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Conserved domains on  [gi|42572785|ref|NP_974489|]
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plasma membrane intrinsic protein 1;4 [Arabidopsis thaliana]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  8849412|11473620|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 45-209 6.73e-68

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member pfam00230:

Pssm-ID: 444743 [Multi-domain]  Cd Length: 223  Bit Score: 207.94  E-value: 6.73e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785    45 ELSSWSFYRAGIAEFIATFLFLYITVLTVMGVKRAPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFL 124
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785   125 ARKLSLTRAVFYMIMQCLGAICGAGVVKGFQPtPYQTLGGGANTVAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRSAR 204
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTV-GLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGS 159


                  ....*
gi 42572785   205 DSHVP 209
Cdd:pfam00230 160 LGTVA 164
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 45-209 6.73e-68

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 207.94  E-value: 6.73e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785    45 ELSSWSFYRAGIAEFIATFLFLYITVLTVMGVKRAPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFL 124
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785   125 ARKLSLTRAVFYMIMQCLGAICGAGVVKGFQPtPYQTLGGGANTVAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRSAR 204
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTV-GLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGS 159


                  ....*
gi 42572785   205 DSHVP 209
Cdd:pfam00230 160 LGTVA 164
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 53-203 2.85e-48

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 157.80  E-value: 2.85e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785  53 RAGIAEFIATFLFLYITVLTVMGVKRAPNmcASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTR 132
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG--ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIR 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42572785 133 AVFYMIMQCLGAICGAGVVKGFQPTPYQTLGGGANTVAH--------GYTKGSGLGAEIIGTFVLVYTVFSATDAKRSA 203
Cdd:cd00333  79 VIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGifgtypspGVSNGNAFFVEFIGTFILVLVVFATTDDPNGP 157
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 57-208 4.02e-43

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 144.36  E-value: 4.02e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785    57 AEFIATFLFLYITVLTVMGVKRApNMCASVGIQ---GIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRA 133
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVA-GAYGAVGGGqflGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42572785   134 VFYMIMQCLGAICGAGVVKGFQPTPYQTLGGGANTVAHGYTKGSGLGAEIIGTFVLVYTVFSATDaKRSARDSHV 208
Cdd:TIGR00861  80 PVYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTD-DRNRVPRGG 153
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 56-216 1.62e-32

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 117.54  E-value: 1.62e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785  56 IAEFIATFLFLYITVLTVMGVKRAPnmcASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAVF 135
Cdd:COG0580   7 LAEFLGTFILVLLGCGVVAVLAGTK---GGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDVLP 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785 136 YMIMQCLGAICGAGVVKG-FQPTPYQTLGGGA-NTV-----AHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRSARdshv 208
Cdd:COG0580  84 YIIAQLLGAFLGAALVYLiYGGHFDATEDGGAkLGVfatspAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPG---- 159


                ....*...
gi 42572785 209 pVWTPLLV 216
Cdd:COG0580 160 -GLAPLAI 166
PLN00166 PLN00166
aquaporin TIP2; Provisional
 44-210 2.57e-17

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 77.67  E-value: 2.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785   44 GELSSWSFYRAGIAEFIATFLFLYITVLTVMGVKRAPNMCA--SVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFG 121
Cdd:PLN00166  10 GDSFSVASLKAYLSEFIATLLFVFAGVGSAIAFAKLTSDAAldPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785  122 LFLARKLSLTRAVFYMIMQCLGAICGAGVVKgfqptpYQTLGGGANT--VAHGYTKGSGLGAEIIGTFVLVYTVF-SATD 198
Cdd:PLN00166  90 LAIGGNITIITGFFYWIAQCLGSIVACLLLV------FVTNGESVPThgVAAGLGAIEGVVMEIVVTFALVYTVYaTAAD 163

                        170
                 ....*....|..
gi 42572785  199 AKRSARDSHVPV 210
Cdd:PLN00166 164 PKKGSLGTIAPI 175
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 45-209 6.73e-68

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 207.94  E-value: 6.73e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785    45 ELSSWSFYRAGIAEFIATFLFLYITVLTVMGVKRAPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFL 124
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785   125 ARKLSLTRAVFYMIMQCLGAICGAGVVKGFQPtPYQTLGGGANTVAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRSAR 204
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTV-GLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGS 159


                  ....*
gi 42572785   205 DSHVP 209
Cdd:pfam00230 160 LGTVA 164
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 53-203 2.85e-48

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 157.80  E-value: 2.85e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785  53 RAGIAEFIATFLFLYITVLTVMGVKRAPNmcASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTR 132
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG--ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIR 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42572785 133 AVFYMIMQCLGAICGAGVVKGFQPTPYQTLGGGANTVAH--------GYTKGSGLGAEIIGTFVLVYTVFSATDAKRSA 203
Cdd:cd00333  79 VIPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGifgtypspGVSNGNAFFVEFIGTFILVLVVFATTDDPNGP 157
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 57-208 4.02e-43

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 144.36  E-value: 4.02e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785    57 AEFIATFLFLYITVLTVMGVKRApNMCASVGIQ---GIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRA 133
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVA-GAYGAVGGGqflGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42572785   134 VFYMIMQCLGAICGAGVVKGFQPTPYQTLGGGANTVAHGYTKGSGLGAEIIGTFVLVYTVFSATDaKRSARDSHV 208
Cdd:TIGR00861  80 PVYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTD-DRNRVPRGG 153
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 56-216 1.62e-32

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 117.54  E-value: 1.62e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785  56 IAEFIATFLFLYITVLTVMGVKRAPnmcASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAVF 135
Cdd:COG0580   7 LAEFLGTFILVLLGCGVVAVLAGTK---GGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDVLP 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785 136 YMIMQCLGAICGAGVVKG-FQPTPYQTLGGGA-NTV-----AHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRSARdshv 208
Cdd:COG0580  84 YIIAQLLGAFLGAALVYLiYGGHFDATEDGGAkLGVfatspAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPG---- 159


                ....*...
gi 42572785 209 pVWTPLLV 216
Cdd:COG0580 160 -GLAPLAI 166
PLN00166 PLN00166
aquaporin TIP2; Provisional
 44-210 2.57e-17

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 77.67  E-value: 2.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785   44 GELSSWSFYRAGIAEFIATFLFLYITVLTVMGVKRAPNMCA--SVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFG 121
Cdd:PLN00166  10 GDSFSVASLKAYLSEFIATLLFVFAGVGSAIAFAKLTSDAAldPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785  122 LFLARKLSLTRAVFYMIMQCLGAICGAGVVKgfqptpYQTLGGGANT--VAHGYTKGSGLGAEIIGTFVLVYTVF-SATD 198
Cdd:PLN00166  90 LAIGGNITIITGFFYWIAQCLGSIVACLLLV------FVTNGESVPThgVAAGLGAIEGVVMEIVVTFALVYTVYaTAAD 163

                        170
                 ....*....|..
gi 42572785  199 AKRSARDSHVPV 210
Cdd:PLN00166 164 PKKGSLGTIAPI 175
PLN00027 PLN00027
aquaporin TIP; Provisional
 43-201 2.74e-17

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 77.52  E-value: 2.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785   43 PGELSSWSFYRAGIAEFIATFLFLYITVLTVMGVKR----APNMCASVGIQGIAWAFGgmIFALVYCTAGISGGHINPAV 118
Cdd:PLN00027  11 PGEASHPDALKAALAEFISTLIFVFAGEGSGMAFNKltdnGSTTPAGLVAAALAHAFA--LFVAVSVGANISGGHVNPAV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785  119 TFGLFLARKLSLTRAVFYMIMQCLGAICGAGVVKgfqptpYQTlgGGANTVAHGYTKGSG----LGAEIIGTFVLVYTVF 194
Cdd:PLN00027  89 TFGAFIGGNITLLRGILYWIAQLLGSVVACLLLK------FST--GGLETSAFSLSSGVGvwnaFVFEIVMTFGLVYTVY 160


                 ....*...
gi 42572785  195 -SATDAKR 201
Cdd:PLN00027 161 aTAVDPKK 168
PLN00167 PLN00167
aquaporin TIP5; Provisional
 53-202 5.63e-17

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 76.87  E-value: 5.63e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785   53 RAGIAEFIATFLFLYITVLTVMGVKR----APNMCASVGIQGIAWAFGgmIFALVYCTAGISGGHINPAVTFGLFLARKL 128
Cdd:PLN00167  23 RSYLAEFISTFFFVFAAVGSAMSSRKlmpdAASDPSSLLIVAIANAFA--LSSAVYIAANISGGHVNPAVTFGMAVGGHI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785  129 SLTRAVFYMIMQCLGAICGAGVVKGF---QPTPYQTLGGgantvahgytKGSGLGAEIIG---TFVLVYTVFSATDAKRS 202
Cdd:PLN00167 101 SVPTAMFYWISQMLASVMACLFLKVTtvgQHVPTYKIAE----------EMTGFGASVLEgvlTFGLVYTVYAAGDPRRG 170
PRK05420 PRK05420
aquaporin Z; Provisional
 56-203 3.89e-13

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 66.14  E-value: 3.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785   56 IAEFIATFlflyitVLTVMGVKRA------PNMcaSVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLS 129
Cdd:PRK05420   6 AAEFFGTF------WLVFGGCGSAvlaaafPEL--GIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785  130 LTRAVFYMIMQCLGAICGAGVV-------KGFQPTpyqTLGGGANTVAH----GYTKGSGLGAEIIGTFVLVYTVFSATD 198
Cdd:PRK05420  78 AKELVPYIIAQVVGGIAAAAVLyliasgkAGFDLA---GSGFASNGYGEhspgGYSLLAALVCEVVLTAFFLLVILGATD 154


                 ....*
gi 42572785  199 AKRSA 203
Cdd:PRK05420 155 KRAPA 159
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 33-216 1.81e-11

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 62.07  E-value: 1.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785   33 KEPPPAPLF-EPGELSSWsfYRAGIAEFIATFLFLYITVLTVMGVKRAPNMCASVGIQgIAWAFGgmIFALVYCTAGISG 111
Cdd:PTZ00016  32 KRPPGGQNFwAPREYRPN--VREYVAEFLGTFVLLFFGEGVVATTHTVGNNGDYLAIT-IGWGLG--VTFGLLVSAGISG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785  112 GHINPAVTFGLFLARKLSLTRAVFYMIMQCLGAICGA----GVVKGF---QPTPYQTLGGGANTVAHGYTKGSGLGA--- 181
Cdd:PTZ00016 107 GHLNPAVTLGNAVFGKFPWKKLPGYFVAQLLGAFVGAacvyGLYYGFfkdHGIPELPWETMANGFAGVFATYPREGNfya 186

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 42572785  182 ---EIIGTFVLVYTVFSATDAKRSARDSHVPVWTPLLV 216
Cdd:PTZ00016 187 ifsELILTAILLLVILAITDPNNCPAFNYLPVAVGLLV 224
PLN00184 PLN00184
aquaporin NIP1; Provisional
 37-200 8.83e-09

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 54.26  E-value: 8.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785   37 PAPLFEPGELSSWS--FYRAGIAEFIATFLFLYITVLTVMGVKRAPNmcaSVGIQGIAWAFGGMIFALVYCTAGISGGHI 114
Cdd:PLN00184  37 PKPLKKQDSLLSVSvpFLQKLIAEVLGTYFLVFTGCASVVVNMQNDN---VVTLPGIAIVWGLTIMVLIYSLGHISGAHI 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785  115 NPAVTFGLFLARKLSLTRAVFYMIMQCLGAICGAGVVKGFQPTPYQTLGGGANTVAHGYTKGSGLGA---EIIGTFVLVY 191
Cdd:PLN00184 114 NPAVTIAFASCGRFPLKQVPAYVISQVIGSTLAAATLRLLFGLDHDVCSGKHDVFIGSSPVGSDLQAfvmEFIVTFYLMF 193

                        170
                 ....*....|
gi 42572785  192 TVFS-ATDAK 200
Cdd:PLN00184 194 IISGvATDNR 203
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 56-218 1.34e-07

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 50.68  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785   56 IAEFIATflflYITVLTVMGVKRAPNM-CASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAV 134
Cdd:PLN00182  46 IAEMIGT----YFIIFSGCGVVVVNVLyGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVP 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785  135 FYMIMQCLGAICGAGVVK-GFQPTPYQTLGgganTVAHGyTKGSGLGAEIIGTFVLVYTVFS-ATDAKRSARDSHVPVWT 212
Cdd:PLN00182 122 LYIGAQLTGSLLASLTLRlMFNVTPEAFFG----TTPTD-SSGQALVAEIIISFLLMFVISGvATDSRAVGELAGIAVGM 196


                 ....*.
gi 42572785  213 PLLVPV 218
Cdd:PLN00182 197 TIILNV 202
PLN00026 PLN00026
aquaporin NIP; Provisional
 50-200 5.39e-06

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 46.01  E-value: 5.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785   50 SFYRAGIAEFIATFLFLYITVLTVMGVKRAPNmcaSVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLS 129
Cdd:PLN00026  69 SLTRKLGAEFVGTFILIFAATAGPIVNQKYDG---AETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFP 145

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42572785  130 LTRAVFYMIMQCLGAICGAGVVKG-FQPtpyqTLGGGANTVAHGYtkGSGLGAEIIGTFVLVYTVFS-ATDAK 200
Cdd:PLN00026 146 WKHVPAYIAAQVSASICASFALKGvFHP----FMSGGVTVPSVST--GQAFALEFIITFNLLFVVTAvATDTR 212
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 50-154 2.50e-05

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 43.58  E-value: 2.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785  50 SFYRAGIAEFIATFLFlyitVLTVMGVKRAPNMCASVGiqgiAWAFGGMIFALVYCTAGISGGHINPAVTFG--LFLARK 127
Cdd:COG0580 129 SLGAAFLTEIIGTFVL----VFVILGITDKRAAPGGLA----PLAIGLLVAAIGLSLGPLTGYAINPARDLGprLFHALG 200

                        90       100       110
                ....*....|....*....|....*....|
gi 42572785 128 LS---LTRAVFYMIMQCLGAICGAGVVKGF 154
Cdd:COG0580 201 KGgsdWGYLWVPIVAPILGAALAALLYRAL 230
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 50-148 6.74e-05

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 42.63  E-value: 6.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785  50 SFYRAGIAEFIATFLFlyitVLTVMGVKRAPNMCASVGIQgiAWAFGGMIFALVYCTAGISGGHINPAVTFG--LFLARK 127
Cdd:cd00333 128 SNGNAFFVEFIGTFIL----VLVVFATTDDPNGPPPGGLA--PLAIGLLVAAIGLAGGPITGASMNPARSLGpaLFTGLA 201

                        90       100
                ....*....|....*....|.
gi 42572785 128 LSLTRAVFYMIMQCLGAICGA 148
Cdd:cd00333 202 RHWHYFWVYWVGPLIGAIAGA 222
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 53-145 4.34e-04

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 40.23  E-value: 4.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42572785   53 RAGIAEFIATFLFLYiTVLTVMGVKRApnMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTR 132
Cdd:PLN00183  46 RMVLAEMVGTFILMF-CVCGIIASTQL--SGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSK 122

                         90
                 ....*....|...
gi 42572785  133 AVFYMIMQCLGAI 145
Cdd:PLN00183 123 VPLYITAQTVGSV 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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