVAAYMMM 312
Cdd:COG2244 344 RYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
135-469 |
3.58e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 43.05 E-value: 3.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 135 LMSLIDTAVIGQGSSLELAALGPATVICDYLCYTFMFLSVATSNLVATSLARQDKDEVQHQISILLFIGLACGVTMMVLT 214
Cdd:cd13135 19 LQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAISSIVYNSIIGVILFLLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 215 rLFGSWALTGVKNAD--IVPAANKYVQIRGLAWPAVLIGWVAQSASLGMKDSWGPLKALAVASAINGVGDVVL----CTF 288
Cdd:cd13135 99 -LFGARIIFVLFGVDgqILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLNVILDYVLifgnFGF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 289 LGYGIAGAAWATMVSQVVAA-YMMMDALNKK----GYSAFSFCVPSPSELLTIFGLAAPVFITMMSKVLFYTLLVYFATS 363
Cdd:cd13135 178 PRLGIIGAAIATTIANVLNLiILVYLCRKIKkltfKLSNTKVLKANIRPYKFTIKLGLPLGGEEFLWNIGNLAVIRILNR 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 364 MGTNIIAAHQVMLQIYTMSTVWGEPLSQTAQSFMPELLFgiNRNLPKARVLLKSLVIIGATLGIVVGTIGTAVPWLFPGI 443
Cdd:cd13135 258 IGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIG--KKDLKEALRIGNICLGLGLLIYIAAAIVFLAFPYKILSL 335
|
330 340
....*....|....*....|....*.
gi 240254498 444 FTRDKVVTSEMHKVIIpyFLALSITP 469
Cdd:cd13135 336 FTNDPELINYSIPYLI--FIIIILFF 359
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
106-450 |
8.53e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 41.81 E-value: 8.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 106 DLATQSIWGQMKEIVMftgPAAGLWLCGPLMSLIDTAVIGQGSSLELAALGPATVIcdylcyTFMFL------SVATSNL 179
Cdd:cd13145 1 DLTKGPIPKLIRKLAI---PASVGFFFNTMFNVVDTFFAGKISTEALAALSLSFPI------FFIIIaigvgiGTGTTAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 180 VATSLARQDKDEVQHQISILLFIGLACGVTMMVLTrLFGSWALTGVKNA--DIVPAANKYVQIRGLAWPAVLIGWVAQSA 257
Cdd:cd13145 72 IGNALGAGDRRKARRYAAQGLSFGIILAILLTVIG-LFAAPPLFRLLGAegDYLDLALEYMDVIFAGSIFFLLNFGLNGI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 258 SLGMKDSWGPLKALAVASAINgvgdVVLCTFLGY--------GIAGAAWATMVSQ-VVAAYMMMDALNKKGYSAF--SFC 326
Cdd:cd13145 151 LNAQGDTKSYRNFLIIGFFLN----IILDPLFIFggggipamGVSGIALATIISQfIGMFYLLYKVRKSGIISGCrlRDF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 327 VPSPSELLTIFGLAAPVFITMMSKVLFYTLLVYFATSMGTNIIAAHQVML---QIYTMSTVW--GEPLSQTAQSfmpell 401
Cdd:cd13145 227 IPRLDVYKEILKQGFPASLNMMTIGLGIFVITYFVGQFGDEAVAAYGIALrieQILLLPTIGlnTAVLSIAGQN------ 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 240254498 402 FGINRNLPKARVLLKSLVIigatlGIVVGTIGTAVPWLFP----GIFTRDKVV 450
Cdd:cd13145 301 FGAKKYDRVRETYKKALKY-----GFVIMVVATVFLLFFAeplmSLFTNDPAV 348
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
113-312 |
6.98e-03 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 39.06 E-value: 6.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 113 WGQMKEIVMFTGPAAGLWLCGPLMSLIDTAVIGQgsslelaALGPATV----ICDYLCYTFMFLSVATSNLVATSLAR-- 186
Cdd:cd13128 202 LKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGY-------FLGDAAVgiynAAYRIAELLLFIPSAISTALFPRISEly 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 187 -QDKDEVQHQISILLFIGLACGVTMMVLTRLFGSWALTGVKNADIVPAANkYVQIrgLAWPAVLIGWVAQSASL--GMKD 263
Cdd:cd13128 275 kNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLPAAL-VLQI--LAWGFLFIFLNGIFGSIlqAIGK 351
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 240254498 264 SWGPLKALAVASAINGVGDVVLCTFlgYGIAGAAWATMVSQVVAAYMMM 312
Cdd:cd13128 352 QKLTLKILLIGALLNVILNLLLIPK--YGIIGAAIATLISEFIIFILLL 398
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
243-371 |
9.66e-03 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 36.78 E-value: 9.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240254498 243 LAWPAVLIGW--VAQSASLGMKDSWGPLKALAVASAINGVGDVVLCTFlgYGIAGAAWATMVSQVVAAYMMMDALNKKGY 320
Cdd:pfam14667 5 LALSIIFLSLstVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPL--FGIVGAAIATVISLLVVALLNLYYLRRYLG 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 240254498 321 SAFSFcvpspSELLTIFGLAAPVFITMMSKVLFYTLLVYFATSMGTNIIAA 371
Cdd:pfam14667 83 LRLLL-----RRLLKPLLAALVMGIVVYLLLLLLGLLLGLALALLLAVLVG 128
|
|
| |
