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Conserved domains on  [gi|42572701|ref|NP_974446|]
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biotin/lipoyl attachment domain-containing protein [Arabidopsis thaliana]

Protein Classification

acetyl-CoA carboxylase biotin carboxyl carrier protein( domain architecture ID 11423502)

acetyl-CoA carboxylase biotin carboxyl carrier protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

CATH:  2.40.50.100
Gene Ontology:  GO:0003989|GO:0006633|GO:0009317
PubMed:  1370469
SCOP:  4002909
TCDB:  3.B.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 25-195 2.03e-16

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 72.24  E-value: 2.03e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572701  25 DETEVAVLQLKVGDFEMNLKRKIGAATNPIPvadiSPTVAPPIPSEPMnksassapspsqakpssekvspfkntsygkpa 104
Cdd:COG0511   6 EESGLTELEVEEGEYKVRIKRGGAAAAAPVA----APAAAAPAAAAPA-------------------------------- 49

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572701 105 klAALEASGSTNYVLVTSPAVGKFQRSRTVKGKkqsPSCKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGD 184
Cdd:COG0511  50 --AAAAAAAASGGGAVKSPMVGTFYRAPSPGAK---PFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQ 124

                       170
                ....*....|.
gi 42572701 185 SVGYGDPLVAV 195
Cdd:COG0511 125 PVEYGQPLFVI 135
 
Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 25-195 2.03e-16

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 72.24  E-value: 2.03e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572701  25 DETEVAVLQLKVGDFEMNLKRKIGAATNPIPvadiSPTVAPPIPSEPMnksassapspsqakpssekvspfkntsygkpa 104
Cdd:COG0511   6 EESGLTELEVEEGEYKVRIKRGGAAAAAPVA----APAAAAPAAAAPA-------------------------------- 49

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572701 105 klAALEASGSTNYVLVTSPAVGKFQRSRTVKGKkqsPSCKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGD 184
Cdd:COG0511  50 --AAAAAAAASGGGAVKSPMVGTFYRAPSPGAK---PFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQ 124

                       170
                ....*....|.
gi 42572701 185 SVGYGDPLVAV 195
Cdd:COG0511 125 PVEYGQPLFVI 135
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 120-195 2.40e-13

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 62.43  E-value: 2.40e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42572701 120 VTSPAVGKFQRsrtvkgkkqsPSCKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLVAV 195
Cdd:cd06850   2 VTAPMPGTVVK----------VLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 120-193 6.10e-09

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 50.68  E-value: 6.10e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42572701   120 VTSPAVGKFQRSRTVKGKKqspscKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLV 193
Cdd:pfam00364   3 IKSPMIGESVREGVVEWLV-----KVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLA 71
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 120-197 1.39e-08

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 53.69  E-value: 1.39e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42572701  120 VTSPAVGKFQRSRTvkgkkqspscKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLVAVLP 197
Cdd:PRK09282 525 VTSPMPGTVVKVKV----------KEGDKVKAGDTVLVLEAMKMENEIQAPVDGTVKEILVKEGDRVNPGDVLMEIEP 592
 
Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 25-195 2.03e-16

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 72.24  E-value: 2.03e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572701  25 DETEVAVLQLKVGDFEMNLKRKIGAATNPIPvadiSPTVAPPIPSEPMnksassapspsqakpssekvspfkntsygkpa 104
Cdd:COG0511   6 EESGLTELEVEEGEYKVRIKRGGAAAAAPVA----APAAAAPAAAAPA-------------------------------- 49

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572701 105 klAALEASGSTNYVLVTSPAVGKFQRSRTVKGKkqsPSCKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGD 184
Cdd:COG0511  50 --AAAAAAAASGGGAVKSPMVGTFYRAPSPGAK---PFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQ 124

                       170
                ....*....|.
gi 42572701 185 SVGYGDPLVAV 195
Cdd:COG0511 125 PVEYGQPLFVI 135
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 120-195 2.40e-13

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 62.43  E-value: 2.40e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42572701 120 VTSPAVGKFQRsrtvkgkkqsPSCKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLVAV 195
Cdd:cd06850   2 VTAPMPGTVVK----------VLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 120-193 6.10e-09

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 50.68  E-value: 6.10e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42572701   120 VTSPAVGKFQRSRTVKGKKqspscKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLV 193
Cdd:pfam00364   3 IKSPMIGESVREGVVEWLV-----KVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLA 71
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 120-197 1.39e-08

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 53.69  E-value: 1.39e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42572701  120 VTSPAVGKFQRSRTvkgkkqspscKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLVAVLP 197
Cdd:PRK09282 525 VTSPMPGTVVKVKV----------KEGDKVKAGDTVLVLEAMKMENEIQAPVDGTVKEILVKEGDRVNPGDVLMEIEP 592
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 144-193 1.61e-06

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 44.01  E-value: 1.61e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 42572701  144 KEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLV 193
Cdd:PRK08225  18 KVGDTVEEGQDVVILESMKMEIPIVAEEAGTVKKINVQEGDFVNEGDVLL 67
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 25-197 3.21e-05

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 43.29  E-value: 3.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572701   25 DETEVAVLQLKVGDFEMNLKRK------IGAAT-------NPIPVADISPTVAPPIPSEPMNKSASSAPSPSQAKPSSEK 91
Cdd:PLN02983 117 DSRDIVELQLKQLDCELVIRKKealpqpPPPAPvvmmqppPPHAMPPASPPAAQPAPSAPASSPPPTPASPPPAKAPKSS 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572701   92 VSPFKntsygkpaklaaleasgstnyvlvtSPAVGKFQRSrtvKGKKQSPSCKEGDAIKEGQVIGYLHQLGTELPVTSDV 171
Cdd:PLN02983 197 HPPLK-------------------------SPMAGTFYRS---PAPGEPPFVKVGDKVQKGQVVCIIEAMKLMNEIEADQ 248

                        170       180
                 ....*....|....*....|....*.
gi 42572701  172 AGEVLKLLSDDGDSVGYGDPLVAVLP 197
Cdd:PLN02983 249 SGTIVEILAEDGKPVSVDTPLFVIEP 274
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
120-195 4.21e-05

biotin carboxyl carrier domain-containing protein;


Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 40.38  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572701  120 VTSPAVGKFQRsrtvkgkKQSPSC----KEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLVAV 195
Cdd:PRK07051   6 IVSPLPGTFYR-------RPSPDAppyvEVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRVVEFLVEDGEPVEAGQVLARI 78
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 26-193 1.79e-04

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 40.23  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572701   26 ETEVAVLQLKVGDFEMNLKRK--------IGAATNPI--PVADISPTVAPPIPSEPMnksassapspsqakPSSEKVSpf 95
Cdd:PRK05641  12 EYEVEVEELGPGKFRVSFEGKtyeveakgLGIDLSAVqeQVPTPAPAPAPAVPSAPT--------------PVAPAAP-- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572701   96 kntsygKPAKLAALEAsgstnyvLVTSPAVGKFQRSRTvkgkkqspscKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEV 175
Cdd:PRK05641  76 ------APAPASAGEN-------VVTAPMPGKILRILV----------REGQQVKVGQGLLILEAMKMENEIPAPKDGVV 132

                        170
                 ....*....|....*...
gi 42572701  176 LKLLSDDGDSVGYGDPLV 193
Cdd:PRK05641 133 KKILVKEGDTVDTGQPLI 150
PRK05889 PRK05889
biotin/lipoyl-binding carrier protein;
144-196 4.30e-04

biotin/lipoyl-binding carrier protein;


Pssm-ID: 180306 [Multi-domain]  Cd Length: 71  Bit Score: 37.48  E-value: 4.30e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 42572701  144 KEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDpLVAVL 196
Cdd:PRK05889  19 NEGDQIGKGDTLVLLESMKMEIPVLAEVAGTVSKVSVSVGDVIQAGD-LIAVI 70
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
144-195 4.60e-03

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 37.22  E-value: 4.60e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 42572701  144 KEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLVAV 195
Cdd:PRK14040 541 TEGQTVAEGDVLLILEAMKMETEIRAAQAGTVRGIAVKEGDAVAVGDTLLTL 592
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 144-195 8.04e-03

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 33.89  E-value: 8.04e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 42572701 144 KEGDAIKEGQVIGylhQLGTE---LPVTSDVAGEVLKLLSDDGDSVGYGDPLVAV 195
Cdd:COG0508  25 KEGDTVKEGDPLA---EVETDkatMEVPAPAAGVLLEILVKEGDTVPVGAVIAVI 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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