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Conserved domains on  [gi|42571491|ref|NP_973836|]
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periodic tryptophan protein 2 [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11456769)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
263-620 3.91e-58

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 204.37  E-value: 3.91e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 263 ASAKVTACDYHQGLDMVVVGFSNGVFGLYQMPDFICIHLLSISRQKLTTAVFNERGNWLTFGCAkLGQLLVWDWRTETYI 342
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA-DGTVRLWDLATGLLL 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 343 LKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKR 422
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 423 YKNYKTYTTPTPRqFVSLTADPSGDVVCAGTLDSfEIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVR 502
Cdd:COG2319 194 GKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADG-TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 503 LWDVfASKGTVETFR-HNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRRDIAggrvmtdrrsaansssg 581
Cdd:COG2319 272 LWDL-ATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV----------------- 333

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 42571491 582 kcfTTLCYSADGGYILAAGTSRYICMYDIADQVLLRRFQ 620
Cdd:COG2319 334 ---RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 750-855 3.11e-26

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


:

Pssm-ID: 461125  Cd Length: 106  Bit Score: 103.40  E-value: 3.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491   750 NEDSLIKKCIFAVAPADIKAVAISVRQKYLERLMEALVDLL-ENCPHLEFILHWCQEICKAHGSSIQRNyRTLLPALRSL 828
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLaERSPHLELLLRWLKFLLRTHGGYLVSN-PDLRPVLRSL 79

                          90       100
                  ....*....|....*....|....*..
gi 42571491   829 QKAITRAHQDLADMCSSNEYTLRYLCS 855
Cdd:pfam04003  80 QKLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 COG2319
WD40 repeat [General function prediction only];
55-419 3.95e-18

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 3.95e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491  55 ICRLASSPDGTFLLAVDEQNRCLFINLPRRVVLHRITFK-DKVGALKFSPNGKFIAVG-IGKLVEIWRspgfrraVLPFE 132
Cdd:COG2319 207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHsGSVRSVAFSPDGRLLASGsADGTVRLWD-------LATGE 279

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 133 RVRTFANSDDKVVSLEWSLDSDYLLVGSRDlaaraftiardgyifswgytekdvkmdesedghseppspvtpdradevmv 212
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDD-------------------------------------------------- 309

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 213 engggvgtelkkrkeydgkglesdeegddddeeymhrgkwvllrkdgcnqasakvtacdyhqgldmvvvgfsngvfglyq 292
Cdd:COG2319     --------------------------------------------------------------------------------

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 293 mpdficihllsisrqklttavfnergnwltfgcaklGQLLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLATGADDNK 372
Cdd:COG2319 310 ------------------------------------GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*..
gi 42571491 373 VKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWD 419
Cdd:COG2319 354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
263-620 3.91e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 204.37  E-value: 3.91e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 263 ASAKVTACDYHQGLDMVVVGFSNGVFGLYQMPDFICIHLLSISRQKLTTAVFNERGNWLTFGCAkLGQLLVWDWRTETYI 342
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA-DGTVRLWDLATGLLL 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 343 LKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKR 422
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 423 YKNYKTYTTPTPRqFVSLTADPSGDVVCAGTLDSfEIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVR 502
Cdd:COG2319 194 GKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADG-TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 503 LWDVfASKGTVETFR-HNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRRDIAggrvmtdrrsaansssg 581
Cdd:COG2319 272 LWDL-ATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV----------------- 333

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 42571491 582 kcfTTLCYSADGGYILAAGTSRYICMYDIADQVLLRRFQ 620
Cdd:COG2319 334 ---RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 298-559 2.16e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 187.54  E-value: 2.16e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 298 CIHLLSISRQKLTTAVFNERGNWLTFGCAkLGQLLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWN 377
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 378 VMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKRYKnyKTYTTPTPRQFV-SLTADPSGDVVCAGTLDS 456
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGHTDWVnSVAFSPDGTFVASSSQDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 457 FeIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWDVFASKgTVETFR-HNHDVLTVAFRPDGKQLA 535
Cdd:cd00200 158 T-IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK-CLGTLRgHENGVNSVAFSPDGYLLA 235

                       250       260
                ....*....|....*....|....
gi 42571491 536 SSTLDGQINFWDTIEGVLMYTIEG 559
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSG 259
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 750-855 3.11e-26

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 103.40  E-value: 3.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491   750 NEDSLIKKCIFAVAPADIKAVAISVRQKYLERLMEALVDLL-ENCPHLEFILHWCQEICKAHGSSIQRNyRTLLPALRSL 828
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLaERSPHLELLLRWLKFLLRTHGGYLVSN-PDLRPVLRSL 79

                          90       100
                  ....*....|....*....|....*..
gi 42571491   829 QKAITRAHQDLADMCSSNEYTLRYLCS 855
Cdd:pfam04003  80 QKLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 COG2319
WD40 repeat [General function prediction only];
55-419 3.95e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 3.95e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491  55 ICRLASSPDGTFLLAVDEQNRCLFINLPRRVVLHRITFK-DKVGALKFSPNGKFIAVG-IGKLVEIWRspgfrraVLPFE 132
Cdd:COG2319 207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHsGSVRSVAFSPDGRLLASGsADGTVRLWD-------LATGE 279

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 133 RVRTFANSDDKVVSLEWSLDSDYLLVGSRDlaaraftiardgyifswgytekdvkmdesedghseppspvtpdradevmv 212
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDD-------------------------------------------------- 309

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 213 engggvgtelkkrkeydgkglesdeegddddeeymhrgkwvllrkdgcnqasakvtacdyhqgldmvvvgfsngvfglyq 292
Cdd:COG2319     --------------------------------------------------------------------------------

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 293 mpdficihllsisrqklttavfnergnwltfgcaklGQLLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLATGADDNK 372
Cdd:COG2319 310 ------------------------------------GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*..
gi 42571491 373 VKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWD 419
Cdd:COG2319 354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 466-505 5.66e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 5.66e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 42571491    466 TGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWD 505
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
346-377 6.65e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 6.65e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 42571491   346 QGHYFDVNCVTYSPDSQLLATGADDNKVKVWN 377
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 364-519 4.22e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.92  E-value: 4.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491  364 LATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLL-SASLDGTVRAWDFKRYKNYKTYTTPTPRQFVSLTA 442
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42571491  443 DpSGDVVCAGTLDSfEIFVWSKKTGQIK-DILSGHEAPVHGLMFSPlTQLLASSSWDYTVRLWDV-FASKGTVETFRHN 519
Cdd:PLN00181 628 E-SGRSLAFGSADH-KVYYYDLRNPKLPlCTMIGHSKTVSYVRFVD-SSTLVSSSTDNTLKLWDLsMSISGINETPLHS 703
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
263-620 3.91e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 204.37  E-value: 3.91e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 263 ASAKVTACDYHQGLDMVVVGFSNGVFGLYQMPDFICIHLLSISRQKLTTAVFNERGNWLTFGCAkLGQLLVWDWRTETYI 342
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA-DGTVRLWDLATGLLL 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 343 LKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKR 422
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 423 YKNYKTYTTPTPRqFVSLTADPSGDVVCAGTLDSfEIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVR 502
Cdd:COG2319 194 GKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADG-TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 503 LWDVfASKGTVETFR-HNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRRDIAggrvmtdrrsaansssg 581
Cdd:COG2319 272 LWDL-ATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV----------------- 333

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 42571491 582 kcfTTLCYSADGGYILAAGTSRYICMYDIADQVLLRRFQ 620
Cdd:COG2319 334 ---RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
264-612 2.93e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 196.29  E-value: 2.93e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 264 SAKVTACDYHQGLDMVVVGFSNGVFGLYQMPDFICIHLLSISRQKLTTAVFNERGNWLTFGCAKlGQLLVWDWRTETYIL 343
Cdd:COG2319  78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD-GTVRLWDLATGKLLR 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 344 KQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKRY 423
Cdd:COG2319 157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 424 KNYKTYTTPTPRqFVSLTADPSGDVVCAGTLDSfEIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRL 503
Cdd:COG2319 237 KLLRTLTGHSGS-VRSVAFSPDGRLLASGSADG-TVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 504 WDVfASKGTVETFR-HNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRRDIAggrvmtdrrsaansssgk 582
Cdd:COG2319 315 WDL-ATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV------------------ 375

                       330       340       350
                ....*....|....*....|....*....|
gi 42571491 583 cfTTLCYSADGGYILAAGTSRYICMYDIAD 612
Cdd:COG2319 376 --TSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 298-559 2.16e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 187.54  E-value: 2.16e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 298 CIHLLSISRQKLTTAVFNERGNWLTFGCAkLGQLLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWN 377
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 378 VMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKRYKnyKTYTTPTPRQFV-SLTADPSGDVVCAGTLDS 456
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGHTDWVnSVAFSPDGTFVASSSQDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 457 FeIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWDVFASKgTVETFR-HNHDVLTVAFRPDGKQLA 535
Cdd:cd00200 158 T-IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK-CLGTLRgHENGVNSVAFSPDGYLLA 235

                       250       260
                ....*....|....*....|....
gi 42571491 536 SSTLDGQINFWDTIEGVLMYTIEG 559
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSG 259
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 264-547 7.10e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 180.22  E-value: 7.10e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 264 SAKVTACDYHQGLDMVVVGFSNGVFGLYQMPDFICIHLLSISRQKLTTAVFNERGNWLtFGCAKLGQLLVWDWRTETYIL 343
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL-ASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 344 KQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKRY 423
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 424 KNYKTYTTPTpRQFVSLTADPSGDVVCAGTLDSfEIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRL 503
Cdd:cd00200 168 KCVATLTGHT-GEVNSVAFSPDGEKLLSSSSDG-TIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 42571491 504 WDVfASKGTVETFR-HNHDVLTVAFRPDGKQLASSTLDGQINFWD 547
Cdd:cd00200 246 WDL-RTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 346-639 3.97e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 158.27  E-value: 3.97e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 346 QGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRawdfkrykn 425
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIR--------- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 426 yktyttptprqfvsltadpsgdvvcagtldsfeifVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWD 505
Cdd:cd00200  77 -----------------------------------LWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 506 VFASKGTVETFRHNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRRDiaggrvmtdrrsaansssgkCFT 585
Cdd:cd00200 122 VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG--------------------EVN 181

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 42571491 586 TLCYSADGGYILAAGTSRYICMYDIADQVLLRRFQiSHNLSLDGVlDFLHSKKM 639
Cdd:cd00200 182 SVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-GHENGVNSV-AFSPDGYL 233
WD40 COG2319
WD40 repeat [General function prediction only];
331-620 2.52e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.91  E-value: 2.52e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 331 LLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSAS 410
Cdd:COG2319  18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 411 LDGTVRAWDFKRyKNYKTYTTPTPRQFVSLTADPSGDVVCAGTLDSfEIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQ 490
Cdd:COG2319  98 ADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG-TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 491 LLASSSWDYTVRLWDVfASKGTVETFR-HNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRrdiaGGRVm 569
Cdd:COG2319 176 LLASGSDDGTVRLWDL-ATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH----SGSV- 249

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 42571491 570 tdrrsaansssgkcfTTLCYSADGGYILAAGTSRYICMYDIADQVLLRRFQ 620
Cdd:COG2319 250 ---------------RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT 285
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 750-855 3.11e-26

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 103.40  E-value: 3.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491   750 NEDSLIKKCIFAVAPADIKAVAISVRQKYLERLMEALVDLL-ENCPHLEFILHWCQEICKAHGSSIQRNyRTLLPALRSL 828
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLaERSPHLELLLRWLKFLLRTHGGYLVSN-PDLRPVLRSL 79

                          90       100
                  ....*....|....*....|....*..
gi 42571491   829 QKAITRAHQDLADMCSSNEYTLRYLCS 855
Cdd:pfam04003  80 QKLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 55-419 1.94e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.26  E-value: 1.94e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491  55 ICRLASSPDGTFLLAVDEQNRCLFINLPRRVVLHRIT-FKDKVGALKFSPNGKFIA-VGIGKLVEIWRSPGFrravlpfE 132
Cdd:cd00200  12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASADGTYLAsGSSDKTIRLWDLETG-------E 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 133 RVRTFANSDDKVVSLEWSLDSDYLLVGSRDLAARAFTIARDGYIFSWgytekdvkmdeseDGHSEPpspvtpdradevmv 212
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-------------RGHTDW-------------- 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 213 engggvgtelkkrkeydgkglesdeegddddeeymhrgkwvllrkdgcnqasakVTACDYHQGLDMVVVGFSNGVFGLYQ 292
Cdd:cd00200 138 ------------------------------------------------------VNSVAFSPDGTFVASSSQDGTIKLWD 163

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 293 MPDFICIHLLSISRQKLTTAVFNERGNWLTFGCAKlGQLLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLATGADDNK 372
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGT 242

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*..
gi 42571491 373 VKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWD 419
Cdd:cd00200 243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
401-620 6.89e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.91  E-value: 6.89e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 401 ADNHSLLSASLDGTVRAWDFKRYKNYKTYTTPTPRQFVSLTADPSGDVvcAGTLDSFEIFVWSKKTGQIKDILSGHEAPV 480
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARL--AAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 481 HGLMFSPLTQLLASSSWDYTVRLWDVFASKGTVETFRHNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGR 560
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 561 RDIAGGRVMT-DRRSAA-----------NSSSGKCFTTL----------CYSADGGYILAAGTSRYICMYDIADQVLLRR 618
Cdd:COG2319 162 SGAVTSVAFSpDGKLLAsgsddgtvrlwDLATGKLLRTLtghtgavrsvAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241


                ..
gi 42571491 619 FQ 620
Cdd:COG2319 242 LT 243
WD40 COG2319
WD40 repeat [General function prediction only];
55-419 3.95e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 3.95e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491  55 ICRLASSPDGTFLLAVDEQNRCLFINLPRRVVLHRITFK-DKVGALKFSPNGKFIAVG-IGKLVEIWRspgfrraVLPFE 132
Cdd:COG2319 207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHsGSVRSVAFSPDGRLLASGsADGTVRLWD-------LATGE 279

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 133 RVRTFANSDDKVVSLEWSLDSDYLLVGSRDlaaraftiardgyifswgytekdvkmdesedghseppspvtpdradevmv 212
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDD-------------------------------------------------- 309

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 213 engggvgtelkkrkeydgkglesdeegddddeeymhrgkwvllrkdgcnqasakvtacdyhqgldmvvvgfsngvfglyq 292
Cdd:COG2319     --------------------------------------------------------------------------------

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 293 mpdficihllsisrqklttavfnergnwltfgcaklGQLLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLATGADDNK 372
Cdd:COG2319 310 ------------------------------------GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*..
gi 42571491 373 VKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWD 419
Cdd:COG2319 354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
32-166 1.18e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 1.18e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491  32 NRVSVTDLSKNHSVTLPLETSTNICRLASSPDGTFLLAVDEQNRCLFINLPRRVVLHRIT-FKDKVGALKFSPNGKFIAV 110
Cdd:COG2319 268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS 347

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 42571491 111 G-IGKLVEIWRSPGFrravlpfERVRTFANSDDKVVSLEWSLDSDYLLVGSRDLAAR 166
Cdd:COG2319 348 GsDDGTVRLWDLATG-------ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
31-162 1.48e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 1.48e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491  31 GNRVSVTDLSKNHSVTLPLETSTNICRLASSPDGTFLLAVDEQNRCLFINLPRRVVLHRIT-FKDKVGALKFSPNGKFIA 109
Cdd:COG2319 225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLA 304

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 42571491 110 VG-IGKLVEIWRspgfrraVLPFERVRTFANSDDKVVSLEWSLDSDYLLVGSRD 162
Cdd:COG2319 305 SGsDDGTVRLWD-------LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD 351
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 466-505 5.66e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 5.66e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 42571491    466 TGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWD 505
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 380-419 3.05e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 3.05e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 42571491    380 SGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWD 419
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 338-377 4.52e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 4.52e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 42571491    338 TETYILKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWN 377
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
346-377 6.65e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 6.65e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 42571491   346 QGHYFDVNCVTYSPDSQLLATGADDNKVKVWN 377
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
381-419 1.08e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 1.08e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 42571491   381 GTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWD 419
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
467-505 1.16e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 1.16e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 42571491   467 GQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWD 505
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 518-547 7.97e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 7.97e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 42571491    518 HNHDVLTVAFRPDGKQLASSTLDGQINFWD 547
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
COG5354 COG5354
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];
461-636 2.09e-04

Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];


Pssm-ID: 227657 [Multi-domain]  Cd Length: 561  Bit Score: 44.87  E-value: 2.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 461 VWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYtVRLWDvFASKGTVETFRHNhDVLTVAFRPDGKQLASstld 540
Cdd:COG5354  16 FWNSQSEVIHTRFESENWPVAYVSESPLGTYLFSEHAAG-VECWG-GPSKAKLVRFRHP-DVKYLDFSPNEKYLVT---- 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491 541 gqinfWDTiEGVLMYTIE----------GRRDIAGGRVMTDRRSAANSSSGKCFttLCYSADGGYIL-AAGTSRYIcmYD 609
Cdd:COG5354  89 -----WSR-EPIIEPEIEispftsknnvFVWDIASGMIVFSFNGISQPYLGWPV--LKFSIDDKYVArVVGSSLYI--HE 158

                       170       180
                ....*....|....*....|....*..
gi 42571491 610 IADQVLLRRFqisHNLSLDGVLDFLHS 636
Cdd:COG5354 159 ITDNIEEHPF---KNLRPVGILDFSIS 182
WD40 pfam00400
WD domain, G-beta repeat;
518-547 4.18e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.18e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 42571491   518 HNHDVLTVAFRPDGKQLASSTLDGQINFWD 547
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 364-519 4.22e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.92  E-value: 4.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491  364 LATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLL-SASLDGTVRAWDFKRYKNYKTYTTPTPRQFVSLTA 442
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42571491  443 DpSGDVVCAGTLDSfEIFVWSKKTGQIK-DILSGHEAPVHGLMFSPlTQLLASSSWDYTVRLWDV-FASKGTVETFRHN 519
Cdd:PLN00181 628 E-SGRSLAFGSADH-KVYYYDLRNPKLPlCTMIGHSKTVSYVRFVD-SSTLVSSSTDNTLKLWDLsMSISGINETPLHS 703
PTZ00421 PTZ00421
coronin; Provisional
 314-422 8.01e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 8.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491  314 FNERGNWLTFGCAKLGQLLVWDWRTE-------TYILKQQGHYFDVNCVTYSPDSQ-LLATGADDNKVKVWNVMSGTCFI 385
Cdd:PTZ00421  83 FNPFDPQKLFTASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVE 162

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 42571491  386 TFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKR 422
Cdd:PTZ00421 163 VIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRD 199
PTZ00420 PTZ00420
coronin; Provisional
 473-547 1.25e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.24  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491  473 LSGHEAPVHGLMFSP-LTQLLASSSWDYTVRLWDVFASKGTVETFR--------HNHDVLTVAFRP-DGKQLASSTLDGQ 542
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDESVKEIKdpqcilkgHKKKISIIDWNPmNYYIMCSSGFDSF 149


                 ....*
gi 42571491  543 INFWD 547
Cdd:PTZ00420 150 VNIWD 154
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 492-563 1.33e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 1.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42571491  492 LASSSWDYTVRLWDVFASKGTVETFRHNHDVLTVAF-RPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRRDI 563
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANI 620
PTZ00421 PTZ00421
coronin; Provisional
 472-566 2.15e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.42  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42571491  472 ILSGHEAPVHGLMFSPL-TQLLASSSWDYTVRLWDVFA-------SKGTVETFRHNHDVLTVAFRPDGKQ-LASSTLDGQ 542
Cdd:PTZ00421  70 ILLGQEGPIIDVAFNPFdPQKLFTASEDGTIMGWGIPEegltqniSDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMV 149

                         90       100
                 ....*....|....*....|....
gi 42571491  543 INFWDTIEGVLMYTIEGRRDIAGG 566
Cdd:PTZ00421 150 VNVWDVERGKAVEVIKCHSDQITS 173
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 352-400 3.28e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.64  E-value: 3.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 42571491   352 VNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFM 400
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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