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Conserved domains on  [gi|42573758|ref|NP_974975|]
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orange protein [Arabidopsis thaliana]

Protein Classification

DnaJ-like cysteine-rich domain-containing protein( domain architecture ID 230175)

DnaJ-like cysteine-rich domain-containing protein contains four repeats of a CxxCxGxG motif and binds zinc ions; similar to Arabidopsis thaliana chloroplastic protein ORANGE involved in chromoplast differentiation

Gene Ontology:  GO:0008270
PubMed:  8617216

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DnaJ_zf super family cl21539
Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of ...
 207-293 1.06e-06

Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of DnaJ/Hsp40 (heat shock protein 40). DnaJ proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonin family. Hsp40 proteins are characterized by the presence of an N-terminal J domain, which mediates the interaction with Hsp70. This central domain contains four repeats of a CxxCxGxG motif and binds to two Zinc ions. It has been implicated in substrate binding.


The actual alignment was detected with superfamily member PLN03165:

Pssm-ID: 473904 [Multi-domain]  Cd Length: 111  Bit Score: 46.73  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573758  207 AVGV-ISALMVVEVNNVKQQEHKR-CKYCLGTGYLACARCSSTGALVLtepvsAIAGGNHSLSppkteRCSNCSGAGKVM 284
Cdd:PLN03165  19 AVGIgIPVFYETQIDNAAKRENTQpCFPCSGTGAQVCRFCVGSGNVTV-----ELGGGEKEVS-----KCINCDGAGSLT 88


                 ....*....
gi 42573758  285 CPTCLCTGM 293
Cdd:PLN03165  89 CTTCQGSGI 97
 
Name Accession Description Interval E-value
PLN03165 PLN03165
chaperone protein dnaJ-related; Provisional
 207-293 1.06e-06

chaperone protein dnaJ-related; Provisional


Pssm-ID: 178709 [Multi-domain]  Cd Length: 111  Bit Score: 46.73  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573758  207 AVGV-ISALMVVEVNNVKQQEHKR-CKYCLGTGYLACARCSSTGALVLtepvsAIAGGNHSLSppkteRCSNCSGAGKVM 284
Cdd:PLN03165  19 AVGIgIPVFYETQIDNAAKRENTQpCFPCSGTGAQVCRFCVGSGNVTV-----ELGGGEKEVS-----KCINCDGAGSLT 88


                 ....*....
gi 42573758  285 CPTCLCTGM 293
Cdd:PLN03165  89 CTTCQGSGI 97
 
Name Accession Description Interval E-value
PLN03165 PLN03165
chaperone protein dnaJ-related; Provisional
 207-293 1.06e-06

chaperone protein dnaJ-related; Provisional


Pssm-ID: 178709 [Multi-domain]  Cd Length: 111  Bit Score: 46.73  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42573758  207 AVGV-ISALMVVEVNNVKQQEHKR-CKYCLGTGYLACARCSSTGALVLtepvsAIAGGNHSLSppkteRCSNCSGAGKVM 284
Cdd:PLN03165  19 AVGIgIPVFYETQIDNAAKRENTQpCFPCSGTGAQVCRFCVGSGNVTV-----ELGGGEKEVS-----KCINCDGAGSLT 88


                 ....*....
gi 42573758  285 CPTCLCTGM 293
Cdd:PLN03165  89 CTTCQGSGI 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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